C3a receptor

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C3a receptor (receptor 1 komplementne komponente 3a, C3AR1) je G protein-spregnuti receptor koji je deo sistema komplementa.

Receptor 1 komplementne komponente 3a
Identifikatori
Simboli	C3AR1; AZ3B; C3AR; HNFAG09
Vanjski ID	OMIM: 605246 MGI: 1097680 HomoloGene: 2992 IUPHAR: C3a GeneCards: C3AR1 Gene
Ontologija gena Molekularna funkcija • aktivnost rodopsinu-sličnog receptora • aktivnost fosfoinozitid fosfolipaze C • receptorska aktivnost • aktivnost receptora komplementne komponente 3a • aktivnost C3a anafilatoksinskog receptora Celularna komponenta • ćelijska membrana • integralno sa ćelijskom membranom Biološki proces • ćelijska motilnost • hemotaksa • kontrakcija glatkog mišića • inflamatorni respons • ćelijski odbrambeni respons • prenos signala • signalni put G-protein spregnutog receptora • elevacija koncentracije jona citosolnog kalcijuma • cirkulacija
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	719	12267
Ensembl	ENSG00000171860	ENSMUSG00000040552
UniProt	Q16581	Q3U4N3
RefSeq (mRNA)	NM_004054	NM_009779
RefSeq (protein)	NP_004045	NP_033909
Lokacija (UCSC)	Chr 12: 8.1 - 8.11 Mb	Chr 6: 122.81 - 122.82 Mb
PubMed pretraga	[1]	[2]

Ligandi ovog receptora su C3a i C4a.

Dodatna literatura

• Sim RB, Laich A (2001). „Serine proteases of the complement system”. Biochem. Soc. Trans. 28 (5): 545–50. PMID 11044372. 
• Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene 138 (1–2): 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Roglic A, Prossnitz ER, Cavanagh SL, et al. (1996). „cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure”. Biochim. Biophys. Acta 1305 (1–2): 39–43. PMID 8605247. 
• Ames RS, Li Y, Sarau HM, et al. (1996). „Molecular cloning and characterization of the human anaphylatoxin C3a receptor”. J. Biol. Chem. 271 (34): 20231–4. DOI:10.1074/jbc.271.34.20231. PMID 8702752. 
• Crass T, Raffetseder U, Martin U, et al. (1996). „Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells”. Eur. J. Immunol. 26 (8): 1944–50. DOI:10.1002/eji.1830260840. PMID 8765043. 
• Ames RS, Nuthulaganti P, Kumar C (1996). „In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins”. FEBS Lett. 395 (2–3): 157–9. DOI:10.1016/0014-5793(96)01018-6. PMID 8898085. 
• Martin U, Bock D, Arseniev L, et al. (1997). „The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes”. J. Exp. Med. 186 (2): 199–207. DOI:10.1084/jem.186.2.199. PMC 2198980. PMID 9221749. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene 200 (1–2): 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Hollmann TJ, Haviland DL, Kildsgaard J, et al. (1998). „Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene”. Mol. Immunol. 35 (3): 137–48. DOI:10.1016/S0161-5890(98)00021-2. PMID 9694514. 
• Lienenklaus S, Ames RS, Tornetta MA, et al. (1998). „Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor”. J. Immunol. 161 (5): 2089–93. PMID 9725198. 
• Davoust N, Jones J, Stahel PF, et al. (1999). „Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells”. Glia 26 (3): 201–11. DOI:10.1002/(SICI)1098-1136(199905)26:3<201::AID-GLIA2>3.0.CO;2-M. PMID 10340761. 
• Settmacher B, Bock D, Saad H, et al. (1999). „Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a”. J. Immunol. 162 (12): 7409–16. PMID 10358194. 
• Feild JA, Foley JJ, Testa TT, et al. (1999). „Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15”. FEBS Lett. 460 (1): 53–6. DOI:10.1016/S0014-5793(99)01317-4. PMID 10571060. 
• Petering H, Köhl J, Weyergraf A, et al. (2000). „Characterization of synthetic C3a analog peptides on human eosinophils in comparison to the native complement component C3a”. J. Immunol. 164 (7): 3783–9. PMID 10725738. 
• Drouin SM, Kildsgaard J, Haviland J, et al. (2001). „Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma”. J. Immunol. 166 (3): 2025–32. PMID 11160252. 
• Ames RS, Lee D, Foley JJ, et al. (2001). „Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models”. J. Immunol. 166 (10): 6341–8. PMID 11342658. 
• Kirchhoff K, Weinmann O, Zwirner J, et al. (2001). „Detection of anaphylatoxin receptors on CD83+ dendritic cells derived from human skin”. Immunology 103 (2): 210–7. DOI:10.1046/j.1365-2567.2001.01197.x. PMC 1783227. PMID 11412308. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Reca R, Mastellos D, Majka M, et al. (2003). „Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1”. Blood 101 (10): 3784–93. DOI:10.1182/blood-2002-10-3233. PMID 12511407. 

Spoljašnje veze

• „Anaphylatoxin Receptors: C3a”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
• MeSH C3AR1+protein,+human