... OF TWO DIFFERENT THERAPIES FOR SPUTUM POSITIVE FOR TUBERCULOSIS WITH DOT'S STRATEGY ... more ... OF TWO DIFFERENT THERAPIES FOR SPUTUM POSITIVE FOR TUBERCULOSIS WITH DOT'S STRATEGY ATAEI B.,LABAF GHASEMI R.,JAVADI ... study was conducted to compare the two different regimens following Dot's Strategy in terms of their efficacy, side effects and ...
Introduction: long-term hemodialysis and kidney transplantation are the most common treatment for... more Introduction: long-term hemodialysis and kidney transplantation are the most common treatment for kidney failure. Regarding the increasing demand of these patients to receive therapeutic services, cost-effectiveness of these methods are compared. Method:This Cross - Sectional research was done to compare cost - effectiveness of long - term hemodialysis and kidney transplantation using Delphi index and patients' medical records. Research population are Kidney patients referring to Shahid Hasherminejad Hospital in 1378. Finding: In this survey expenses of 1378 were tallied. Findings show that kidney transplantation expenses were 38% and 18.5% of long-term hemodialysis for male and female patients, respectively. In Delphi Scale, effectiveness of kidney hausplautation was 7 times more than long-term hemodialysis. In summation, cost-effectiveness of kidney Hausplantation is 8 times more than hemodialysis. Conclusion: Long-term dialysis average expenses are four times more than kidney transplantation index of effectiveness in kidney transplantation method was more than long-term dialysis up-to the age 54 in the research population.Cost-effectiveaess of kidney transplantation method in different age groups is 3-14 times more than long-term dialysis.
In recent years, nanotechnology has improved life with continuous growth in different fields. Nan... more In recent years, nanotechnology has improved life with continuous growth in different fields. Nanoparticles can be employed in industry, imaging, engineering, and various biomedical filed because of their special physicochemical properties like rapid, effective, highly specific solutions, higher stability, biodegradability, biocompatibility, and cost. In this line, veterinary medicine has been influenced by nanotechnology in prevention, diagnosis, and treatment of diseases, cancer therapy, immunization, vaccine production, drug delivery, and health besides to related issues of animal production, maintenance, and welfare. The other important point is the interwoven linkage between animals and humans whether as a food source or as a companionship. Inorganic nanoparticles, polymeric, solid lipid, liposomal, nanocrystal, nanotubes, nanoemulsions, micelles, mesoporous silica nanoparticles, and dendrimers are kinds of nanoparticles that can be used widely. In this review, the impacts of n...
The worthwhile intellectual synthesis proposing that nothing makes sense except in light of conte... more The worthwhile intellectual synthesis proposing that nothing makes sense except in light of context has also revolutionized pharmaceutical science putting patients’ genomic context at the center of attention in a rapidly developing area known as pharmacogenomics. As a result, an alternative approach to medicine referred to as personalized medicine was born considering the individual-specific genomic context the hardcore of any diagnostic, prognostic, and therapeutic intervention. Therefore, a considerable need has been created to address questions based on the underlying genotypic characteristics of patients. Depressive spectrum disorders are a cluster of closely-linked psychiatric disorders with a growing incidence rate across the world. Although there are multiple therapeutic approaches to treating depressive spectrum disorders, pharmacotherapy is still considered one of the most effective strategies. Among the therapeutic antidepressant drugs, selective serotonin reuptake inhibit...
Cannabis sativa L. Cannabaceae, used for psychoactive rituals in Mesopotamia. Here, we investigat... more Cannabis sativa L. Cannabaceae, used for psychoactive rituals in Mesopotamia. Here, we investigated in vitro inhibitory activity of methyl alcohol extract derived from leaves and resin of cannabis against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Moreover, the binding affinity (BA; kcal/mol) of selected phytochemicals of cannabis to AChE and BChE has been predicted in silico. Phytochemicals of cannabis had acceptable BA towards AChE ranging from – 6.4 (beta-pinene) to – 11.4 (campesterol) and BChE ranging from – 5.5 (alpha-pinene) to – 9.8 (cannabioxepane). All cannabinoids, flavonoids (apigenin), terpenes, and phytosterols of cannabis were double inhibitors due they utilized hydrogen bonds and hydrophobically interacted with both catalytic triad and peripheral anionic site (PAS) of AChE and BChE. Campesterol is phytosterol docked with AChE and BChE via hydrogen bond and it will be a lead-like molecule for further drug design. Delta-9-Tetrahydrocannabinolic acid has been docked with AChE and BChE and it can be a candidate molecule for further drug design. To sum up, this study not only approved cholinesterase inhibitory effects of cannabis but also suggested an array of phytocompounds as hit small molecules for discovery or design of ecofriendly botanical antiinsectants or phytonootropic drugs.
Universal Journal of Pharmaceutical Research, 2022
Aim and objective: Vanillin-rich drink (Vimto®) is a popular drink among women. The aim of this s... more Aim and objective: Vanillin-rich drink (Vimto®) is a popular drink among women. The aim of this study was to evaluate anti-breast cancer potential of Vimto®. Methods: the chemical composition of Vimto® has been determined by gas chromatography and foodinformatics used to identify its putative binders to canonical targets of breast cancer. The binding affinity (kcal/mol) of the target proteins of breast cancer and the phytocompounds was computationally obtained. Results: Major aliphatic hydrocarbons of Vimto® were hydroxymethyl furfurole, tetradecane, hexadecane, dodecane, octadecane and 9-octadecenamide while aromatic hydrocarbons were vanillin, benzoic acid, diisooctyl phthalate, butanoic acid, piperonal, bis (2-ethylhexyl) phthalate, and germacrene D. 9-octadecenamidebound firmly to HER2 (human epidermal growth factor receptor 2) and warrant experimental studies. All aromatic hydrocarbons expect benzoic acid and vanillin showed reliable BA with HER2. Germacrene D showed acceptable...
Aging men experience a decline in the concentration of androgens specially testosterone. This dec... more Aging men experience a decline in the concentration of androgens specially testosterone. This decline could cause oxidative stress which potentially leads to immunosenescence. Coenzyme Q10 (CoQ10) could have beneficial effects on immunosenescence incidence in aging men. To investigate whether testosterone deficiency alters total antioxidant capacity (TAC) of plasma after orchidectomy and could exogenous CoQ10 affect these alterations, we supplemented andropause mouse with three different levels of dietary CoQ10 and evaluated the TAC of plasma. 36 adult male mice were assigned to six groups, namely normal control (NC) group receiving normal chow diet, normal mice receiving 125 mg/kg/day of CoQ10 (C125), bilateral orchidectomized (BOX) group receiving normal chow diet, and three other orchidectomized groups, namely BOX 125, 250 & 500 groups receiving 125, 250, and 500 mg/kg/day of CoQ10 mixed with normal chow diet. After 96 days, blood samples were collected and the plasma was kept on...
Iranian Journal of Pharmacology and Therapeutics, 2017
Baluchi's formulation is an herbal blend including Date, Almond, Cinnamon, and Pumpkinseed, w... more Baluchi's formulation is an herbal blend including Date, Almond, Cinnamon, and Pumpkinseed, which have the Powerful antioxidant role and stimulate the brain to produce neurotransmitters. Cholinergic system plays an important role in learning and memory. Prescribing Baluchi's formulation is effective in animal cognitive behavior. The aim of this study was to evaluate the effects of antidepressant By Baluchi's formulation compound on decreased memory due to scopolamine in mice by relying on behavioral tests. It has also been observed that anticholinergic medicines such as scopolamine may cause disorder in the consolidation process in the memory of human beings and animals. So 40 Albino mice (25-30 g) were divided into five groups (+ & controls and three treatments). During seven consecutive days, the mice received Baluchi's formulation (1, 2, 4 g/kg oral) thirty minutes before scopolamine (1mg/kg i.p.). At the same time, spatial memory and depression parameters were me...
... OF TWO DIFFERENT THERAPIES FOR SPUTUM POSITIVE FOR TUBERCULOSIS WITH DOT'S STRATEGY ... more ... OF TWO DIFFERENT THERAPIES FOR SPUTUM POSITIVE FOR TUBERCULOSIS WITH DOT'S STRATEGY ATAEI B.,LABAF GHASEMI R.,JAVADI ... study was conducted to compare the two different regimens following Dot's Strategy in terms of their efficacy, side effects and ...
Introduction: long-term hemodialysis and kidney transplantation are the most common treatment for... more Introduction: long-term hemodialysis and kidney transplantation are the most common treatment for kidney failure. Regarding the increasing demand of these patients to receive therapeutic services, cost-effectiveness of these methods are compared. Method:This Cross - Sectional research was done to compare cost - effectiveness of long - term hemodialysis and kidney transplantation using Delphi index and patients' medical records. Research population are Kidney patients referring to Shahid Hasherminejad Hospital in 1378. Finding: In this survey expenses of 1378 were tallied. Findings show that kidney transplantation expenses were 38% and 18.5% of long-term hemodialysis for male and female patients, respectively. In Delphi Scale, effectiveness of kidney hausplautation was 7 times more than long-term hemodialysis. In summation, cost-effectiveness of kidney Hausplantation is 8 times more than hemodialysis. Conclusion: Long-term dialysis average expenses are four times more than kidney transplantation index of effectiveness in kidney transplantation method was more than long-term dialysis up-to the age 54 in the research population.Cost-effectiveaess of kidney transplantation method in different age groups is 3-14 times more than long-term dialysis.
In recent years, nanotechnology has improved life with continuous growth in different fields. Nan... more In recent years, nanotechnology has improved life with continuous growth in different fields. Nanoparticles can be employed in industry, imaging, engineering, and various biomedical filed because of their special physicochemical properties like rapid, effective, highly specific solutions, higher stability, biodegradability, biocompatibility, and cost. In this line, veterinary medicine has been influenced by nanotechnology in prevention, diagnosis, and treatment of diseases, cancer therapy, immunization, vaccine production, drug delivery, and health besides to related issues of animal production, maintenance, and welfare. The other important point is the interwoven linkage between animals and humans whether as a food source or as a companionship. Inorganic nanoparticles, polymeric, solid lipid, liposomal, nanocrystal, nanotubes, nanoemulsions, micelles, mesoporous silica nanoparticles, and dendrimers are kinds of nanoparticles that can be used widely. In this review, the impacts of n...
The worthwhile intellectual synthesis proposing that nothing makes sense except in light of conte... more The worthwhile intellectual synthesis proposing that nothing makes sense except in light of context has also revolutionized pharmaceutical science putting patients’ genomic context at the center of attention in a rapidly developing area known as pharmacogenomics. As a result, an alternative approach to medicine referred to as personalized medicine was born considering the individual-specific genomic context the hardcore of any diagnostic, prognostic, and therapeutic intervention. Therefore, a considerable need has been created to address questions based on the underlying genotypic characteristics of patients. Depressive spectrum disorders are a cluster of closely-linked psychiatric disorders with a growing incidence rate across the world. Although there are multiple therapeutic approaches to treating depressive spectrum disorders, pharmacotherapy is still considered one of the most effective strategies. Among the therapeutic antidepressant drugs, selective serotonin reuptake inhibit...
Cannabis sativa L. Cannabaceae, used for psychoactive rituals in Mesopotamia. Here, we investigat... more Cannabis sativa L. Cannabaceae, used for psychoactive rituals in Mesopotamia. Here, we investigated in vitro inhibitory activity of methyl alcohol extract derived from leaves and resin of cannabis against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Moreover, the binding affinity (BA; kcal/mol) of selected phytochemicals of cannabis to AChE and BChE has been predicted in silico. Phytochemicals of cannabis had acceptable BA towards AChE ranging from – 6.4 (beta-pinene) to – 11.4 (campesterol) and BChE ranging from – 5.5 (alpha-pinene) to – 9.8 (cannabioxepane). All cannabinoids, flavonoids (apigenin), terpenes, and phytosterols of cannabis were double inhibitors due they utilized hydrogen bonds and hydrophobically interacted with both catalytic triad and peripheral anionic site (PAS) of AChE and BChE. Campesterol is phytosterol docked with AChE and BChE via hydrogen bond and it will be a lead-like molecule for further drug design. Delta-9-Tetrahydrocannabinolic acid has been docked with AChE and BChE and it can be a candidate molecule for further drug design. To sum up, this study not only approved cholinesterase inhibitory effects of cannabis but also suggested an array of phytocompounds as hit small molecules for discovery or design of ecofriendly botanical antiinsectants or phytonootropic drugs.
Universal Journal of Pharmaceutical Research, 2022
Aim and objective: Vanillin-rich drink (Vimto®) is a popular drink among women. The aim of this s... more Aim and objective: Vanillin-rich drink (Vimto®) is a popular drink among women. The aim of this study was to evaluate anti-breast cancer potential of Vimto®. Methods: the chemical composition of Vimto® has been determined by gas chromatography and foodinformatics used to identify its putative binders to canonical targets of breast cancer. The binding affinity (kcal/mol) of the target proteins of breast cancer and the phytocompounds was computationally obtained. Results: Major aliphatic hydrocarbons of Vimto® were hydroxymethyl furfurole, tetradecane, hexadecane, dodecane, octadecane and 9-octadecenamide while aromatic hydrocarbons were vanillin, benzoic acid, diisooctyl phthalate, butanoic acid, piperonal, bis (2-ethylhexyl) phthalate, and germacrene D. 9-octadecenamidebound firmly to HER2 (human epidermal growth factor receptor 2) and warrant experimental studies. All aromatic hydrocarbons expect benzoic acid and vanillin showed reliable BA with HER2. Germacrene D showed acceptable...
Aging men experience a decline in the concentration of androgens specially testosterone. This dec... more Aging men experience a decline in the concentration of androgens specially testosterone. This decline could cause oxidative stress which potentially leads to immunosenescence. Coenzyme Q10 (CoQ10) could have beneficial effects on immunosenescence incidence in aging men. To investigate whether testosterone deficiency alters total antioxidant capacity (TAC) of plasma after orchidectomy and could exogenous CoQ10 affect these alterations, we supplemented andropause mouse with three different levels of dietary CoQ10 and evaluated the TAC of plasma. 36 adult male mice were assigned to six groups, namely normal control (NC) group receiving normal chow diet, normal mice receiving 125 mg/kg/day of CoQ10 (C125), bilateral orchidectomized (BOX) group receiving normal chow diet, and three other orchidectomized groups, namely BOX 125, 250 & 500 groups receiving 125, 250, and 500 mg/kg/day of CoQ10 mixed with normal chow diet. After 96 days, blood samples were collected and the plasma was kept on...
Iranian Journal of Pharmacology and Therapeutics, 2017
Baluchi's formulation is an herbal blend including Date, Almond, Cinnamon, and Pumpkinseed, w... more Baluchi's formulation is an herbal blend including Date, Almond, Cinnamon, and Pumpkinseed, which have the Powerful antioxidant role and stimulate the brain to produce neurotransmitters. Cholinergic system plays an important role in learning and memory. Prescribing Baluchi's formulation is effective in animal cognitive behavior. The aim of this study was to evaluate the effects of antidepressant By Baluchi's formulation compound on decreased memory due to scopolamine in mice by relying on behavioral tests. It has also been observed that anticholinergic medicines such as scopolamine may cause disorder in the consolidation process in the memory of human beings and animals. So 40 Albino mice (25-30 g) were divided into five groups (+ & controls and three treatments). During seven consecutive days, the mice received Baluchi's formulation (1, 2, 4 g/kg oral) thirty minutes before scopolamine (1mg/kg i.p.). At the same time, spatial memory and depression parameters were me...
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