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'''Otto Heinrich Warburg''' ([[October 8]], [[1883]] - [[August 1]], [[1970]]) was a [[Germany|German]] [[chemist]].<ref name="nobel">{{cite web |url=http://nobelprize.org/nobel_prizes/medicine/laureates/1931/warburg-bio.html |title=Biography of Otto Warburg |accessdate=2009-07-02 |publisher=The Nobel Foundation}}</ref> After earning his doctorate degrees in medicine and chemistry, he started to investigate how [[oxygen]] is consumed by [[ |
'''Otto Heinrich Warburg''' ([[October 8]], [[1883]] - [[August 1]], [[1970]]) was a [[Germany|German]] [[chemist]].<ref name="nobel">{{cite web |url=http://nobelprize.org/nobel_prizes/medicine/laureates/1931/warburg-bio.html |title=Biography of Otto Warburg |accessdate=2009-07-02 |publisher=The Nobel Foundation}}</ref> After earning his doctorate degrees in medicine and chemistry, he started to investigate how [[oxygen]] is consumed by [[cell]]s in a living [[organism]]. His studies led him to identify the role of the [[cytochrome]]s.<ref>{{Cite web|title=Otto Warburg {{!}} Nobel Prize, Cell Respiration, Metabolism {{!}} Britannica|url=https://www.britannica.com/biography/Otto-Warburg|access-date=2024-02-06|website=www.britannica.com|language=en}}</ref> |
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He won the 1931 [[Nobel Prize in Physiology or Medicine]] for the discovery of the [[respiratory system|respiratory]] [[enzyme]]. |
He won the 1931 [[Nobel Prize in Physiology or Medicine]] for the discovery of the [[respiratory system|respiratory]] [[enzyme]]. |
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==Cancer== |
==Cancer== |
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In the 1920s, Warburg and his colleagues observed that [[tumor]]s take up higher amounts of [[glucose]] than their surrounding tissues. Although consuming glucose is helpful for mammals because it is a [[nutrient]], tumor cells consumed too much glucose despite having working [[mitochondria]] and enough presence of oxygen. This observation is called the [[Warburg effect]].<ref name=":0">{{Cite journal|last=Liberti|first=Maria V.|last2=Locasale|first2=Jason W.|date=2016 |
In the 1920s, Warburg and his colleagues observed that [[tumor]]s take up higher amounts of [[glucose]] than their surrounding tissues. Although consuming glucose is helpful for mammals because it is a [[nutrient]], tumor cells consumed too much glucose despite having working [[mitochondria]] and enough presence of oxygen. This observation is called the [[Warburg effect]].<ref name=":0">{{Cite journal|last=Liberti|first=Maria V.|last2=Locasale|first2=Jason W.|date=March 2016|title=The Warburg Effect: How Does it Benefit Cancer Cells?|url=https://linkinghub.elsevier.com/retrieve/pii/S0968000415002418|journal=Trends in Biochemical Sciences|language=en|volume=41|issue=3|pages=211–218|doi=10.1016/j.tibs.2015.12.001|pmc=PMC4783224|pmid=26778478}}</ref> |
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Following this observation, Warburg and his colleagues concluded: to kill a tumor cell, it must be deprived of glucose.<ref name=":0" /> |
Following this observation, Warburg and his colleagues concluded: to kill a tumor cell, it must be deprived of glucose.<ref name=":0" /> |
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Revision as of 23:30, 16 February 2024
Otto Heinrich Warburg | |
|---|---|
 Otto Warburg | |
| Born | October 8, 1883 |
| Died | August 1, 1970 |
| Alma mater | University of Berlin University of Heidelberg |
| Awards | Nobel Prize in Physiology or Medicine (1931) |
| Scientific career | |
| Institutions | Kaiser Wilhelm Institute (now Max Planck Institute) for Biology Berlin, Germany |
Otto Heinrich Warburg (October 8, 1883 - August 1, 1970) was a German chemist.[1] After earning his doctorate degrees in medicine and chemistry, he started to investigate how oxygen is consumed by cells in a living organism. His studies led him to identify the role of the cytochromes.[2]
He won the 1931 Nobel Prize in Physiology or Medicine for the discovery of the respiratory enzyme.
Cancer
In the 1920s, Warburg and his colleagues observed that tumors take up higher amounts of glucose than their surrounding tissues. Although consuming glucose is helpful for mammals because it is a nutrient, tumor cells consumed too much glucose despite having working mitochondria and enough presence of oxygen. This observation is called the Warburg effect.[3]
Following this observation, Warburg and his colleagues concluded: to kill a tumor cell, it must be deprived of glucose.[3]
References
- ↑ "Biography of Otto Warburg". The Nobel Foundation. Retrieved 2009-07-02.
- ↑ "Otto Warburg | Nobel Prize, Cell Respiration, Metabolism | Britannica". www.britannica.com. Retrieved 2024-02-06.
- ↑ 3.0 3.1 Liberti, Maria V.; Locasale, Jason W. (March 2016). "The Warburg Effect: How Does it Benefit Cancer Cells?". Trends in Biochemical Sciences. 41 (3): 211–218. doi:10.1016/j.tibs.2015.12.001. PMC 4783224. PMID 26778478.
{{cite journal}}: CS1 maint: PMC format (link)
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