High-intensity interval training (HIIT) is an efficient method to improve vascular function, maxi... more High-intensity interval training (HIIT) is an efficient method to improve vascular function, maximal oxygen consumption, and muscle mitochondrial capacity. However, acute HIIT overstresses the oxidative system and causes muscle soreness and damage. The aim of the present study was to investigate the effects of date seeds on exercise-induced oxidative stress and aerobic and anaerobic performance following HIIT sessions. Thirty-six physically active men and women aged 18–35 years were assigned to take 26 g/d of date seed powder (DSP,n18) or wheat bran powder (placebo,n18) before and after HIIT workouts for 14 d. Total antioxidant capacity (TAC), oxidative stress index (OSI), total oxidant status (TOS), superoxide dismutase (SOD), glutathione peroxidase (GPx), uric acid, malondialdehyde (MDA), and 8-iso-PGF2αwere determined at baseline, at the end of the intervention, and 24-h post-intervention. We used the Cooper and running-based anaerobic sprint test to assess aerobic and anaerobic ...
Sleep quality is influenced by various physiological and psychological parameters. We aimed to in... more Sleep quality is influenced by various physiological and psychological parameters. We aimed to investigate the predictors of sleep quality, including eating behavior patterns, body mass index, self-efficacy, and coping strategies among university students. Three hypotheses were tested: 1) self-efficacy could predict sleep quality; 2) coping strategies could predict sleep quality and 3) eating behavior patterns and body mass index could mediate the association of self-efficacy and coping strategies with sleep quality. In a cross-sectional study, Sherer’s self-efficacy questionnaire, Jalowiec coping scale, eating behavioral patterns, and Pittsburgh’s sleep quality index questionnaires were collected from 250 female university students. The results of analyzing data using the structural equation modeling approach showed that the first and second hypotheses were fully confirmed but the third hypothesis was only partially supported. Higher self-efficacy and problem-focused coping strategies could positively predict better sleep quality, but higher emotion-focused coping strategies negatively predicted good sleep quality. Moreover, eating behavior patterns and body mass index could mediate the association between self-efficacy and emotion-focused (but not problem-focused) coping strategies with sleep quality. In brief, the total effects of self-efficacy, emotion-focused, and problem-focused coping strategies on sleep quality were β = −0.260, β = 0.327 and β = −0.209; p < 0.001, respectively. The present study provides new evidence about the predictors of sleep quality among university students. However, further studies are required with longitudinal design and with more objective assessments of sleep quality.
Background Vitamin D supplementation exerts several supporting effects on improving glycemic stat... more Background Vitamin D supplementation exerts several supporting effects on improving glycemic status, however, results are inconclusive. Thus, in the present study, we aimed to conduct an umbrella of meta-analysis regarding the impact of vitamin D on type 2 diabetes (T2DM) biomarkers. Methods The Scopus, PubMed, Web of Science, Embase, and Google Scholar online databases were searched up to March 2022. All meta-analyses evaluating the impact of vitamin D supplementation on T2DM biomarkers were considered eligible. Overall, 37 meta-analyses were included in this umbrella meta-analysis. Results Our findings indicated that vitamin D supplementation significantly decreased fasting blood sugar (FBS) (WMD = − 3.08; 95% CI: − 3.97, − 2.19, p < 0.001, and SMD = − 0.26; 95% CI: − 0.38, − 0.14, p < 0.001), hemoglobin A1c (HbA1c) (WMD = − 0.05; 95% CI: − 0.10, − 0.01, p = 0.016, and SMD = − 0.16; 95% CI: − 0.27, − 0.05, p = 0.004), insulin concentrations (WMD = − 2.62; 95% CI: − 4.11...
Methods: This descriptive cross-sectional study was conducted on 857 primary school students of T... more Methods: This descriptive cross-sectional study was conducted on 857 primary school students of Tabriz city in 2012-2013. First, BMI of each person was calculated, and according to the NCHS standard curves, the values below the 5 th percentile were considered as malnutrition and underweight, between the 85 th -95 th percentiles as overweight, and equal to or above the 95 th percentile as obesity. Data were analyzed by one-sample t-test and t-test. The significance level was considered to be p<0.05.
Background: High intensity and endurance exercises lead to exercise-induced oxidative stress (EIO... more Background: High intensity and endurance exercises lead to exercise-induced oxidative stress (EIOS), exercise-induced muscle damage (EIMD), and inflammation, which are the influencing factors on muscle soreness, localized swelling, and sport performance. Therefore, the purpose of this study is to determine the effectiveness of Tribulus terrestris (TT) as an herbal supplement with antioxidant and anti-inflammatory properties on the nutritional, oxidative stress, and anti/inflammatory status, as well as the sport performance of recreational runners.Methods/design: This study is a double-blind, randomized, placebo-controlled trial, which will be conducted among recreational runners of Tabriz stadiums, Iran. Thirty-four recreational runners will be selected, and participants will be assigned randomly to two groups: to receive 500 mg TT supplement or placebo capsules twice daily for two weeks. Both groups will do the high-intensity interval training (HIIT) workouts during the study. Base...
The effects of co-supplementing Camelina oil and a prebiotic as modulators of the gut microbiota ... more The effects of co-supplementing Camelina oil and a prebiotic as modulators of the gut microbiota on cardiometabolic risk factors and mental health in patients with NAFLD.
BACKGROUND AND OBJECTIVES Coronary artery disease (CAD) is a major cause of death worldwide. Chro... more BACKGROUND AND OBJECTIVES Coronary artery disease (CAD) is a major cause of death worldwide. Chronic stable angina (CSA) is the primary sign of CAD. Oxidative stress and inflammation play a substantial role in pathogenesis and progression of CAD. The aim of this study was to investigate the effects of oral administration of powdered Melissa officinalis (MO) on biomarkers of oxidative stress, inflammation, and lipid profile in patients with CSA. METHODS AND STUDY DESIGN A randomized, double-blind, placebo-controlled clinical trial was performed in 80 patients with CSA. The subjects were randomly assigned to obtaineither oral MO 3 g/d (n=40) or placebo (n=40) for eight weeks. Anthropometric indices, biomarkers of oxidative stress, inflammation, and lipid profile were evaluated at baseline and post-intervention. RESULTS The mean serum concentrations of triglycerides, total-cholesterol, LDL-cholesterol, and malondialdehyde (MDA), and high sensitive C-Reactive Protein (hs-CRP) were lower...
Obesity prevalence have tripled in the past decades. It is logical to consider new approaches to ... more Obesity prevalence have tripled in the past decades. It is logical to consider new approaches to halt its prevalence. In this concept, considering the effect of interaction between fatty acid desaturase 2 (FADS2) gene variants and dietary advanced glycation end products (AGEs) on obesity-related characteristics seems to be challenging. The present cross-sectional study conducted among 347 obese individuals. A validated semi-quantitative 147-item food frequency questionnaire (FFQ) was used to estimate dietary intakes and American multiethnic database was used to calculate AGEs content of food items which were not available in Iranian Food Composition Table (FCT). FADS2 gene variants were determined according to Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Analysis of covariance (ANCOVA) was used to evaluate the modifier effect of FADS2 gene-dietary AGEs on biochemical values. Based on our findings, no significant differences was reported in term of b...
Background and Objective: Nowadays, consumption of functional foods is favored because of their h... more Background and Objective: Nowadays, consumption of functional foods is favored because of their health promoting characteristics. Also there is an increasing demand for nondairy products because of lactose intolerance in dairies. Fig juice as a source of dietary fiber and other nutrients would be a functional food. Adding probiotics and prebiotics makes it more functional for daily use. No study has yet been done on synbiotic fig juice. Accordingly, the aim of this study was to characterize synbiotic fig juice prepared by Lactobacillus delbrueckii and inulin. Material and Methods: Samples consisted of control fig juice; fig juice fermented by Lactobacillus delbrueckii (probiotic) and fig juice containing inulin fermented by Lactobacillus delbrueckii (synbiotic) were produced. Physico-chemical parameters, total phenolic content, antioxidant capacity and microbial survival aspects were analyzed during the fermentation period. Aforementioned parameters were also evaluated in 4 weeks wi...
Recently emerged coronavirus, known as SARS-CoV-2 or Covid-19 is considered as a serious threat f... more Recently emerged coronavirus, known as SARS-CoV-2 or Covid-19 is considered as a serious threat for human health. Due to unavailable specific drugs for this virus, there is an urgent need for supportive cares. Epigenetic immune boosting approaches and developing anti-inflammatory agents by gut-associated bioactive macronutrients can be plausible protective cares for COVID-19. Suitable intake of bioactive macronutrients including prebiotics, fatty acids, proteins and branched-chain amino acids may result in anti-viral responses through modulating macrophages and dendritic cells via Toll-like receptors, decreasing viral load, inactivating the enveloped viruses, increasing the anti-inflammatory metabolites and inhibiting the proliferation of microbial organisms. Bioactive macronutrients may help in promotion of immunological responses and recovery acceleration against Covid-19. This review focuses on the mechanisms of bioactive macronutrients and related clinical trials on enveloped vi...
Exposure to food toxins generate multiple adverse health effects. Heavy metals, antibioticsresidu... more Exposure to food toxins generate multiple adverse health effects. Heavy metals, antibioticsresidue, mycotoxins, pesticides and some food additives are examples of the most importantfood toxins. The common mechanism of toxicity and carcinogenicity effects of food toxins is thegeneration of oxidative stress that leads to DNA damages. Moreover, based on epidemiologicevidence unhealthy eating habits and food toxicities are associated with cancers occurrence.Therefore, application of bioactive food additives as harmless or safe components in foodindustry is expensive. Nigella sativa L. is a broadly used herb-drug for various diseases all overthe world and has been used as preservative and food additive. Based on various studies N. sativahas shown various pharmacological activities including therapeutic efficacy against differenthuman diseases and antioxidant anti-inflammatory effects against environmental toxins. N.sativa decreases the adverse health effects induced by mentioned food tox...
High-intensity interval training (HIIT) is an efficient method to improve vascular function, maxi... more High-intensity interval training (HIIT) is an efficient method to improve vascular function, maximal oxygen consumption, and muscle mitochondrial capacity. However, acute HIIT overstresses the oxidative system and causes muscle soreness and damage. The aim of the present study was to investigate the effects of date seeds on exercise-induced oxidative stress and aerobic and anaerobic performance following HIIT sessions. Thirty-six physically active men and women aged 18–35 years were assigned to take 26 g/d of date seed powder (DSP,n18) or wheat bran powder (placebo,n18) before and after HIIT workouts for 14 d. Total antioxidant capacity (TAC), oxidative stress index (OSI), total oxidant status (TOS), superoxide dismutase (SOD), glutathione peroxidase (GPx), uric acid, malondialdehyde (MDA), and 8-iso-PGF2αwere determined at baseline, at the end of the intervention, and 24-h post-intervention. We used the Cooper and running-based anaerobic sprint test to assess aerobic and anaerobic ...
Sleep quality is influenced by various physiological and psychological parameters. We aimed to in... more Sleep quality is influenced by various physiological and psychological parameters. We aimed to investigate the predictors of sleep quality, including eating behavior patterns, body mass index, self-efficacy, and coping strategies among university students. Three hypotheses were tested: 1) self-efficacy could predict sleep quality; 2) coping strategies could predict sleep quality and 3) eating behavior patterns and body mass index could mediate the association of self-efficacy and coping strategies with sleep quality. In a cross-sectional study, Sherer’s self-efficacy questionnaire, Jalowiec coping scale, eating behavioral patterns, and Pittsburgh’s sleep quality index questionnaires were collected from 250 female university students. The results of analyzing data using the structural equation modeling approach showed that the first and second hypotheses were fully confirmed but the third hypothesis was only partially supported. Higher self-efficacy and problem-focused coping strategies could positively predict better sleep quality, but higher emotion-focused coping strategies negatively predicted good sleep quality. Moreover, eating behavior patterns and body mass index could mediate the association between self-efficacy and emotion-focused (but not problem-focused) coping strategies with sleep quality. In brief, the total effects of self-efficacy, emotion-focused, and problem-focused coping strategies on sleep quality were β = −0.260, β = 0.327 and β = −0.209; p < 0.001, respectively. The present study provides new evidence about the predictors of sleep quality among university students. However, further studies are required with longitudinal design and with more objective assessments of sleep quality.
Background Vitamin D supplementation exerts several supporting effects on improving glycemic stat... more Background Vitamin D supplementation exerts several supporting effects on improving glycemic status, however, results are inconclusive. Thus, in the present study, we aimed to conduct an umbrella of meta-analysis regarding the impact of vitamin D on type 2 diabetes (T2DM) biomarkers. Methods The Scopus, PubMed, Web of Science, Embase, and Google Scholar online databases were searched up to March 2022. All meta-analyses evaluating the impact of vitamin D supplementation on T2DM biomarkers were considered eligible. Overall, 37 meta-analyses were included in this umbrella meta-analysis. Results Our findings indicated that vitamin D supplementation significantly decreased fasting blood sugar (FBS) (WMD = − 3.08; 95% CI: − 3.97, − 2.19, p < 0.001, and SMD = − 0.26; 95% CI: − 0.38, − 0.14, p < 0.001), hemoglobin A1c (HbA1c) (WMD = − 0.05; 95% CI: − 0.10, − 0.01, p = 0.016, and SMD = − 0.16; 95% CI: − 0.27, − 0.05, p = 0.004), insulin concentrations (WMD = − 2.62; 95% CI: − 4.11...
Methods: This descriptive cross-sectional study was conducted on 857 primary school students of T... more Methods: This descriptive cross-sectional study was conducted on 857 primary school students of Tabriz city in 2012-2013. First, BMI of each person was calculated, and according to the NCHS standard curves, the values below the 5 th percentile were considered as malnutrition and underweight, between the 85 th -95 th percentiles as overweight, and equal to or above the 95 th percentile as obesity. Data were analyzed by one-sample t-test and t-test. The significance level was considered to be p<0.05.
Background: High intensity and endurance exercises lead to exercise-induced oxidative stress (EIO... more Background: High intensity and endurance exercises lead to exercise-induced oxidative stress (EIOS), exercise-induced muscle damage (EIMD), and inflammation, which are the influencing factors on muscle soreness, localized swelling, and sport performance. Therefore, the purpose of this study is to determine the effectiveness of Tribulus terrestris (TT) as an herbal supplement with antioxidant and anti-inflammatory properties on the nutritional, oxidative stress, and anti/inflammatory status, as well as the sport performance of recreational runners.Methods/design: This study is a double-blind, randomized, placebo-controlled trial, which will be conducted among recreational runners of Tabriz stadiums, Iran. Thirty-four recreational runners will be selected, and participants will be assigned randomly to two groups: to receive 500 mg TT supplement or placebo capsules twice daily for two weeks. Both groups will do the high-intensity interval training (HIIT) workouts during the study. Base...
The effects of co-supplementing Camelina oil and a prebiotic as modulators of the gut microbiota ... more The effects of co-supplementing Camelina oil and a prebiotic as modulators of the gut microbiota on cardiometabolic risk factors and mental health in patients with NAFLD.
BACKGROUND AND OBJECTIVES Coronary artery disease (CAD) is a major cause of death worldwide. Chro... more BACKGROUND AND OBJECTIVES Coronary artery disease (CAD) is a major cause of death worldwide. Chronic stable angina (CSA) is the primary sign of CAD. Oxidative stress and inflammation play a substantial role in pathogenesis and progression of CAD. The aim of this study was to investigate the effects of oral administration of powdered Melissa officinalis (MO) on biomarkers of oxidative stress, inflammation, and lipid profile in patients with CSA. METHODS AND STUDY DESIGN A randomized, double-blind, placebo-controlled clinical trial was performed in 80 patients with CSA. The subjects were randomly assigned to obtaineither oral MO 3 g/d (n=40) or placebo (n=40) for eight weeks. Anthropometric indices, biomarkers of oxidative stress, inflammation, and lipid profile were evaluated at baseline and post-intervention. RESULTS The mean serum concentrations of triglycerides, total-cholesterol, LDL-cholesterol, and malondialdehyde (MDA), and high sensitive C-Reactive Protein (hs-CRP) were lower...
Obesity prevalence have tripled in the past decades. It is logical to consider new approaches to ... more Obesity prevalence have tripled in the past decades. It is logical to consider new approaches to halt its prevalence. In this concept, considering the effect of interaction between fatty acid desaturase 2 (FADS2) gene variants and dietary advanced glycation end products (AGEs) on obesity-related characteristics seems to be challenging. The present cross-sectional study conducted among 347 obese individuals. A validated semi-quantitative 147-item food frequency questionnaire (FFQ) was used to estimate dietary intakes and American multiethnic database was used to calculate AGEs content of food items which were not available in Iranian Food Composition Table (FCT). FADS2 gene variants were determined according to Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Analysis of covariance (ANCOVA) was used to evaluate the modifier effect of FADS2 gene-dietary AGEs on biochemical values. Based on our findings, no significant differences was reported in term of b...
Background and Objective: Nowadays, consumption of functional foods is favored because of their h... more Background and Objective: Nowadays, consumption of functional foods is favored because of their health promoting characteristics. Also there is an increasing demand for nondairy products because of lactose intolerance in dairies. Fig juice as a source of dietary fiber and other nutrients would be a functional food. Adding probiotics and prebiotics makes it more functional for daily use. No study has yet been done on synbiotic fig juice. Accordingly, the aim of this study was to characterize synbiotic fig juice prepared by Lactobacillus delbrueckii and inulin. Material and Methods: Samples consisted of control fig juice; fig juice fermented by Lactobacillus delbrueckii (probiotic) and fig juice containing inulin fermented by Lactobacillus delbrueckii (synbiotic) were produced. Physico-chemical parameters, total phenolic content, antioxidant capacity and microbial survival aspects were analyzed during the fermentation period. Aforementioned parameters were also evaluated in 4 weeks wi...
Recently emerged coronavirus, known as SARS-CoV-2 or Covid-19 is considered as a serious threat f... more Recently emerged coronavirus, known as SARS-CoV-2 or Covid-19 is considered as a serious threat for human health. Due to unavailable specific drugs for this virus, there is an urgent need for supportive cares. Epigenetic immune boosting approaches and developing anti-inflammatory agents by gut-associated bioactive macronutrients can be plausible protective cares for COVID-19. Suitable intake of bioactive macronutrients including prebiotics, fatty acids, proteins and branched-chain amino acids may result in anti-viral responses through modulating macrophages and dendritic cells via Toll-like receptors, decreasing viral load, inactivating the enveloped viruses, increasing the anti-inflammatory metabolites and inhibiting the proliferation of microbial organisms. Bioactive macronutrients may help in promotion of immunological responses and recovery acceleration against Covid-19. This review focuses on the mechanisms of bioactive macronutrients and related clinical trials on enveloped vi...
Exposure to food toxins generate multiple adverse health effects. Heavy metals, antibioticsresidu... more Exposure to food toxins generate multiple adverse health effects. Heavy metals, antibioticsresidue, mycotoxins, pesticides and some food additives are examples of the most importantfood toxins. The common mechanism of toxicity and carcinogenicity effects of food toxins is thegeneration of oxidative stress that leads to DNA damages. Moreover, based on epidemiologicevidence unhealthy eating habits and food toxicities are associated with cancers occurrence.Therefore, application of bioactive food additives as harmless or safe components in foodindustry is expensive. Nigella sativa L. is a broadly used herb-drug for various diseases all overthe world and has been used as preservative and food additive. Based on various studies N. sativahas shown various pharmacological activities including therapeutic efficacy against differenthuman diseases and antioxidant anti-inflammatory effects against environmental toxins. N.sativa decreases the adverse health effects induced by mentioned food tox...
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