The abundance of a transcript is determined by its rate of synthesis and its rate of degradation;
however, global methods for quantifying RNA abundance cannot distinguish variation in …

Degradation of mRNA contributes to variation in transcript abundance. Studies of individual
mRNAs have shown that both cis and trans factors affect mRNA degradation rates. However, …

Cell growth rate is regulated in response to the abundance and molecular form of essential
nutrients. In Saccharomyces cerevisiae (budding yeast), the molecular form of environmental …

Background Dynamic transcriptional regulation is critical for an organism’s response to
environmental signals and yet remains elusive to capture. Such transcriptional regulation is …

Coordination of neocortical oscillations has been hypothesized to underlie the “binding”
essential to cognitive function. However, the mechanisms that generate neocortical oscillations …

Corticospinal neurons (SPI), thick-tufted pyramidal neurons in motor cortex layer 5B that
project caudally via the medullary pyramids, display distinct class-specific electrophysiological …

Electrophysiological oscillations in the brain have been shown to occur as multicycle events,
with onset and offset dependent on behavioral and cognitive state. To provide a baseline …

A large number of physiomic pathologies can produce hyperexcitability in cortex. Depending
on severity, cortical hyperexcitability may manifest clinically as a hyperkinetic movement …

A fundamental assumption, common to the vast majority of high-throughput transcriptome
analyses, is that the expression of most genes is unchanged among samples and that total …

Technological advances in electrode construction and digital signal processing now allow
recording simultaneous extracellular action potential discharges from many single neurons, …