The performance of high-temperature components of aero-engines under the Creep-Fatigue Interaction (CFI) behavior gets more attention recently. In this research, the creep-fatigue tests of two superalloys of Powder Metallurgy (PM) FGH96 and direct aging GH4169 were performed at 650 °C with different types of dwell, and the fracture morphology of FGH96 specimens was observed by Scanning Electron Microscopy (SEM) to analyze the creep-fatigue fracture feature and crack initiation. Additionally, according to phenomenology, the effect of dwell was introduced to develop a new uniaxial fatigue life prediction model based on the total strain equation, which has capability to take dwell time and load ratio into account together. The equations were utilized to model the test data of PM FGH96 and GH4169, together with data of another superalloy PM FGH95 conducted previously. A prominent prediction ability of the model in creep-fatigue life prediction of different superalloys has been manifested. Most data points of test data and estimated data are located within two times scatter band, which is ideal in engineering.