Two molecules of type IV collagen are linked via the COOH-terminal non-collagenous domain (NCI do... more Two molecules of type IV collagen are linked via the COOH-terminal non-collagenous domain (NCI domain). In this way, type IV collagen forms the main framework of basement membrane. We have developed sandwich Enzyme-Linked Immunosorbent Assay (ELISA) for human serum type IV collage peptide monoclonals for CO5 and CO6 recognizing two different determinants on the central triplex of human collagen molecules. Using this, we explored the possibility that serum levels of type IV collagen (Col IV) are an indicator of early diabetic nephropathy (DN). Serum type IV collagen levels were determined by ELISA in 36 patients with diabetic nephropathy. Serum hemoglobin A1c (HbA1c) and in twenty-four hour urinary albumin excretion rates (UAER) were measured at the same time. A relationship was found between serum levels of this collagen IV and the presence of diabetic nephropathy. That is, serum levels of type IV collagen in diabetic nephropathy were significantly higher than those found in non-insulin-dependent diabetic (NIDDM) patients without nephropathy and in healthy subjects (HS). It is possible that an elevated serum collagen type IV level reflects increased synthetic activity in basement membrane collagen type IV. Serum type IV collagen may be a useful marker for monitoring the dynamics of basement membrane metabolism and in this way serve as a clinical indicator of the progression or the activity of diabetic nephropathy and a marker for the assessment of therapeutic effects.
In job market, there's an increased demand for application-oriented t... more In job market, there's an increased demand for application-oriented talents. Computer Supported Collaborative Learning (CSCL) is an important model of practice teaching for the training of the application-oriented talents. The status of practice teaching is studied based on the characteristics of the Information Management and Information System (IMIS). Computer Supported Collaborative Learning is introduced to break the shackles of the
Background Several studies conducted during the past two decades suggested increasing trend of ch... more Background Several studies conducted during the past two decades suggested increasing trend of childhood allergic diseases in China. However, few studies have provided detailed description of geographic variation and explored risk factors of these diseases. This study investigated the pattern and risk factors of asthma, allergic rhinitis and eczema in eight metropolitan cities in China. Methods We conducted a cross-sectional survey during November-December 2005 in eight metropolitan cities in China. A total of 23791 children aged 6-13 years participated in this survey. Questions from the standard questionnaire of the International Study of Asthma and Allergies in Children (ISAAC) were used to examine the pattern of current asthma, allergic rhinitis and eczema. Logistic regression analyses were performed to assess the risk factors for childhood allergies. Results The average prevalence of childhood asthma, allergic rhinitis and eczema across the eight cities was 3∙3% (95% Confidence interval (CI): 3∙1%, 3∙6%), 9∙8% (95% CI: 9∙4%, 10∙2%) and 5∙5% (95% CI: 5∙2%, 5∙8%), respectively. Factors related to lifestyle, mental health and socio-economic status were found to be associated with the prevalence of childhood allergies. These risk factors were unevenly distributed across cities and disproportionately affected the local prevalence. Conclusions There was apparent geographic variation of childhood allergies in China. Socio-environmental factors had strong impacts on the prevalence of childhood allergies; but these impacts differed across regions. Thus public health policies should specifically target at the local risk factors for each individual area.
Journal of University of Science and Technology Beijing, 2006
The hot deformation behavior of FGH96 superalloys at 10701170°C and 5×10 −4 -2×10 −1 s −1 were i... more The hot deformation behavior of FGH96 superalloys at 10701170°C and 5×10 −4 -2×10 −1 s −1 were investigated by means of the isothermal compression tests at a Gleeble-1500 thermal mechanical simulator. The results show that dynamic recovery acts as the main softening ...
Two molecules of type IV collagen are linked via the COOH-terminal non-collagenous domain (NCI do... more Two molecules of type IV collagen are linked via the COOH-terminal non-collagenous domain (NCI domain). In this way, type IV collagen forms the main framework of basement membrane. We have developed sandwich Enzyme-Linked Immunosorbent Assay (ELISA) for human serum type IV collage peptide monoclonals for CO5 and CO6 recognizing two different determinants on the central triplex of human collagen molecules. Using this, we explored the possibility that serum levels of type IV collagen (Col IV) are an indicator of early diabetic nephropathy (DN). Serum type IV collagen levels were determined by ELISA in 36 patients with diabetic nephropathy. Serum hemoglobin A1c (HbA1c) and in twenty-four hour urinary albumin excretion rates (UAER) were measured at the same time. A relationship was found between serum levels of this collagen IV and the presence of diabetic nephropathy. That is, serum levels of type IV collagen in diabetic nephropathy were significantly higher than those found in non-insulin-dependent diabetic (NIDDM) patients without nephropathy and in healthy subjects (HS). It is possible that an elevated serum collagen type IV level reflects increased synthetic activity in basement membrane collagen type IV. Serum type IV collagen may be a useful marker for monitoring the dynamics of basement membrane metabolism and in this way serve as a clinical indicator of the progression or the activity of diabetic nephropathy and a marker for the assessment of therapeutic effects.
In job market, there's an increased demand for application-oriented t... more In job market, there's an increased demand for application-oriented talents. Computer Supported Collaborative Learning (CSCL) is an important model of practice teaching for the training of the application-oriented talents. The status of practice teaching is studied based on the characteristics of the Information Management and Information System (IMIS). Computer Supported Collaborative Learning is introduced to break the shackles of the
Background Several studies conducted during the past two decades suggested increasing trend of ch... more Background Several studies conducted during the past two decades suggested increasing trend of childhood allergic diseases in China. However, few studies have provided detailed description of geographic variation and explored risk factors of these diseases. This study investigated the pattern and risk factors of asthma, allergic rhinitis and eczema in eight metropolitan cities in China. Methods We conducted a cross-sectional survey during November-December 2005 in eight metropolitan cities in China. A total of 23791 children aged 6-13 years participated in this survey. Questions from the standard questionnaire of the International Study of Asthma and Allergies in Children (ISAAC) were used to examine the pattern of current asthma, allergic rhinitis and eczema. Logistic regression analyses were performed to assess the risk factors for childhood allergies. Results The average prevalence of childhood asthma, allergic rhinitis and eczema across the eight cities was 3∙3% (95% Confidence interval (CI): 3∙1%, 3∙6%), 9∙8% (95% CI: 9∙4%, 10∙2%) and 5∙5% (95% CI: 5∙2%, 5∙8%), respectively. Factors related to lifestyle, mental health and socio-economic status were found to be associated with the prevalence of childhood allergies. These risk factors were unevenly distributed across cities and disproportionately affected the local prevalence. Conclusions There was apparent geographic variation of childhood allergies in China. Socio-environmental factors had strong impacts on the prevalence of childhood allergies; but these impacts differed across regions. Thus public health policies should specifically target at the local risk factors for each individual area.
Journal of University of Science and Technology Beijing, 2006
The hot deformation behavior of FGH96 superalloys at 10701170°C and 5×10 −4 -2×10 −1 s −1 were i... more The hot deformation behavior of FGH96 superalloys at 10701170°C and 5×10 −4 -2×10 −1 s −1 were investigated by means of the isothermal compression tests at a Gleeble-1500 thermal mechanical simulator. The results show that dynamic recovery acts as the main softening ...
Uploads
Papers by Yiwen Zhang