Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy, 2008
The polyisoprenylated benzophenones machuone and clusiachromene A have been isolated from the fru... more The polyisoprenylated benzophenones machuone and clusiachromene A have been isolated from the fruits of Clusia columnaris. The hexane extract of the young branches with leaves afforded a new euphane derivative, whose structure was elucidated by spectroscopic methods. On the contrary, the most polar EtOAc and ButOH extracts were constituted of flavonoid C-glucosides (isovitexin, vitexin and vitexin-2"-xyloside) and seven biflavonoids of the so-called Garcinia group.
Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy, 2006
Forty eight ethanolic crude extracts and fractions (hexane, dichloromethane, ethyl acetate and n-... more Forty eight ethanolic crude extracts and fractions (hexane, dichloromethane, ethyl acetate and n-butanol) from ten Brazilian plants (Leguminosae, Monimiaceae and Verbenaceae), 1 from Costa Rica (Verbenaceae) and 1 from Argentina (Verbenaceae) were screened for anti-mycobacterium activity against Mycobacterium tuberculosis (ATCC-27294H37Rv), by the Alamar Blue test, at a fixed concentration of 100 µg/mL. Out of the forty eight, seven were active at this concentration, corresponding to Lantana trifolia (hexane and dichloromethane extracts from leaves), Vitex cooperi (methanol:water, 1:1 extract from barks), Lippia lacunosa (hexane and dichloromethane extracts from leaves) and Lippia rotundifolia (hexane and dichloromethane extracts from leaves), all from the Verbenaceae family.
Lippia lacunosa and L. rotundifolia (Verbenaceae) are two Brazilian species of complex taxonomic ... more Lippia lacunosa and L. rotundifolia (Verbenaceae) are two Brazilian species of complex taxonomic delimitation. The composition of the essential oils from leaves and flowers of these plants was investigated by gas chromatography (GC) and gas chromatography coupled with mass spectrometry (GC-MS) analysis. The major components of the essential oils of flowers and leaves of L. lacunosa were: myrcene (14.7% and 11.9%), myrcenone (45.2% and 64.2%), Z-ocimenone (5.7% and 5.2%), and E-ocimenone (14.7% and 4.1%), respectively; whereas in L. rotundifolia (flowers and leaves) were a-pinene (8.7% and 1.8%), myrcene (5.1% and 3.6%), limonene (26.0% and 7.9 %), cis-pinocamphone (4.5% and 3.1%) and myrtenal (22.3% and 16.7%), respectively. The essential oils from L. lacunosa exhibited a strong and pleasant mango aroma, which was related to the presence of myrcene and myrcenone. The marked differences in the chemical composition of their essential oils may represent a powerful tool for the botanical classification.
Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy, 2002
O extrato bruto em acetona/ água das folhas de Pseudopiptadenia contorta foi purificado rendendo ... more O extrato bruto em acetona/ água das folhas de Pseudopiptadenia contorta foi purificado rendendo frações e substâncias puras. A atividade antioxidante foi avaliada para o extrato e frações, empregando-se o teste químico do DPPH. As frações contendo taninos condensados e substâncias fenólicas de baixo peso molecular mostraram ser as responsáveis pela atividade antioxidante do extrato bruto das folhas de P. contorta.
Revista Brasileira De Ciencias Farmaceuticas, 2008
Thirty-six plant extracts from the brazilian Atlantic Forest were tested for their antimycobacter... more Thirty-six plant extracts from the brazilian Atlantic Forest were tested for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv and M. kansasii, using the method REMA in seriate concentrations of 100 to 0.20 µg/mL. Among the thirty six extracts tested, five were active against M. tuberculosis, and three of these extracts also showed activity against M. kansasii. Cytotoxicity test with VERO cells was performed with the five extracts active against M. tuberculosis. Only the extract of Peschiera affinis was identified as non-toxic in the concentration of 100µg/mL.
The isolation and NMR data of seco-lupane triterpenes and coumarins from Platypodium elegans are ... more The isolation and NMR data of seco-lupane triterpenes and coumarins from Platypodium elegans are reported.
Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy, 2008
The polyisoprenylated benzophenones machuone and clusiachromene A have been isolated from the fru... more The polyisoprenylated benzophenones machuone and clusiachromene A have been isolated from the fruits of Clusia columnaris. The hexane extract of the young branches with leaves afforded a new euphane derivative, whose structure was elucidated by spectroscopic methods. On the contrary, the most polar EtOAc and ButOH extracts were constituted of flavonoid C-glucosides (isovitexin, vitexin and vitexin-2"-xyloside) and seven biflavonoids of the so-called Garcinia group.
Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy, 2006
Forty eight ethanolic crude extracts and fractions (hexane, dichloromethane, ethyl acetate and n-... more Forty eight ethanolic crude extracts and fractions (hexane, dichloromethane, ethyl acetate and n-butanol) from ten Brazilian plants (Leguminosae, Monimiaceae and Verbenaceae), 1 from Costa Rica (Verbenaceae) and 1 from Argentina (Verbenaceae) were screened for anti-mycobacterium activity against Mycobacterium tuberculosis (ATCC-27294H37Rv), by the Alamar Blue test, at a fixed concentration of 100 µg/mL. Out of the forty eight, seven were active at this concentration, corresponding to Lantana trifolia (hexane and dichloromethane extracts from leaves), Vitex cooperi (methanol:water, 1:1 extract from barks), Lippia lacunosa (hexane and dichloromethane extracts from leaves) and Lippia rotundifolia (hexane and dichloromethane extracts from leaves), all from the Verbenaceae family.
Lippia lacunosa and L. rotundifolia (Verbenaceae) are two Brazilian species of complex taxonomic ... more Lippia lacunosa and L. rotundifolia (Verbenaceae) are two Brazilian species of complex taxonomic delimitation. The composition of the essential oils from leaves and flowers of these plants was investigated by gas chromatography (GC) and gas chromatography coupled with mass spectrometry (GC-MS) analysis. The major components of the essential oils of flowers and leaves of L. lacunosa were: myrcene (14.7% and 11.9%), myrcenone (45.2% and 64.2%), Z-ocimenone (5.7% and 5.2%), and E-ocimenone (14.7% and 4.1%), respectively; whereas in L. rotundifolia (flowers and leaves) were a-pinene (8.7% and 1.8%), myrcene (5.1% and 3.6%), limonene (26.0% and 7.9 %), cis-pinocamphone (4.5% and 3.1%) and myrtenal (22.3% and 16.7%), respectively. The essential oils from L. lacunosa exhibited a strong and pleasant mango aroma, which was related to the presence of myrcene and myrcenone. The marked differences in the chemical composition of their essential oils may represent a powerful tool for the botanical classification.
Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy, 2002
O extrato bruto em acetona/ água das folhas de Pseudopiptadenia contorta foi purificado rendendo ... more O extrato bruto em acetona/ água das folhas de Pseudopiptadenia contorta foi purificado rendendo frações e substâncias puras. A atividade antioxidante foi avaliada para o extrato e frações, empregando-se o teste químico do DPPH. As frações contendo taninos condensados e substâncias fenólicas de baixo peso molecular mostraram ser as responsáveis pela atividade antioxidante do extrato bruto das folhas de P. contorta.
Revista Brasileira De Ciencias Farmaceuticas, 2008
Thirty-six plant extracts from the brazilian Atlantic Forest were tested for their antimycobacter... more Thirty-six plant extracts from the brazilian Atlantic Forest were tested for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv and M. kansasii, using the method REMA in seriate concentrations of 100 to 0.20 µg/mL. Among the thirty six extracts tested, five were active against M. tuberculosis, and three of these extracts also showed activity against M. kansasii. Cytotoxicity test with VERO cells was performed with the five extracts active against M. tuberculosis. Only the extract of Peschiera affinis was identified as non-toxic in the concentration of 100µg/mL.
The isolation and NMR data of seco-lupane triterpenes and coumarins from Platypodium elegans are ... more The isolation and NMR data of seco-lupane triterpenes and coumarins from Platypodium elegans are reported.
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