Experimental evidence indicates that arginine vasopressin (AVP) may contribute to the rise of blo... more Experimental evidence indicates that arginine vasopressin (AVP) may contribute to the rise of blood pressure (BP) in hypertension induced by renal failure and sodium overload. We studied the AVP inhibitor [1-(B-mercapto-B,B-cyclopentamethylenepropionic acid)-2-(O-methyl)tyrosine] AVP in 12 normal and seven hypertensive subjects with end-stage renal disease. To test the agent's capacity to block the pressor action of exogenous AVP In humans, we constructed a dose-response curve with AVP doses of 1 to 20 mU/kg, raising BP by up to 30 mm Hg. Subsequently, five volunteers receive intravenous (i.v.) doses of 0.1 mg, and five volunteers received 0.5 mg of the inhibitor. The dose-response curve was then repeated with AVP doses up to 200 mU/kg. Both doses of the inhibitor shifted the curve to the right and downward, with the BP response to 20 mU/kg AVP being inhibited by 23% and 80% respectively. The duration of action of the compound was tested in two additional subjects, and was found to be over 3 hours. We then tested the compound in seven hypertensive patients with end-stage renal failure. Two days before dialysis, patients received a 150 mEq/day Na diet. After an additional Na load of 180 mEq via i.v. saline over 3 hours under constant BP and ECG monitoring, they received an i.v. bolus of 0.5 mg AVP inhibitor. A moderate BP fall occurred in five patients; it was maximal at 45 to 60 minutes and returned to baseline by 70 to 90 minutes.(ABSTRACT TRUNCATED AT 250 WORDS)
The perception of taste is an important factor related to quality of life of people. Disorders of... more The perception of taste is an important factor related to quality of life of people. Disorders of this perception can lead to consumption of toxic substances or excessive consumption of substances which may interfere in the treatment of diseases such as hypertension and diabetes. This perception is the sum of the chemical senses (taste and smell) and tactile sensations. The main sponsors are the taste buds, which are localized at the entrance of digestive system. This sensation is variable according to the psychological and cultural development of individuals and has great importance in the development and determination of the quality of food. The objective of this work is gather knowledge about perception of taste and perception threshold
Experimental evidence indicates that arginine vasopressin (AVP) may contribute to the rise of blo... more Experimental evidence indicates that arginine vasopressin (AVP) may contribute to the rise of blood pressure (BP) in hypertension induced by renal failure and sodium overload. We studied the AVP inhibitor [1-(B-mercapto-B,B-cyclopentamethylenepropionic acid)-2-(O-methyl)tyrosine] AVP in 12 normal and seven hypertensive subjects with end-stage renal disease. To test the agent's capacity to block the pressor action of exogenous AVP In humans, we constructed a dose-response curve with AVP doses of 1 to 20 mU/kg, raising BP by up to 30 mm Hg. Subsequently, five volunteers receive intravenous (i.v.) doses of 0.1 mg, and five volunteers received 0.5 mg of the inhibitor. The dose-response curve was then repeated with AVP doses up to 200 mU/kg. Both doses of the inhibitor shifted the curve to the right and downward, with the BP response to 20 mU/kg AVP being inhibited by 23% and 80% respectively. The duration of action of the compound was tested in two additional subjects, and was found to be over 3 hours. We then tested the compound in seven hypertensive patients with end-stage renal failure. Two days before dialysis, patients received a 150 mEq/day Na diet. After an additional Na load of 180 mEq via i.v. saline over 3 hours under constant BP and ECG monitoring, they received an i.v. bolus of 0.5 mg AVP inhibitor. A moderate BP fall occurred in five patients; it was maximal at 45 to 60 minutes and returned to baseline by 70 to 90 minutes.(ABSTRACT TRUNCATED AT 250 WORDS)
The perception of taste is an important factor related to quality of life of people. Disorders of... more The perception of taste is an important factor related to quality of life of people. Disorders of this perception can lead to consumption of toxic substances or excessive consumption of substances which may interfere in the treatment of diseases such as hypertension and diabetes. This perception is the sum of the chemical senses (taste and smell) and tactile sensations. The main sponsors are the taste buds, which are localized at the entrance of digestive system. This sensation is variable according to the psychological and cultural development of individuals and has great importance in the development and determination of the quality of food. The objective of this work is gather knowledge about perception of taste and perception threshold
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Papers by Rogerio Mulinari