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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
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1964 2
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1970 3
1971 1
1973 3
1975 1
1977 2
1978 1
1980 2
1983 1
1987 1
1988 3
1989 2
1990 2
1991 5
1992 2
1993 2
1994 4
1995 4
1996 10
1997 9
1998 11
1999 18
2000 29
2001 42
2002 48
2003 43
2004 50
2005 66
2006 67
2007 74
2008 83
2009 70
2010 88
2011 80
2012 103
2013 84
2014 82
2015 82
2016 86
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2018 106
2019 92
2020 85
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2025 1

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1,912 results

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Page 1
Brominated chalcones as promising antileishmanial agents.
Barreto TSA, Santos TAC, Silva ARST, Costa EV, Pinheiro LA, Fernandes RPM, Scher R, Alves PB. Barreto TSA, et al. Bioorg Med Chem Lett. 2024 Nov 26:130042. doi: 10.1016/j.bmcl.2024.130042. Online ahead of print. Bioorg Med Chem Lett. 2024. PMID: 39608687
In this study, 21 chalcones brominated were synthesized via the Claisen-Schmidt condensation synthesis and characterized by UHRMS and NMR. The biological activity was evaluated for antiprotozoal potential against Leishmania amazonensis and cytotoxicity against L929 fibrobl …
In this study, 21 chalcones brominated were synthesized via the Claisen-Schmidt condensation synthesis and characterized by UHRMS and …
Impact of Transition-State Aromaticity on Selective Radical-Radical Coupling of Triarylimidazolyl Radicals.
Okamoto K, Hatano S, Abe M. Okamoto K, et al. J Am Chem Soc. 2024 Nov 27. doi: 10.1021/jacs.4c14095. Online ahead of print. J Am Chem Soc. 2024. PMID: 39604257
Aromaticity has been reported to have an important effect not only in the reactivity and structure of ground-state molecules but also on the electronically excited states and transition states in pericyclic reactions such as the Diels-Alder reaction and the Cope-Claisen re …
Aromaticity has been reported to have an important effect not only in the reactivity and structure of ground-state molecules but also on the …
Silver-Catalyzed Thio-Claisen Rearrangement of Aryl Sulfoxides with AIBN.
Yang G, Huang H. Yang G, et al. J Org Chem. 2024 Nov 27. doi: 10.1021/acs.joc.4c02548. Online ahead of print. J Org Chem. 2024. PMID: 39602563
In this regard, we report the activator-free Pummerer-type transformation, a silver-catalyzed thio-Claisen rearrangement of aryl sulfoxides with AIBN. Facilitated by silver catalyst, AIBN is transformed into highly reactive ketenimine in situ, which directly captures the s …
In this regard, we report the activator-free Pummerer-type transformation, a silver-catalyzed thio-Claisen rearrangement of aryl sulf …
Bronsted Acid-Catalyzed, Asymmetric Allenoate Claisen Reaction.
Hamilton RE, Berkley EA, Laufer IK, Ruos ME, Smith B, Dahi AN, Gallagher TJ, Justo V, Warner F, Wenzel AG. Hamilton RE, et al. J Org Chem. 2024 Nov 26. doi: 10.1021/acs.joc.4c02062. Online ahead of print. J Org Chem. 2024. PMID: 39589082
An auxiliary-based protocol is described for an asymmetric allenoate Claisen rearrangement. Silicated tosic acid (10 mol %) was used as an inexpensive, user-friendly catalyst. ...
An auxiliary-based protocol is described for an asymmetric allenoate Claisen rearrangement. Silicated tosic acid (10 mol %) was used …
Total synthesis and antibacterial evaluation of lupalbigenin and isolupalbigenin.
Liao L, Wang N, Mei L, Long B, Luo T, Wang MQ, Lu L, Dong HB. Liao L, et al. J Asian Nat Prod Res. 2024 Nov 21:1-12. doi: 10.1080/10286020.2024.2428794. Online ahead of print. J Asian Nat Prod Res. 2024. PMID: 39570290
In this study, we achieved the first gram-scale synthesis of lupalbigenin (1) from commercially available genistein (2), with a yield of 47.7%. The key step was a Claisen rearrangement that simultaneously installed two prenyl groups at the C-6 and C-11 positions of lupalbi …
In this study, we achieved the first gram-scale synthesis of lupalbigenin (1) from commercially available genistein (2), with a yield of 47. …
Design and synthesis of a novel curcumin-combretastatin A4 molecular skeleton: two pharmacophores.
Ponraj P, Rajendran S. Ponraj P, et al. RSC Adv. 2024 Nov 20;14(50):37227-37233. doi: 10.1039/d4ra06618a. eCollection 2024 Nov 19. RSC Adv. 2024. PMID: 39569108 Free PMC article.
The logical design and synthesis of a novel compound combretastatin A-4-integrated curcumin is presented. Claisen condensation of phenylacetone with ethyl acetates formed 1,5-diphenylpentane-2,4-dione. ...
The logical design and synthesis of a novel compound combretastatin A-4-integrated curcumin is presented. Claisen condensation of phe …
Design and Synthesis of Acyclic Boronic Acid Arginase Inhibitors.
Shields JD, Aquila BM, Emmons D, Finlay MRV, Gangl ET, Gu C, Mlynarski SN, Petersen J, Pop-Damkov P, Sha L, Simpson I, Tavakoli S, Tentarelli S, Wang H, Ye Q, Zheng X. Shields JD, et al. J Med Chem. 2024 Nov 14. doi: 10.1021/acs.jmedchem.4c02295. Online ahead of print. J Med Chem. 2024. PMID: 39540340
We began our drug discovery campaign by building off the beta-position of the literature inhibitor ABH (1). A divergent synthesis with an Ireland-Claisen rearrangement as the key step allowed access to numerous compounds, some of which we crystallized in the active site of …
We began our drug discovery campaign by building off the beta-position of the literature inhibitor ABH (1). A divergent synthesis with an Ir …
Synthesis of bis-Chalcones Based on Green Chemistry Strategies and Their Cytotoxicity Toward Human MeWo and A375 Melanoma Cell Lines.
Olender D, Pawełczyk A, Leśków A, Sowa-Kasprzak K, Zaprutko L, Diakowska D. Olender D, et al. Molecules. 2024 Oct 31;29(21):5171. doi: 10.3390/molecules29215171. Molecules. 2024. PMID: 39519811 Free PMC article.
All bis-chalcones were synthesized with terephthalaldehyde and an appropriate aromatic ketone as substrates in Claisen-Schmidt condensation. All the obtained compounds were tested regarding their roles as potential anticancer agents. ...
All bis-chalcones were synthesized with terephthalaldehyde and an appropriate aromatic ketone as substrates in Claisen-Schmidt conden …
Size and shape matter for micellar catalysis using light-responsive azobenzene surfactants.
Blayo C, Jones BE, Bennison MJ, Evans RC. Blayo C, et al. Org Biomol Chem. 2024 Nov 7. doi: 10.1039/d4ob01587h. Online ahead of print. Org Biomol Chem. 2024. PMID: 39509081 Free PMC article.
The micellar catalysis of a model Claisen-Schmidt aldol condensation reaction using heterogeneous nanoreactors based on cationic azobenzene trimethylammonium bromide (AzoTAB) photosurfactants is investigated. ...
The micellar catalysis of a model Claisen-Schmidt aldol condensation reaction using heterogeneous nanoreactors based on cationic azob …
1,912 results