Larva currens is the most typical cutaneous manifestation of human strongyloidiasis. 1 The recomm... more Larva currens is the most typical cutaneous manifestation of human strongyloidiasis. 1 The recommended therapy for strongyloidiasis is oral tiabendazole or albendazole, but the former is poorly tolerated while the latter is poorly effective. 2 Oral ivermectin, the current drug of choice for onchocerciasis, 3 has recently been reported as very effective and well tolerated in patients with gastrointestinal helminthiases, such as strongyloidiasis. 4,5 These findings prompted us to test this drug in three cases of larva currens. Report of Cases. Case 1. A 38-year-old man weighing 66 kg was first seen in August 1990. He was born in Brazil and had lived there up until 1987. He complained of recurrent episodes of watery diarrhea, abdominal discomfort, and nausea; larva currens appeared in 1985. The blood count showed mild hypereosinophilia (0.7×10 9 /L) and a stool test was positive for Strongyloides stercoralis larvae. We treated him with 2 tablets of
Larva currens is the most typical cutaneous manifestation of human strongyloidiasis. 1 The recomm... more Larva currens is the most typical cutaneous manifestation of human strongyloidiasis. 1 The recommended therapy for strongyloidiasis is oral tiabendazole or albendazole, but the former is poorly tolerated while the latter is poorly effective. 2 Oral ivermectin, the current drug of choice for onchocerciasis, 3 has recently been reported as very effective and well tolerated in patients with gastrointestinal helminthiases, such as strongyloidiasis. 4,5 These findings prompted us to test this drug in three cases of larva currens. Report of Cases. Case 1. A 38-year-old man weighing 66 kg was first seen in August 1990. He was born in Brazil and had lived there up until 1987. He complained of recurrent episodes of watery diarrhea, abdominal discomfort, and nausea; larva currens appeared in 1985. The blood count showed mild hypereosinophilia (0.7×10 9 /L) and a stool test was positive for Strongyloides stercoralis larvae. We treated him with 2 tablets of
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1994
Ivermectin is highly effective against animal intestinal nematodes and is used in the treatment o... more Ivermectin is highly effective against animal intestinal nematodes and is used in the treatment of onchocerciasis in humans. A study was undertaken to compare the efficacy of the drug with that of albendazole in the treatment of uncomplicated strongyloidiasis. Sixty patients with confirmed Strongyloides stercoralis infection were enrolled in an open randomized study and given either albendazole, 400 mg/d for 3 d or ivermectin, 150-200 micrograms/kg in a single dose. Efficacy and tolerance were evaluated on days 7, 30 and 90. Each visit included a parasitological examination of 3 stool specimens, using saline and Kato smears and formalin-ether and Baermann concentrations. Fifty-three patients were eligible for evaluation. Parasitological cure was obtained in 24 of the 29 patients treated with ivermectin (83%) and in 9 of the 24 patients who were given albendazole (38%); ivermectin was significantly more effective than albendazole (P < 0.01). Clinical and biological adverse reactio...
Ivermectin is highly effective against animal intestinal nematodes and is used in the treatment o... more Ivermectin is highly effective against animal intestinal nematodes and is used in the treatment of onchocerciasis in humans. A study was undertaken to compare the efficacy of the drug with that of albendazole in the treatment of uncomplicated strongyloidiasis. Sixty patients with confirmed Strongyloides stercoralis infection were enrolled in an open randomized study and given either albendazole, 400 mg/d for 3 d or ivermectin, 150-200 micrograms/kg in a single dose. Efficacy and tolerance were evaluated on days 7, 30 and 90. Each visit included a parasitological examination of 3 stool specimens, using saline and Kato smears and formalin-ether and Baermann concentrations. Fifty-three patients were eligible for evaluation. Parasitological cure was obtained in 24 of the 29 patients treated with ivermectin (83%) and in 9 of the 24 patients who were given albendazole (38%); ivermectin was significantly more effective than albendazole (P &lt; 0.01). Clinical and biological adverse reactions were negligible in both treatment groups. The 20 patients who failed therapy were given a second treatment course with 150-200 micrograms/kg of ivermectin in a single dose or on 2 consecutive days. Sixteen patients were cured and the other 4 had only incomplete follow-up. Ivermectin therefore constitutes an acceptable therapeutic alternative for uncomplicated strongyloidiasis.
Larva currens is the most typical cutaneous manifestation of human strongyloidiasis. 1 The recomm... more Larva currens is the most typical cutaneous manifestation of human strongyloidiasis. 1 The recommended therapy for strongyloidiasis is oral tiabendazole or albendazole, but the former is poorly tolerated while the latter is poorly effective. 2 Oral ivermectin, the current drug of choice for onchocerciasis, 3 has recently been reported as very effective and well tolerated in patients with gastrointestinal helminthiases, such as strongyloidiasis. 4,5 These findings prompted us to test this drug in three cases of larva currens. Report of Cases. Case 1. A 38-year-old man weighing 66 kg was first seen in August 1990. He was born in Brazil and had lived there up until 1987. He complained of recurrent episodes of watery diarrhea, abdominal discomfort, and nausea; larva currens appeared in 1985. The blood count showed mild hypereosinophilia (0.7×10 9 /L) and a stool test was positive for Strongyloides stercoralis larvae. We treated him with 2 tablets of
Larva currens is the most typical cutaneous manifestation of human strongyloidiasis. 1 The recomm... more Larva currens is the most typical cutaneous manifestation of human strongyloidiasis. 1 The recommended therapy for strongyloidiasis is oral tiabendazole or albendazole, but the former is poorly tolerated while the latter is poorly effective. 2 Oral ivermectin, the current drug of choice for onchocerciasis, 3 has recently been reported as very effective and well tolerated in patients with gastrointestinal helminthiases, such as strongyloidiasis. 4,5 These findings prompted us to test this drug in three cases of larva currens. Report of Cases. Case 1. A 38-year-old man weighing 66 kg was first seen in August 1990. He was born in Brazil and had lived there up until 1987. He complained of recurrent episodes of watery diarrhea, abdominal discomfort, and nausea; larva currens appeared in 1985. The blood count showed mild hypereosinophilia (0.7×10 9 /L) and a stool test was positive for Strongyloides stercoralis larvae. We treated him with 2 tablets of
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1994
Ivermectin is highly effective against animal intestinal nematodes and is used in the treatment o... more Ivermectin is highly effective against animal intestinal nematodes and is used in the treatment of onchocerciasis in humans. A study was undertaken to compare the efficacy of the drug with that of albendazole in the treatment of uncomplicated strongyloidiasis. Sixty patients with confirmed Strongyloides stercoralis infection were enrolled in an open randomized study and given either albendazole, 400 mg/d for 3 d or ivermectin, 150-200 micrograms/kg in a single dose. Efficacy and tolerance were evaluated on days 7, 30 and 90. Each visit included a parasitological examination of 3 stool specimens, using saline and Kato smears and formalin-ether and Baermann concentrations. Fifty-three patients were eligible for evaluation. Parasitological cure was obtained in 24 of the 29 patients treated with ivermectin (83%) and in 9 of the 24 patients who were given albendazole (38%); ivermectin was significantly more effective than albendazole (P < 0.01). Clinical and biological adverse reactio...
Ivermectin is highly effective against animal intestinal nematodes and is used in the treatment o... more Ivermectin is highly effective against animal intestinal nematodes and is used in the treatment of onchocerciasis in humans. A study was undertaken to compare the efficacy of the drug with that of albendazole in the treatment of uncomplicated strongyloidiasis. Sixty patients with confirmed Strongyloides stercoralis infection were enrolled in an open randomized study and given either albendazole, 400 mg/d for 3 d or ivermectin, 150-200 micrograms/kg in a single dose. Efficacy and tolerance were evaluated on days 7, 30 and 90. Each visit included a parasitological examination of 3 stool specimens, using saline and Kato smears and formalin-ether and Baermann concentrations. Fifty-three patients were eligible for evaluation. Parasitological cure was obtained in 24 of the 29 patients treated with ivermectin (83%) and in 9 of the 24 patients who were given albendazole (38%); ivermectin was significantly more effective than albendazole (P &lt; 0.01). Clinical and biological adverse reactions were negligible in both treatment groups. The 20 patients who failed therapy were given a second treatment course with 150-200 micrograms/kg of ivermectin in a single dose or on 2 consecutive days. Sixteen patients were cured and the other 4 had only incomplete follow-up. Ivermectin therefore constitutes an acceptable therapeutic alternative for uncomplicated strongyloidiasis.
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Papers by Ruben Mayorga