Electroosmotically induced hydraulic pumping on microchips: differential ion transport
CT Culbertson, RS Ramsey, JM Ramsey - Analytical Chemistry, 2000 - ACS Publications
CT Culbertson, RS Ramsey, JM Ramsey
Analytical Chemistry, 2000•ACS PublicationsThe theory behind and operation of an electroosmotically induced hydraulic pump for
microfluidic devices is reported. This microchip functional element consists of a tee
intersection with one inlet channel and two outlet channels. The inlet channel is maintained
at high voltage while one outlet channel is kept at ground and the other channel has no
electric potential applied. A pressure-induced flow of buffer is created in both outlet channels
of the tee by reducing electroosmosis in the ground channel relative to that of the inlet …
microfluidic devices is reported. This microchip functional element consists of a tee
intersection with one inlet channel and two outlet channels. The inlet channel is maintained
at high voltage while one outlet channel is kept at ground and the other channel has no
electric potential applied. A pressure-induced flow of buffer is created in both outlet channels
of the tee by reducing electroosmosis in the ground channel relative to that of the inlet …
The theory behind and operation of an electroosmotically induced hydraulic pump for microfluidic devices is reported. This microchip functional element consists of a tee intersection with one inlet channel and two outlet channels. The inlet channel is maintained at high voltage while one outlet channel is kept at ground and the other channel has no electric potential applied. A pressure-induced flow of buffer is created in both outlet channels of the tee by reducing electroosmosis in the ground channel relative to that of the inlet channel. Spatially selective reduction of electroosmosis is accomplished by coating the walls of the ground channel with a viscous polymer. The pump is shown to differentially transport ions down the two outlet channels. This ion discrimination ability of the pump is examined as a function of an analyte's electrophoretic velocity. In addition, we demonstrate that an anion can be rejected from the ground channel and made to flow only into the field-free channel if the electrophoretic velocity of the anion is greater than the pressure-generated flow in the ground channel. The velocity threshold at which anion rejection occurs can be selectively tuned by changing the flow resistance in the field-free channel relative to the ground channel.
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