Wearable sensors provide a foundation for development of wearable robotic technology to be used in clinical applications. Inertial motion capture (IMC) has emerged as a viable alternative to more cumbersome, non-portable optical methods. Previous work has validated the accuracy of IMC for gait compared to optical motion capture (OMC). However, it is unclear how well IMC can measure the small changes in gait function needed to gauge recovery. In this study, we evaluate the sensitivity of IMC compared to OMC to small changes in gait on a cohort of unimpaired individuals during treadmill walking. Eight individuals walked on a split-belt treadmill in three-minute trials with five randomized conditions: right belt speed decrementing at 0.05 m/s from 1.0 m/s, all with left belt held at 1.0 m/s, simulating recovery of hemiparetic gait. We extracted the root mean square deviation (RMSD) of joint kinematics between limbs and within the limb with modulated gait speed as the main outcome measure. We used linear mixed models to identify differences in sensitivity to changes in gait asymmetry and gait speed. Based on these models, we estimated the minimal detectible interval in gait parameters. We found that IMC was capable of measuring a difference in gait speed of 0.08 m/s, roughly the equivalent of two weeks recovery progress. Statistically we could not conclude a difference of sensitivity between IMC and OMC, although there is a strong trend that IMC is more sensitive to changes in gait. We conclude that IMC is a valid tool to measure progress in gait kinematics over the course of recovery.