Nanofibers mats of chitosan (CTS)/polyvinyl alcohol (PVA)/halloysite nanoclay and drug loaded CTS... more Nanofibers mats of chitosan (CTS)/polyvinyl alcohol (PVA)/halloysite nanoclay and drug loaded CTS/PVA/halloysite nanoclay//3-glycidyoxypropyl trimethoxysilane were fabricated using the electrospinning method. Electrospun nanofiber samples were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). FTIR confirmed the chemical and physical bonding among ingredients such as CTS, PVA, nanoclay and crosslinker in the nanofibers. SEM images showed the development of uniform nanofibers. The average nanofiber diameter was observed in the range of 50–200 nm. Antimicrobial activity was examined against E. coli and S. aurus bacteria. The results obtained indicated that all nanofiber samples showed significant antimicrobial activity against the Gram-positive as well as Gram-negative bacteria. TGA results indicated that the thermal stability of nanofibers increased with the addition of the crosslinker. The drug r...
International Journal of Biological Macromolecules, 2022
Chitosan (Cs) based biomaterials seem to be indispensable for neovasculogenesis and angiogenesis ... more Chitosan (Cs) based biomaterials seem to be indispensable for neovasculogenesis and angiogenesis that ensure accelerated wound healing. Cs/poly (vinyl alcohol) (PVA) bio-constructs were cross-linked and investigated with varying concentrations of aminopropyltriethoxysilane (APTES). This study comprised of three phases: fabrication of hydrogels, characterization, assessment of angiogenic potential along with toxico-pathological effects, wound healing efficacy in chick and mice, respectively. The hydrogels were characterized by FTIR, SEM and TGA and the swelling response was examined in different solvents. The hydrogels swelling ratio was decreased with increasing amount of APTES, showed the highest swelling at acidic and basic pH while low swelling at neutral pH. Chorioallantoic membranes (CAM) assay was performed to study in-vivo angiogenesis, toxicological, morphological, biochemical and histological analyses in developing chicks. The results showed remarkably improved angiogenesis with little deviations in morphological, histological features and liver enzymes of chick embryos at higher concentrations of APTES. Besides, full thickness wounds were excised on mice dorsolateral skin to assess the wound healing. The rate of wound size reduction was significantly higher after topical application of hydrogels with elevated levels of crosslinker. Hence, the hydrogels showed enhanced angiogenesis, accelerated wound healing with little or no observable in-vivo toxicity.
International journal of biological macromolecules, Jan 4, 2017
Silane crosslinked biopolymer based novel pH-responsive hydrogels were fabricated by blending the... more Silane crosslinked biopolymer based novel pH-responsive hydrogels were fabricated by blending the cationic (chitosan) and anionic (alginate) polymers with poly(vinyl alcohol). Tetraethoxysilane (TEOS) was used, as a crosslinker in different amounts due to its nonhazardous nature, to study its impact on physical and chemical properties of the prepared injectable hydrogels along with the controlled release of drug. The swelling response of the prepared hydrogels was examined in different solvent media which exhibited decreased swelling ratio with increase in the amount of TEOS. All the fabricated hydrogels represented highest swelling at acidic pH while low swelling at basic and neutral pH. This specific pH sensitive behavior at pH 7 made them an appropriate candidate for the injectable controlled drug delivery in which Neomycin Sulfate (NMS) was successfully loaded on suitable hydrogel (comprising 50μL TEOS) to study its release mechanism. The results revealed that in simulated gastr...
International journal of biological macromolecules, Jan 11, 2017
Novel biodegradable films were prepared by blending guar gum, chitosan and poly (vinyl alcohol) h... more Novel biodegradable films were prepared by blending guar gum, chitosan and poly (vinyl alcohol) having mint (ME) and grapefruit peel (GE) extracts and crosslinked with nontoxic tetraethoxysilane (TEOS). The co-concentration effect of TEOS with natural extracts on the films was studied. FTIR analysis confirmed the presence of incorporated components and the developed interactions among the polymer chains. The surface morphology of the films by SEM showed the hydrophilic character due to porous network structure. The films having both ME and GE with maximum amount of crosslinker (100μL), showed maximum swelling (58g/g) and stability while the optical properties showed increased protection against UV light. This film sample showed compact network structure which enhanced the ultimate tensile strength (40.03MPa) and elongation at break (104.8%). ME/GE conferred the antioxidant properties determined by radical scavenging activity and total phenolic contents (TPC) as ME films have greater...
Nanofibers mats of chitosan (CTS)/polyvinyl alcohol (PVA)/halloysite nanoclay and drug loaded CTS... more Nanofibers mats of chitosan (CTS)/polyvinyl alcohol (PVA)/halloysite nanoclay and drug loaded CTS/PVA/halloysite nanoclay//3-glycidyoxypropyl trimethoxysilane were fabricated using the electrospinning method. Electrospun nanofiber samples were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). FTIR confirmed the chemical and physical bonding among ingredients such as CTS, PVA, nanoclay and crosslinker in the nanofibers. SEM images showed the development of uniform nanofibers. The average nanofiber diameter was observed in the range of 50–200 nm. Antimicrobial activity was examined against E. coli and S. aurus bacteria. The results obtained indicated that all nanofiber samples showed significant antimicrobial activity against the Gram-positive as well as Gram-negative bacteria. TGA results indicated that the thermal stability of nanofibers increased with the addition of the crosslinker. The drug r...
International Journal of Biological Macromolecules, 2022
Chitosan (Cs) based biomaterials seem to be indispensable for neovasculogenesis and angiogenesis ... more Chitosan (Cs) based biomaterials seem to be indispensable for neovasculogenesis and angiogenesis that ensure accelerated wound healing. Cs/poly (vinyl alcohol) (PVA) bio-constructs were cross-linked and investigated with varying concentrations of aminopropyltriethoxysilane (APTES). This study comprised of three phases: fabrication of hydrogels, characterization, assessment of angiogenic potential along with toxico-pathological effects, wound healing efficacy in chick and mice, respectively. The hydrogels were characterized by FTIR, SEM and TGA and the swelling response was examined in different solvents. The hydrogels swelling ratio was decreased with increasing amount of APTES, showed the highest swelling at acidic and basic pH while low swelling at neutral pH. Chorioallantoic membranes (CAM) assay was performed to study in-vivo angiogenesis, toxicological, morphological, biochemical and histological analyses in developing chicks. The results showed remarkably improved angiogenesis with little deviations in morphological, histological features and liver enzymes of chick embryos at higher concentrations of APTES. Besides, full thickness wounds were excised on mice dorsolateral skin to assess the wound healing. The rate of wound size reduction was significantly higher after topical application of hydrogels with elevated levels of crosslinker. Hence, the hydrogels showed enhanced angiogenesis, accelerated wound healing with little or no observable in-vivo toxicity.
International journal of biological macromolecules, Jan 4, 2017
Silane crosslinked biopolymer based novel pH-responsive hydrogels were fabricated by blending the... more Silane crosslinked biopolymer based novel pH-responsive hydrogels were fabricated by blending the cationic (chitosan) and anionic (alginate) polymers with poly(vinyl alcohol). Tetraethoxysilane (TEOS) was used, as a crosslinker in different amounts due to its nonhazardous nature, to study its impact on physical and chemical properties of the prepared injectable hydrogels along with the controlled release of drug. The swelling response of the prepared hydrogels was examined in different solvent media which exhibited decreased swelling ratio with increase in the amount of TEOS. All the fabricated hydrogels represented highest swelling at acidic pH while low swelling at basic and neutral pH. This specific pH sensitive behavior at pH 7 made them an appropriate candidate for the injectable controlled drug delivery in which Neomycin Sulfate (NMS) was successfully loaded on suitable hydrogel (comprising 50μL TEOS) to study its release mechanism. The results revealed that in simulated gastr...
International journal of biological macromolecules, Jan 11, 2017
Novel biodegradable films were prepared by blending guar gum, chitosan and poly (vinyl alcohol) h... more Novel biodegradable films were prepared by blending guar gum, chitosan and poly (vinyl alcohol) having mint (ME) and grapefruit peel (GE) extracts and crosslinked with nontoxic tetraethoxysilane (TEOS). The co-concentration effect of TEOS with natural extracts on the films was studied. FTIR analysis confirmed the presence of incorporated components and the developed interactions among the polymer chains. The surface morphology of the films by SEM showed the hydrophilic character due to porous network structure. The films having both ME and GE with maximum amount of crosslinker (100μL), showed maximum swelling (58g/g) and stability while the optical properties showed increased protection against UV light. This film sample showed compact network structure which enhanced the ultimate tensile strength (40.03MPa) and elongation at break (104.8%). ME/GE conferred the antioxidant properties determined by radical scavenging activity and total phenolic contents (TPC) as ME films have greater...
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Papers by Sehrish Jabeen