Promoted as full PROFESSOR in 2004. From January 2005 to onward I took over the charge of Chairman, Department of Physiology and Pharmacology and Director Academics, University of Agriculture, Faisalabad. From 2011-2013 I was on contract basis with Univ. as Professor and Principal, Sub Campus, University of Agriculture, Toba Tek Singh. As Principal, I managed Rs 502 Million from HEC/Planning commission for the uplift of the Sub Campus. In addition, I served (on deputation) at the Al-Fateh Medical University, Tripoli, Libya as VISITING PROFESSOR from 1996-1999.
Vinorelbine and docetaxel are two active agents in the treatment of metastatic breast cancer. Whe... more Vinorelbine and docetaxel are two active agents in the treatment of metastatic breast cancer. When given together, these drugs exhibit synergistic antitumor activity without significant pharmacokinetic interaction. The dose-limiting toxicities of this combination are neutropenic fever and mucositis. Adding granulocyte colony-stimulating factor (G-CSF) might lessen the toxicity and increase the maximum tolerated dose (MTD) of this combination. The aim of this study was to determine the MTD of vinorelbine and docetaxel given in combination with G-CSF. Between August 1997 and December 1998, 14 patients with metastatic breast cancer were enrolled in this study. All patients had received doxorubicin-based therapy, and 46% had received paclitaxel in the adjuvant or neoadjuvant setting. Patients were treated with vinorelbine at a starting dose of 20 mg/m2 intravenously over 10 min on days 1 and 5 and docetaxel at a starting dose of 85 mg/m2 intravenously over 1 hr on day 1, following the vinorelbine. Treatments were repeated every 21 days. Prophylactic G-CSF 5 mcg/kg was given subcutaneously on days 3-10. Toxicity was graded according to the National Cancer Institute's grading system. A total of 65 cycles was administered at dose levels 0, -1, -2, and -3. The median absolute granulocyte count nadir for all courses was 200 mm(-3) (range, 0.1-7700 mm(-3)), and the median time to this nadir was 9 days (range, 7-30). The median platelet nadir was 163 (range, 27-401 k), and the median time to this nadir was 8 days (range, 7-30). The most common grade 3 nonhematologic toxicities for all courses were fatigue and myalgia, which occurred in 32 and 10 cycles, respectively. Neutropenic fever was encountered in 11 cycles. Three patients developed colitis-like pictures, two of whom died as a result. Consequently, the protocol was closed to accrual before a MTD was reached. The combination of vinorelbine, docetaxel, and G-CSF in our hands has proven to be a toxic regimen, even when relatively low doses of vinorelbine and docetaxel are given. Meticulous observation of patients receiving this combination is warranted since the combination resulted in two deaths in this study.
... Recently in [16] Karthik et.al demonstrated speech enhancement using variable step size LMS (... more ... Recently in [16] Karthik et.al demonstrated speech enhancement using variable step size LMS (VSSLMS) algorithms. ... Figure 1 shows an adaptive filter with a primary input i(n), that is noisy speech signal S(n) with additive noise C(n). While the reference input is noise r(n), which ...
International Journal of Social and Economic Research, 2014
The main objective of this paper is to examine the link between remittances and economic growth i... more The main objective of this paper is to examine the link between remittances and economic growth in Bangladesh based on annual time series data ranges from 1976 to 2011. Using Granger causalities under Vector Autoregression (VAR) methodology to investigate the six possible directions that might link remittances and economic growth, trade and economic growth; and inflation and economic growth, we found bi-directional causality between remittances and economic growth, uni-directional causality between inflation and economic growth and no causality between trade and economic growth. In short period using impulse response functions, shocks on remittance growth could help to explain the effects on economic growth and similarly shocks on economic growth could help to explain the remittances growth in Bangladesh.
Vinorelbine (Navelbine) has significant activity against breast carcinoma and is less neurotoxic ... more Vinorelbine (Navelbine) has significant activity against breast carcinoma and is less neurotoxic than vinblastine. Because vinblastine has improved activity when administered by continuous infusion, we conducted a Phase I-II study to determine the maximum tolerated dose (MTD) of vinorelbine when given by continuous infusion and the response rates to it in heavily pretreated metastatic breast cancer patients. Between April 1994 and August 1997, 87 patients were entered in the study. All were female and had proven metastatic breast cancer. Ninety-five percent of them had received prior doxorubicin treatment, and 74% had received prior paclitaxel treatment. In Phase I of the study, all patients received 8 mg of vinorelbine by intravenous (i.v.) bolus followed by a continuous infusion of vinorelbine over 96 hr. When the MTD was determined, patients were entered in the Phase II arm to assess treatment responses and cumulative toxic reactions. In the Phase I arm (43 patients, 182 cycles), we determined the MTD of vinorelbine to be 8 mg by i.v. bolus followed by a continuous infusion of 11 mg/m2/day over 4 days. The dose-limiting toxic reaction was grade 3-4 granulocytopenia in 35% of the cycles and neutropenic fever in 15% of the cycles. Forty-four patients (193 cycles) were treated at the MTD. Seven (16%) of them had a response (2 complete responses, 5 partial responses). The median durations of response and survival were 4.3 and 8.6 months, respectively. However, cumulative toxic reactions (neutropenic fever and stomatitis) in 22 patients (50%) required dose reductions. A continuous infusion of vinorelbine can be safely administered but with a narrow therapeutic index because of cumulative toxic reactions. We recommend a modified MTD of vinorelbine: 8 mg by i.v. bolus followed by a continuous infusion of 10 mg/m2/day over 4 days. However, this treatment schedule offers no apparent advantage over the commonly used weekly vinorelbine schedule.
The development of anthracycline/paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) ... more The development of anthracycline/paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) combinations has gone through several phases or generations. The first dose escalation studies used prolonged infusions of doxorubicin (48 to 72 hours) and paclitaxel (24 hours). Myelosuppression, mucositis, and neutropenic fever were dose limiting, and a sequence-dependent interaction was noted. In a second phase, doxorubicin was administered by bolus, without changing the schedule of the taxane. More recently, bolus doxorubicin was combined with 3-hour paclitaxel infusions. Higher doses of both agents were administered in this latter schedule, with higher overall response rates reported. Excessive cardiac toxicity was reported with the initial trials that used this schedule. Confirmatory studies are under way pursuing several alternatives to reduce the risk of cardiac toxicity; these include limiting the cumulative dose of doxorubicin, inserting an interval between the administration of the two drugs, and adding a cardioprotective agent to the combination. The high degree of antitumor activity of this combination is quite encouraging, and additional evaluation of this regimen in controlled trials is warranted in metastatic and high-risk primary breast cancer.
Recent advancement in technologies like fermentation procedures resulted in the increased yields ... more Recent advancement in technologies like fermentation procedures resulted in the increased yields of recombinant proteins of biopharmaceutical and medicinal importance. Consequently, there is an important task to develop simple and easily scalable methods that facilitate the production of high quality recombinant protein. Most of the recent reports described the expression of Recombinant human IL-1receptor antagonist in Escherichia coli using isopropyl-β-D-thiogalacto pyranoside (IPTG), a non-metabolizable and expensive compound, as expression inducer. In the present study, we describe the expression and one step purification of gallbladder derived rhIL-1Ra by auto-induction in E. coli. This method involves special media recipes that automatically induced the target protein expression from T7 promoter and allow the production of the target protein in high yield than conventional IPTG induction method. In addition to fermentation process improvements, one step purification strategy is...
Innovative techniques of using 'Artificial Neural Networks' (ANN) for improving the perfo... more Innovative techniques of using 'Artificial Neural Networks' (ANN) for improving the performance of the pitch axis attitude control system of Space Station Freedom using Control Moment Gyros (CMGs) are investigated. The first technique uses a feedforward ANN with multilayer perceptrons to obtain an on-line controller which improves the performance of the control system via a model following approach. The second
Crimean-Congo hemorrhagic fever (CCHF) is a vector-borne viral disease, widely distributed in dif... more Crimean-Congo hemorrhagic fever (CCHF) is a vector-borne viral disease, widely distributed in different regions of the world. The fever is caused by the CCHF virus (CCHFV), which belongs to the Nairovirus genus and Bunyaviridae family. The virus is clustered in seven genotypes, which are Africa-1, Africa-2, Africa-3, Europe-1, Europe-2, Asia-1 and Asia-2. The virus is highly pathogenic in nature, easily transmissible and has a high case fatality rate of 10-40%. The reservoir and vector of CCHFV are the ticks of the Hyalomma genus. Therefore, the circulation of this virus depends upon the distribution of the ticks. The virus can be transmitted from tick to animal, animal to human and human to human. The major symptoms include headache, high fever, abdominal pain, myalgia, hypotension and flushed face. As the disease progresses, severe symptoms start appearing, which include petechiae, ecchymosis, epistaxis, bleeding gums and emesis. Enzyme-linked immunosorbent assay, quantitative polymerase chain reaction, antigen detection, serum neutralization and isolation of the virus by cell culture are the diagnostic techniques used for this viral infection. There is no specific antiviral therapy available thus far. However, ribavirin has been approved by the World Health Organization for the treatment of CCHFV infection. Awareness campaigns regarding the risk factors and control measures can aid in reducing the spread of this disease to a greater extent, particularly in developing countries.
The right atrium (RA) plays a pivotal role in electromechanical and endocrine regulation of the h... more The right atrium (RA) plays a pivotal role in electromechanical and endocrine regulation of the heart. Its peculiar anatomical features and phasic mechanical function make it distinct from ventricles. Various invasive and noninvasive techniques have been used to elucidate RA structure and function. Of these modalities, echocardiography has distinct advantages over others. Several conventional measures of RA function through echocardiography have been described in the literature, but they are load dependent. A relatively new technique is speckle tracking-derived strain, which is relatively less dependent on loading conditions. Speckle tracking echocardiography tracks acoustic scatters (speckles) of myocardium frame-by-frame to calculate strain or deformation of the myocardium. Speckle tracking echocardiography has been used extensively for strain assessment of the right and left ventricle to detect subtle disease pathology, to gain mechanistic insight, as a marker of ischemic metabolic memory, as an endpoint in clinical trials, and as a functional assessment tool. The RA is a relatively neglected chamber, as it is mostly studied for assessment of atrial mass lesions, for electrophysiological studies, and in animal models for physiological assessment. However, its role in the systolic and diastolic function of the right heart, pulmonary vascular pathology, congenital heart diseases, and combined electromechanical activation phenomena has been less explored or unexplored. Speckle tracking echocardiography is an ideal tool for the assessment of the RA because of its regional and global functional characterization, angle independence, and high temporal resolution.
The herbal plants can be used alone or in combination with other plants to treat different ailmen... more The herbal plants can be used alone or in combination with other plants to treat different ailments and are relatively safer, less expensive and have fewer side effects. Gentamicin (GM) induced tubular damage, vascular and glomerular dysfunction and altered tubular reabsorption leads to hematological and electrolyte disturbances. The effects of aqueous extracts of Rosa damascena (250mg/kg and 500mg/kg), Cichorium intybus (250mg/kg and 500mg/kg) and their mixture (250mg/kg and 500mg/kg) on serum electrolytes and hematological parameters was evaluated against gentamicin (80mg/kg) induced toxicity in albino rabbits by using the standard drug silymarin (200mg/kg). The study period was from 0-21 days and blood samples were collected at 0, 7th, 14th and 21st day. Analysis was done by using the standard protocols and results were subjected to two way analysis of variance and duncan multiple range test as applicable. Statistically significant (p≤0.01) increase in levels of potassium, erythr...
Gentamicin is an aminoglycoside antibiotic comprised of a mixture of related gentamicin component... more Gentamicin is an aminoglycoside antibiotic comprised of a mixture of related gentamicin components and fractions and is used to treat many types of bacterial infections, particularly those caused by Gram-negative organisms. Herbal plants can be used for the prevention and treatment of kidney damage. Therefore, the nephroprotective activity of aqueous extract of Rosa damascena (250 and 500 mg/kg), Cichorium intybus (250 and 500mg/kg) and their mixture (250 and 500 mg/kg) was evaluated on gentamicin (80 mg/kg) induced toxicity in albino rabbits by using the standard drug silymarin (200 mg/kg). The study period was from 0-21 days and blood samples were collected at 0, 7 th , 14 th and 21 st day. The biochemical analysis was done by using the standard protocols and kit methods. Serum urea and creatinine are the reliable markers to access the renal function. The results were subjected to two way analysis of variance and Duncan Multiple Range test as applicable. The gentamicin caused a si...
This study was planned to investigate the comparative effect of vitamin E and C, probiotics, prot... more This study was planned to investigate the comparative effect of vitamin E and C, probiotics, protein level and the combination of these treatments on body weight, serum total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), aspartate aminotransferase (AST), alanine aminotransferase (ALT), triiodothyronine (T-3), thyroxine (T-4), cortisol and some minerals in Zn-induced male broiler breeders. A total of 180 Hubbard male broiler breeders (65 weeks of age) were induced to moult. After moulting, the birds were randomly distributed into six groups. One group was fed vitamin E (100 IU/kg feed), second group was fed vitamin C (500 IU/kg feed), third group was fed probiotics (50 mg/L), fourth group was fed lower protein level (14% crude protein) and the fifth group was fed the combination of the mentioned treatments. The sixth group served as control. The results revealed that serum TAC significantly increased (P<0.05) while TOS and OSI decreased (P&l...
Vinorelbine and docetaxel are two active agents in the treatment of metastatic breast cancer. Whe... more Vinorelbine and docetaxel are two active agents in the treatment of metastatic breast cancer. When given together, these drugs exhibit synergistic antitumor activity without significant pharmacokinetic interaction. The dose-limiting toxicities of this combination are neutropenic fever and mucositis. Adding granulocyte colony-stimulating factor (G-CSF) might lessen the toxicity and increase the maximum tolerated dose (MTD) of this combination. The aim of this study was to determine the MTD of vinorelbine and docetaxel given in combination with G-CSF. Between August 1997 and December 1998, 14 patients with metastatic breast cancer were enrolled in this study. All patients had received doxorubicin-based therapy, and 46% had received paclitaxel in the adjuvant or neoadjuvant setting. Patients were treated with vinorelbine at a starting dose of 20 mg/m2 intravenously over 10 min on days 1 and 5 and docetaxel at a starting dose of 85 mg/m2 intravenously over 1 hr on day 1, following the vinorelbine. Treatments were repeated every 21 days. Prophylactic G-CSF 5 mcg/kg was given subcutaneously on days 3-10. Toxicity was graded according to the National Cancer Institute&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s grading system. A total of 65 cycles was administered at dose levels 0, -1, -2, and -3. The median absolute granulocyte count nadir for all courses was 200 mm(-3) (range, 0.1-7700 mm(-3)), and the median time to this nadir was 9 days (range, 7-30). The median platelet nadir was 163 (range, 27-401 k), and the median time to this nadir was 8 days (range, 7-30). The most common grade 3 nonhematologic toxicities for all courses were fatigue and myalgia, which occurred in 32 and 10 cycles, respectively. Neutropenic fever was encountered in 11 cycles. Three patients developed colitis-like pictures, two of whom died as a result. Consequently, the protocol was closed to accrual before a MTD was reached. The combination of vinorelbine, docetaxel, and G-CSF in our hands has proven to be a toxic regimen, even when relatively low doses of vinorelbine and docetaxel are given. Meticulous observation of patients receiving this combination is warranted since the combination resulted in two deaths in this study.
... Recently in [16] Karthik et.al demonstrated speech enhancement using variable step size LMS (... more ... Recently in [16] Karthik et.al demonstrated speech enhancement using variable step size LMS (VSSLMS) algorithms. ... Figure 1 shows an adaptive filter with a primary input i(n), that is noisy speech signal S(n) with additive noise C(n). While the reference input is noise r(n), which ...
International Journal of Social and Economic Research, 2014
The main objective of this paper is to examine the link between remittances and economic growth i... more The main objective of this paper is to examine the link between remittances and economic growth in Bangladesh based on annual time series data ranges from 1976 to 2011. Using Granger causalities under Vector Autoregression (VAR) methodology to investigate the six possible directions that might link remittances and economic growth, trade and economic growth; and inflation and economic growth, we found bi-directional causality between remittances and economic growth, uni-directional causality between inflation and economic growth and no causality between trade and economic growth. In short period using impulse response functions, shocks on remittance growth could help to explain the effects on economic growth and similarly shocks on economic growth could help to explain the remittances growth in Bangladesh.
Vinorelbine (Navelbine) has significant activity against breast carcinoma and is less neurotoxic ... more Vinorelbine (Navelbine) has significant activity against breast carcinoma and is less neurotoxic than vinblastine. Because vinblastine has improved activity when administered by continuous infusion, we conducted a Phase I-II study to determine the maximum tolerated dose (MTD) of vinorelbine when given by continuous infusion and the response rates to it in heavily pretreated metastatic breast cancer patients. Between April 1994 and August 1997, 87 patients were entered in the study. All were female and had proven metastatic breast cancer. Ninety-five percent of them had received prior doxorubicin treatment, and 74% had received prior paclitaxel treatment. In Phase I of the study, all patients received 8 mg of vinorelbine by intravenous (i.v.) bolus followed by a continuous infusion of vinorelbine over 96 hr. When the MTD was determined, patients were entered in the Phase II arm to assess treatment responses and cumulative toxic reactions. In the Phase I arm (43 patients, 182 cycles), we determined the MTD of vinorelbine to be 8 mg by i.v. bolus followed by a continuous infusion of 11 mg/m2/day over 4 days. The dose-limiting toxic reaction was grade 3-4 granulocytopenia in 35% of the cycles and neutropenic fever in 15% of the cycles. Forty-four patients (193 cycles) were treated at the MTD. Seven (16%) of them had a response (2 complete responses, 5 partial responses). The median durations of response and survival were 4.3 and 8.6 months, respectively. However, cumulative toxic reactions (neutropenic fever and stomatitis) in 22 patients (50%) required dose reductions. A continuous infusion of vinorelbine can be safely administered but with a narrow therapeutic index because of cumulative toxic reactions. We recommend a modified MTD of vinorelbine: 8 mg by i.v. bolus followed by a continuous infusion of 10 mg/m2/day over 4 days. However, this treatment schedule offers no apparent advantage over the commonly used weekly vinorelbine schedule.
The development of anthracycline/paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) ... more The development of anthracycline/paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) combinations has gone through several phases or generations. The first dose escalation studies used prolonged infusions of doxorubicin (48 to 72 hours) and paclitaxel (24 hours). Myelosuppression, mucositis, and neutropenic fever were dose limiting, and a sequence-dependent interaction was noted. In a second phase, doxorubicin was administered by bolus, without changing the schedule of the taxane. More recently, bolus doxorubicin was combined with 3-hour paclitaxel infusions. Higher doses of both agents were administered in this latter schedule, with higher overall response rates reported. Excessive cardiac toxicity was reported with the initial trials that used this schedule. Confirmatory studies are under way pursuing several alternatives to reduce the risk of cardiac toxicity; these include limiting the cumulative dose of doxorubicin, inserting an interval between the administration of the two drugs, and adding a cardioprotective agent to the combination. The high degree of antitumor activity of this combination is quite encouraging, and additional evaluation of this regimen in controlled trials is warranted in metastatic and high-risk primary breast cancer.
Recent advancement in technologies like fermentation procedures resulted in the increased yields ... more Recent advancement in technologies like fermentation procedures resulted in the increased yields of recombinant proteins of biopharmaceutical and medicinal importance. Consequently, there is an important task to develop simple and easily scalable methods that facilitate the production of high quality recombinant protein. Most of the recent reports described the expression of Recombinant human IL-1receptor antagonist in Escherichia coli using isopropyl-β-D-thiogalacto pyranoside (IPTG), a non-metabolizable and expensive compound, as expression inducer. In the present study, we describe the expression and one step purification of gallbladder derived rhIL-1Ra by auto-induction in E. coli. This method involves special media recipes that automatically induced the target protein expression from T7 promoter and allow the production of the target protein in high yield than conventional IPTG induction method. In addition to fermentation process improvements, one step purification strategy is...
Innovative techniques of using 'Artificial Neural Networks' (ANN) for improving the perfo... more Innovative techniques of using 'Artificial Neural Networks' (ANN) for improving the performance of the pitch axis attitude control system of Space Station Freedom using Control Moment Gyros (CMGs) are investigated. The first technique uses a feedforward ANN with multilayer perceptrons to obtain an on-line controller which improves the performance of the control system via a model following approach. The second
Crimean-Congo hemorrhagic fever (CCHF) is a vector-borne viral disease, widely distributed in dif... more Crimean-Congo hemorrhagic fever (CCHF) is a vector-borne viral disease, widely distributed in different regions of the world. The fever is caused by the CCHF virus (CCHFV), which belongs to the Nairovirus genus and Bunyaviridae family. The virus is clustered in seven genotypes, which are Africa-1, Africa-2, Africa-3, Europe-1, Europe-2, Asia-1 and Asia-2. The virus is highly pathogenic in nature, easily transmissible and has a high case fatality rate of 10-40%. The reservoir and vector of CCHFV are the ticks of the Hyalomma genus. Therefore, the circulation of this virus depends upon the distribution of the ticks. The virus can be transmitted from tick to animal, animal to human and human to human. The major symptoms include headache, high fever, abdominal pain, myalgia, hypotension and flushed face. As the disease progresses, severe symptoms start appearing, which include petechiae, ecchymosis, epistaxis, bleeding gums and emesis. Enzyme-linked immunosorbent assay, quantitative polymerase chain reaction, antigen detection, serum neutralization and isolation of the virus by cell culture are the diagnostic techniques used for this viral infection. There is no specific antiviral therapy available thus far. However, ribavirin has been approved by the World Health Organization for the treatment of CCHFV infection. Awareness campaigns regarding the risk factors and control measures can aid in reducing the spread of this disease to a greater extent, particularly in developing countries.
The right atrium (RA) plays a pivotal role in electromechanical and endocrine regulation of the h... more The right atrium (RA) plays a pivotal role in electromechanical and endocrine regulation of the heart. Its peculiar anatomical features and phasic mechanical function make it distinct from ventricles. Various invasive and noninvasive techniques have been used to elucidate RA structure and function. Of these modalities, echocardiography has distinct advantages over others. Several conventional measures of RA function through echocardiography have been described in the literature, but they are load dependent. A relatively new technique is speckle tracking-derived strain, which is relatively less dependent on loading conditions. Speckle tracking echocardiography tracks acoustic scatters (speckles) of myocardium frame-by-frame to calculate strain or deformation of the myocardium. Speckle tracking echocardiography has been used extensively for strain assessment of the right and left ventricle to detect subtle disease pathology, to gain mechanistic insight, as a marker of ischemic metabolic memory, as an endpoint in clinical trials, and as a functional assessment tool. The RA is a relatively neglected chamber, as it is mostly studied for assessment of atrial mass lesions, for electrophysiological studies, and in animal models for physiological assessment. However, its role in the systolic and diastolic function of the right heart, pulmonary vascular pathology, congenital heart diseases, and combined electromechanical activation phenomena has been less explored or unexplored. Speckle tracking echocardiography is an ideal tool for the assessment of the RA because of its regional and global functional characterization, angle independence, and high temporal resolution.
The herbal plants can be used alone or in combination with other plants to treat different ailmen... more The herbal plants can be used alone or in combination with other plants to treat different ailments and are relatively safer, less expensive and have fewer side effects. Gentamicin (GM) induced tubular damage, vascular and glomerular dysfunction and altered tubular reabsorption leads to hematological and electrolyte disturbances. The effects of aqueous extracts of Rosa damascena (250mg/kg and 500mg/kg), Cichorium intybus (250mg/kg and 500mg/kg) and their mixture (250mg/kg and 500mg/kg) on serum electrolytes and hematological parameters was evaluated against gentamicin (80mg/kg) induced toxicity in albino rabbits by using the standard drug silymarin (200mg/kg). The study period was from 0-21 days and blood samples were collected at 0, 7th, 14th and 21st day. Analysis was done by using the standard protocols and results were subjected to two way analysis of variance and duncan multiple range test as applicable. Statistically significant (p≤0.01) increase in levels of potassium, erythr...
Gentamicin is an aminoglycoside antibiotic comprised of a mixture of related gentamicin component... more Gentamicin is an aminoglycoside antibiotic comprised of a mixture of related gentamicin components and fractions and is used to treat many types of bacterial infections, particularly those caused by Gram-negative organisms. Herbal plants can be used for the prevention and treatment of kidney damage. Therefore, the nephroprotective activity of aqueous extract of Rosa damascena (250 and 500 mg/kg), Cichorium intybus (250 and 500mg/kg) and their mixture (250 and 500 mg/kg) was evaluated on gentamicin (80 mg/kg) induced toxicity in albino rabbits by using the standard drug silymarin (200 mg/kg). The study period was from 0-21 days and blood samples were collected at 0, 7 th , 14 th and 21 st day. The biochemical analysis was done by using the standard protocols and kit methods. Serum urea and creatinine are the reliable markers to access the renal function. The results were subjected to two way analysis of variance and Duncan Multiple Range test as applicable. The gentamicin caused a si...
This study was planned to investigate the comparative effect of vitamin E and C, probiotics, prot... more This study was planned to investigate the comparative effect of vitamin E and C, probiotics, protein level and the combination of these treatments on body weight, serum total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), aspartate aminotransferase (AST), alanine aminotransferase (ALT), triiodothyronine (T-3), thyroxine (T-4), cortisol and some minerals in Zn-induced male broiler breeders. A total of 180 Hubbard male broiler breeders (65 weeks of age) were induced to moult. After moulting, the birds were randomly distributed into six groups. One group was fed vitamin E (100 IU/kg feed), second group was fed vitamin C (500 IU/kg feed), third group was fed probiotics (50 mg/L), fourth group was fed lower protein level (14% crude protein) and the fifth group was fed the combination of the mentioned treatments. The sixth group served as control. The results revealed that serum TAC significantly increased (P<0.05) while TOS and OSI decreased (P&l...
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