Objetivo: Avaliar a segregação, tratamento e destino dos resíduos radiológicos dado pelos cirurgi... more Objetivo: Avaliar a segregação, tratamento e destino dos resíduos radiológicos dado pelos cirurgiõesdentistas de Pelotas que possuem aparelhos de raios-X em uso no consultório odontológico e cadastrados na Vigilância Sanitária; e analisar o conhecimento dos mesmos acerca de sustentabilidade. Materiais e Métodos: Quarenta cirurgiões-dentistas de Pelotas-RS responderam um formulário contendo 16 perguntas que abordaram o conhecimento destes profissionais sobre a sustentabilidade, separação dos componentes sólidos do filme radiográfico, tratamento das soluções processadoras no consultório, destino final dos resíduos e usocorreto do gerenciamento como ferramenta de marketing. Resultados: Verificou-se que 35,0% da amostra relatou lançar o revelador e o fixador em esgoto comum sem antes neutralizá-los. A maioria dos participantes(67,5%) afirmou acreditar no potencial poluidor da água de lavagem do filme durante o seu processamento, embora 65,0% deles relataram descartar o material diretamente em esgoto comum. Com relação à segregaçãodos resíduos sólidos, 37,5% dos dentistas disseram não separar os componentes do filme radiográfico. A maior parte deles (90,0%) afirmou ter conhecimento sobre desenvolvimento sustentável, 95,0% tentavampreservar o meio ambiente quando descartavam os resíduos do seu consultório e 70,0% acreditavam que a destinação apropriada dos resíduos poderia se mostrar economicamente viável. Conclusões: A maioria dosprofissionais afirmou ter conhecimento de desenvolvimento sustentável e tentar preservar o meio ambiente quando descartavam os resíduos produzidos no consultório. Há dificuldade, por parte dos cirurgiões-dentistas,no descarte dos efluentes líquidos, mas grande parte consegue classificar e segregar adequadamente os resíduos do filme radiográfico.Descritores: Resíduos odontológicos. Resíduos tóxicos. Desenvolvimento sustentável. Radiografia.
ETHNOPHARMACOLOGICAL RELEVANCE The antimicrobial potential of propolis - a honey bee product - wa... more ETHNOPHARMACOLOGICAL RELEVANCE The antimicrobial potential of propolis - a honey bee product - was correlated with its traditional use as a natural medicine, mainly known for antimicrobial and antioxidant properties. Moreover, research on natural products in dentistry has increased in recent years in the search for products with greater therapeutic activity, lower toxicity, better biocompatibility, and more affordable cost to the population. OBJECTIVE Considering that the beneficial effect of propolis is acknowledged for several oral conditions, this study aimed to synthesize the research and technological forecasts of existing evidence on the use of propolis extract as a potential antimicrobial agent in dentistry. METHODS Studies were identified through an investigation in the PubMed, Web of Science, Scopus, and Scielo electronic databases. Additionally, the following patent databases were screened: Google Patents, WIPO, INPI, Espacenet, and Questel Orbit. The data were tabulated and analyzed using Microsoft Office Excel 2013 and Questel Orbit. RESULTS A total of 174 scientific articles and 276 patents fulfilled all the criteria and were included in the investigation. The highest number of patents (n = 144) was produced by China. Additionally, the most prevalent studies were performed on an experimental basis (72%), followed by clinical studies (n = 27) and review articles (n = 21). The effect of using propolis has been extensively observed in oral care products, periodontics, pathology, and cariology, among other dental specialties. CONCLUSION It was possible to identify the current scientific and technological scenario of the application of propolis in dentistry, with the number of patents increasing in recent years. However, all studies related to the use of propolis in dentistry have shown a potentially safe antimicrobial agent in an extensive field of application.
MicroRNAs (miRNAs) are responsible for regulating gene expression post-transcriptionally. Are inv... more MicroRNAs (miRNAs) are responsible for regulating gene expression post-transcriptionally. Are involved in several biological processes, such as wound healing. Understanding the miRNAs involved in this process is fundamental for the development of new therapies. So, due to the need to understand the role of these molecules, we aimed systematically review the literature in order to identify which miRNAs are involved in the wound healing and determine, through bioinformatics analysis, which signaling pathways are associated with these miRNAs. An electronic search was performed in the following databases: National Library of Medicine National Institutes of Health (PubMed), Science Direct, Scifinder, Scopus and Web of Science, using the descriptors: “(microRNA [MeSH])” and “(skin [MeSH])” and “(wound healing [MeSH])”. After the search, two independent and previously calibrated reviewers selected the articles that analyzed the expression pattern of miRNAs in wound healing in in vivo studies, using the software Zotero bibliography manager. Following, bioinformatic analysis was performed using the software DIANA Tools, mirPath v.3 and the data was interpreted. The bioinformatics analysis revealed that on the day 1 there were 13 union pathways, eight of which were statistically significant. Still on the day 1, among the miRNAs that had a decrease in their expression, 12 of 17 union pathways found were statistically significant. On the day 5, among the miRNAs with an increase in expression, 16 union pathways were found, 12 of which were statistically significant. Finally, among the miRNAs with decreased expression, 11 of 15 union pathways found were statistically significant. Although it has been found substantial heterogeneity in the studies, with this systematic review, it was possible to study the panorama of miRNAs that may be altered in the wound healing. The present review summarizes existing evidence of miRNAs associated to wound healing, and these findings can contribute to new therapeutic approaches.
Objetivo: Avaliar a segregação, tratamento e destino dos resíduos radiológicos dado pelos cirurgi... more Objetivo: Avaliar a segregação, tratamento e destino dos resíduos radiológicos dado pelos cirurgiõesdentistas de Pelotas que possuem aparelhos de raios-X em uso no consultório odontológico e cadastrados na Vigilância Sanitária; e analisar o conhecimento dos mesmos acerca de sustentabilidade. Materiais e Métodos: Quarenta cirurgiões-dentistas de Pelotas-RS responderam um formulário contendo 16 perguntas que abordaram o conhecimento destes profissionais sobre a sustentabilidade, separação dos componentes sólidos do filme radiográfico, tratamento das soluções processadoras no consultório, destino final dos resíduos e usocorreto do gerenciamento como ferramenta de marketing. Resultados: Verificou-se que 35,0% da amostra relatou lançar o revelador e o fixador em esgoto comum sem antes neutralizá-los. A maioria dos participantes(67,5%) afirmou acreditar no potencial poluidor da água de lavagem do filme durante o seu processamento, embora 65,0% deles relataram descartar o material diretamente em esgoto comum. Com relação à segregaçãodos resíduos sólidos, 37,5% dos dentistas disseram não separar os componentes do filme radiográfico. A maior parte deles (90,0%) afirmou ter conhecimento sobre desenvolvimento sustentável, 95,0% tentavampreservar o meio ambiente quando descartavam os resíduos do seu consultório e 70,0% acreditavam que a destinação apropriada dos resíduos poderia se mostrar economicamente viável. Conclusões: A maioria dosprofissionais afirmou ter conhecimento de desenvolvimento sustentável e tentar preservar o meio ambiente quando descartavam os resíduos produzidos no consultório. Há dificuldade, por parte dos cirurgiões-dentistas,no descarte dos efluentes líquidos, mas grande parte consegue classificar e segregar adequadamente os resíduos do filme radiográfico.Descritores: Resíduos odontológicos. Resíduos tóxicos. Desenvolvimento sustentável. Radiografia.
ETHNOPHARMACOLOGICAL RELEVANCE The antimicrobial potential of propolis - a honey bee product - wa... more ETHNOPHARMACOLOGICAL RELEVANCE The antimicrobial potential of propolis - a honey bee product - was correlated with its traditional use as a natural medicine, mainly known for antimicrobial and antioxidant properties. Moreover, research on natural products in dentistry has increased in recent years in the search for products with greater therapeutic activity, lower toxicity, better biocompatibility, and more affordable cost to the population. OBJECTIVE Considering that the beneficial effect of propolis is acknowledged for several oral conditions, this study aimed to synthesize the research and technological forecasts of existing evidence on the use of propolis extract as a potential antimicrobial agent in dentistry. METHODS Studies were identified through an investigation in the PubMed, Web of Science, Scopus, and Scielo electronic databases. Additionally, the following patent databases were screened: Google Patents, WIPO, INPI, Espacenet, and Questel Orbit. The data were tabulated and analyzed using Microsoft Office Excel 2013 and Questel Orbit. RESULTS A total of 174 scientific articles and 276 patents fulfilled all the criteria and were included in the investigation. The highest number of patents (n = 144) was produced by China. Additionally, the most prevalent studies were performed on an experimental basis (72%), followed by clinical studies (n = 27) and review articles (n = 21). The effect of using propolis has been extensively observed in oral care products, periodontics, pathology, and cariology, among other dental specialties. CONCLUSION It was possible to identify the current scientific and technological scenario of the application of propolis in dentistry, with the number of patents increasing in recent years. However, all studies related to the use of propolis in dentistry have shown a potentially safe antimicrobial agent in an extensive field of application.
MicroRNAs (miRNAs) are responsible for regulating gene expression post-transcriptionally. Are inv... more MicroRNAs (miRNAs) are responsible for regulating gene expression post-transcriptionally. Are involved in several biological processes, such as wound healing. Understanding the miRNAs involved in this process is fundamental for the development of new therapies. So, due to the need to understand the role of these molecules, we aimed systematically review the literature in order to identify which miRNAs are involved in the wound healing and determine, through bioinformatics analysis, which signaling pathways are associated with these miRNAs. An electronic search was performed in the following databases: National Library of Medicine National Institutes of Health (PubMed), Science Direct, Scifinder, Scopus and Web of Science, using the descriptors: “(microRNA [MeSH])” and “(skin [MeSH])” and “(wound healing [MeSH])”. After the search, two independent and previously calibrated reviewers selected the articles that analyzed the expression pattern of miRNAs in wound healing in in vivo studies, using the software Zotero bibliography manager. Following, bioinformatic analysis was performed using the software DIANA Tools, mirPath v.3 and the data was interpreted. The bioinformatics analysis revealed that on the day 1 there were 13 union pathways, eight of which were statistically significant. Still on the day 1, among the miRNAs that had a decrease in their expression, 12 of 17 union pathways found were statistically significant. On the day 5, among the miRNAs with an increase in expression, 16 union pathways were found, 12 of which were statistically significant. Finally, among the miRNAs with decreased expression, 11 of 15 union pathways found were statistically significant. Although it has been found substantial heterogeneity in the studies, with this systematic review, it was possible to study the panorama of miRNAs that may be altered in the wound healing. The present review summarizes existing evidence of miRNAs associated to wound healing, and these findings can contribute to new therapeutic approaches.
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Papers by Rafael Guerra Lund