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Six new quassinoids from Picrasma chinese P·Y. Chen and their cytotoxicity activity

Fitoterapia. 2024 Sep:177:106094. doi: 10.1016/j.fitote.2024.106094. Epub 2024 Jun 25.

Abstract

In the present study, six new compounds namely, picralactones CH (1-6) along with nine known compounds (7-15) were isolated from the branches and leaves of Picrasma chinese P.Y. Chen. Their structures were determined with the help of spectroscopic techniques such as NMR, HR-ESI-MS, UV, IR and CD. Cytotoxicity of all compounds was evaluated against MDA-MB-231, SW-620 and HepG2 human cancer cell lines. Compound 4 showed cytotoxic activities.

Keywords: Cytotoxicity activity; Picrasma chinese P.Y. Chen; Quassinoids.

MeSH terms

  • Antineoplastic Agents, Phytogenic* / isolation & purification
  • Antineoplastic Agents, Phytogenic* / pharmacology
  • Cell Line, Tumor
  • East Asian People
  • Humans
  • Molecular Structure
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Picrasma* / chemistry
  • Plant Leaves* / chemistry
  • Plant Stems / chemistry
  • Quassins* / chemistry
  • Quassins* / isolation & purification
  • Quassins* / pharmacology

Substances

  • Antineoplastic Agents, Phytogenic
  • Quassins
  • Phytochemicals