CutFEM forward modeling for EEG source analysis

T Erdbrügger, A Westhoff, M Höltershinken… - Frontiers in Human …, 2023 - frontiersin.org
T Erdbrügger, A Westhoff, M Höltershinken, JO Radecke, Y Buschermöhle, A Buyx, F Wallois
Frontiers in Human Neuroscience, 2023frontiersin.org
Introduction Source analysis of Electroencephalography (EEG) data requires the
computation of the scalp potential induced by current sources in the brain. This so-called
EEG forward problem is based on an accurate estimation of the volume conduction effects in
the human head, represented by a partial differential equation which can be solved using
the finite element method (FEM). FEM offers flexibility when modeling anisotropic tissue
conductivities but requires a volumetric discretization, a mesh, of the head domain …
Introduction
Source analysis of Electroencephalography (EEG) data requires the computation of the scalp potential induced by current sources in the brain. This so-called EEG forward problem is based on an accurate estimation of the volume conduction effects in the human head, represented by a partial differential equation which can be solved using the finite element method (FEM). FEM offers flexibility when modeling anisotropic tissue conductivities but requires a volumetric discretization, a mesh, of the head domain. Structured hexahedral meshes are easy to create in an automatic fashion, while tetrahedral meshes are better suited to model curved geometries. Tetrahedral meshes, thus, offer better accuracy but are more difficult to create.
Methods
We introduce CutFEM for EEG forward simulations to integrate the strengths of hexahedra and tetrahedra. It belongs to the family of unfitted finite element methods, decoupling mesh and geometry representation. Following a description of the method, we will employ CutFEM in both controlled spherical scenarios and the reconstruction of somatosensory-evoked potentials.
Results
CutFEM outperforms competing FEM approaches with regard to numerical accuracy, memory consumption, and computational speed while being able to mesh arbitrarily touching compartments.
Discussion
CutFEM balances numerical accuracy, computational efficiency, and a smooth approximation of complex geometries that has previously not been available in FEM-based EEG forward modeling.
Frontiers