Neuropathic pain (NP) is the most prevalent and debilitating form of chronic pain, caused by inju... more Neuropathic pain (NP) is the most prevalent and debilitating form of chronic pain, caused by injuries or diseases of the somatosensory system. Since current first-line treatments only provide poor symptomatic relief, the search for new therapeutic strategies for managing NP is an active field of investigation. Multiple mechanisms contribute to the genesis and maintenance of NP, including damage caused by oxidative stress. The naturally occurring antioxidant alpha-lipoic acid (ALA) is a promising therapeutic agent for the management of NP. Several pre-clinical in vitro and in vivo studies as well as clinical trials demonstrate the analgesic potential of ALA in the management of NP. The beneficial biological activities of ALA are reflected in the various patents for the development of ALA-based innovative products. This review demonstrates the therapeutic potential of ALA in the management of NP by discussing its analgesic effects by multiple antioxidant mechanisms as well as the use ...
Background: Antimicrobial resistance has been a threat to human health ever since the accelerated... more Background: Antimicrobial resistance has been a threat to human health ever since the accelerated consumption of antibiotics began. Materials & methods: The present systematic review was carried out using a free and specialized online database – Espacenet – and a survey for patents of antimicrobial agents from 2010 to 2021, selecting 33 recent patents that claimed compounds with antimicrobial activity against resistant strains of Gram-negative bacteria. Results: Some different and new approaches to the development of the patented antibacterial agents were identified, such as antimicrobial peptides, nanomaterials and natural extracts. Conclusion: Some alternatives to modern antibiotics with diminished effectiveness due to antimicrobial resistance were spotted. Nevertheless, many challenges remain to establish a robust and sustainable antibacterial R&D pipeline.
O uso de antimicrobianos e extremamente frequente durante a terapia odontologica, porem sua assoc... more O uso de antimicrobianos e extremamente frequente durante a terapia odontologica, porem sua associacao com anticoncepcionais orais pode diminuir a eficacia destes ultimos. A presente revisao de literatura tem como objetivo informar ao cirurgiao-dentista acerca das possiveis interacoes que esses medicamentos podem oferecer aos contraceptivos orais, de forma que sejam relatadas as principais caracteristicas sobre farmacodinâmica e farmacocinetica. Foi realizado um estudo descritivo nas bases de dados Pubmed, MEDLINE, Scielo, LILACS, onde foram encontrados trabalhos julgados relevantes para inclusao nesta revisao; sendo incluidos artigos, teses e livros que relacionassem anticoncepcionais orais e antimicrobianos. Alguns antimicrobianos, em seus mecanismos, diminuem o ciclo entero-hepatico do estrogeno, induzem enzimas microssomais citocromo P450 no figado, aumentam a excrecao de estrogenos; provocando, assim, a reducao na eficacia dos contraceptivos hormonais. Ainda nos dias atuais, gr...
The evaluation of antimicrobial activity has been t he subject of research, mainly due to the pre... more The evaluation of antimicrobial activity has been t he subject of research, mainly due to the presence of bacterial multidrug resistance of conventional treatments. Th is research aimed to investigate the antimicrobial and cytotoxic activity of ethanolic crude extracts from leaves, l eaf sheath, and stem of Cocos nucifera Linn (green dwarf coconut tree) in vitro. The antimicrobial activity was eval u ted against gram-positive bacteria S. aureus and Gram-negative bacterias E. coli and P. aeruginosa and the Candica albicans fungus, through the methods of agar diffu sion and identification of minimum inhibitory concentration through microdilution. The cell viability assay was performed using the J774 cell line by MTT. The sheath and lea f extracts of C. nucifera L. inhibited bacterial gr owth of S. aureus and P. aeruginosa with the minimum inhibitor y concentration of growth of 10 mg (5%), and there was no inhibition of E. coli and C. albicans growth at a c oncentration of 1.5 x 10 6 C...
Compreendendo que nas últimas décadas os psicobióticos, uma nova classe de probióticos, direciona... more Compreendendo que nas últimas décadas os psicobióticos, uma nova classe de probióticos, direcionaram muitos pesquisadores a se concentrarem no estudo dos mesmos em relação ao seu potencial terapêutico para transtornos psíquicos, o presente estudo compilou dados da literatura científica a respeito das recentes descobertas relacionadas aos psicobióticos como uma potencial alternativa para o tratamento da ansiedade. Para tal foi realizada uma revisão integrativa de literatura, por meio de consultas a artigos publicados nos últimos seis anos por meio das bases de dados PubMed/MEDLINE e SciELO, utilizando os seguintes descritores:"Probiotics and anxiety", "Psycobiotcs and anxiety", publicados na íntegra em inglês. Totalizando 267 estudos encontrados, dos quais meramente 14 artigos foram elegíveis. A princípio foram discutidos os benefícios gerados pelos psicobióticos para a saúde mental, bem como sua importância na compreensão dos mecanismos envolvidos na relação do e...
O uso de repositores hidroeletroliticos, apesar da sua acao benefica quando se trata da hidrataca... more O uso de repositores hidroeletroliticos, apesar da sua acao benefica quando se trata da hidratacao e reposicao de minerais corporais, apresenta efeitos colaterais na cavidade oral com acao direta na estrutura dentaria, promovendo desmineralizacao, diminuicao do pH bucal e erosao dentaria, predispondo a sensibilidade. O presente estudo buscou analisar a literatura publicada referente a sensibilidade dentaria associada ao uso de repositores hidroeletroliticos, atraves de uma revisao sistematica nas bases de dados: Neville, PubMed, Scielo e Liliacs no periodo de 2006 a 2016, utilizando os descritores “Dentin sensitivity” e “acidic beverages”. Desta forma, esta pesquisa consistiu no estabelecimento de criterios de inclusao e exclusao, seguidos da analise critica e interpretacao dos dados e, por fim, apresentacao dos resultados. Ao todo, 20 artigos foram encontrados. A exclusao de 15 artigos se deu por nao responderem a questao norteadora, resultando em apenas 5 artigos que compuseram a ...
Experimental in vivo study aimed to characterize the anxiolytic-like effect of the Citrus limon f... more Experimental in vivo study aimed to characterize the anxiolytic-like effect of the Citrus limon fruit peel’s essential oil (CLEO) in animal models of anxiety, besides evaluating the viability J774.A1 cells in vitro through the MTT reduction method at the concentrations of 10 and 100 µg/mL. The anxiolytic behavior was evaluated in Swiss mice (n = 8) using the methodology of Elevated Plus-Maze (EPM) and Open-Field (OF). CLEO was tested by inhalation at the doses of 100, 200, and 400 µL, and as control, animals were subjected to inhalation of the vehicle (saline solution 0.9% + Tween80®) and intraperitoneal administration of diazepam (1.5 mg/kg). In the cell viability assay, it was observed that none of the concentrations showed cytotoxicity. OF test showed significant anxiolytic activity at all tested doses of OECL, compared to the control group, without changing the motor performance of the animals. Corroborating OF data, the EPM test confirmed anxiolytic activity in at least two dos...
Introducao: As doencas cronicas nao transmissiveis (DCNT) estao entre as principais causas de mor... more Introducao: As doencas cronicas nao transmissiveis (DCNT) estao entre as principais causas de mortalidade no mundo. No Brasil, a prevalencia de DCNT decresce 1,8% ao ano devido as acoes na atencao primaria a saude. Problemas relacionados a medicamentos (PRMs) sao encontrados entre os portadores de DCNT, evidenciando a importância do farmaceutico no cuidado em saude, a fim de proporcionar melhorias terapeuticas. Objetivo: Assim, este trabalho teve como objetivo descrever o perfil das intervencoes farmaceuticas realizadas no acompanhamento farmacoterapeutico de portadores de DCNT na Farmacia Universitaria da UFBA (FU-UFBA), de setembro de 2019 a fevereiro de 2020. Material e metodos: Baseado no desenho de pesquisa descritivo e transversal (CEP UFBA n. 2.578.262), foram utilizados dados secundarios do banco de dados da FU-UFBA. As intervencoes farmaceuticas realizadas foram classificadas como: aconselhamento ao paciente/cuidador sobre tratamento medicamentoso, medidas nao-farmacologica...
The present study aimed to know about the use of medicinal plants in the wounds treatment and its... more The present study aimed to know about the use of medicinal plants in the wounds treatment and its forms of use. This is a descriptive study with qualitative approach which was developed in a clinical nursing specialized in wound care and in a University Hospital in Maceio – Alagoas city, northeastern Brazil. Thirty patients bearers of wounds were interviewed, where 70% made use of medicinal plants to treat their injuries. The most cited species were Stryphnodendron adstringens (“barbatimao”), Hyptis pectinata (“sambacaita”) and Schinus terebinthifolia Raddi (“aroeira”). The two etiologies most frequently cited by the participants patients were varicose ulcers and diabetic foot. The main form of preparation and administration was by bathing of the wound with tea made with dry plant leaf. Patients mainly followed their empirical knowledge, healers and elderly family members as a source of indication for use. Studies in this segment concerning use of medicinal plants by individuals wit...
Neuropathic pain (NP) is the most prevalent and debilitating form of chronic pain, caused by inju... more Neuropathic pain (NP) is the most prevalent and debilitating form of chronic pain, caused by injuries or diseases of the somatosensory system. Since current first-line treatments only provide poor symptomatic relief, the search for new therapeutic strategies for managing NP is an active field of investigation. Multiple mechanisms contribute to the genesis and maintenance of NP, including damage caused by oxidative stress. The naturally occurring antioxidant alpha-lipoic acid (ALA) is a promising therapeutic agent for the management of NP. Several pre-clinical in vitro and in vivo studies as well as clinical trials demonstrate the analgesic potential of ALA in the management of NP. The beneficial biological activities of ALA are reflected in the various patents for the development of ALA-based innovative products. This review demonstrates the therapeutic potential of ALA in the management of NP by discussing its analgesic effects by multiple antioxidant mechanisms as well as the use ...
Background: Antimicrobial resistance has been a threat to human health ever since the accelerated... more Background: Antimicrobial resistance has been a threat to human health ever since the accelerated consumption of antibiotics began. Materials & methods: The present systematic review was carried out using a free and specialized online database – Espacenet – and a survey for patents of antimicrobial agents from 2010 to 2021, selecting 33 recent patents that claimed compounds with antimicrobial activity against resistant strains of Gram-negative bacteria. Results: Some different and new approaches to the development of the patented antibacterial agents were identified, such as antimicrobial peptides, nanomaterials and natural extracts. Conclusion: Some alternatives to modern antibiotics with diminished effectiveness due to antimicrobial resistance were spotted. Nevertheless, many challenges remain to establish a robust and sustainable antibacterial R&D pipeline.
O uso de antimicrobianos e extremamente frequente durante a terapia odontologica, porem sua assoc... more O uso de antimicrobianos e extremamente frequente durante a terapia odontologica, porem sua associacao com anticoncepcionais orais pode diminuir a eficacia destes ultimos. A presente revisao de literatura tem como objetivo informar ao cirurgiao-dentista acerca das possiveis interacoes que esses medicamentos podem oferecer aos contraceptivos orais, de forma que sejam relatadas as principais caracteristicas sobre farmacodinâmica e farmacocinetica. Foi realizado um estudo descritivo nas bases de dados Pubmed, MEDLINE, Scielo, LILACS, onde foram encontrados trabalhos julgados relevantes para inclusao nesta revisao; sendo incluidos artigos, teses e livros que relacionassem anticoncepcionais orais e antimicrobianos. Alguns antimicrobianos, em seus mecanismos, diminuem o ciclo entero-hepatico do estrogeno, induzem enzimas microssomais citocromo P450 no figado, aumentam a excrecao de estrogenos; provocando, assim, a reducao na eficacia dos contraceptivos hormonais. Ainda nos dias atuais, gr...
The evaluation of antimicrobial activity has been t he subject of research, mainly due to the pre... more The evaluation of antimicrobial activity has been t he subject of research, mainly due to the presence of bacterial multidrug resistance of conventional treatments. Th is research aimed to investigate the antimicrobial and cytotoxic activity of ethanolic crude extracts from leaves, l eaf sheath, and stem of Cocos nucifera Linn (green dwarf coconut tree) in vitro. The antimicrobial activity was eval u ted against gram-positive bacteria S. aureus and Gram-negative bacterias E. coli and P. aeruginosa and the Candica albicans fungus, through the methods of agar diffu sion and identification of minimum inhibitory concentration through microdilution. The cell viability assay was performed using the J774 cell line by MTT. The sheath and lea f extracts of C. nucifera L. inhibited bacterial gr owth of S. aureus and P. aeruginosa with the minimum inhibitor y concentration of growth of 10 mg (5%), and there was no inhibition of E. coli and C. albicans growth at a c oncentration of 1.5 x 10 6 C...
Compreendendo que nas últimas décadas os psicobióticos, uma nova classe de probióticos, direciona... more Compreendendo que nas últimas décadas os psicobióticos, uma nova classe de probióticos, direcionaram muitos pesquisadores a se concentrarem no estudo dos mesmos em relação ao seu potencial terapêutico para transtornos psíquicos, o presente estudo compilou dados da literatura científica a respeito das recentes descobertas relacionadas aos psicobióticos como uma potencial alternativa para o tratamento da ansiedade. Para tal foi realizada uma revisão integrativa de literatura, por meio de consultas a artigos publicados nos últimos seis anos por meio das bases de dados PubMed/MEDLINE e SciELO, utilizando os seguintes descritores:"Probiotics and anxiety", "Psycobiotcs and anxiety", publicados na íntegra em inglês. Totalizando 267 estudos encontrados, dos quais meramente 14 artigos foram elegíveis. A princípio foram discutidos os benefícios gerados pelos psicobióticos para a saúde mental, bem como sua importância na compreensão dos mecanismos envolvidos na relação do e...
O uso de repositores hidroeletroliticos, apesar da sua acao benefica quando se trata da hidrataca... more O uso de repositores hidroeletroliticos, apesar da sua acao benefica quando se trata da hidratacao e reposicao de minerais corporais, apresenta efeitos colaterais na cavidade oral com acao direta na estrutura dentaria, promovendo desmineralizacao, diminuicao do pH bucal e erosao dentaria, predispondo a sensibilidade. O presente estudo buscou analisar a literatura publicada referente a sensibilidade dentaria associada ao uso de repositores hidroeletroliticos, atraves de uma revisao sistematica nas bases de dados: Neville, PubMed, Scielo e Liliacs no periodo de 2006 a 2016, utilizando os descritores “Dentin sensitivity” e “acidic beverages”. Desta forma, esta pesquisa consistiu no estabelecimento de criterios de inclusao e exclusao, seguidos da analise critica e interpretacao dos dados e, por fim, apresentacao dos resultados. Ao todo, 20 artigos foram encontrados. A exclusao de 15 artigos se deu por nao responderem a questao norteadora, resultando em apenas 5 artigos que compuseram a ...
Experimental in vivo study aimed to characterize the anxiolytic-like effect of the Citrus limon f... more Experimental in vivo study aimed to characterize the anxiolytic-like effect of the Citrus limon fruit peel’s essential oil (CLEO) in animal models of anxiety, besides evaluating the viability J774.A1 cells in vitro through the MTT reduction method at the concentrations of 10 and 100 µg/mL. The anxiolytic behavior was evaluated in Swiss mice (n = 8) using the methodology of Elevated Plus-Maze (EPM) and Open-Field (OF). CLEO was tested by inhalation at the doses of 100, 200, and 400 µL, and as control, animals were subjected to inhalation of the vehicle (saline solution 0.9% + Tween80®) and intraperitoneal administration of diazepam (1.5 mg/kg). In the cell viability assay, it was observed that none of the concentrations showed cytotoxicity. OF test showed significant anxiolytic activity at all tested doses of OECL, compared to the control group, without changing the motor performance of the animals. Corroborating OF data, the EPM test confirmed anxiolytic activity in at least two dos...
Introducao: As doencas cronicas nao transmissiveis (DCNT) estao entre as principais causas de mor... more Introducao: As doencas cronicas nao transmissiveis (DCNT) estao entre as principais causas de mortalidade no mundo. No Brasil, a prevalencia de DCNT decresce 1,8% ao ano devido as acoes na atencao primaria a saude. Problemas relacionados a medicamentos (PRMs) sao encontrados entre os portadores de DCNT, evidenciando a importância do farmaceutico no cuidado em saude, a fim de proporcionar melhorias terapeuticas. Objetivo: Assim, este trabalho teve como objetivo descrever o perfil das intervencoes farmaceuticas realizadas no acompanhamento farmacoterapeutico de portadores de DCNT na Farmacia Universitaria da UFBA (FU-UFBA), de setembro de 2019 a fevereiro de 2020. Material e metodos: Baseado no desenho de pesquisa descritivo e transversal (CEP UFBA n. 2.578.262), foram utilizados dados secundarios do banco de dados da FU-UFBA. As intervencoes farmaceuticas realizadas foram classificadas como: aconselhamento ao paciente/cuidador sobre tratamento medicamentoso, medidas nao-farmacologica...
The present study aimed to know about the use of medicinal plants in the wounds treatment and its... more The present study aimed to know about the use of medicinal plants in the wounds treatment and its forms of use. This is a descriptive study with qualitative approach which was developed in a clinical nursing specialized in wound care and in a University Hospital in Maceio – Alagoas city, northeastern Brazil. Thirty patients bearers of wounds were interviewed, where 70% made use of medicinal plants to treat their injuries. The most cited species were Stryphnodendron adstringens (“barbatimao”), Hyptis pectinata (“sambacaita”) and Schinus terebinthifolia Raddi (“aroeira”). The two etiologies most frequently cited by the participants patients were varicose ulcers and diabetic foot. The main form of preparation and administration was by bathing of the wound with tea made with dry plant leaf. Patients mainly followed their empirical knowledge, healers and elderly family members as a source of indication for use. Studies in this segment concerning use of medicinal plants by individuals wit...
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