TAS2R1
| Receptor ukusa tip 2 član 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | TAS2R1; T2R1; TRB7 | ||||||||||
| Vanjski ID | OMIM: 604796 MGI: 2681253 HomoloGene: 10480 IUPHAR: GeneCards: TAS2R1 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 50834 | 57254 | |||||||||
| Ensembl | ENSG00000169777 | ENSMUSG00000045267 | |||||||||
| UniProt | Q9NYW7 | Q9JKT2 | |||||||||
| RefSeq (mRNA) | NM_019599.2 | NM_020503.2 | |||||||||
| RefSeq (protein) | NP_062545.1 | NP_065249.2 | |||||||||
| Lokacija (UCSC) |
Chr 5: 9.63 - 9.63 Mb |
Chr 15: 32.11 - 32.11 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Receptor ukusa tip 2 član 1 je protein koji je kod ljudi kodiran TAS2R1 genom.[1][2][3]
Ovaj protein je član familije of mogućih receptora ukusa. On pripada grupi G protein spregnutih receptora i specifično je izražen u ćelijama ukusa jezika i epitela nepci. On deluje kao receptor gorkog ukusa. Ovaj receptor ukusa ne sadrži introne. Njegov gen se nalazi na hromozomu 5p15, na lokaciji genetičkog lokusa (PROP) koji kontroliše detekciju gorkog jedinjenja 6-n-propil-2-thiouracil.[3]
Reference
[уреди | уреди извор]- ^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000). „A novel family of mammalian taste receptors”. Cell. 100 (6): 693—702. PMID 10761934. doi:10.1016/S0092-8674(00)80705-9.
- ^ Matsunami H, Montmayeur JP, Buck LB (2000). „A family of candidate taste receptors in human and mouse”. Nature. 404 (6778): 601—4. PMID 10766242. doi:10.1038/35007072.
- ^ а б „Entrez Gene: TAS2R1 taste receptor, type 2, member 1”.
Literatura
[уреди | уреди извор]- Kinnamon SC (2000). „A plethora of taste receptors”. Neuron. 25 (3): 507—10. PMID 10774719. doi:10.1016/S0896-6273(00)81054-5.
- Margolskee RF (2002). „Molecular mechanisms of bitter and sweet taste transduction”. J. Biol. Chem. 277 (1): 1—4. PMID 11696554. doi:10.1074/jbc.R100054200.
- Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste”. Curr. Opin. Neurobiol. 12 (4): 366—71. PMID 12139982. doi:10.1016/S0959-4388(02)00345-8.
- Chandrashekar J; Mueller KL; Hoon MA; et al. (2000). „T2Rs function as bitter taste receptors”. Cell. 100 (6): 703—11. PMID 10761935. doi:10.1016/S0092-8674(00)80706-0.
- Firestein S (2000). „The good taste of genomics”. Nature. 404 (6778): 552—3. PMID 10766221. doi:10.1038/35007167.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Zhang Y; Hoon MA; Chandrashekar J; et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways”. Cell. 112 (3): 293—301. PMID 12581520. doi:10.1016/S0092-8674(03)00071-0.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes”. Mol. Biol. Evol. 22 (3): 432—6. PMID 15496549. doi:10.1093/molbev/msi027.
- Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates”. Genetics. 170 (1): 313—26. PMC 1449719 . PMID 15744053. doi:10.1534/genetics.104.037523.