Numerous papers over the years have stated that the original meaning of the term homology is hist... more Numerous papers over the years have stated that the original meaning of the term homology is historical and morphological and denotes organs/structures in two or more species derived from the same structure in their latest common ancestor. However, several more recent papers have extended the use of the term to cover organs/structures which are organised through the expression of homologous genes. This usage has created an ambiguity about the meaning of the term, and we propose to remove this by proposing a new term, homocracy, for organs/structures which are organised through the expression of identical patterning genes. We want to emphasise that the terms homologous and homocratic are not mutually exclusive. Many homologous structures are in all probability homocratic, whereas only a small number of homocratic structures are homologous.
The cellular distribution of histone H1(0) has been examined immunohistochemically in the rat bra... more The cellular distribution of histone H1(0) has been examined immunohistochemically in the rat brain. H1(0) accumulates in neurons and glial cells during postnatal development. In neurons, immunoreactivity increases progressively from about postnatal day 10, and reaches a distribution pattern similar to that of adult rats by postnatal day 20. Immunoreactivity in glial cells shows a prominent increase from postnatal day 20 to adult age. The accumulation of H1(0) during postnatal development appears to be correlated with terminal differentiation and maturation. Although immunoreactive neurons are widely distributed in all areas of the central nervous system, many neurons do not express immunoreactivity. For instance in the cerebellum, Purkinje neurons are negative. In females, the number of immunoreactive neurons in the arcuate area of the hypothalamus increases during postnatal development. In contrast, the percentage of immunoreactive neurons in males is low at all ages studied. The expression of H1(0) in the ventromedial part of the arcuate is reversibly and negatively regulated during the estrous cycle by the level of plasma estradiol. Ovariectomy increases the number of immunoreactive neurons while the restoration of the physiological levels of estradiol results in the opposite effect. Early postnatal androgenization of females suppresses the increment in the number of immunoreactive neurons in both the dorsolateral and the ventromedial parts of the arcuate during postnatal development, thus leading to permanently decreased levels of H1(0) immunoreactivity in postpuberal females.
Xenacoelomorpha is, most probably, a monophyletic group that includes three clades: Acoela, Nemer... more Xenacoelomorpha is, most probably, a monophyletic group that includes three clades: Acoela, Nemertodermatida and Xenoturbellida. The group still has contentious phylogenetic affinities; though most authors place it as the sister group of the remaining bilaterians, some would include it as a fourth phylum within the Deuterostomia. Over the past few years, our group, along with others, has undertaken a systematic study of the microscopic anatomy of these worms; our main aim is to understand the structure and development of the nervous system. This research plan has been aided by the use of molecular/developmental tools, the most important of which has been the sequencing of the complete genomes and transcriptomes of different members of the three clades. The data obtained has been used to analyse the evolutionary history of gene families and to study their expression patterns during development, in both space and time. A major focus of our research is the origin of 'cephalized'...
The ability of some animals to regrow their head and brain after decapitation provides a striking... more The ability of some animals to regrow their head and brain after decapitation provides a striking example of the regenerative capacity within the animal kingdom. The acoel worm Symsagittifera roscoffensis can regrow its head, brain and sensory head organs within only a few weeks after decapitation. How rapidly and to what degree it also reacquires its functionality to control behavior however remains unknown. We provide here a neuroanatomical map of the brain neuropils of the adult S. roscoffensis and show that after decapitation a normal neuroanatomical organization of the brain is restored in the majority of animals. By testing different behaviors we further show that functionality of both sensory perception and the underlying brain architecture are restored within weeks after decapitation. Interestingly not all behaviors are restored at the same speed and to the same extent. While we find that phototaxis recovered rapidly, geotaxis is not restored within 7 weeks. Our findings sho...
... Standard Article. Origin of Bilaterian Hox Patterning System. Eduardo Moreno,; Pedro Martínez... more ... Standard Article. Origin of Bilaterian Hox Patterning System. Eduardo Moreno,; Pedro Martínez. ... No 'bona fide' Hox genes were isolated in any of the mentioned studies, suggesting that Hox genes probably evolved after the divergence of the ctenophores. Hox Genes in Cnidaria. ...
Journal of experimental zoology. Part B, Molecular and developmental evolution, Jan 15, 2011
We have characterized the homologs of an actin, a troponin I, and a tropomyosin gene in the acoel... more We have characterized the homologs of an actin, a troponin I, and a tropomyosin gene in the acoel Symsagittifera roscoffensis. These genes are expressed in muscles and most likely coexpressed in at least a subset of them. In addition, and for the first time for Acoela, we have produced a species-specific muscular marker, an antibody against the tropomyosin protein. We have followed tropomyosin gene and protein expression during postembryonic development and during the posterior regeneration of amputated adults, showing that preexisting muscle fibers contribute to the wound closure. The three genes characterized in this study interact in the striated muscles of vertebrates and invertebrates, where troponin I and tropomyosin are key regulators of the contraction of the sarcomere. S. roscoffensis and all other acoels so far described have only smooth muscles, but the molecular architecture of these is the same as that of striated fibers of other bilaterians. Given the proposed basal po...
Numerous papers over the years have stated that the original meaning of the term homology is hist... more Numerous papers over the years have stated that the original meaning of the term homology is historical and morphological and denotes organs/structures in two or more species derived from the same structure in their latest common ancestor. However, several more recent papers have extended the use of the term to cover organs/structures which are organised through the expression of homologous genes. This usage has created an ambiguity about the meaning of the term, and we propose to remove this by proposing a new term, homocracy, for organs/structures which are organised through the expression of identical patterning genes. We want to emphasise that the terms homologous and homocratic are not mutually exclusive. Many homologous structures are in all probability homocratic, whereas only a small number of homocratic structures are homologous.
The cellular distribution of histone H1(0) has been examined immunohistochemically in the rat bra... more The cellular distribution of histone H1(0) has been examined immunohistochemically in the rat brain. H1(0) accumulates in neurons and glial cells during postnatal development. In neurons, immunoreactivity increases progressively from about postnatal day 10, and reaches a distribution pattern similar to that of adult rats by postnatal day 20. Immunoreactivity in glial cells shows a prominent increase from postnatal day 20 to adult age. The accumulation of H1(0) during postnatal development appears to be correlated with terminal differentiation and maturation. Although immunoreactive neurons are widely distributed in all areas of the central nervous system, many neurons do not express immunoreactivity. For instance in the cerebellum, Purkinje neurons are negative. In females, the number of immunoreactive neurons in the arcuate area of the hypothalamus increases during postnatal development. In contrast, the percentage of immunoreactive neurons in males is low at all ages studied. The expression of H1(0) in the ventromedial part of the arcuate is reversibly and negatively regulated during the estrous cycle by the level of plasma estradiol. Ovariectomy increases the number of immunoreactive neurons while the restoration of the physiological levels of estradiol results in the opposite effect. Early postnatal androgenization of females suppresses the increment in the number of immunoreactive neurons in both the dorsolateral and the ventromedial parts of the arcuate during postnatal development, thus leading to permanently decreased levels of H1(0) immunoreactivity in postpuberal females.
Xenacoelomorpha is, most probably, a monophyletic group that includes three clades: Acoela, Nemer... more Xenacoelomorpha is, most probably, a monophyletic group that includes three clades: Acoela, Nemertodermatida and Xenoturbellida. The group still has contentious phylogenetic affinities; though most authors place it as the sister group of the remaining bilaterians, some would include it as a fourth phylum within the Deuterostomia. Over the past few years, our group, along with others, has undertaken a systematic study of the microscopic anatomy of these worms; our main aim is to understand the structure and development of the nervous system. This research plan has been aided by the use of molecular/developmental tools, the most important of which has been the sequencing of the complete genomes and transcriptomes of different members of the three clades. The data obtained has been used to analyse the evolutionary history of gene families and to study their expression patterns during development, in both space and time. A major focus of our research is the origin of 'cephalized'...
The ability of some animals to regrow their head and brain after decapitation provides a striking... more The ability of some animals to regrow their head and brain after decapitation provides a striking example of the regenerative capacity within the animal kingdom. The acoel worm Symsagittifera roscoffensis can regrow its head, brain and sensory head organs within only a few weeks after decapitation. How rapidly and to what degree it also reacquires its functionality to control behavior however remains unknown. We provide here a neuroanatomical map of the brain neuropils of the adult S. roscoffensis and show that after decapitation a normal neuroanatomical organization of the brain is restored in the majority of animals. By testing different behaviors we further show that functionality of both sensory perception and the underlying brain architecture are restored within weeks after decapitation. Interestingly not all behaviors are restored at the same speed and to the same extent. While we find that phototaxis recovered rapidly, geotaxis is not restored within 7 weeks. Our findings sho...
... Standard Article. Origin of Bilaterian Hox Patterning System. Eduardo Moreno,; Pedro Martínez... more ... Standard Article. Origin of Bilaterian Hox Patterning System. Eduardo Moreno,; Pedro Martínez. ... No 'bona fide' Hox genes were isolated in any of the mentioned studies, suggesting that Hox genes probably evolved after the divergence of the ctenophores. Hox Genes in Cnidaria. ...
Journal of experimental zoology. Part B, Molecular and developmental evolution, Jan 15, 2011
We have characterized the homologs of an actin, a troponin I, and a tropomyosin gene in the acoel... more We have characterized the homologs of an actin, a troponin I, and a tropomyosin gene in the acoel Symsagittifera roscoffensis. These genes are expressed in muscles and most likely coexpressed in at least a subset of them. In addition, and for the first time for Acoela, we have produced a species-specific muscular marker, an antibody against the tropomyosin protein. We have followed tropomyosin gene and protein expression during postembryonic development and during the posterior regeneration of amputated adults, showing that preexisting muscle fibers contribute to the wound closure. The three genes characterized in this study interact in the striated muscles of vertebrates and invertebrates, where troponin I and tropomyosin are key regulators of the contraction of the sarcomere. S. roscoffensis and all other acoels so far described have only smooth muscles, but the molecular architecture of these is the same as that of striated fibers of other bilaterians. Given the proposed basal po...
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Papers by Pedro Martinez