Prevalence of diabetes and other cardiovascular risk factors in an Iranian population with acute ... more Prevalence of diabetes and other cardiovascular risk factors in an Iranian population with acute coronary syndrome
Introduction: Use of SPECT/CT data is the most accurate method for patient-specific internal dosi... more Introduction: Use of SPECT/CT data is the most accurate method for patient-specific internal dosimetry when isotopes emit single gamma rays. The manual or semi-automatic segmentation of organs is a major obstacle that slows down and limits the patient-specific dosimetry. Using digital phantoms that mimic patient’s anatomy can bypass the segmentation step and facilitate the dosimetry process. In this study, the results of a patient-specific dosimetry based on CT data and XCAT phantom, a flexible phantom with predefined organs, are compared. Methods: The dosimetry results (S-value and SAF) were calculated for a patient with breast cancer who received Samarium-153 ethylenediamine-N,N,N′,N′-tetrakis(methylenephosphonic acid (153Sm-EDTMP). Biodistribution of activity was obtained from the SPECT scan. The anatomical data and attenuation map were extracted from CT as well as the XCAT phantom with different BMIs. GATE Monte-Carlo simulator was used to calculate the dose to different organs ...
Iranian Journal of Pharmaceutical Research : IJPR, 2020
99mTc-HMPAO labeled platelet (LP) imaging may integrate thrombosis imaging into routine clinical ... more 99mTc-HMPAO labeled platelet (LP) imaging may integrate thrombosis imaging into routine clinical procedures. In the current study, we assessed the feasibility of the use of 99mTc-HMPAO LP for imaging of small clots in an animal model. Thrombosis was induced by application of FeCl3 solution in the distal part of the inferior vena cava (IVC) of a 6100 g anesthetized rabbit and in a male Wistar rat weighing 420 g. Twenty minutes later, 178 MBq 99mTc-HMPAO LP was injected. 99mTc-HMPAO LP preparation was done as defined and standardized in a previous report. Whole body and SPECT imaging were done 60, 90, and 120 min after tracer injection. Then, the clotted part of the vein was extracted and then its activity and pathologic evaluations were compared with the proximal part of the IVC at a similar volume. A 17 × 6 mm clot was clearly detected with both planar and SPECT imaging. The count to pixel ratio (CPR) of the clotted part of the vein was 35, 40, and 40 compared to the non-clotted vei...
We report a young male with an initial excisional biopsy report of melanoma of the lower back, re... more We report a young male with an initial excisional biopsy report of melanoma of the lower back, referred to our hospital for complete excision and sentinel lymph node (SLN) biopsy. Four peritumoral intradermal Tc-99m phytate injection was performed and SLNs were detected in both axillary and right inguinal regions. On the biopsy only the right axillary SLN was metastatic leading to right axillary lymph nodes dissection 6 days later. No other surgical intervention was done for two other lymphatic drainage basins. On follow up the patient noted a right axillary mass with highly suspicious ultrasound findings. Metastatic work up was negative. Second axillary lymph node dissection confirmed conglomerated lymph nodes metastases in this area. Multiple drainage basins in the trunk melanoma are common and many authors have concern about changing in lymphatic drainage pattern after SLN biopsy and surgical manipulation. This case showed correct initial diagnosis of involved lymph nodes in one...
BACKGROUND Hypertension is a major risk factor for non-communicable diseases. Yet, Nation-wide pr... more BACKGROUND Hypertension is a major risk factor for non-communicable diseases. Yet, Nation-wide prevalence and trend reports in developing countries are sparsely available. METHODS Data from three cycles of Survey of Risk Factors of Non-communicable Diseases (SuRFNCD) 2005 - 2011 were aggregated. In 2011, 8218 adults aged 25 - 70 years were enrolled. For trend analysis 68850, 4184, and 7416 adults aged 25 - 64 years were included from 2005, 2007, and 2011 surveys, respectively. Hypertension was defined as systolic blood pressure (SBP) ≥ 140 mmHg, diastolic blood pressure (DBP) ≥ 90 mmHg, or receiving anti-hypertensive medication. Pre-hypertension was defined as SBP between 120 - 139 or DBP between 80 - 89 mmHg. The status of awareness, non-pharmacologic treatment (management), pharmacologic treatment, and control (SBP < 140 mmHg, and DBP < 90 mmHg) among hypertensive individuals were also determined. RESULTS 25.6% (95%CI: 23.5 - 27.5) of the adults aged 25 - 70 years had hypert...
INTRODUCTION Estimating glomerular filtration rate (eGFR) using different formulas is common clin... more INTRODUCTION Estimating glomerular filtration rate (eGFR) using different formulas is common clinical practice for evaluating kidney function and drug dosing. But, the performance of available eGFR equations is questionable during early days after kidney transplantation. METHODS This study compared the performance of three common eGFR equations (Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)) in relation with measured GFR (mGFR) using clearance of Tc-99m-diethylenetriaminepentaacetic acid, 7 to 10 days post kidney transplantation. Agreement of mGFR and different eGFR equations in the staging of kidney function and dosing of 8 common antimicrobials were assessed. RESULT Thirty kidney and 5 simultaneous pancreas-kidney transplant recipients were included. CG applying total body weight (CGTBW) had the lowest bias (-12 mL/min/ 1.73 m2) and the highest percentage of estimation within 30% of mGFR (71.4%)....
Background: There are disputed reports of the beneficial effects of magnetic fields on glucose ho... more Background: There are disputed reports of the beneficial effects of magnetic fields on glucose homeostasis. Continuing from our previous work, we studied the effect of a constant magnetic field on blood glucose and weight gain in laboratory mice. Methods: 28 young, female bALB/c mice were randomly allocated into four groups A, B, C and D. Group A were placed in a constant magnetic field for 20 days, group B for 20 days in a 'placebo' field, group C for 10 days in a constant magnetic field, after which the field was removed, and group D for 10 days in a 'placebo' field, which was then removed the remaining 10 days of the study. The induction force of the magnetic field was 500 gauss, and was generated by two natural magnet bars. 'Placebo' fields were created by two identical looking bars of granite. The mice were weighed daily and had their blood glucose measured at the end of the 20-day study. Results: Weight gain was similar in the four groups. Blood g...
Background: The outcome and complications of liver hydatid cyst surgeries with new and old techni... more Background: The outcome and complications of liver hydatid cyst surgeries with new and old techniques are not well determined. We intended to present the results of operations done for patients with hepatic hydatid cyst in an endemic area. Methods: Data of 112 patients referred and operated for liver hydatid cyst, in Imam Khomeini Hospital complex, Tehran, Iran, from 2015 to 2018, were collected including demographic characteristics, operation parameters and complication related statistics. The variables were presented for different surgical methods including operations with and without omentoplasty. Results: Patients aged 39. 3 ± 13. 9 yr (70 females; 63. 5%). Most frequent clinical complaint was vague abdominal pain (n=45; 40. 2%). The most prevalent comorbidity was hypertension (18; 16.0%). Conservative methods were chosen more frequently including omentoplasty (44; 39. 3%), cyst drainage (27; 24. 1%), cyst resection (19; 17%) and marsupialization (3; 2. 7%). Overall, 56 patients...
The practical diagnostic performance of Prospective Investigative Study of Acute Pulmonary Emboli... more The practical diagnostic performance of Prospective Investigative Study of Acute Pulmonary Embolism Diagnosis (PISAPED) criteria for the detection of acute pulmonary thromboembolism (APTE) in hospitalized patients is not yet well determined. This is the report of the initial results of our recently implemented protocol to employ PISAPED. One hundred and forty-seven pulmonary perfusion scans with 1–3 mCi 99mTc-MAA of patients of a single pulmonologist were included. Patients with suspicious perfusion defects underwent single-photon emission computed tomography. Interpretations were done by consensus of two nuclear medicine specialists. Comparisons were done with chest X-ray or chest computed tomography when available. The interpreters had access to the clinical records. The scans were reported based on the PISAPED criteria as negative or positive for APTE or indeterminate. Patients were followed up for 6.2 ± 5.3 months when the final diagnosis confirming or excluding APTE was achieve...
Neuroendocrine tumours (NETs) arise from secondary epithelial cell lines in the gastrointestinal ... more Neuroendocrine tumours (NETs) arise from secondary epithelial cell lines in the gastrointestinal or respiratory system organs. The rate of development of these tumours varies from an indolent to an aggressive course, typically being initially asymptomatic. The identification of these tumours is difficult, particularly because the primary tumour is often small and undetectable by conventional anatomical imaging. Consequently, diagnosis of NETs is complicated and has been a significant challenge until recently. In the last 30 years, the advent of novel nuclear medicine diagnostic procedures has led to a substantial increase in NET detection. Great varieties of exclusive single photon emission computed tomography (SPECT) and positron emission tomography (PET) radiopharmaceuticals for detecting NETs are being applied successfully in clinical settings, including [111In]In-pentetreotide, [99mTc]Tc-HYNIC-TOC/TATE, [68Ga]Ga-DOTA-TATE, and [64Cu]Cu-DOTA-TOC/TATE. Among these tracers for func...
A 45-year-old woman presented with a headache and visual complaints. Brain MRI revealed a large m... more A 45-year-old woman presented with a headache and visual complaints. Brain MRI revealed a large mass in the right occipital cortex. The tumor was surgically removed and pathological examination showed papillary carcinoma originating from thyroid gland. She had a history of thyroid surgery 27 years ago indicating papillary thyroid cancer with central neck lymph node involvement followed by no additional treatments. CT scan showed a mass in the right kidney and multiple liver cysts. She was referred and treated with curative dose of radioiodine. A post therapeutic iodine scan showed accumulation of the tracer in the right kidney and disseminated uptake in the lungs and neck, with no focal uptake in the liver. To increase iodine accumulation in the lungs with curative intention, the right kidney was surgically resected. Forty-five days after nephrectomy, the patient received her second dose of radioiodine. In the second post therapy scan, the uptake in the lungs and neck was significan...
Introduction: We evaluated the performance of muscle perfusion scan (MPS) to assess muscle perfus... more Introduction: We evaluated the performance of muscle perfusion scan (MPS) to assess muscle perfusion reserve (MPR) for prediction of incident diabetic foot ulcerations (DFU). Methods: We recruited 41 diabetic patients without any history of DFU. Five mCi 99m Tc-MIBI was injected intravenously during repetitive dorsal and plantar right foot flexions. Then posterior calves were imaged and the counts of the region of interests (ROI) over the right and left calves were collected. MPR was calculated as the percentage of counts of right calf ROI-counts of left calf ROI / counts of left calf ROI. Six patients did not complete the study, 3 of them due to technical errors. Patients were followed for possible occurrence of DFU for at least 12 months.
The relationship between oxidant/antioxidant markers and proteinuria in type 2 diabetes is not cl... more The relationship between oxidant/antioxidant markers and proteinuria in type 2 diabetes is not clear, partly because of the potentially confounding effect of renal function which tends to become impaired during the course of diabetes. We measured oxidized low-density lipoproteins (Ox-LDL), malondialdehyde (MDA) and extracellular superoxide dismutase (EC-SOD) in 142 type 2 diabetic patients (67 men). Renal function was assessed by plasma creatinine and glomerular filtration rate. The group with proteinuria (n=78) was closely similar to the normoalbuminuric group (n=64) in age; body mass index; smoking habit; history of coronary artery disease; diabetes duration; use of lipid-lowering, antihypertensive and antidiabetic agents; blood pressure; fasting blood glucose; hemoglobin A1C and lipid profile. However, renal function was poorer and the proportion of males was higher in patients with proteinuria. When the effects of sex and renal function were controlled for, proteinuria was not a...
Medical science monitor : international medical journal of experimental and clinical research, 2007
BACKGROUND There are reports concerning a rise in blood glucose in 0.01- and 0.001-Tesla and weig... more BACKGROUND There are reports concerning a rise in blood glucose in 0.01- and 0.001-Tesla and weight loss in 0.9-Tesla constant electromagnetic fields. This study aimed to examine the effect of a 0.05-Tesla constant magnetic field on weight gain and blood glucose homeostasis in BALB/c mice. MATERIAL/METHODS Twenty-two young BALB/c mice were randomly divided into two equal groups. The experimental group was exposed to a 0.05-Tesla constant magnetic field created by permanent magnets for at least 10 hours a day. Apart from exposure to the magnetic field, the experimental cases and controls were kept in similar environmental conditions. The mice in both groups were weighed daily for 30 days: 10 days before, 10 days during, and 10 days after exposure to the constant magnetic field. After 30 days, the experimental group was again exposed to the magnetic field for 15 days. On the 45th day of the study, blood samples were obtained from both groups to measure blood glucose. RESULTS There was...
Introduction:The external beam radiation therapy for patients with left breast cancer at the mast... more Introduction:The external beam radiation therapy for patients with left breast cancer at the mastectomy site may cause myocardial perfusion abnormalities. We intended to study the change of these abnormalities at short and long term post radiotherapy follow up. Methods: Twenty patients with left and 20 patients with right breast cancer comprised the exposed and control groups, respectively. The patients had low risk for coronary disease. They underwent myocardial perfusion scans (MPS) 3 years after the external beam radiation therapy at the bed of modified radical mastectomy. These subjects were recruited from two bigger cohorts with previously reported data of scans at 6 months. The scans were acquired after injections of about 20 mCi MIBI at peak pharmacologic stress and at rest. The change of the perfusion abnormalities by both visual assessment and quantifications (Autoquant) at the baseline and 3 years follow up time are compared between exposed and control patients. Results: T...
Background Diagnosis of aortic graft infection is challenging, and delayed diagnosis is associate... more Background Diagnosis of aortic graft infection is challenging, and delayed diagnosis is associated with poor prognosis. Positron emission tomography/computed tomography (PET/CT) has improved diagnostic accuracy. Case summary A patient with a history of congenital heart disease was admitted due to fever. He had a history of four cardiac surgeries, including the Bentall procedure for endocarditis. Blood cultures were negative. A semi-mobile mass was detected in the distal portion of the aortic tube graft in echocardiography. PET/CT scan was used to confirm tube graft infection and to support proceeding to cardiac surgery. Discussion Using multimodality imaging, including PET/CT scan in combination with echocardiography, can improve diagnostic accuracy for the detection of aortic tube graft infection, infection of prosthetic valves, or intra-cardiac devices, especially in high-risk surgical cases.
Prevalence of diabetes and other cardiovascular risk factors in an Iranian population with acute ... more Prevalence of diabetes and other cardiovascular risk factors in an Iranian population with acute coronary syndrome
Introduction: Use of SPECT/CT data is the most accurate method for patient-specific internal dosi... more Introduction: Use of SPECT/CT data is the most accurate method for patient-specific internal dosimetry when isotopes emit single gamma rays. The manual or semi-automatic segmentation of organs is a major obstacle that slows down and limits the patient-specific dosimetry. Using digital phantoms that mimic patient’s anatomy can bypass the segmentation step and facilitate the dosimetry process. In this study, the results of a patient-specific dosimetry based on CT data and XCAT phantom, a flexible phantom with predefined organs, are compared. Methods: The dosimetry results (S-value and SAF) were calculated for a patient with breast cancer who received Samarium-153 ethylenediamine-N,N,N′,N′-tetrakis(methylenephosphonic acid (153Sm-EDTMP). Biodistribution of activity was obtained from the SPECT scan. The anatomical data and attenuation map were extracted from CT as well as the XCAT phantom with different BMIs. GATE Monte-Carlo simulator was used to calculate the dose to different organs ...
Iranian Journal of Pharmaceutical Research : IJPR, 2020
99mTc-HMPAO labeled platelet (LP) imaging may integrate thrombosis imaging into routine clinical ... more 99mTc-HMPAO labeled platelet (LP) imaging may integrate thrombosis imaging into routine clinical procedures. In the current study, we assessed the feasibility of the use of 99mTc-HMPAO LP for imaging of small clots in an animal model. Thrombosis was induced by application of FeCl3 solution in the distal part of the inferior vena cava (IVC) of a 6100 g anesthetized rabbit and in a male Wistar rat weighing 420 g. Twenty minutes later, 178 MBq 99mTc-HMPAO LP was injected. 99mTc-HMPAO LP preparation was done as defined and standardized in a previous report. Whole body and SPECT imaging were done 60, 90, and 120 min after tracer injection. Then, the clotted part of the vein was extracted and then its activity and pathologic evaluations were compared with the proximal part of the IVC at a similar volume. A 17 × 6 mm clot was clearly detected with both planar and SPECT imaging. The count to pixel ratio (CPR) of the clotted part of the vein was 35, 40, and 40 compared to the non-clotted vei...
We report a young male with an initial excisional biopsy report of melanoma of the lower back, re... more We report a young male with an initial excisional biopsy report of melanoma of the lower back, referred to our hospital for complete excision and sentinel lymph node (SLN) biopsy. Four peritumoral intradermal Tc-99m phytate injection was performed and SLNs were detected in both axillary and right inguinal regions. On the biopsy only the right axillary SLN was metastatic leading to right axillary lymph nodes dissection 6 days later. No other surgical intervention was done for two other lymphatic drainage basins. On follow up the patient noted a right axillary mass with highly suspicious ultrasound findings. Metastatic work up was negative. Second axillary lymph node dissection confirmed conglomerated lymph nodes metastases in this area. Multiple drainage basins in the trunk melanoma are common and many authors have concern about changing in lymphatic drainage pattern after SLN biopsy and surgical manipulation. This case showed correct initial diagnosis of involved lymph nodes in one...
BACKGROUND Hypertension is a major risk factor for non-communicable diseases. Yet, Nation-wide pr... more BACKGROUND Hypertension is a major risk factor for non-communicable diseases. Yet, Nation-wide prevalence and trend reports in developing countries are sparsely available. METHODS Data from three cycles of Survey of Risk Factors of Non-communicable Diseases (SuRFNCD) 2005 - 2011 were aggregated. In 2011, 8218 adults aged 25 - 70 years were enrolled. For trend analysis 68850, 4184, and 7416 adults aged 25 - 64 years were included from 2005, 2007, and 2011 surveys, respectively. Hypertension was defined as systolic blood pressure (SBP) ≥ 140 mmHg, diastolic blood pressure (DBP) ≥ 90 mmHg, or receiving anti-hypertensive medication. Pre-hypertension was defined as SBP between 120 - 139 or DBP between 80 - 89 mmHg. The status of awareness, non-pharmacologic treatment (management), pharmacologic treatment, and control (SBP < 140 mmHg, and DBP < 90 mmHg) among hypertensive individuals were also determined. RESULTS 25.6% (95%CI: 23.5 - 27.5) of the adults aged 25 - 70 years had hypert...
INTRODUCTION Estimating glomerular filtration rate (eGFR) using different formulas is common clin... more INTRODUCTION Estimating glomerular filtration rate (eGFR) using different formulas is common clinical practice for evaluating kidney function and drug dosing. But, the performance of available eGFR equations is questionable during early days after kidney transplantation. METHODS This study compared the performance of three common eGFR equations (Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)) in relation with measured GFR (mGFR) using clearance of Tc-99m-diethylenetriaminepentaacetic acid, 7 to 10 days post kidney transplantation. Agreement of mGFR and different eGFR equations in the staging of kidney function and dosing of 8 common antimicrobials were assessed. RESULT Thirty kidney and 5 simultaneous pancreas-kidney transplant recipients were included. CG applying total body weight (CGTBW) had the lowest bias (-12 mL/min/ 1.73 m2) and the highest percentage of estimation within 30% of mGFR (71.4%)....
Background: There are disputed reports of the beneficial effects of magnetic fields on glucose ho... more Background: There are disputed reports of the beneficial effects of magnetic fields on glucose homeostasis. Continuing from our previous work, we studied the effect of a constant magnetic field on blood glucose and weight gain in laboratory mice. Methods: 28 young, female bALB/c mice were randomly allocated into four groups A, B, C and D. Group A were placed in a constant magnetic field for 20 days, group B for 20 days in a 'placebo' field, group C for 10 days in a constant magnetic field, after which the field was removed, and group D for 10 days in a 'placebo' field, which was then removed the remaining 10 days of the study. The induction force of the magnetic field was 500 gauss, and was generated by two natural magnet bars. 'Placebo' fields were created by two identical looking bars of granite. The mice were weighed daily and had their blood glucose measured at the end of the 20-day study. Results: Weight gain was similar in the four groups. Blood g...
Background: The outcome and complications of liver hydatid cyst surgeries with new and old techni... more Background: The outcome and complications of liver hydatid cyst surgeries with new and old techniques are not well determined. We intended to present the results of operations done for patients with hepatic hydatid cyst in an endemic area. Methods: Data of 112 patients referred and operated for liver hydatid cyst, in Imam Khomeini Hospital complex, Tehran, Iran, from 2015 to 2018, were collected including demographic characteristics, operation parameters and complication related statistics. The variables were presented for different surgical methods including operations with and without omentoplasty. Results: Patients aged 39. 3 ± 13. 9 yr (70 females; 63. 5%). Most frequent clinical complaint was vague abdominal pain (n=45; 40. 2%). The most prevalent comorbidity was hypertension (18; 16.0%). Conservative methods were chosen more frequently including omentoplasty (44; 39. 3%), cyst drainage (27; 24. 1%), cyst resection (19; 17%) and marsupialization (3; 2. 7%). Overall, 56 patients...
The practical diagnostic performance of Prospective Investigative Study of Acute Pulmonary Emboli... more The practical diagnostic performance of Prospective Investigative Study of Acute Pulmonary Embolism Diagnosis (PISAPED) criteria for the detection of acute pulmonary thromboembolism (APTE) in hospitalized patients is not yet well determined. This is the report of the initial results of our recently implemented protocol to employ PISAPED. One hundred and forty-seven pulmonary perfusion scans with 1–3 mCi 99mTc-MAA of patients of a single pulmonologist were included. Patients with suspicious perfusion defects underwent single-photon emission computed tomography. Interpretations were done by consensus of two nuclear medicine specialists. Comparisons were done with chest X-ray or chest computed tomography when available. The interpreters had access to the clinical records. The scans were reported based on the PISAPED criteria as negative or positive for APTE or indeterminate. Patients were followed up for 6.2 ± 5.3 months when the final diagnosis confirming or excluding APTE was achieve...
Neuroendocrine tumours (NETs) arise from secondary epithelial cell lines in the gastrointestinal ... more Neuroendocrine tumours (NETs) arise from secondary epithelial cell lines in the gastrointestinal or respiratory system organs. The rate of development of these tumours varies from an indolent to an aggressive course, typically being initially asymptomatic. The identification of these tumours is difficult, particularly because the primary tumour is often small and undetectable by conventional anatomical imaging. Consequently, diagnosis of NETs is complicated and has been a significant challenge until recently. In the last 30 years, the advent of novel nuclear medicine diagnostic procedures has led to a substantial increase in NET detection. Great varieties of exclusive single photon emission computed tomography (SPECT) and positron emission tomography (PET) radiopharmaceuticals for detecting NETs are being applied successfully in clinical settings, including [111In]In-pentetreotide, [99mTc]Tc-HYNIC-TOC/TATE, [68Ga]Ga-DOTA-TATE, and [64Cu]Cu-DOTA-TOC/TATE. Among these tracers for func...
A 45-year-old woman presented with a headache and visual complaints. Brain MRI revealed a large m... more A 45-year-old woman presented with a headache and visual complaints. Brain MRI revealed a large mass in the right occipital cortex. The tumor was surgically removed and pathological examination showed papillary carcinoma originating from thyroid gland. She had a history of thyroid surgery 27 years ago indicating papillary thyroid cancer with central neck lymph node involvement followed by no additional treatments. CT scan showed a mass in the right kidney and multiple liver cysts. She was referred and treated with curative dose of radioiodine. A post therapeutic iodine scan showed accumulation of the tracer in the right kidney and disseminated uptake in the lungs and neck, with no focal uptake in the liver. To increase iodine accumulation in the lungs with curative intention, the right kidney was surgically resected. Forty-five days after nephrectomy, the patient received her second dose of radioiodine. In the second post therapy scan, the uptake in the lungs and neck was significan...
Introduction: We evaluated the performance of muscle perfusion scan (MPS) to assess muscle perfus... more Introduction: We evaluated the performance of muscle perfusion scan (MPS) to assess muscle perfusion reserve (MPR) for prediction of incident diabetic foot ulcerations (DFU). Methods: We recruited 41 diabetic patients without any history of DFU. Five mCi 99m Tc-MIBI was injected intravenously during repetitive dorsal and plantar right foot flexions. Then posterior calves were imaged and the counts of the region of interests (ROI) over the right and left calves were collected. MPR was calculated as the percentage of counts of right calf ROI-counts of left calf ROI / counts of left calf ROI. Six patients did not complete the study, 3 of them due to technical errors. Patients were followed for possible occurrence of DFU for at least 12 months.
The relationship between oxidant/antioxidant markers and proteinuria in type 2 diabetes is not cl... more The relationship between oxidant/antioxidant markers and proteinuria in type 2 diabetes is not clear, partly because of the potentially confounding effect of renal function which tends to become impaired during the course of diabetes. We measured oxidized low-density lipoproteins (Ox-LDL), malondialdehyde (MDA) and extracellular superoxide dismutase (EC-SOD) in 142 type 2 diabetic patients (67 men). Renal function was assessed by plasma creatinine and glomerular filtration rate. The group with proteinuria (n=78) was closely similar to the normoalbuminuric group (n=64) in age; body mass index; smoking habit; history of coronary artery disease; diabetes duration; use of lipid-lowering, antihypertensive and antidiabetic agents; blood pressure; fasting blood glucose; hemoglobin A1C and lipid profile. However, renal function was poorer and the proportion of males was higher in patients with proteinuria. When the effects of sex and renal function were controlled for, proteinuria was not a...
Medical science monitor : international medical journal of experimental and clinical research, 2007
BACKGROUND There are reports concerning a rise in blood glucose in 0.01- and 0.001-Tesla and weig... more BACKGROUND There are reports concerning a rise in blood glucose in 0.01- and 0.001-Tesla and weight loss in 0.9-Tesla constant electromagnetic fields. This study aimed to examine the effect of a 0.05-Tesla constant magnetic field on weight gain and blood glucose homeostasis in BALB/c mice. MATERIAL/METHODS Twenty-two young BALB/c mice were randomly divided into two equal groups. The experimental group was exposed to a 0.05-Tesla constant magnetic field created by permanent magnets for at least 10 hours a day. Apart from exposure to the magnetic field, the experimental cases and controls were kept in similar environmental conditions. The mice in both groups were weighed daily for 30 days: 10 days before, 10 days during, and 10 days after exposure to the constant magnetic field. After 30 days, the experimental group was again exposed to the magnetic field for 15 days. On the 45th day of the study, blood samples were obtained from both groups to measure blood glucose. RESULTS There was...
Introduction:The external beam radiation therapy for patients with left breast cancer at the mast... more Introduction:The external beam radiation therapy for patients with left breast cancer at the mastectomy site may cause myocardial perfusion abnormalities. We intended to study the change of these abnormalities at short and long term post radiotherapy follow up. Methods: Twenty patients with left and 20 patients with right breast cancer comprised the exposed and control groups, respectively. The patients had low risk for coronary disease. They underwent myocardial perfusion scans (MPS) 3 years after the external beam radiation therapy at the bed of modified radical mastectomy. These subjects were recruited from two bigger cohorts with previously reported data of scans at 6 months. The scans were acquired after injections of about 20 mCi MIBI at peak pharmacologic stress and at rest. The change of the perfusion abnormalities by both visual assessment and quantifications (Autoquant) at the baseline and 3 years follow up time are compared between exposed and control patients. Results: T...
Background Diagnosis of aortic graft infection is challenging, and delayed diagnosis is associate... more Background Diagnosis of aortic graft infection is challenging, and delayed diagnosis is associated with poor prognosis. Positron emission tomography/computed tomography (PET/CT) has improved diagnostic accuracy. Case summary A patient with a history of congenital heart disease was admitted due to fever. He had a history of four cardiac surgeries, including the Bentall procedure for endocarditis. Blood cultures were negative. A semi-mobile mass was detected in the distal portion of the aortic tube graft in echocardiography. PET/CT scan was used to confirm tube graft infection and to support proceeding to cardiac surgery. Discussion Using multimodality imaging, including PET/CT scan in combination with echocardiography, can improve diagnostic accuracy for the detection of aortic tube graft infection, infection of prosthetic valves, or intra-cardiac devices, especially in high-risk surgical cases.
Uploads