El virus de la viruela símica es un orthopoxvirus de características zoonóticas endémico en l... more El virus de la viruela símica es un orthopoxvirus de características zoonóticas endémico en las regiones de África Central y África Occidental, donde causa brotes desde 1970. En las últimas décadas se registró un aumento exponencial de casos, probablemente asociado a la disminución en la inmunidad conferida por la vacuna antivariólica, discontinuada luego de la erradicación de la viruela. En los últimos años se registraron casos esporádicos fuera del continente africano, siempre relacionados epidemiológicamente a la permanencia en áreas endémicas o contacto con animales infectados. Desde el 13 de mayo de 2022 se encuentra en curso el mayor brote de viruela símica registrado fuera de las áreas endémicas de África, con casos en los cinco continentes. La extensión, el impacto y la duración del brote permanecen aún inciertos.
La enfermedad de Chagas fue descubierta hace más de un siglo y sigue siendo, según la Organizac... more La enfermedad de Chagas fue descubierta hace más de un siglo y sigue siendo, según la Organización Mundial de la Salud, una enfermedad tropical desatendida que afecta entre 6 y 7 millones de personas en todo el mundo. Es endémica en 21 países de América Latina, donde se transmite por vía vectorial a los seres humanos y otros mamíferos, principalmente por las heces de insectos triatominos que se alimentan de sangre. La infección generalmente cursa en forma asintomática, pero tres de cada diez personas pueden presentar afección cardiaca o del sistema digestivo. Detectada a tiempo y en su fase inicial, puede curarse o mejorar su evolución clínica. Como problema de salud se ha asociado históricamente a la pobreza y al entorno rural de Latinoamérica, pero en la actualidad es un problema de salud global que ha traspasado las fronteras de la región y hoy podemos encontrar una persona afectada de Chagas en cualquier lugar del planeta. Algunos datos sobre esta enfermedad inte...
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2.... more Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2. COVID-19 leads, in most patients, to mild-to-moderate symptoms, but some develop severe disease and succumbed to death. People with medical conditions have a higher risk of death than those without them. Chagas disease (CD) can cause cardiac diseases in approximately one-third of affected people. The aim of this study is to find out if there is any clinical association between Chagas disease and COVID-19 severity. This is a cohort study of 29 patients who were hospitalized with COVID-19 and had a diagnosis of chronic Trypanosoma cruzi infection. This coinfected cohort was matched by sex, age, presence of comorbidities, and requirement of hospitalization on intensive care unit (ICU) at admission with a control cohort of patients hospitalized due to COVID-19 without CD in a 3:1 ratio (n = 87). The clinical outcomes evaluated were as follows: days of hospitalization, death, and requirement...
El tratamiento convencional de los pacientes con dermatosis ampollares autoinmunes se basa en la ... more El tratamiento convencional de los pacientes con dermatosis ampollares autoinmunes se basa en la inmunosupresion global con el uso de corticosteroides y otros inmunosupresores a fin de disminuir los titulos de autoanticuerpos responsables de estas enfermedades. En los ultimos anos, la aparicion de la terapia biologica ha mejorado el manejo y el pronostico de estas patologias. El rituximab (RTX) es un anticuerpo monoclonal quimerico de origen murino, cuyo blanco es la molecula CD20, tanto de linfocitos B normales como malignos, cuyo uso lleva a una rapida deplecion de estas celulas durante 6 a 9 meses. En la Argentina, la Administracion Nacional de Medicamentos, Alimentos y Tecnologia Medica (ANMAT) aprobo su utilizacion en 2012 para las mismas indicaciones que la Food and Drug Administration (FDA). Su uso en las enfermedades ampollares es una indicacion por fuera de las aceptadas (off label), aunque algunos autores ya lo consideran la primera linea de tratamiento para los pacientes ...
Fil: de Roodt, Adolfo Rafael. Ministerio de Salud de la Nacion. Direccion Nacional de Institutos ... more Fil: de Roodt, Adolfo Rafael. Ministerio de Salud de la Nacion. Direccion Nacional de Institutos de Investigacion. Administracion Nacional de Laboratorios e Institutos de Salud "Doctor Carlos G. Malbran". Instituto Nacional de Produccion de Biologicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Chagas disease reactivation in HIV-positive people is an opportunistic infection with 79 to 100% ... more Chagas disease reactivation in HIV-positive people is an opportunistic infection with 79 to 100% mortality. It commonly involves the central nervous system (CNS).
Despite the great number of spiders in the world, only a small group of them is capable of produc... more Despite the great number of spiders in the world, only a small group of them is capable of producing death in humans. In Argentina, there are only three of the four genera of spiders considered of high risk to humans: Latrodectus is present in rural areas, Phoneutria is restricted to small regions while Loxosceles is distributed throughout the country. Accidents by Loxosceles represent around 4% of the total number produced by venomous animals in Argentina. The bite is accidental and may produce considerable local necrosis with scar formation and ulcers of slow and difficult healing that may require surgical repair. Some bitten people may suffer from intravascular hemolysis, disseminated coagulation and acute renal insufficiency leading to death. Despite the great number of studies performed on Loxosceles venoms, at present, the physiopathological course of poisoning is not clear and there is not common criteria for its treatment. In this review, biological and epidemiological data ...
We describe the epidemiological and clinical findings of 13 patients with diagnosis of infection ... more We describe the epidemiological and clinical findings of 13 patients with diagnosis of infection by St. Louis encephalitis virus, transmitted between January and March 2010 in Buenos Aires Metropolitan Area (AMBA). Thirteen patients, average age 38 years, had an acute onset with hyperthermia and headache. Between days two and ten of the onset of symptoms, 7/13 patients had signs and symptoms of neurological involvement. This was characterized by meningitis without encephalic sings in 1/7 and in 6/7 the most frequent findings were: stiff neck, disorientation, photophobia, confusion and language impairment. Two MR and one EEG revealed signs of involvement of temporal lobes. The cerebrospinal fluid showed pleocytosis with predominance of mononuclear cells, normal glucose and moderately elevated protein. There were no fatalities cases. In 6/13 patients the initial clinical suspicion was dengue. As epidemic virus circulation had not been previously reported in the AMBA it can be consider...
We describe a case of a 32-year-old man, resident in Buenos Aires, with dermatologic manifestatio... more We describe a case of a 32-year-old man, resident in Buenos Aires, with dermatologic manifestations compatible with gnathostomiasis. The patient had traveled to Colombia in the month prior to the onset of symptoms. There, he repeatedly ate ceviche (raw fish marinated in lemon juice). He presented with an erythematous migratory panniculitis accompanied by eosinophilia. He underwent skin biopsy of a lesion and pathological diagnosis was "eosinophilic panniculitis". The triad of migratory panniculitis, eosinophilia and consume of raw fish during the trip to Colombia was suggestive of gnathostomiasis. Ivermectin treatment started out with good initial response but subsequent relapse. We performed a new treatment with the same drug with good results and no relapses during three years of follow up. The dermatological disease is common upon return from a trip, and is the third leading cause of morbidity in travelers. It is very important to recognize cutaneous manifestations of d...
El virus de la viruela símica es un orthopoxvirus de características zoonóticas endémico en l... more El virus de la viruela símica es un orthopoxvirus de características zoonóticas endémico en las regiones de África Central y África Occidental, donde causa brotes desde 1970. En las últimas décadas se registró un aumento exponencial de casos, probablemente asociado a la disminución en la inmunidad conferida por la vacuna antivariólica, discontinuada luego de la erradicación de la viruela. En los últimos años se registraron casos esporádicos fuera del continente africano, siempre relacionados epidemiológicamente a la permanencia en áreas endémicas o contacto con animales infectados. Desde el 13 de mayo de 2022 se encuentra en curso el mayor brote de viruela símica registrado fuera de las áreas endémicas de África, con casos en los cinco continentes. La extensión, el impacto y la duración del brote permanecen aún inciertos.
La enfermedad de Chagas fue descubierta hace más de un siglo y sigue siendo, según la Organizac... more La enfermedad de Chagas fue descubierta hace más de un siglo y sigue siendo, según la Organización Mundial de la Salud, una enfermedad tropical desatendida que afecta entre 6 y 7 millones de personas en todo el mundo. Es endémica en 21 países de América Latina, donde se transmite por vía vectorial a los seres humanos y otros mamíferos, principalmente por las heces de insectos triatominos que se alimentan de sangre. La infección generalmente cursa en forma asintomática, pero tres de cada diez personas pueden presentar afección cardiaca o del sistema digestivo. Detectada a tiempo y en su fase inicial, puede curarse o mejorar su evolución clínica. Como problema de salud se ha asociado históricamente a la pobreza y al entorno rural de Latinoamérica, pero en la actualidad es un problema de salud global que ha traspasado las fronteras de la región y hoy podemos encontrar una persona afectada de Chagas en cualquier lugar del planeta. Algunos datos sobre esta enfermedad inte...
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2.... more Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2. COVID-19 leads, in most patients, to mild-to-moderate symptoms, but some develop severe disease and succumbed to death. People with medical conditions have a higher risk of death than those without them. Chagas disease (CD) can cause cardiac diseases in approximately one-third of affected people. The aim of this study is to find out if there is any clinical association between Chagas disease and COVID-19 severity. This is a cohort study of 29 patients who were hospitalized with COVID-19 and had a diagnosis of chronic Trypanosoma cruzi infection. This coinfected cohort was matched by sex, age, presence of comorbidities, and requirement of hospitalization on intensive care unit (ICU) at admission with a control cohort of patients hospitalized due to COVID-19 without CD in a 3:1 ratio (n = 87). The clinical outcomes evaluated were as follows: days of hospitalization, death, and requirement...
El tratamiento convencional de los pacientes con dermatosis ampollares autoinmunes se basa en la ... more El tratamiento convencional de los pacientes con dermatosis ampollares autoinmunes se basa en la inmunosupresion global con el uso de corticosteroides y otros inmunosupresores a fin de disminuir los titulos de autoanticuerpos responsables de estas enfermedades. En los ultimos anos, la aparicion de la terapia biologica ha mejorado el manejo y el pronostico de estas patologias. El rituximab (RTX) es un anticuerpo monoclonal quimerico de origen murino, cuyo blanco es la molecula CD20, tanto de linfocitos B normales como malignos, cuyo uso lleva a una rapida deplecion de estas celulas durante 6 a 9 meses. En la Argentina, la Administracion Nacional de Medicamentos, Alimentos y Tecnologia Medica (ANMAT) aprobo su utilizacion en 2012 para las mismas indicaciones que la Food and Drug Administration (FDA). Su uso en las enfermedades ampollares es una indicacion por fuera de las aceptadas (off label), aunque algunos autores ya lo consideran la primera linea de tratamiento para los pacientes ...
Fil: de Roodt, Adolfo Rafael. Ministerio de Salud de la Nacion. Direccion Nacional de Institutos ... more Fil: de Roodt, Adolfo Rafael. Ministerio de Salud de la Nacion. Direccion Nacional de Institutos de Investigacion. Administracion Nacional de Laboratorios e Institutos de Salud "Doctor Carlos G. Malbran". Instituto Nacional de Produccion de Biologicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Chagas disease reactivation in HIV-positive people is an opportunistic infection with 79 to 100% ... more Chagas disease reactivation in HIV-positive people is an opportunistic infection with 79 to 100% mortality. It commonly involves the central nervous system (CNS).
Despite the great number of spiders in the world, only a small group of them is capable of produc... more Despite the great number of spiders in the world, only a small group of them is capable of producing death in humans. In Argentina, there are only three of the four genera of spiders considered of high risk to humans: Latrodectus is present in rural areas, Phoneutria is restricted to small regions while Loxosceles is distributed throughout the country. Accidents by Loxosceles represent around 4% of the total number produced by venomous animals in Argentina. The bite is accidental and may produce considerable local necrosis with scar formation and ulcers of slow and difficult healing that may require surgical repair. Some bitten people may suffer from intravascular hemolysis, disseminated coagulation and acute renal insufficiency leading to death. Despite the great number of studies performed on Loxosceles venoms, at present, the physiopathological course of poisoning is not clear and there is not common criteria for its treatment. In this review, biological and epidemiological data ...
We describe the epidemiological and clinical findings of 13 patients with diagnosis of infection ... more We describe the epidemiological and clinical findings of 13 patients with diagnosis of infection by St. Louis encephalitis virus, transmitted between January and March 2010 in Buenos Aires Metropolitan Area (AMBA). Thirteen patients, average age 38 years, had an acute onset with hyperthermia and headache. Between days two and ten of the onset of symptoms, 7/13 patients had signs and symptoms of neurological involvement. This was characterized by meningitis without encephalic sings in 1/7 and in 6/7 the most frequent findings were: stiff neck, disorientation, photophobia, confusion and language impairment. Two MR and one EEG revealed signs of involvement of temporal lobes. The cerebrospinal fluid showed pleocytosis with predominance of mononuclear cells, normal glucose and moderately elevated protein. There were no fatalities cases. In 6/13 patients the initial clinical suspicion was dengue. As epidemic virus circulation had not been previously reported in the AMBA it can be consider...
We describe a case of a 32-year-old man, resident in Buenos Aires, with dermatologic manifestatio... more We describe a case of a 32-year-old man, resident in Buenos Aires, with dermatologic manifestations compatible with gnathostomiasis. The patient had traveled to Colombia in the month prior to the onset of symptoms. There, he repeatedly ate ceviche (raw fish marinated in lemon juice). He presented with an erythematous migratory panniculitis accompanied by eosinophilia. He underwent skin biopsy of a lesion and pathological diagnosis was "eosinophilic panniculitis". The triad of migratory panniculitis, eosinophilia and consume of raw fish during the trip to Colombia was suggestive of gnathostomiasis. Ivermectin treatment started out with good initial response but subsequent relapse. We performed a new treatment with the same drug with good results and no relapses during three years of follow up. The dermatological disease is common upon return from a trip, and is the third leading cause of morbidity in travelers. It is very important to recognize cutaneous manifestations of d...
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