User profiles for David E. Kozono
 | David KozonoVerified email at lroc.harvard.edu Cited by 8742 |
Association of left anterior descending coronary artery radiation dose with major adverse cardiac events and mortality in patients with non–small cell lung cancer
Importance Radiotherapy accelerates coronary heart disease (CHD), but the dose to critical
cardiac substructures has not been systematically studied in lung cancer. Objective To …
cardiac substructures has not been systematically studied in lung cancer. Objective To …
Cardiac radiation dose, cardiac disease, and mortality in patients with lung cancer
Background : Radiotherapy-associated cardiac toxicity studies in patients with locally
advanced non–small cell lung cancer (NSCLC) have been limited by small sample size and …
advanced non–small cell lung cancer (NSCLC) have been limited by small sample size and …
Definitive primary therapy in patients presenting with oligometastatic non-small cell lung cancer
Purpose Although palliative chemotherapy is the standard of care for patients with diagnoses
of stage IV non-small cell lung cancer (NSCLC), patients with a small metastatic burden, “…
of stage IV non-small cell lung cancer (NSCLC), patients with a small metastatic burden, “…
TGF-β inhibition rescues hematopoietic stem cell defects and bone marrow failure in Fanconi anemia
H Zhang, DE Kozono, KW O'Connor, S Vidal-Cardenas… - Cell stem cell, 2016 - cell.com
Fanconi anemia (FA) is an inherited DNA repair disorder characterized by progressive bone
marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition. A …
marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition. A …
Clinical validation of deep learning algorithms for radiotherapy targeting of non-small-cell lung cancer: an observational study
Background Artificial intelligence (AI) and deep learning have shown great potential in
streamlining clinical tasks. However, most studies remain confined to in silico validation in small …
streamlining clinical tasks. However, most studies remain confined to in silico validation in small …
Necroptosis is a novel mechanism of radiation-induced cell death in anaplastic thyroid and adrenocortical cancers
BACKGROUND: Necroptosis is a recently described mechanism of programmed cellular
death. We hypothesize that necroptosis plays an important role in radiation-induced cell death …
death. We hypothesize that necroptosis plays an important role in radiation-induced cell death …
Aggressive therapy for patients with non-small cell lung carcinoma and synchronous brain-only oligometastatic disease is associated with long-term survival
Objectives Optimal therapy for patients with non-small cell lung carcinoma (NSCLC) presenting
with synchronous brain-only oligometastases (SBO) is not well defined. We sought to …
with synchronous brain-only oligometastases (SBO) is not well defined. We sought to …
Cutaneous radiation-associated angiosarcoma of the breast: poor prognosis in a rare secondary malignancy
EA Morgan, DE Kozono, Q Wang, CM Mery… - Annals of surgical …, 2012 - Springer
Background Cutaneous radiation-associated angiosarcoma of the breast (CRAASBr) is a
rare complication of radiation therapy (RT) administered for primary breast cancer treatment. …
rare complication of radiation therapy (RT) administered for primary breast cancer treatment. …
[HTML][HTML] Updated patterns of failure after multimodality therapy for malignant pleural mesothelioma
Objective We have previously described patterns of failure after extrapleural pneumonectomy
and multimodality therapy for malignant pleural mesothelioma and sought to update our …
and multimodality therapy for malignant pleural mesothelioma and sought to update our …
[HTML][HTML] Mean heart dose is an inadequate surrogate for left anterior descending coronary artery dose and the risk of major adverse cardiac events in lung cancer …
Purpose Mean heart dose (MHD) over 10 Gy and left anterior descending (LAD) coronary
artery volume (V) receiving 15 Gy (V15Gy) greater than 10% can significantly increase the risk …
artery volume (V) receiving 15 Gy (V15Gy) greater than 10% can significantly increase the risk …