Randomized controlled trials (RCTs) examining the efficacy of different forms of therapy for depr... more Randomized controlled trials (RCTs) examining the efficacy of different forms of therapy for depression are relatively common. However, there are not many RCTs comparing neurocognitive effects of these treatments. Neurocognitive changes across three types of treatment for depression were compared. Long-term psychodynamic psychotherapy (LTPP) was compared with fluoxetine treatment, and their combination, in the treatment of moderate depression. A 272 adult patients with beck depression inventory (BDI) scores 20-35 were randomized to receive LTPP, fluoxetine monotherapy or their combination for a 24 months period. The Wechsler adult intelligence scale version III (WAIS-III) was the primary neuropsychological measure. Multilevel mixed model analyses indicated that there were neurocognitive changes within and between treatments, with statistically significant differences over time (p>.01). LTPP and combined treatment seemed to be more efficacious in modifying specific areas of cognition than fluoxetine alone. Sample very homogenous, threatening external validity. LTPP and its combination with fluoxetine demonstrated to be effective for specific neurocognitive increasing in patients with moderate depression. This study suggests marked differences over time in the neurocognitive effects between the three treatment forms compared. Results found here may be of clinical relevance for building bridges between pharmacotherapy and psychodynamic psychotherapy.
Background Antidepressant medication (ADM) and psychotherapy are effective treatments for major d... more Background Antidepressant medication (ADM) and psychotherapy are effective treatments for major depressive disorder (MDD). It is unclear, however, if treatments differ in their effectiveness at the symptom level and whether symptom information can be utilised to inform treatment allocation. The present study synthesises comparative effectiveness information from randomised controlled trials (RCTs) of ADM versus psychotherapy for MDD at the symptom level and develops and tests the Symptom-Oriented Therapy (SOrT) metric for precision treatment allocation. Methods First, we conducted systematic review and meta-analyses of RCTs comparing ADM and psychotherapy at the individual symptom level. We searched PubMed Medline, PsycINFO, and the Cochrane Central Register of Controlled Trials databases, a database specific for psychotherapy RCTs, and looked for unpublished RCTs. Random-effects meta-analyses were applied on sum-scores and for individual symptoms for the Hamilton Rating Scale for D...
A Scale for the Assessment of Positive Symptoms (SAPS) objetiva avaliar sintomas positivos, como ... more A Scale for the Assessment of Positive Symptoms (SAPS) objetiva avaliar sintomas positivos, como alucinações, delírios, comportamento e pensamento desorganizado em indivíduos com manifestações psicóticas. O presente estudo teve como objetivo traduzir e adaptar culturalmente a escala SAPS para o português brasileiro. A construção do trabalho foi dividida em duas etapas: 1) Tradução e adaptação do instrumento; e 2) Cálculo do índice de validade de conteúdo. Participaram da pesquisa 11 profissionais com experiência na área de saúde mental. Os resultados apontaram níveis de compreensão dos itens da SAPS acima de 81,8%. Referente aos índices de validade de conteúdo, todos os tópicos apresentaram indicadores com medidas entre 0,64 e 1,00, sinalizando níveis adequados. Portanto, pode-se concluir que a escala SAPS está adequada para uso no Brasil, pois apresentou alto grau de concordância entre os avaliadores, e bons índices de validade de conteúdo. Sugerem-se novos estudos que verifiquem o...
Additional file 4: Table S5. Development and considerations of a Symptom-Oriented Therapy (SOrT) ... more Additional file 4: Table S5. Development and considerations of a Symptom-Oriented Therapy (SOrT) metric. Table S5- Hypothetical SOrT Metric Computation for Three Patients.
Additional file 3 Tables S2-S4. Content overlap assessment of Beck Depression Inventory (BDI) and... more Additional file 3 Tables S2-S4. Content overlap assessment of Beck Depression Inventory (BDI) and Hamilton Rating Scale for Depression (HAM-D). Table S2- Content Overlap of HAM-D and BDI-II Items Sorted by Item Numbering. Table S3- Content Overlap of HAM-D and BDI-II Items Sorted by Equivalent Items. Table S4- Content Overlap of BDI-I and BDI-II Items Sorted by Item Numbering.
Additional file 11: Tables S19-S20. Overview of available data and materials from original studie... more Additional file 11: Tables S19-S20. Overview of available data and materials from original studies and presented work. Table S19 Availability of Original Study Data. Table S20. Online File Overview as Available on https://osf.io/qzjc9/.
Additional file 10. Discussion on nominally significant treatment differences of psychotherapy an... more Additional file 10. Discussion on nominally significant treatment differences of psychotherapy and ADM for specific depressive symptoms.
The aim of this paper was to investigate the concept of resilience by studying texts published in... more The aim of this paper was to investigate the concept of resilience by studying texts published in the field of psychoanalysis (over a ten-year period). Through a systematic review of articles published between 2004 and 2014, using descriptors in Portuguese, Spanish and English. Five data bases were searched, namely Pubmed, Lilacs, Scielo, BVS Index Psi and PsycInfo. We gathered 280 published items, including articles, papers, reviews and other types of material. After exclusion criteria, 11 articles were selected for analysis. The majority of the analysed articles were theoretical reviews. The concept of resilience in Psychoanalysis tends to be related to other concepts (e.g. trauma and violence). By itself it indicates an ability that was built fundamentally in through relationships: between subjects, and between subjects and their environments. The studies agree on the notion of resilience as a process that goes beyond simple adaptation. It is in fact an ability to survive, relate...
Randomized controlled trials (RCTs) examining the efficacy of different forms of therapy for depr... more Randomized controlled trials (RCTs) examining the efficacy of different forms of therapy for depression are relatively common. However, there are not many RCTs comparing neurocognitive effects of these treatments. Neurocognitive changes across three types of treatment for depression were compared. Long-term psychodynamic psychotherapy (LTPP) was compared with fluoxetine treatment, and their combination, in the treatment of moderate depression. A 272 adult patients with beck depression inventory (BDI) scores 20-35 were randomized to receive LTPP, fluoxetine monotherapy or their combination for a 24 months period. The Wechsler adult intelligence scale version III (WAIS-III) was the primary neuropsychological measure. Multilevel mixed model analyses indicated that there were neurocognitive changes within and between treatments, with statistically significant differences over time (p>.01). LTPP and combined treatment seemed to be more efficacious in modifying specific areas of cognition than fluoxetine alone. Sample very homogenous, threatening external validity. LTPP and its combination with fluoxetine demonstrated to be effective for specific neurocognitive increasing in patients with moderate depression. This study suggests marked differences over time in the neurocognitive effects between the three treatment forms compared. Results found here may be of clinical relevance for building bridges between pharmacotherapy and psychodynamic psychotherapy.
Background Antidepressant medication (ADM) and psychotherapy are effective treatments for major d... more Background Antidepressant medication (ADM) and psychotherapy are effective treatments for major depressive disorder (MDD). It is unclear, however, if treatments differ in their effectiveness at the symptom level and whether symptom information can be utilised to inform treatment allocation. The present study synthesises comparative effectiveness information from randomised controlled trials (RCTs) of ADM versus psychotherapy for MDD at the symptom level and develops and tests the Symptom-Oriented Therapy (SOrT) metric for precision treatment allocation. Methods First, we conducted systematic review and meta-analyses of RCTs comparing ADM and psychotherapy at the individual symptom level. We searched PubMed Medline, PsycINFO, and the Cochrane Central Register of Controlled Trials databases, a database specific for psychotherapy RCTs, and looked for unpublished RCTs. Random-effects meta-analyses were applied on sum-scores and for individual symptoms for the Hamilton Rating Scale for D...
A Scale for the Assessment of Positive Symptoms (SAPS) objetiva avaliar sintomas positivos, como ... more A Scale for the Assessment of Positive Symptoms (SAPS) objetiva avaliar sintomas positivos, como alucinações, delírios, comportamento e pensamento desorganizado em indivíduos com manifestações psicóticas. O presente estudo teve como objetivo traduzir e adaptar culturalmente a escala SAPS para o português brasileiro. A construção do trabalho foi dividida em duas etapas: 1) Tradução e adaptação do instrumento; e 2) Cálculo do índice de validade de conteúdo. Participaram da pesquisa 11 profissionais com experiência na área de saúde mental. Os resultados apontaram níveis de compreensão dos itens da SAPS acima de 81,8%. Referente aos índices de validade de conteúdo, todos os tópicos apresentaram indicadores com medidas entre 0,64 e 1,00, sinalizando níveis adequados. Portanto, pode-se concluir que a escala SAPS está adequada para uso no Brasil, pois apresentou alto grau de concordância entre os avaliadores, e bons índices de validade de conteúdo. Sugerem-se novos estudos que verifiquem o...
Additional file 4: Table S5. Development and considerations of a Symptom-Oriented Therapy (SOrT) ... more Additional file 4: Table S5. Development and considerations of a Symptom-Oriented Therapy (SOrT) metric. Table S5- Hypothetical SOrT Metric Computation for Three Patients.
Additional file 3 Tables S2-S4. Content overlap assessment of Beck Depression Inventory (BDI) and... more Additional file 3 Tables S2-S4. Content overlap assessment of Beck Depression Inventory (BDI) and Hamilton Rating Scale for Depression (HAM-D). Table S2- Content Overlap of HAM-D and BDI-II Items Sorted by Item Numbering. Table S3- Content Overlap of HAM-D and BDI-II Items Sorted by Equivalent Items. Table S4- Content Overlap of BDI-I and BDI-II Items Sorted by Item Numbering.
Additional file 11: Tables S19-S20. Overview of available data and materials from original studie... more Additional file 11: Tables S19-S20. Overview of available data and materials from original studies and presented work. Table S19 Availability of Original Study Data. Table S20. Online File Overview as Available on https://osf.io/qzjc9/.
Additional file 10. Discussion on nominally significant treatment differences of psychotherapy an... more Additional file 10. Discussion on nominally significant treatment differences of psychotherapy and ADM for specific depressive symptoms.
The aim of this paper was to investigate the concept of resilience by studying texts published in... more The aim of this paper was to investigate the concept of resilience by studying texts published in the field of psychoanalysis (over a ten-year period). Through a systematic review of articles published between 2004 and 2014, using descriptors in Portuguese, Spanish and English. Five data bases were searched, namely Pubmed, Lilacs, Scielo, BVS Index Psi and PsycInfo. We gathered 280 published items, including articles, papers, reviews and other types of material. After exclusion criteria, 11 articles were selected for analysis. The majority of the analysed articles were theoretical reviews. The concept of resilience in Psychoanalysis tends to be related to other concepts (e.g. trauma and violence). By itself it indicates an ability that was built fundamentally in through relationships: between subjects, and between subjects and their environments. The studies agree on the notion of resilience as a process that goes beyond simple adaptation. It is in fact an ability to survive, relate...
Uploads
Papers by Andre Bastos