Topical treatment of acute adenoviral keratoconjunctivitis with 0.2% cidofovir and 1% cyclosporine: a controlled clinical pilot study

J Hillenkamp, T Reinhard, RS Ross… - Archives of …, 2001 - jamanetwork.com
Objective To evaluate the efficacy of 0.2% cidofovir eyedrops and 1% cyclosporine eyedrops
administered 4 times daily (qid) to treat acute adenoviral keratoconjunctivitis. Methods A
randomized, controlled, double-masked study was conducted on 39 patients with acute
adenoviral keratoconjunctivitis of recent onset. Patients were divided into 4 treatment
groups:(1) cidofovir qid,(2) cyclosporine qid,(3) cidofovir+ cyclosporine qid, and (4) sodium
chloride qid (control). The diagnosis was confirmed using adenoviral polymerase chain …