María Jover-Cobos E-mail: maria.jover@gmail.com/ m.cobos@ucl.ac.uk Place of Birth: Seville Date of Birth: Jan 5, 1977 Address: Flat 87, 5-7 Hornsey St, N7 8GD, London, United Kingdom. Phone number: +44(0)7553034907 Posts held Post-Doctoral researcher. 2011-2013. Marie-Curie Intra-European Fellowship (Seventh Framework Programme:People). UCL Institute for Liver & Digestive Health. Royal Free Campus. Hepatology. University College London. United Kingdom. Post-Doctoral researcher. 2007-2011. CIBERehd (Network Biomedical Research Center for Hepatic and Gastroenterology diseases), Digestive, University Hospital of Valme, Seville. Spain. PhD. 2002-2006 Department of Biochemistry, Faculty of Pharmacy and Universitary Hospital of Valme, summa cum laude by University of Seville, Spain. Diploma (DEA). 1999 - 2001 Department of Biochemistry. Faculty of Pharmacy, University of Seville, Spain. Pharmacy Degree. 1994-1999 University of Seville, Seville, Spain. Instituto de Bachillerato Murillo (BMSc equivalent). 1990-1994. Ministerio de Educacion y Ciencia. Sevilla. List of other professional activities: 1. Non-formal training, diploma courses EASL course Basic School of Hepatology, Course 3: Vascular Biology of the Liver Health and Disease, 12 horas, de European External CME credits. Lisboa del 1-3 de Febrero de 2008. III On line Course of Determination of Drugs by HPLC in biological samples. Universidad de Salamanca. Acreditado por la Comisión de Formación Continuada del Spanish National Health System with 3,4 credits. Febrero-junio 2008. II On Line Course of Interpretation of Clinical Analysis. Colegio Oficial de Farmacéuticos de Granada. 108 horas, 18,2 créditos por la Dirección General de Calidad, Investigación y Gestión del Conocimiento (Ref: DDK4538_01). Enero-Septiembre 2007. VI Course Advances in Hepatology. PhD Program "Internal Medicine". 15 hours (1.5 credits), Malaga, Spain, 25-26 May 2007. "Update Course on Hepatology". 19-21 February 2007. Accredited by the General Administration of Quality, Research and Knowledge Management Spanish National Health System with 1 credit. Expte.06-5349. "XXXVII Course Meeting of the Andalusian Society of Digestive Pathology. 19-21 October 2006. Accredited by the General Administration of Quality, Research and Knowledge Management Andalusian Health Service with 2.23 credits. Expte.262/06. Course "Administrative Procedure". Duration 150 hours. Accredited Journal. School of Health and Social de Canarias. Spanish Foundation for Education and Health and Social Studies. 2006. Course "Risk prevention in the health sector". Duration 80 hours. Accredited Journal. School of Health and Social de Canarias. Spanish Foundation for Education and Health and Social Studies. 2006. Course "Rules and health administration". Duration 270 hours. Accredited Journal. School of Health and Social de Canarias. Spanish Foundation for Education and Health and Social Studies. 2006. Course "Control-HACCP and food hygiene". Duration 81 hours. Accredited Journal. School of Health and Social de Canarias. Spanish Foundation for Education and Health and Social Studies. 2006. Assessment of exposure to pesticides. Spanish National Media Center for the Protection of Spanish National Institute of Occupational Safety and Health at Work. Duration: 10 hours. 27-28 May 2002. Course on working conditions in the laboratory. Spanish National Media Center for the Protection of National Institute of Occupational Safety and Health at Work. Duration: 10 hours. October 2000. Course Assessment of Exposure to Chemical Agents. Spanish National Media Center for the Protection of Spanish National Institute of Occupational Safety and Health at Work. Duration: 20 hours. April 2000. "Spin-off" Program "InnovaEmpresa". EOI Spanish Business School, EOI Foundation. Duration 500 h. 26 February-8-July 2004. 2. Teaching experience Fundamentals of teaching Course (University College London), United Kingdom, ongoing, 2013. Teach PhD students Theoretical-Practical Course-"Amino Acid Analysis by HPLC". April 2005. I and II Course "Introduction to chemo-informatics. Proteomics module. First and second edition, 2003 and 2004. University of Seville,Spain. Official Aptitude Pedagogical Course 2001 (CAP). University of Seville, Spain. 3. Clinical Research. Participation in Clinical Trials as collaborator or Study Coordinator I have run clinical studies as a study co-ordinator. The Glutamine challenge test was developed by the Seville group and I coordinated that clinical study (published in Hepatology). More recently, I have coordinated a clinical study involving multiple groups that focussed on the genetic alterations of Glutaminase (published in the Annals of Internal Medicine). More recently, I have been running Hepatitis C clinical trials as a coordinator. 4. Experience in international centers Duration: 18 months. UCL Institute of Hepatology, London. Supervisor: Prof. Rajiv Jalan, Nathan Davies. June 2009- September 2009; May-April 2011. Duration: over 3 months (non uninterruptedly). Surgery Department. Universitary Hospital of Tromsø. Supervisors: Lars M. Ytrebø and Arthur Revhaug. Tromsø, Norway 2007. 5. Animals experimentation: A,B and C Accredited by the Spanish Ministry of Agriculture in 2006, Junta de Andalucia in categories A, B and C to developing, carrying out procedures in experimental animals and their care. Personal Licence Holder, UK. Other relevant information: Languages: Spanish and English English: Advance level spoken, written. Making Master of English Language Course HOME Español, BBC, 2008. 2nd-up course in English Language Institute. University of Seville,Spain. Performing on-line course for BBC Basic French Pronunciation and Public Speaking Course. University College London. Language Centre, 18.5 hours, June 2010. Academic Writing Course. University College London. Language Centre, 18.5 hours, June 2010. Other courses about laboratory techniques and advances and updates on liver diseases: ROCHE Course: Sample Shipping. Posting Rules according to IATA, 18 April 2008. XVI Update Course in Hepatology, Seville, 16 and 17 November 2007. Courses Bristol-Myers. Clinicals Trials: Pharmacogenetic Research, Adverse Event Reporting, Monitoring Resposibilities at BMS, Study documentation, 2007. Update Course in Hepatology. 19-21 February 2007. Accredited by the General Administration of Quality, Research and Knowledge Management National Health System with 1 credit. Expte.06-5349. Assistance to the International Meeting "Frontiers in Hepatology (V)". Pamplona, 6th October, 2006. Course "Update in Hepatology". University Hospitals Virgen del Rocío. 25 and 26 November 2005. Course "Update in Hepatology". University Hospitals Virgen del Rocío. 14 and 15 January 2005. Seminar "Current Status and Future Prospects of Toxicology". Faculty of Pharmacy. University of Seville. 27 and 28 November 2003. Advances in Molecular Medicine Workshop IV. Sponsored by the BBVA Foundation for assistance. Madrid, 3-5 November 2003. Proteomic Seminar Tour 2003. Amersham Biosciences Europe GmbH. Faculty of Pharmacy. Universidad Complutense de Madrid. June 26, 2003. Liquid chromatography (FPLC): Protein Purification System for Äkta platform and control software UnicornTM. Amersham Biosciences Europe GMBH. Bioforum, Madrid. 28-29 May 2003. Basic Electrophoresis. Seminar by Dr. Reiner Westermeier. Amersham Biosciences Europe GmbH. Faculty of Pharmacy. Universidad Complutense de Madrid. April 10, 2003. I Seminar Andalusian Anti-Aging Medicine. Royal and Illustrious Official College of Physicians of Seville. Spanish Society of Anti-Aging Medicine and Longevity. March 8, 2003. Course Analysis of amino acids by HPLC in ITYCAL (Institute of Food Science and Technology). University of Leon. 17 - 21 December 2000. Seminar on "Grand Challenges of modern medicine", recognized by the University of Seville. December 1997. Publications Patent Number: P200931265. Glutaminase Inhibitor, Date: 24th-12-2009. Authors: Manuel Romero Gómez, Juan Dionisio Bautista Palomas, Jose Manuel Vega Pérez, Fernando Iglesias Guerra, Ignácio Periñán Dominguez, Maria del Mar Díaz Herrero, María Jover Cobos. Institutions: Fundacion Valme, Universidad de Sevilla, Grupo CTS532, CIBERehd. Tittle: Uso del compuesto N-fenil-N'-(3-metil-2-butenil)tiourea para la elaboración de medicamentos destinados al tratamiento de la encefalopatía hepática. 1. Jover M, Guerra I., Gutiérrez J.F., and Bautista J. Increased antifungal activity of Trichoderma viride-NBT-1.1 induced by sonolised crawfish chitin. At Chitin Enzymology, 2001 (edited by R.A.A.Muzzarelli). Atec, Italy, 397-402. 2. Bautista J., Jover M., Gutiérrez J.F., Corpas R., Cremades O., Fontiveros E., Iglesias F., and Vega J. Preparation of Crawfish Chitin by "in situ" Lactic Acid Production. Process Biochemistry 2001;37, 229-234. 3. Cremades O., Ponce E., Corpas R., Gutiérrez J.F., Jover M., Alvarez-Ossorio M.C. and Bautista J. Procesing of Crawfish (Procambarus clarkii) for the preparation of Carotenoproteins and Chitin. Journal of Agricultural and Food Chemistry.2001;49 (11) 5468.5472. 4. Parrado J, Miramontes E, Jover M, Márquez JC, Mejías M, Collantes de Terán L, Absi E., Bautista J. Prevention of brain protein and lipid oxidation elicited by a water-soluble oryzanol enzymatic extract derived from rice bran. European Journal Nutrition, 2003;(42)6,307-314. 5. Cremades O, Parrado P, Álvarez-Ossorio MC, Jover M, Collantes de Terán L, Gutiérrez JF and Bautista J. Isolation and characterization of carotenoproteins from crayfish (Procambarus clarkii) Food Chemistry 2003;82 (4) 559-566. 6. Jover M., Romero-Gómez M. Glutaminasa Intestinal y Encefalopatía Hepática (Spanish). GH Formación Continuada 2005, vol 4 Julio-agosto. 7. Parrado J, Miramontes E, Jover M, Gutiérrez JF, Collantes de Terán L, Bautista J. Preparation of a rice bran enzymatic extract with potential use as functional food. Food Chemistry 98.2006. 742-748. 8. Parrado J., Collantes L., Jover M., Bautista J. Lipophilic Hydroxytyrosyl Esters: Antioxidant Activity in Lipid Matrices and Biological Systems. J. Agric. Food Chem. 2006; 3779-3785. 9. Jover M, Díaz D, Fontiveros E., Collantes de Terán L., Parrado J., Camacho I., Bautista J. and Romero-Gómez M. Protein oxidation in astrocyte of porto-caval shunted rats: role of oxidative stress in hepatic encephalopathy. J Hepatol 2006; (Supl 2);44:S76. 10. Romero-Gómez M., Jover M., Díaz-Gómez D., Collantes de Terán L., Rodrigo R., Camacho I., Echevarría M., Felipo V., Bautista J.D. Phosphate-Activated Glutaminase Activity Is Enhanced In Brain, Intestine And Kidneys Of Rats Following Portacaval Anastomosis. World J Gastroenterol 2006;12(15):2406-2411. 11. Cremades O, Parrado J, Jover M, Collantes de Terán L, Gutiérrez JF, Bautista Palomas JD. Nutritional treatment of cancer cachexia in rats. Use of a diet formulated with a crayfish enzymatic extract. Eur J Nutr. 2007 Sep;46(6):347-53. Epub 2007 Aug 4. 12. Romero-Gómez M., Jover M., Bautista JD. Role of ammonia in the pathogenesis of hepatic encephalopathy. International Hepatology Updates: Hepatic encephalopathy. March 2008. ISBN: 978-84-96762-59-6. 13. Romero-Gómez M, Jover M, Galán JJ and Ruiz A. Gut ammonia production and its modulation. Metab Brain Dis. 2009 Mar;24(1):147-57. 14. Jover M, Hoyas E, Grande L, Romero-Gómez. Minimal Hepatic Encephalopathy. M.Rev Gastroenterol Mex. 2009 Jan-Mar; 74(1):26-34. Spanish. 15. Ytrebø LM, Kristiansen RG, Mæhre H, Fuskevåg OM, Kalstad T, Revhaug A, Jover Cobos M, Jalan R, and Rose CF. L-Ornithine Phenylacetate Attenuates Increased Arterial and Extracellular Brain Ammonia and Prevents Intracranial Hypertension in Pigs with Acute Liver Failure. Hepatology 2009; 50, No. 1:165-174. 16. Romero-Gomez M., Jover M., Del Campo J. A., Royo JL, Hoyas E, Galan JJ, Montoliu C, Baccaro E, Guevara M, Cordoba J, Soriano G, Navarro JM, Martinez-Sierra C, Grande L, Galindo A, Mira E, Manes S, Ruiz A. Variations in the Promoter Region of the Glutaminase Gene and the Development of Hepatic Encephalopathy in Patients With Cirrhosis. Annals of Internal Medicine 2010; Sep 7: 153(5);281-288. (IF:17.457). 17. Jiménez B, Montoliu C, MacIntyre D, Serra M, Wassell A, Jover M, Romero-Gómez M, Rodrigo J, Pineda-Lucena A, Felipo V. The serum metabolic signature of Minimal Hepatic Encephalopathy by H-Nuclear Magnetic Resonance. J Proteome Res 2010; Oct 1:9(10): 5180-5187. 18. Jover-Cobos M, Davies D, Jalan R, Romero-Gomez M. The rise of Glutaminase in end-stage liver diseases. Book:Liver transplantation-Basic issues, Edited by Hesham Abdeldayem and Naglaa Allam p. m. ISBN 978-953-51-0016-4. Intech. February 2012. 19. Díaz-Gómez D, Jover M, del-Campo JA, Galindo A, Romero-Gómez M. Experimental models for hepatic encephalopathy. Rev Esp Enferm Dig. 2011 Oct; 103(10):536-41. Review. English, Spanish. 20. Shah N, Dhar D, El Zahraa Mohammed F, Habtesion A, Davies NA, Jover-Cobos M, Macnaughtan J, Sharma V, Olde Damink S W.M., Mookerjee RP, Jalan R. Prevention of acute kidney injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression. J Hepatol. 2012; May:56(5):1047-53. 21. Jover-Cobos M, Davies D, Sharify Y, Jalan R. Ornithine phenylacetate: A novel strategy for the treatment of Hepatic Encephalopathy. Hepatic Encephalopathy. Edited by Kevin D. Mullen and Ravi Prakash. Humana Press, 2012.ISBN 978-1-61779-835-1. 22. Shah N, El Zahraa Mohammed F, Jover-Cobos M, Macnaughtan J, Davies, N., Moore K, Moreau R, Paradis, V, Mookerjee RP, Jalan R. Increased renal expression and urinary excretion of TLR4 in acute kidney injury associated with cirrhosis. Liver international 2013 Mar;33(3):398-409. 23. Jover-Cobos M, Noiret L, Sharifi Y, Jalan R. Ornithine phenylacetate revisited. Metab Brain Dis 2013 Mar (DOI 10.1007/s11011-013-9391-5). 24. (Sent). Jover-Cobos M, Noiret L, Lee K, Sharma V, Habtesion A, Romero-Gomez M, Davies NA, Jalan R. Glutamine synthetase and glutaminase: important targets for therapy of hyperammonemia in cirrhosis. J Hepatol. A number of peer reviewed abstracts as poster or oral presentations during the years 1999-2012 in International meetings (European, American, Spanish and British Association for the Study of the Liver, International Symposium for Hepatic Encephalopathy and Nitrogen Metabolism, International Symposium on Hepatic Encephalopathy) and Awards and Active participation in Meetings list is available upon request. London, 18th March 2013 Sing: María Jover Cobos