Autophagy is a process of degradation of macromolecules in the cytoplasm, particularly
proteins of a long half-life, as well as whole organelles, in eukaryotic cells. Lysosomes play …

Alzheimer's disease is one of severe neurological diseases for which no effective treatment
is currently available. The use of genistein (5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-…

Phage display technology, which is based on the presentation of peptide sequences on the
surface of bacteriophage virions, was developed over 30 years ago. Improvements in phage …

Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure. …

Huntington disease (HD) is a neurodegenerative disorder caused by a mutation in the HTT
gene. The expansion of CAG triplets leads to the appearance of misfolded HTT (huntingtin) …

The phage display technology is based on the presentation of peptide sequences on the
surface of virions of bacteriophages. Its development led to creation of sophisticated systems …

Huntington’s disease (HD) is a monogenic disorder, caused by mutations in the HTT gene
which result in expansion of CAG triplets. The product of the mutated gene is misfolded …

Enrofloxacin is a compound that originates from a group of fluoroquinolones that is widely
used in veterinary medicine as an antibacterial agent (this antibiotic is not approved for use as …

In this study, we have asked whether proteasome composition and function are affected in
cells derived from patients suffering from all types of mucopolysaccharidosis (MPS), an …

The oxytocin receptor (OXTR), encoded by the OXTR gene, is responsible for the signal
transduction after binding its ligand, oxytocin. Although this signaling is primarily involved in …