Deoxynivalenol induces toxic effects in the ovaries of pigs: an ex vivo approach
JR Gerez, SS Desto, APFRL Bracarense - Theriogenology, 2017 - Elsevier
Deoxynivalenol (DON) is a frequently found trichothecene mycotoxin that elicits toxic effects
on humans and animals. In pigs, DON induces changes in digestive and immune systems.
Effects on the reproductive system are scarce and mainly based in in vitro models. The aim
of this study was to evaluate, using an ex vivo model, the effects of DON on the morphology
of ovaries of pigs in all stages of follicular development. Six 5-month-old pigs were used for
sampling the explants. Thirty-six explants were incubated for 48 hours in culture medium (n …
on humans and animals. In pigs, DON induces changes in digestive and immune systems.
Effects on the reproductive system are scarce and mainly based in in vitro models. The aim
of this study was to evaluate, using an ex vivo model, the effects of DON on the morphology
of ovaries of pigs in all stages of follicular development. Six 5-month-old pigs were used for
sampling the explants. Thirty-six explants were incubated for 48 hours in culture medium (n …