Inactivation is the process by which an open channel enters a stable nonconducting
conformation after a depolarizing change in membrane potential. Inactivation is a widespread …

We have developed a mathematical model of the mouse ventricular myocyte action potential
(AP) from voltage-clamp data of the underlying currents and Ca 2+ transients. Wherever …

The human ether à-go-go-related gene (HERG) encodes a K+ channel that is believed to
be the basis of the delayed rectified current, IKr, in cardiac muscle. We studied HERG …

Toxoplasma gondii is a protozoan pathogen in the phylum Apicomplexa that resides within
an intracellular parasitophorous vacuole (PV) that is selectively permeable to small …

Autism and autism spectrum disorder (ASD) typically arise from a mixture of environmental
influences and multiple genetic alterations. In some rare cases, such as Timothy syndrome (…

Aims Familial hypertrophic cardiomyopathy (HCM) is one the most common heart disorders,
with gene mutations in the cardiac sarcomere. Studying HCM with patient-specific induced …

1. A fast inactivating transient K+ current (FK1) cloned from ferret ventricle and expressed in
Xenopus oocytes was studied using the two‐electrode voltage clamp technique. Removal of …

The biophysical characteristics and α subunits underlying calcium-independent transient
outward potassium current (I to ) phenotypes expressed in ferret left ventricular epicardial (LV …

Background Human-induced pluripotent stem cell (h-iPSC)–derived cardiac myocytes are a
unique model in which human myocyte function and dysfunction are studied, especially …

Voltage-gated potassium channel β subunits are cytoplasmic proteins that co-purify with the
pore-forming α subunits. One of these subunits, Kvβ1 from rat brain, was previously …