Background Remdesivir, a nucleotide analogue prodrug that inhibits viral RNA polymerases,
has shown in vitro activity against SARS-CoV-2. Methods We provided remdesivir on a …

Background Remdesivir is an RNA polymerase inhibitor with potent antiviral activity in vitro
and efficacy in animal models of coronavirus disease 2019 (Covid-19). Methods We …

Importance Remdesivir demonstrated clinical benefit in a placebo-controlled trial in patients
with severe coronavirus disease 2019 (COVID-19), but its effect in patients with moderate …

Group B adenoviruses, a subgenus of human Adenoviridae, are associated with a variety of
often-fatal illnesses in immunocompromised individuals, including bone marrow transplant …

Cyclic nucleotide–gated ion channels in olfactory sensory neurons (OSNs) are hypothesized
to play a critical role in olfaction. However, it has not been demonstrated that the cAMP …

Background The novel prodrug tenofovir alafenamide delivers the nucleotide reverse
transcriptase inhibitor tenofovir to target cells more efficiently at a lower dose than tenofovir …

Adenoviruses (Ad) are efficient vehicles for gene delivery in vitro and in vivo. Therefore,
they are a promising tool in gene therapy, particularly in the treatment of cancer and …

Background Tenofovir alafenamide is a novel prodrug formulated to deliver the active
metabolite to target cells more efficiently than tenofovir disoproxil fumarate at a lower dose, …

Background & Aims Tenofovir alafenamide (TAF) is a new prodrug of tenofovir developed to
treat patients with chronic hepatitis B virus (HBV) infection at a lower dose than tenofovir …

Importance Treatment of hepatitis C virus (HCV) infection in patients also infected with human
immunodeficiency virus (HIV) has been limited due to drug interactions with antiretroviral …