The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its virulent variants causin... more The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its virulent variants causing coronavirus disease 2019 (COVID-19) COVID-19 has spread rapidly worldwide, and is highly contagious. A comprehensive search was conducted for the most current published information about SARS-CoV-2, COVID-19, and oral health. Clinical studies, case reports, in vivo studies, and any current published evidence on SARS-CoV-2 and COVID-19 were included in this review. Survival against SARS-CoV-2 infection may be partially dependent on periodontal health, good oral hygiene, and access to dental care. Optimum oral health, maintaining good systemic health, and elimination of smoking habits may be beneficial for the prevention and management of COVID-19 infections.
The objective of this systematic review was to perform a comprehensive overview of systematic rev... more The objective of this systematic review was to perform a comprehensive overview of systematic reviews and meta-analyses pertaining to peri-implantitis in humans, including the prevalence and incidence, the diagnostic findings, the microbial findings, the effects of systemic diseases, and the treatment of peri-implantitis. Electronic databases were searched for systematic reviews and meta-analyses of peri-implantitis. In view of the limitations of the included systematic reviews, the outcome of this overview suggested that: 1) the occurrence of peri-implantitis was higher in patients with periodontitis, in patients who smoke, and after 5 years of implant function; 2) the microbial profile of peri-implantitis was different from periodontitis; 3) the risk for peri-implantitis was higher in patients with uncontrolled diabetes and cardiovascular disease; 4) there was no strong evidence to suggest the most effective treatment intervention for peri-implantitis, although most peri-implantit...
The objective of this systematic review was to perform a comprehensive overview of systematic rev... more The objective of this systematic review was to perform a comprehensive overview of systematic reviews and meta-analyses of surgical and patient factors affecting marginal bone loss around osseointegrated dental implants in humans. Electronic databases were searched for systematic reviews and meta-analyses published up to November 2015. Of the 41 articles selected, 11 evaluated implant factors, 10 evaluated patient factors, 19 evaluated surgical protocol-related factors, and one evaluated all three factors. The chosen studies were AMSTAR rated for quality. The following parameters have statistically significant effect on marginal bone loss: (1) marginal bone loss was significantly more in patients with periodontitis than in periodontally healthy patients; (2) significantly greater in generalized aggressive periodontitis patients compared with chronic periodontitis patients; (3) significantly less in alveolar socket preservation techniques; (4) significantly more in alveolar ridge aug...
Implant surfaces are continuously being improved to achieve faster osseointegration and a stronge... more Implant surfaces are continuously being improved to achieve faster osseointegration and a stronger bone to implant interface. This review will present the various implant surfaces, the parameters for implant surface characterization, and the corresponding in vitro human cell-based studies determining the strength and quality of the bone-implant contact. These in vitro cell-based studies are the basis for animal and clinical studies and are the prelude to further reviews on how these surfaces would perform when subjected to the oral environment and functional loading.
Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)
As the incidence of implant placement expands, so too does the occurrence of implant-related path... more As the incidence of implant placement expands, so too does the occurrence of implant-related pathological conditions such as peri-implant mucositis and peri-implantitis. This article will discuss implementation of a laser protocol that serves as a treatment modality designed specifically to help save ailing and failing implants. This multi-stage approach incorporates application of laser energy from a particular Nd:YAG laser with variable pulse width. This laser wavelength has demonstrated a variety of capabilities that may contribute to its clinical effectiveness. Representative long-term results of this treatment method are described, and a case depicting the protocol is presented.
Leukocytes from two patients with chronic granulomatous disease of childhood (CGD) and from one f... more Leukocytes from two patients with chronic granulomatous disease of childhood (CGD) and from one female carrier were examined for their capacity to induce germination of Clostridium botulinum type A spores in vitro. Normal human leukocytes induced germination of C. botulinum spores to the same extent as guinea pig neutrophils. Germination was depressed by more than half when cells from CGD patients were used. A noticeable, but less severe, abnormality was present in leukocytes from a female carrier for this X-linked trait. CGD leukocytes are defective in cellular production of H(2)O(2), and the latter is known to be effective in inducing germination of clostridial spores. Lysozyme is also known to be effective in spore germination and is present in CGD leukocytes in normal amounts. The posibility that C. botulinum spores require a mechanism which sensitizes them to the action of H(2)O(2) and lysozyme is raised, and it is suggested that the methodology used in this work measures a def...
21-Dehydroxylation, a feature of metabolism of corticoids in humans, was observed in mixed cultur... more 21-Dehydroxylation, a feature of metabolism of corticoids in humans, was observed in mixed cultures of fecal flora of normal individuals on a Western diet. The model substrate, 11-deoxycorticosterone (DOC), was metabolized to 3alpha-21-dihydroxy-5beta-pregnan-20-one (THDOC), 3alpha-hydroxy-5beta-pregnan20-one (pregnanolone), and to two unidentified structures, metabolites X and Y. DOC was not metabolized in all media supporting growth of fecal flora. Conversion required an initial pH between 6.0 and 8.0. 21-Dehydroxylation occurred within 4 days of incubation in media inoculated with 10-minus 1 to 10-minus 7 fecal suspensions. In higher dilutions, containing obligatory anaerobes only, DOC was converted to metabolite X and sometimes also to metabolite Y. The yield of pregnanolone was related to the promptness with which the specimen was processed, to the presence of cysteine in the medium, and to the concentrationof substrate (optimum, 16 to 64 mug of DOC per ml). The yield of THDOC ...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its virulent variants causin... more The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its virulent variants causing coronavirus disease 2019 (COVID-19) COVID-19 has spread rapidly worldwide, and is highly contagious. A comprehensive search was conducted for the most current published information about SARS-CoV-2, COVID-19, and oral health. Clinical studies, case reports, in vivo studies, and any current published evidence on SARS-CoV-2 and COVID-19 were included in this review. Survival against SARS-CoV-2 infection may be partially dependent on periodontal health, good oral hygiene, and access to dental care. Optimum oral health, maintaining good systemic health, and elimination of smoking habits may be beneficial for the prevention and management of COVID-19 infections.
The objective of this systematic review was to perform a comprehensive overview of systematic rev... more The objective of this systematic review was to perform a comprehensive overview of systematic reviews and meta-analyses pertaining to peri-implantitis in humans, including the prevalence and incidence, the diagnostic findings, the microbial findings, the effects of systemic diseases, and the treatment of peri-implantitis. Electronic databases were searched for systematic reviews and meta-analyses of peri-implantitis. In view of the limitations of the included systematic reviews, the outcome of this overview suggested that: 1) the occurrence of peri-implantitis was higher in patients with periodontitis, in patients who smoke, and after 5 years of implant function; 2) the microbial profile of peri-implantitis was different from periodontitis; 3) the risk for peri-implantitis was higher in patients with uncontrolled diabetes and cardiovascular disease; 4) there was no strong evidence to suggest the most effective treatment intervention for peri-implantitis, although most peri-implantit...
The objective of this systematic review was to perform a comprehensive overview of systematic rev... more The objective of this systematic review was to perform a comprehensive overview of systematic reviews and meta-analyses of surgical and patient factors affecting marginal bone loss around osseointegrated dental implants in humans. Electronic databases were searched for systematic reviews and meta-analyses published up to November 2015. Of the 41 articles selected, 11 evaluated implant factors, 10 evaluated patient factors, 19 evaluated surgical protocol-related factors, and one evaluated all three factors. The chosen studies were AMSTAR rated for quality. The following parameters have statistically significant effect on marginal bone loss: (1) marginal bone loss was significantly more in patients with periodontitis than in periodontally healthy patients; (2) significantly greater in generalized aggressive periodontitis patients compared with chronic periodontitis patients; (3) significantly less in alveolar socket preservation techniques; (4) significantly more in alveolar ridge aug...
Implant surfaces are continuously being improved to achieve faster osseointegration and a stronge... more Implant surfaces are continuously being improved to achieve faster osseointegration and a stronger bone to implant interface. This review will present the various implant surfaces, the parameters for implant surface characterization, and the corresponding in vitro human cell-based studies determining the strength and quality of the bone-implant contact. These in vitro cell-based studies are the basis for animal and clinical studies and are the prelude to further reviews on how these surfaces would perform when subjected to the oral environment and functional loading.
Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)
As the incidence of implant placement expands, so too does the occurrence of implant-related path... more As the incidence of implant placement expands, so too does the occurrence of implant-related pathological conditions such as peri-implant mucositis and peri-implantitis. This article will discuss implementation of a laser protocol that serves as a treatment modality designed specifically to help save ailing and failing implants. This multi-stage approach incorporates application of laser energy from a particular Nd:YAG laser with variable pulse width. This laser wavelength has demonstrated a variety of capabilities that may contribute to its clinical effectiveness. Representative long-term results of this treatment method are described, and a case depicting the protocol is presented.
Leukocytes from two patients with chronic granulomatous disease of childhood (CGD) and from one f... more Leukocytes from two patients with chronic granulomatous disease of childhood (CGD) and from one female carrier were examined for their capacity to induce germination of Clostridium botulinum type A spores in vitro. Normal human leukocytes induced germination of C. botulinum spores to the same extent as guinea pig neutrophils. Germination was depressed by more than half when cells from CGD patients were used. A noticeable, but less severe, abnormality was present in leukocytes from a female carrier for this X-linked trait. CGD leukocytes are defective in cellular production of H(2)O(2), and the latter is known to be effective in inducing germination of clostridial spores. Lysozyme is also known to be effective in spore germination and is present in CGD leukocytes in normal amounts. The posibility that C. botulinum spores require a mechanism which sensitizes them to the action of H(2)O(2) and lysozyme is raised, and it is suggested that the methodology used in this work measures a def...
21-Dehydroxylation, a feature of metabolism of corticoids in humans, was observed in mixed cultur... more 21-Dehydroxylation, a feature of metabolism of corticoids in humans, was observed in mixed cultures of fecal flora of normal individuals on a Western diet. The model substrate, 11-deoxycorticosterone (DOC), was metabolized to 3alpha-21-dihydroxy-5beta-pregnan-20-one (THDOC), 3alpha-hydroxy-5beta-pregnan20-one (pregnanolone), and to two unidentified structures, metabolites X and Y. DOC was not metabolized in all media supporting growth of fecal flora. Conversion required an initial pH between 6.0 and 8.0. 21-Dehydroxylation occurred within 4 days of incubation in media inoculated with 10-minus 1 to 10-minus 7 fecal suspensions. In higher dilutions, containing obligatory anaerobes only, DOC was converted to metabolite X and sometimes also to metabolite Y. The yield of pregnanolone was related to the promptness with which the specimen was processed, to the presence of cysteine in the medium, and to the concentrationof substrate (optimum, 16 to 64 mug of DOC per ml). The yield of THDOC ...
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Papers by Jon B Suzuki