Mulple primary tumors in a single paent are relavely rare when four or more disnct lesions are co... more Mulple primary tumors in a single paent are relavely rare when four or more disnct lesions are considered. Herein, we report a case of woman with four different primary tumors: meningioma, renal angiomyolipoma, spinal ependymoma and high-grade so� �ssue sarcoma. There was no family history and hereditary syndrome. The genec analysis was completely normal. To best of our knowledge, the present paent is the first case in the literature, who presented with these four types of tumors.
Turkish journal of obstetrics and gynecology, 2017
Sleep disorders affect 54.9% of gynaecologic cancer survivors. The effect of treatment methods on... more Sleep disorders affect 54.9% of gynaecologic cancer survivors. The effect of treatment methods on sleep quality is not clear. This study evaluated the sleep quality of survivors of endometrial cancer and compared the effects of different treatments on sleep quality. Patients were categorised as surgery (group 1), surgery + brachytherapy (BRT) (group 2), surgery + external beam radiation therapy (EBRT) (group 3), and surgery + EBRT + BRT + chemotherapy (group 4). Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. The PSQI was completed by the participants before surgery, 1, 3, and 6 months after each treatment was completed. The PSQI scores were compared between the different measurement times and different study groups. This study enrolled 114 patients with a mean age of 58.1±11 years. The number of participants in each group was 53 (46.5%), 14 (12.3%), 12 (10.5%), and 35 (30.7%), respectively. At baseline, 28 (24.6%) patients reported poor sle...
To evaluate effects of halofuginone (H) on radiation-induced lung injury (RILI), 60 rats were div... more To evaluate effects of halofuginone (H) on radiation-induced lung injury (RILI), 60 rats were divided into six groups: Group (G) 1 control, G2 radiotherapy (RT) only, G3 and G4 2. 5 and 5 μg H and G5 and G6 RT + 2.5 and 5 μg H groups, respectively. A single dose of 12 Gy RT was given to both lungs. H was applied intraperitoneally with daily doses, until animals were killed at 6 and 16 weeks after RT. At 6th and 16th weeks of RT, five rats from each group were killed. Lung tissues were dissected for light and electron microscopy. Chronic inflammation, fibrosis and transforming growth factor-beta (TGF)-β scores of all study groups were significantly different at 6th and 16th week ( p < 0.001). Chronic inflammation, fibrosis and TGF-β scores of G2 were higher than G5 and G6 at 6th and 16th weeks of RT. At 16th week, fibrosis and TGF-β scores of G5 were higher than G6 ( p = 0.040 and 0.028, respectively). Electron microscopical findings also supported these results. Therefore, H may ...
ABSTRACT Background: Palliave whole brain radiotherapy (WBRT) has been the standard treatment fo... more ABSTRACT Background: Palliave whole brain radiotherapy (WBRT) has been the standard treatment for brain metastases. Ionizing radiaon is known to be one of the most potent cataractogenic agents. We aimed to evaluate two different radiotherapy techniques with respect to the doses received by the organs at risk (OAR) in paents with brain metastasis who undergone WBRT. Materials and Methods: Ten consecuve paents with brain metastasis were included. For each paent, two different treatment plans were created for whole brain. Helmet‐field (HF) (anterior border was 2 cm posterior to lens, inferior border was the boom of C2 vertebra) and classical technique with collimaon (CT) (anterior border was defined as skin fall off, inferior border was the boom of cranial base) were generated for all paents. Two techniques were compared with respect to the doses received by the OAR including bilateral lenses, opc nerves and eye‐balls, the dose homogeneity index (DHI), and the monitor unit c...
A�er cura ve treatment of Hodgkin’s lymphoma, increased risk of certain solid tumors has been rep... more A�er cura ve treatment of Hodgkin’s lymphoma, increased risk of certain solid tumors has been reported. To best of our knowledge this is the first report of metachronous pancrea c adenocarcinoma which developed outside the previous radia on field in a pa ent with relapse Hodgkin’s lymphoma. Herein we present an 81-year-old female who developed pancrea c adenocarcinoma four years a�er the cura ve treatment of Hodgkin’s lymphoma.
Background: We aimed to compare field-in-field technique (FIF) with conformal tangential field ra... more Background: We aimed to compare field-in-field technique (FIF) with conformal tangential field radiotherapy (CRT) in terms of dosimetric benefits for early stage breast cancer radiotherapy. Materials and Methods: Twenty consecutive left-side breast cancer patients who underwent breast-conserving surgery were included to the study. For each patient, two different treatment plans were created for the entire breast. FIF plans and CRT plans were compared for doses in the planning target volume (PTV), the organ at risk (OAR) volume including ipsilateral lung, heart, left ascending coronary artery (LAD) and the contralateral breast, the homogeneity index (HI), and the monitor unit (MU) counts required for the treatment. Paired samples t-test was used for statistical analysis. Results: The FIF technique significantly reduced the maximum dose of the PTV as well as the mean doses of the heart, LAD, ipsilateral lung and the contralateral breast (p values were <0.001 for each). When the OAR...
European review for medical and pharmacological sciences, 2012
5-hydroxytryptamine receptor type-3 (5-HT3) antagonists are widely used for prophylaxis of chemot... more 5-hydroxytryptamine receptor type-3 (5-HT3) antagonists are widely used for prophylaxis of chemotherapy-induced nausea and vomiting (CINV) and regarded to have a high safety profile. However, several electrocardiographic changes and cardiac arrhythmias have been reported due to administration of 5-HT3 antagonists. Only prolongation of QT interval has been investigated as an index of potential for life-threatening arrhythmias in adult patients using 5-HT3 antagonists. Recently, increase in transmural dispersion of repolarization (TDR) has been proposed as a more reliable determinant of arrhythmogenic potential. To assess the effects of palonosetron, a second-generation 5-HT3 antagonist, on the T-wave peak to T-wave end (TpTe) interval which has been proposed as a reliable index of spatial TDR. A total of 50 consecutive cancer patients (aged: 57 +/- 12 years) who were scheduled to receive emetogenic chemotherapy were included to the study. Baseline12-lead electrocardiography (ECG) rec...
Mulple primary tumors in a single paent are relavely rare when four or more disnct lesions are co... more Mulple primary tumors in a single paent are relavely rare when four or more disnct lesions are considered. Herein, we report a case of woman with four different primary tumors: meningioma, renal angiomyolipoma, spinal ependymoma and high-grade so� �ssue sarcoma. There was no family history and hereditary syndrome. The genec analysis was completely normal. To best of our knowledge, the present paent is the first case in the literature, who presented with these four types of tumors.
Turkish journal of obstetrics and gynecology, 2017
Sleep disorders affect 54.9% of gynaecologic cancer survivors. The effect of treatment methods on... more Sleep disorders affect 54.9% of gynaecologic cancer survivors. The effect of treatment methods on sleep quality is not clear. This study evaluated the sleep quality of survivors of endometrial cancer and compared the effects of different treatments on sleep quality. Patients were categorised as surgery (group 1), surgery + brachytherapy (BRT) (group 2), surgery + external beam radiation therapy (EBRT) (group 3), and surgery + EBRT + BRT + chemotherapy (group 4). Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. The PSQI was completed by the participants before surgery, 1, 3, and 6 months after each treatment was completed. The PSQI scores were compared between the different measurement times and different study groups. This study enrolled 114 patients with a mean age of 58.1±11 years. The number of participants in each group was 53 (46.5%), 14 (12.3%), 12 (10.5%), and 35 (30.7%), respectively. At baseline, 28 (24.6%) patients reported poor sle...
To evaluate effects of halofuginone (H) on radiation-induced lung injury (RILI), 60 rats were div... more To evaluate effects of halofuginone (H) on radiation-induced lung injury (RILI), 60 rats were divided into six groups: Group (G) 1 control, G2 radiotherapy (RT) only, G3 and G4 2. 5 and 5 μg H and G5 and G6 RT + 2.5 and 5 μg H groups, respectively. A single dose of 12 Gy RT was given to both lungs. H was applied intraperitoneally with daily doses, until animals were killed at 6 and 16 weeks after RT. At 6th and 16th weeks of RT, five rats from each group were killed. Lung tissues were dissected for light and electron microscopy. Chronic inflammation, fibrosis and transforming growth factor-beta (TGF)-β scores of all study groups were significantly different at 6th and 16th week ( p < 0.001). Chronic inflammation, fibrosis and TGF-β scores of G2 were higher than G5 and G6 at 6th and 16th weeks of RT. At 16th week, fibrosis and TGF-β scores of G5 were higher than G6 ( p = 0.040 and 0.028, respectively). Electron microscopical findings also supported these results. Therefore, H may ...
ABSTRACT Background: Palliave whole brain radiotherapy (WBRT) has been the standard treatment fo... more ABSTRACT Background: Palliave whole brain radiotherapy (WBRT) has been the standard treatment for brain metastases. Ionizing radiaon is known to be one of the most potent cataractogenic agents. We aimed to evaluate two different radiotherapy techniques with respect to the doses received by the organs at risk (OAR) in paents with brain metastasis who undergone WBRT. Materials and Methods: Ten consecuve paents with brain metastasis were included. For each paent, two different treatment plans were created for whole brain. Helmet‐field (HF) (anterior border was 2 cm posterior to lens, inferior border was the boom of C2 vertebra) and classical technique with collimaon (CT) (anterior border was defined as skin fall off, inferior border was the boom of cranial base) were generated for all paents. Two techniques were compared with respect to the doses received by the OAR including bilateral lenses, opc nerves and eye‐balls, the dose homogeneity index (DHI), and the monitor unit c...
A�er cura ve treatment of Hodgkin’s lymphoma, increased risk of certain solid tumors has been rep... more A�er cura ve treatment of Hodgkin’s lymphoma, increased risk of certain solid tumors has been reported. To best of our knowledge this is the first report of metachronous pancrea c adenocarcinoma which developed outside the previous radia on field in a pa ent with relapse Hodgkin’s lymphoma. Herein we present an 81-year-old female who developed pancrea c adenocarcinoma four years a�er the cura ve treatment of Hodgkin’s lymphoma.
Background: We aimed to compare field-in-field technique (FIF) with conformal tangential field ra... more Background: We aimed to compare field-in-field technique (FIF) with conformal tangential field radiotherapy (CRT) in terms of dosimetric benefits for early stage breast cancer radiotherapy. Materials and Methods: Twenty consecutive left-side breast cancer patients who underwent breast-conserving surgery were included to the study. For each patient, two different treatment plans were created for the entire breast. FIF plans and CRT plans were compared for doses in the planning target volume (PTV), the organ at risk (OAR) volume including ipsilateral lung, heart, left ascending coronary artery (LAD) and the contralateral breast, the homogeneity index (HI), and the monitor unit (MU) counts required for the treatment. Paired samples t-test was used for statistical analysis. Results: The FIF technique significantly reduced the maximum dose of the PTV as well as the mean doses of the heart, LAD, ipsilateral lung and the contralateral breast (p values were <0.001 for each). When the OAR...
European review for medical and pharmacological sciences, 2012
5-hydroxytryptamine receptor type-3 (5-HT3) antagonists are widely used for prophylaxis of chemot... more 5-hydroxytryptamine receptor type-3 (5-HT3) antagonists are widely used for prophylaxis of chemotherapy-induced nausea and vomiting (CINV) and regarded to have a high safety profile. However, several electrocardiographic changes and cardiac arrhythmias have been reported due to administration of 5-HT3 antagonists. Only prolongation of QT interval has been investigated as an index of potential for life-threatening arrhythmias in adult patients using 5-HT3 antagonists. Recently, increase in transmural dispersion of repolarization (TDR) has been proposed as a more reliable determinant of arrhythmogenic potential. To assess the effects of palonosetron, a second-generation 5-HT3 antagonist, on the T-wave peak to T-wave end (TpTe) interval which has been proposed as a reliable index of spatial TDR. A total of 50 consecutive cancer patients (aged: 57 +/- 12 years) who were scheduled to receive emetogenic chemotherapy were included to the study. Baseline12-lead electrocardiography (ECG) rec...
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