My research activities focused on the isolation of organic compounds from medicinal plants, evaluation of microbial activities of plants extract against human pathogens, determination of plants secondary metabolites, biosynthesis of nanoparticles from medicinal plants, toxicological evaluation of herbal drugs, estimation of cancer risk incurred from the use of herbal drugs, the use of computational chemistry tools to predict the safety level of herbal drugs and for the production of novel compounds from medicinal plants and herbs in solve the challenges of multi drug resistant. Phone: +2348036021055 Address: Department of Pure and Applied chemistry Ladoke Akintola University of Technology, Ogbomoso.
The "conflict" between humans and diseases caused by pathogens has been a conti... more The "conflict" between humans and diseases caused by pathogens has been a continuous war for centuries which has resulted into the death of a large number of humans. Despite the discovery of several synthetic drugs for the eradication of pathogenic diseases, the massive abuse of these drugs has caused the pathogens to develop resistance genes toward available medications used for preventing and curing pathogenic diseases. Nanotechnology has been discovered as a crucial tool for the synthesis of nanomaterials with important applications such as wound healing, antimicrobial, and biofilm activities and many other merits across several fields. A significant number of researchers have validated the synthesis of nanobiomaterials from microorganisms. Among other methods used for the synthesis of nanomaterials, mycosynthesis of nanomaterials is attractive because it enhances high yields of protein production, and easy handling with little or no toxicity. Likewise, this synthetic process helps in coating the nanomaterials with biomolecules found in organism cells, which can improve its stability and may promote its biological efficiency. The aim of this review is to present comprehensive information on the wound healing, antimicrobial, and biofilm inhibitory activities of mycosynthesized nanobiomaterials. Furthermore, this review significantly summarized the synthetic processes, optimum conditions, and characterization tools required for the mycosynthesis of nanabiomaterials.
Developments in nanotechnology and natural product research toward the search for novel antibacte... more Developments in nanotechnology and natural product research toward the search for novel antibacterial agents have drawn the interest of many scientists to the synthesis of silver nanoparticles (AgNPs) from natural product (especially plants) due to its numerous benefits over other methods of synthesis such as been easy, economical, convenient, and environmental friendly. Aside from the aforementioned advantages, the synthesis of AgNPs from medicinal plant has been reported as the best approach of synthesizing AgNPs with great biological activities due to the numerous biomolecules found in plants. Recently, the number of researches toward the improvement of the yield, morphological properties, analytical techniques, and the development of optimal conditions and exact mechanism for synthesizing AgNPs from plants have been increasing tremendously. In this review, we present a comprehensive report on the recent development in the synthesis, optimization conditions, mechanism, and charac...
The delinquent peril of bacterial infections affecting human kind is becoming unbearable. This st... more The delinquent peril of bacterial infections affecting human kind is becoming unbearable. This study was embarked on to investigate the antimicrobial activity of biosynthesized silver nanoparticles (AgNPs) using Garcinia kola bark extract against some bacteria strains. Fresh barks of Garcinia kola were obtained from the “Gbeleju” farm land in Irele town in Ondo state region of Nigeria. Exactly 0.4 g of previously pulverized bark of Garcinia kola was immersed into 20 mL of distilled water and heated at 60–70°C for 10 minutes yielding the extract. The biosynthesized nanoparticle was characterized with UV spectroscope, Fourier infrared spectroscope (FTIR), transmission electron microscope (TEM), and energy dispersive X-Ray analyzer (EDX). Then, 0.2 g of the silver nanoparticles was dissolved in 2 ml of water to yield 100 mg/ml of the stock solution which was further diluted for the antibacterial analysis via the disc diffusion method. The result obtained from the analytical characteriz...
Nanoscience and nanotechnology are currently undergoing several developments that will impact sev... more Nanoscience and nanotechnology are currently undergoing several developments that will impact several industries across the global in due season. The wide applications of nanoparticles in biomedicine, pharmacy, phytochemistry, research institute, catalysis, textile, waste water management, chemistry, food preservatives, and paint have led to new area of discoveries for many researchers and industries. The biological method of synthesizing silver nanoparticles (AgNPs) had tremendously gained wide popularity due to its environmental friendly conditions of synthesis. Numerous biological entities namely; plants, bacteria, essential oil, fungi, algae, and yeasts had been used as reducing and capping agent for the synthesis of AgNPs. All scientific investigations have ascertained the uniqueness of AgNPs as therapeutic agent against cancer, virus, bacterial, and fungal infections. This review provides detailed scientific information about the various methods of synthesis, optimization conditions, mechanism, and characterization techniques for the synthesis of AgNPs with efficient yield and morphological properties. Furthermore, concise advancement in the antibacterial, antiviral, antifungal, antioxidant, and anticancer activities of AgNPs mediated from plant sources from recently published articles were enumerated.
Decomposition of carbon steel via corrosion process has caused a serious damage to several organi... more Decomposition of carbon steel via corrosion process has caused a serious damage to several organisations worldwide. Despite efforts put in place to curb this menace by scientists, havoc caused by corrosion of metal still remain. Therefore, in a way to find effective corrosion inhibitor, (Z)-N'-(1-phenylethylidene) benzohydrazide derivatives was optimised using density functional theory and the obtained molecular descriptors correlated well with the experimental percentage inhibition efficiency. Also, the developed quantitative structure-activity relationship study (QSAR) model revealed that dipole moment impeccably define anti-corrosion properties of (Z)-N'-(1-phenylethylidene) benzohydrazide Derivatives.
A study of heavy metals levels in Wazo market top soils, Ogbomoso was conducted during dry and ra... more A study of heavy metals levels in Wazo market top soils, Ogbomoso was conducted during dry and rainy season in year 2015 to ascertain status of the soils. Soil samples were collected from five different spots within the market in the month of February, March, June and July. Some physicochemical parameters (pH and total organic carbon) of the soils were determined. The samples were further digested with HClO4, HNO3 and H2SO4 mixture, and digests were analysed for heavy metals using atomic absorption spectrophotometry. The mean levels of heavy metals during the dry season were 249±27.85 mg/kg for Zn, 5.5±1.12 mg/kg for Co, 10±6.00 mg/kg for Cd, 196±60.11 mg/kg for Pb, 14.5±7.63 mg/kg for Ni and 28±6.32 mg/kg for Cu, while during the rainy season the levels of 301±23.88 mg/kg for Zn, 5±0.00 mg/kg for Co, 9±7.87 mg/kg for Cd, 198.5±92.38 mg/kg for Pb, 20.5±8.97 mg/kg for Ni and 45.5±9.76 mg/kg for Cu were observed. The levels of metals based on average concentration during the dry and r...
SARS-CoV-2 (Covid 19) continues to be a great threat to lives globally as it causes illnesses suc... more SARS-CoV-2 (Covid 19) continues to be a great threat to lives globally as it causes illnesses such as the common cold, severe acute respiratory syndrome and spreads easily among people. In this work, thirteen molecular compounds were studied via quantum chemical calculations, molecular docking, and dynamic simulation, and ADMET (absorption, distribution, metabolism, excretion, and toxicity). The obtained descriptors (Log P, HBA, HBD, and molecular weight) showed that the studied compounds have the ability to act as a drug. Thus, it was detected that all the studied selected compounds possess a better tendency to inhibit main coronavirus protease; however, compound C1 has a higher tendency to inhibit main coronavirus protease than the other compounds, including the standard (Chloroquine). ADMET properties of compound C1 proved that the predicted ADMET level was better than the ADMET properties of the referenced drug.
The conviction that herbal drugs have enormous health benefits has led to increase the rate of th... more The conviction that herbal drugs have enormous health benefits has led to increase the rate of their consumption by Nigerians. The aim of this study was to assess the carcinogenic property of some popularly consumed anti-diarrheal herbal drugs via polycyclic aromatic hydrocarbons (PAHs) quantification. Three prevalent anti-diarrhea herbal drugs , Odunmo herbal drug (Hibiscus rosa-sinensis and Bacopamonnieri), Orogun herbal mixture (Hibiscus sabdariffaI and Hedera helix), and Alora herbal syrup (Aloe vera and Hibiscus sabdariffaI) were bought for the purpose of this study and they were coded as samples A, B, and C, respectively. The ultrasonic extraction of the herbal drugs was carried out using standard procedures. The crude extracts obtained were purified using a chromatographic method. The concentrations of PAHs were quantified using gas chromatography flame ionization detector (GCFID). The diagnostic indices, group distribution, toxicity equivalence and exposure dosage were estim...
Asian Journal of Organic & Medicinal Chemistry, 2021
Breast cancer still remains one of the precarious ailments among humans globally. The vulnerabili... more Breast cancer still remains one of the precarious ailments among humans globally. The vulnerability of this ailment in homeopathic world remains colossal and this has drawn the attention of seasoned researchers to find lasting solution to this hazard. Therefore, 10 novel 1,2,4-thiadiazole-1,2,4-triazole derivatives were studied so as to explore their anti-breast cancer activities. The studied compounds were optimized using Spartan 14 and the QSAR study was executed by using Gretl and MATLAB. Also, docking study was observed using Pymol (for treating downloaded protein), Autodock Tool (for locating binding site in the downloaded protein and for converting ligand and receptor to .pdbqt format from .pdb format), Auto dock vina (for docking calculation) and discovery studio (for viewing the nonbonding interaction between the docked complexes). The selected descriptors were used to developed effective QSAR model and it was observed that the developed QSAR model using artificial neural ne...
Data from eight 1,2,4-thiadiazole-1,2,4-triazole derivatives were used to observe the anti-epider... more Data from eight 1,2,4-thiadiazole-1,2,4-triazole derivatives were used to observe the anti-epidermal growth factor receptor kinase activities of 1,2,4-thiadiazole-1,2,4-triazole analogues thereby reducing human lung cancer. The software used to achieve this work were Spartan 14, Pymol, mgltools_win32_1.5.6, Auto dock vina and biovia2019.ds2019client. Also, the developed QSAR model was developed using the screened descriptors so as to inspect the closeness between the experimental IC50 and the predicted IC50. More so, the binding affinity from 1,2,4-thiadiazole-1,2,4-triazole derivatives - epidermal growth factor receptor kinase complexes using molecular docking approach were reported. Also, the ADMET properties for selected compounds and proposed compounds with better binding affinity were reported.
Gold nanoparticles (AuNPs) are one of the prominent metal nanoparticles (NPs) with a broad range ... more Gold nanoparticles (AuNPs) are one of the prominent metal nanoparticles (NPs) with a broad range of applications in various fields of science and technology. The demand for the use of AuNPs has been increasing on a regular basis. To meet such a demand, intensive research is required on optimizing synthesis approaches. Among various methods reported for the synthesis of AuNPs, biological methods using plant extract have been found to be simple, effective, cheap and environmental friendly because the gold salt is only reduced with biomolecules existing in plant extract. Various methods of AuNPs synthesis using different plant extracts have long been developed. Several techniques have been adopted in the characterization of the synthesized AuNPs. The antibacterial, antioxidant, anticancer and catalytic activities of AuNPs from plant extract have shown promising activities useful for several biomedical applications. This review focuses on the synthesis, optimization conditions, characterization and applications of biosynthesized AuNPs using plant extracts.
This research centred on the evaluation of the antifungal potency of gold nanoparticles (AuNPs) s... more This research centred on the evaluation of the antifungal potency of gold nanoparticles (AuNPs) synthesized from Garcinia kola leaves. The leaves of Garcinia kola obtained were thoroughly rinsed, air dried, pulverized and extracted. The extract obtained was mixed with aqueous solution of gold chloride to form gold nanoparticle and were characterized. The antifungal screening of the synthesized gold nanoparticles was carried out via the Agar disc diffusion method. The ultraviolet (UV) analysis showed an absorption wavelength at 536.12 nm. The scanning electron microscopic (SEM) image confirmed uniform distribution of the synthesized gold nanoparticles. The transmission electron microscope (TEM) analysis confirmed that the particle size are in the range of 8.21 to 19.00 nm. The broad inhibitory zones against test fungi displayed by the synthesized nanoparticles confirmed the synthesized gold nanoparticles as a good antifungal source. This study establish a simple, easy and environmental friendly approach of synthesizing gold nanoparticles.
The need to devise another method of synthesizing nanoparticles from sources that are eco-friendl... more The need to devise another method of synthesizing nanoparticles from sources that are eco-friendly, non-hazardous and cost effectiveness is of great importance in preventing environmental and health problems. The aim of this study was to evaluate the efficiency of Garcinia kola leaves as reducing and stabilizing agent for silver nanoparticles synthesis. The leaves of Garcinia kola obtained were authenticated, air dried, pulverized and extracted. The extract was mixed with aqueous solution of silver nitrate solution to form silver nanoparticles and were characterized using Ultra violet (UV) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), Energy-dispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD). The antibacterial investigation of the synthesized silver nanoparticle was carried out following the disk diffusion method. UV analysis revealed the silver surface plasmon band at 425.18 nm,...
The aim of this study was to assess the safety level of some bottled water produced in Okitipupa,... more The aim of this study was to assess the safety level of some bottled water produced in Okitipupa, Ondo State Nigeria. Several packs of bottled water were obtained from three different manufacturers. Some physicochemical parameters and heavy metals were investigated to assess the quality of the bottle water using standard methods. The results from the physicochemical parameters and heavy metals were in with World Health Organization (WHO) standard for drinking water when compared. This study confirmed that the analyzed bottled water has good quality. Therefore, these bottled water are said to be safe for drinking.
The use of herbal drugs for the treatment of various ailments especially diabetes mellitus has gr... more The use of herbal drugs for the treatment of various ailments especially diabetes mellitus has greatly increased recently due to the approval and recommendation from regulatory bodies. The safety level of these herbal drugs has not been clearly understood. This study was designed to determine the functional groups responsible for the anti-diabetic activity of these drugs and also to estimate their heavy metal concentrations. Three most popularly sold and readily available anti-diabetic herbal drugs were purchased from Okitipupa Market in Ondo State. The Fourier Transform Infrared Spectroscopy (FTIR) analysis was done by scanning the samples on Shimadzu FTIR machine at a wavelength of 4000 – 500 cm. For the heavy metals analysis, the herbal drug samples were digested using standard method and analyzed on an Atomic Absorption Spectrophotometer (AAS). The FTIR spectral revealed absorption bands corresponding to -OH, C-H, C=O, C=C and S=O functional groups. The concentrations of the sel...
Schoolof Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, China. Dep... more Schoolof Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, China. Department of Pure and Applied Chemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria. Department of Agricultural Economics, Ladoke Akintola University of Technology, Ogbomoso, Nigeria. Department of Anatomy, Osun State University, Osogbo, Nigeria Department of Basic Sciences, Adeleke University, P.M.B. 250, Ede, Osun State, Nigeria. Department of Chemistry, Louisiana State University, Louisiana, USA folorunsoaderonkesimi@gmail.com
The "conflict" between humans and diseases caused by pathogens has been a conti... more The "conflict" between humans and diseases caused by pathogens has been a continuous war for centuries which has resulted into the death of a large number of humans. Despite the discovery of several synthetic drugs for the eradication of pathogenic diseases, the massive abuse of these drugs has caused the pathogens to develop resistance genes toward available medications used for preventing and curing pathogenic diseases. Nanotechnology has been discovered as a crucial tool for the synthesis of nanomaterials with important applications such as wound healing, antimicrobial, and biofilm activities and many other merits across several fields. A significant number of researchers have validated the synthesis of nanobiomaterials from microorganisms. Among other methods used for the synthesis of nanomaterials, mycosynthesis of nanomaterials is attractive because it enhances high yields of protein production, and easy handling with little or no toxicity. Likewise, this synthetic process helps in coating the nanomaterials with biomolecules found in organism cells, which can improve its stability and may promote its biological efficiency. The aim of this review is to present comprehensive information on the wound healing, antimicrobial, and biofilm inhibitory activities of mycosynthesized nanobiomaterials. Furthermore, this review significantly summarized the synthetic processes, optimum conditions, and characterization tools required for the mycosynthesis of nanabiomaterials.
Developments in nanotechnology and natural product research toward the search for novel antibacte... more Developments in nanotechnology and natural product research toward the search for novel antibacterial agents have drawn the interest of many scientists to the synthesis of silver nanoparticles (AgNPs) from natural product (especially plants) due to its numerous benefits over other methods of synthesis such as been easy, economical, convenient, and environmental friendly. Aside from the aforementioned advantages, the synthesis of AgNPs from medicinal plant has been reported as the best approach of synthesizing AgNPs with great biological activities due to the numerous biomolecules found in plants. Recently, the number of researches toward the improvement of the yield, morphological properties, analytical techniques, and the development of optimal conditions and exact mechanism for synthesizing AgNPs from plants have been increasing tremendously. In this review, we present a comprehensive report on the recent development in the synthesis, optimization conditions, mechanism, and charac...
The delinquent peril of bacterial infections affecting human kind is becoming unbearable. This st... more The delinquent peril of bacterial infections affecting human kind is becoming unbearable. This study was embarked on to investigate the antimicrobial activity of biosynthesized silver nanoparticles (AgNPs) using Garcinia kola bark extract against some bacteria strains. Fresh barks of Garcinia kola were obtained from the “Gbeleju” farm land in Irele town in Ondo state region of Nigeria. Exactly 0.4 g of previously pulverized bark of Garcinia kola was immersed into 20 mL of distilled water and heated at 60–70°C for 10 minutes yielding the extract. The biosynthesized nanoparticle was characterized with UV spectroscope, Fourier infrared spectroscope (FTIR), transmission electron microscope (TEM), and energy dispersive X-Ray analyzer (EDX). Then, 0.2 g of the silver nanoparticles was dissolved in 2 ml of water to yield 100 mg/ml of the stock solution which was further diluted for the antibacterial analysis via the disc diffusion method. The result obtained from the analytical characteriz...
Nanoscience and nanotechnology are currently undergoing several developments that will impact sev... more Nanoscience and nanotechnology are currently undergoing several developments that will impact several industries across the global in due season. The wide applications of nanoparticles in biomedicine, pharmacy, phytochemistry, research institute, catalysis, textile, waste water management, chemistry, food preservatives, and paint have led to new area of discoveries for many researchers and industries. The biological method of synthesizing silver nanoparticles (AgNPs) had tremendously gained wide popularity due to its environmental friendly conditions of synthesis. Numerous biological entities namely; plants, bacteria, essential oil, fungi, algae, and yeasts had been used as reducing and capping agent for the synthesis of AgNPs. All scientific investigations have ascertained the uniqueness of AgNPs as therapeutic agent against cancer, virus, bacterial, and fungal infections. This review provides detailed scientific information about the various methods of synthesis, optimization conditions, mechanism, and characterization techniques for the synthesis of AgNPs with efficient yield and morphological properties. Furthermore, concise advancement in the antibacterial, antiviral, antifungal, antioxidant, and anticancer activities of AgNPs mediated from plant sources from recently published articles were enumerated.
Decomposition of carbon steel via corrosion process has caused a serious damage to several organi... more Decomposition of carbon steel via corrosion process has caused a serious damage to several organisations worldwide. Despite efforts put in place to curb this menace by scientists, havoc caused by corrosion of metal still remain. Therefore, in a way to find effective corrosion inhibitor, (Z)-N'-(1-phenylethylidene) benzohydrazide derivatives was optimised using density functional theory and the obtained molecular descriptors correlated well with the experimental percentage inhibition efficiency. Also, the developed quantitative structure-activity relationship study (QSAR) model revealed that dipole moment impeccably define anti-corrosion properties of (Z)-N'-(1-phenylethylidene) benzohydrazide Derivatives.
A study of heavy metals levels in Wazo market top soils, Ogbomoso was conducted during dry and ra... more A study of heavy metals levels in Wazo market top soils, Ogbomoso was conducted during dry and rainy season in year 2015 to ascertain status of the soils. Soil samples were collected from five different spots within the market in the month of February, March, June and July. Some physicochemical parameters (pH and total organic carbon) of the soils were determined. The samples were further digested with HClO4, HNO3 and H2SO4 mixture, and digests were analysed for heavy metals using atomic absorption spectrophotometry. The mean levels of heavy metals during the dry season were 249±27.85 mg/kg for Zn, 5.5±1.12 mg/kg for Co, 10±6.00 mg/kg for Cd, 196±60.11 mg/kg for Pb, 14.5±7.63 mg/kg for Ni and 28±6.32 mg/kg for Cu, while during the rainy season the levels of 301±23.88 mg/kg for Zn, 5±0.00 mg/kg for Co, 9±7.87 mg/kg for Cd, 198.5±92.38 mg/kg for Pb, 20.5±8.97 mg/kg for Ni and 45.5±9.76 mg/kg for Cu were observed. The levels of metals based on average concentration during the dry and r...
SARS-CoV-2 (Covid 19) continues to be a great threat to lives globally as it causes illnesses suc... more SARS-CoV-2 (Covid 19) continues to be a great threat to lives globally as it causes illnesses such as the common cold, severe acute respiratory syndrome and spreads easily among people. In this work, thirteen molecular compounds were studied via quantum chemical calculations, molecular docking, and dynamic simulation, and ADMET (absorption, distribution, metabolism, excretion, and toxicity). The obtained descriptors (Log P, HBA, HBD, and molecular weight) showed that the studied compounds have the ability to act as a drug. Thus, it was detected that all the studied selected compounds possess a better tendency to inhibit main coronavirus protease; however, compound C1 has a higher tendency to inhibit main coronavirus protease than the other compounds, including the standard (Chloroquine). ADMET properties of compound C1 proved that the predicted ADMET level was better than the ADMET properties of the referenced drug.
The conviction that herbal drugs have enormous health benefits has led to increase the rate of th... more The conviction that herbal drugs have enormous health benefits has led to increase the rate of their consumption by Nigerians. The aim of this study was to assess the carcinogenic property of some popularly consumed anti-diarrheal herbal drugs via polycyclic aromatic hydrocarbons (PAHs) quantification. Three prevalent anti-diarrhea herbal drugs , Odunmo herbal drug (Hibiscus rosa-sinensis and Bacopamonnieri), Orogun herbal mixture (Hibiscus sabdariffaI and Hedera helix), and Alora herbal syrup (Aloe vera and Hibiscus sabdariffaI) were bought for the purpose of this study and they were coded as samples A, B, and C, respectively. The ultrasonic extraction of the herbal drugs was carried out using standard procedures. The crude extracts obtained were purified using a chromatographic method. The concentrations of PAHs were quantified using gas chromatography flame ionization detector (GCFID). The diagnostic indices, group distribution, toxicity equivalence and exposure dosage were estim...
Asian Journal of Organic & Medicinal Chemistry, 2021
Breast cancer still remains one of the precarious ailments among humans globally. The vulnerabili... more Breast cancer still remains one of the precarious ailments among humans globally. The vulnerability of this ailment in homeopathic world remains colossal and this has drawn the attention of seasoned researchers to find lasting solution to this hazard. Therefore, 10 novel 1,2,4-thiadiazole-1,2,4-triazole derivatives were studied so as to explore their anti-breast cancer activities. The studied compounds were optimized using Spartan 14 and the QSAR study was executed by using Gretl and MATLAB. Also, docking study was observed using Pymol (for treating downloaded protein), Autodock Tool (for locating binding site in the downloaded protein and for converting ligand and receptor to .pdbqt format from .pdb format), Auto dock vina (for docking calculation) and discovery studio (for viewing the nonbonding interaction between the docked complexes). The selected descriptors were used to developed effective QSAR model and it was observed that the developed QSAR model using artificial neural ne...
Data from eight 1,2,4-thiadiazole-1,2,4-triazole derivatives were used to observe the anti-epider... more Data from eight 1,2,4-thiadiazole-1,2,4-triazole derivatives were used to observe the anti-epidermal growth factor receptor kinase activities of 1,2,4-thiadiazole-1,2,4-triazole analogues thereby reducing human lung cancer. The software used to achieve this work were Spartan 14, Pymol, mgltools_win32_1.5.6, Auto dock vina and biovia2019.ds2019client. Also, the developed QSAR model was developed using the screened descriptors so as to inspect the closeness between the experimental IC50 and the predicted IC50. More so, the binding affinity from 1,2,4-thiadiazole-1,2,4-triazole derivatives - epidermal growth factor receptor kinase complexes using molecular docking approach were reported. Also, the ADMET properties for selected compounds and proposed compounds with better binding affinity were reported.
Gold nanoparticles (AuNPs) are one of the prominent metal nanoparticles (NPs) with a broad range ... more Gold nanoparticles (AuNPs) are one of the prominent metal nanoparticles (NPs) with a broad range of applications in various fields of science and technology. The demand for the use of AuNPs has been increasing on a regular basis. To meet such a demand, intensive research is required on optimizing synthesis approaches. Among various methods reported for the synthesis of AuNPs, biological methods using plant extract have been found to be simple, effective, cheap and environmental friendly because the gold salt is only reduced with biomolecules existing in plant extract. Various methods of AuNPs synthesis using different plant extracts have long been developed. Several techniques have been adopted in the characterization of the synthesized AuNPs. The antibacterial, antioxidant, anticancer and catalytic activities of AuNPs from plant extract have shown promising activities useful for several biomedical applications. This review focuses on the synthesis, optimization conditions, characterization and applications of biosynthesized AuNPs using plant extracts.
This research centred on the evaluation of the antifungal potency of gold nanoparticles (AuNPs) s... more This research centred on the evaluation of the antifungal potency of gold nanoparticles (AuNPs) synthesized from Garcinia kola leaves. The leaves of Garcinia kola obtained were thoroughly rinsed, air dried, pulverized and extracted. The extract obtained was mixed with aqueous solution of gold chloride to form gold nanoparticle and were characterized. The antifungal screening of the synthesized gold nanoparticles was carried out via the Agar disc diffusion method. The ultraviolet (UV) analysis showed an absorption wavelength at 536.12 nm. The scanning electron microscopic (SEM) image confirmed uniform distribution of the synthesized gold nanoparticles. The transmission electron microscope (TEM) analysis confirmed that the particle size are in the range of 8.21 to 19.00 nm. The broad inhibitory zones against test fungi displayed by the synthesized nanoparticles confirmed the synthesized gold nanoparticles as a good antifungal source. This study establish a simple, easy and environmental friendly approach of synthesizing gold nanoparticles.
The need to devise another method of synthesizing nanoparticles from sources that are eco-friendl... more The need to devise another method of synthesizing nanoparticles from sources that are eco-friendly, non-hazardous and cost effectiveness is of great importance in preventing environmental and health problems. The aim of this study was to evaluate the efficiency of Garcinia kola leaves as reducing and stabilizing agent for silver nanoparticles synthesis. The leaves of Garcinia kola obtained were authenticated, air dried, pulverized and extracted. The extract was mixed with aqueous solution of silver nitrate solution to form silver nanoparticles and were characterized using Ultra violet (UV) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), Energy-dispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD). The antibacterial investigation of the synthesized silver nanoparticle was carried out following the disk diffusion method. UV analysis revealed the silver surface plasmon band at 425.18 nm,...
The aim of this study was to assess the safety level of some bottled water produced in Okitipupa,... more The aim of this study was to assess the safety level of some bottled water produced in Okitipupa, Ondo State Nigeria. Several packs of bottled water were obtained from three different manufacturers. Some physicochemical parameters and heavy metals were investigated to assess the quality of the bottle water using standard methods. The results from the physicochemical parameters and heavy metals were in with World Health Organization (WHO) standard for drinking water when compared. This study confirmed that the analyzed bottled water has good quality. Therefore, these bottled water are said to be safe for drinking.
The use of herbal drugs for the treatment of various ailments especially diabetes mellitus has gr... more The use of herbal drugs for the treatment of various ailments especially diabetes mellitus has greatly increased recently due to the approval and recommendation from regulatory bodies. The safety level of these herbal drugs has not been clearly understood. This study was designed to determine the functional groups responsible for the anti-diabetic activity of these drugs and also to estimate their heavy metal concentrations. Three most popularly sold and readily available anti-diabetic herbal drugs were purchased from Okitipupa Market in Ondo State. The Fourier Transform Infrared Spectroscopy (FTIR) analysis was done by scanning the samples on Shimadzu FTIR machine at a wavelength of 4000 – 500 cm. For the heavy metals analysis, the herbal drug samples were digested using standard method and analyzed on an Atomic Absorption Spectrophotometer (AAS). The FTIR spectral revealed absorption bands corresponding to -OH, C-H, C=O, C=C and S=O functional groups. The concentrations of the sel...
Schoolof Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, China. Dep... more Schoolof Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, China. Department of Pure and Applied Chemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria. Department of Agricultural Economics, Ladoke Akintola University of Technology, Ogbomoso, Nigeria. Department of Anatomy, Osun State University, Osogbo, Nigeria Department of Basic Sciences, Adeleke University, P.M.B. 250, Ede, Osun State, Nigeria. Department of Chemistry, Louisiana State University, Louisiana, USA folorunsoaderonkesimi@gmail.com
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