TAS2R38
Receptor ukusa tip 2 član 38 je protein koji je kod ljudi kodiran TAS2R38 genom. TAS2R38 je receptor gorkog ukusa. Različiti genotipi ovog receptora utiču na sposobnost prepoznavanja ukusa 6-n-propiltiouracila (PROP)[1] i feniltiokarbamida (PTC).[2][3] Though it has often been proposed that varying taste receptor genotypes could influence tasting ability, TAS2R38 is one of the only taste receptors shown to have this function.[4]
| Receptor ukusa tip 2 član 38 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | TAS2R38; PTC; T2R38; T2R61 | ||||||||||
| Vanjski ID | OMIM: 607751 MGI: 2681306 HomoloGene: 47976 IUPHAR: GeneCards: TAS2R38 Gene | ||||||||||
| |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5726 | 387513 | |||||||||
| Ensembl | ENSG00000257138 | ENSMUSG00000058250 | |||||||||
| UniProt | P59533 | Q7TQA6 | |||||||||
| RefSeq (mRNA) | NM_176817.4 | NM_001001451.1 | |||||||||
| RefSeq (protein) | NP_789787.4 | NP_001001451.1 | |||||||||
| Lokacija (UCSC) |
Chr 7: 141.67 - 141.67 Mb |
Chr 6: 40.56 - 40.56 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Prenos signala
уредиKao i kod svih TAS2R proteina, TAS2R38 koristi G-protein gustducin kao svoj primarni metod prenosa signala. Jedinice α i βγ su esencijalne za prenos signala ukusa.[5]
Reference
уреди- ^ Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, Snyder DJ, Bartoshuk LM (2004). „Bitter Receptor Gene (TAS2R38), 6-n-Propylthiouracil (PROP) Bitterness and Alcohol Intake”. Alcoholism, clinical and experimental research. 28 (11): 1629—1637. PMC 1397913
. PMID 15547448. doi:10.1097/01.ALC.0000145789.55183.D4.
- ^ Prodi DA, Drayna D, Forabosco P, Palmas MA, Maestrale GB, Piras D, Pirastu M, Angius A (2004). „Bitter Taste Study in a Sardinian Genetic Isolate Supports the Association of Phenylthiocarbamide Sensitivity to the TAS2R38 Bitter Receptor Gene”. Chemical Senses. 29 (8): 697—702. PMID 15466815. doi:10.1093/chemse/bjh074.
- ^ Kim UK, Drayna D (2004). „Genetics of individual differences in bitter taste perception: Lessons from the PTC gene”. Clinical Genetics. 67 (4): 275—280. PMID 15733260. doi:10.1111/j.1399-0004.2004.00361.x.
- ^ Bachmanov AA, Beauchamp GK (2007). „Taste Receptor Genes”. Annual Review of Nutrition. 27: 389—414. PMC 2721271 . PMID 17444812. doi:10.1146/annurev.nutr.26.061505.111329.
- ^ Margolskee RF (2001). „Molecular Mechanisms of Bitter and Sweet Taste Transduction”. Journal of Biological Chemistry. 277 (1): 1—4. PMID 11696554. doi:10.1074/jbc.R100054200.
Literatura
уреди- Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste”. Curr. Opin. Neurobiol. 12 (4): 366—71. PMID 12139982. doi:10.1016/S0959-4388(02)00345-8.
- Anne-Spence M; Falk CT; Neiswanger K; et al. (1984). „Estimating the recombination frequency for the PTC-Kell linkage”. Hum. Genet. 67 (2): 183—6. PMID 6745938. doi:10.1007/BF00272997.
- Bufe B; Hofmann T; Krautwurst D; et al. (2002). „The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides”. Nat. Genet. 32 (3): 397—401. PMID 12379855. doi:10.1038/ng1014.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Zhang Y; Hoon MA; Chandrashekar J; et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways”. Cell. 112 (3): 293—301. PMID 12581520. doi:10.1016/S0092-8674(03)00071-0.
- Conte C; Ebeling M; Marcuz A; et al. (2003). „Identification and characterization of human taste receptor genes belonging to the TAS2R family”. Cytogenet. Genome Res. 98 (1): 45—53. PMID 12584440. doi:10.1159/000068546.
- Scherer SW; Cheung J; MacDonald JR; et al. (2003). „Human Chromosome 7: DNA Sequence and Biology”. Science. 300 (5620): 767—72. PMC 2882961 . PMID 12690205. doi:10.1126/science.1083423.
- Pronin AN, Tang H, Connor J, Keung W (2005). „Identification of ligands for two human bitter T2R receptors”. Chem. Senses. 29 (7): 583—93. PMID 15337684. doi:10.1093/chemse/bjh064.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes”. Mol. Biol. Evol. 22 (3): 432—6. PMID 15496549. doi:10.1093/molbev/msi027.
- Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates”. Genetics. 170 (1): 313—26. PMC 1449719 . PMID 15744053. doi:10.1534/genetics.104.037523.
Spoljašnje veze
уреди- TAS2R38+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)
- TAS2R38 Gene Card
- TAS2R38 OMIM Page