International Journal Of Community Medicine And Public Health
Background: Tuberculosis is a communicable disease caused by Mycobacterium tuberculosis bacteria ... more Background: Tuberculosis is a communicable disease caused by Mycobacterium tuberculosis bacteria spread by droplet infection. India is classified to be among those with a high TB burden, contributing 26% of the total TB cases, globally. The objective of this study is to access the clinical and demographic characteristics of patients with tuberculosis to determine the nature of disease, its co-morbidities, and treatment profile of the patients attending the revised National TB control programme clinics.Method: This study was carried out with data collection from the District Tuberculosis Office (DTO) section of Purba Bardhaman district, West Bengal. Data relevant to the study were collected for four consecutive years, from 2017 to 2020, and were analysed using suitable statistical software.Results: In the year 2017, 2018, 2019 and 2020, there were 6569, 5534, 5964 and 4012 reported cases of TB, respectively. Out of the total cases, 73.78% were male patients. It was observed that 97.2...
Indian Journal of Health Sciences and Biomedical Research (KLEU)
This meta-analysis investigated the significant association between human leukocyte antigen (HLA)... more This meta-analysis investigated the significant association between human leukocyte antigen (HLA)-G 14-bp insertion/deletion and +3142G>C polymorphisms with susceptibility to rheumatoid arthritis (RA). This relationship has been scrutinized in several studies, and the findings are controversial. The association studies related to HLA-G gene polymorphisms and RA were extracted from PubMed, Mendeley, ScienceDirect, and Google Scholar databases up to December 31, 2020. Finally, a total of 1516 cases and 1683 control samples were chosen from 7 published research articles for this meta-analysis. A significant association was evaluated using the pooled odds ratios (ORs) and 95% confidence intervals (CIs) under allelic, dominant, recessive, and additive models. Overall, there is absence of significant association between 14-bp ins/del polymorphism and RA (recessive model:
Indian journal of clinical biochemistry : IJCB, 2013
Immunoglobulin (Ig) E has been shown to be a major contributing factor for the development of bro... more Immunoglobulin (Ig) E has been shown to be a major contributing factor for the development of bronchial hyperresponsiveness in asthma. An elevation in serum IgE levels contributes to asthma and is considered a potent predictor of the development of asthma. The objectives of the present study were to estimate the levels of total serum IgE in asthmatic and healthy control subjects and to investigate the relationship of various demographic and clinical characteristics with the total serum IgE level in asthmatics. We measured the levels of total serum IgE using the ELISA kits (AccuBind, Monobind Inc., USA). The relevant demographic and clinical data were obtained using the questionnaire. The results showed that asthmatic children had significantly elevated level of total serum IgE compared to that of the healthy controls. The levels of total IgE and IL-4 in sera of 44 asthmatic children showed a significant positive correlation. Total serum IgE >150 IU/mL was found to be significantl...
Asthma is a heterogeneous disease for which a strong genetic basis is firmly established. It is a... more Asthma is a heterogeneous disease for which a strong genetic basis is firmly established. It is a complex disorder influenced by gene-environment interaction. Human leukocyte antigen (HLA) genes have been shown to be consistently associated with asthma and its related phenotypes in various populations. The aim of this study was to determine the frequency of the selected HLA classes I and II allelic groups in asthmatic and control groups. HLA typing was performed using polymerase chain reaction-sequence-specific typing (PCR-SSP) method. The allele frequency was estimated by direct counting. Frequency of each HLA allelic group was compared between asthmatic group and control group using χ(2) test. P-value was corrected by multiplying with the number of the allelic groups studied. Odds ratio (OR) and its corresponding 95% confidence interval (CI) for each allelic group were calculated using graphpad instat 3.10. The results of this study showed a significantly higher frequency of HLA-D...
International Journal Of Community Medicine And Public Health
Background: Tuberculosis is a communicable disease caused by Mycobacterium tuberculosis bacteria ... more Background: Tuberculosis is a communicable disease caused by Mycobacterium tuberculosis bacteria spread by droplet infection. India is classified to be among those with a high TB burden, contributing 26% of the total TB cases, globally. The objective of this study is to access the clinical and demographic characteristics of patients with tuberculosis to determine the nature of disease, its co-morbidities, and treatment profile of the patients attending the revised National TB control programme clinics.Method: This study was carried out with data collection from the District Tuberculosis Office (DTO) section of Purba Bardhaman district, West Bengal. Data relevant to the study were collected for four consecutive years, from 2017 to 2020, and were analysed using suitable statistical software.Results: In the year 2017, 2018, 2019 and 2020, there were 6569, 5534, 5964 and 4012 reported cases of TB, respectively. Out of the total cases, 73.78% were male patients. It was observed that 97.2...
Indian Journal of Health Sciences and Biomedical Research (KLEU)
This meta-analysis investigated the significant association between human leukocyte antigen (HLA)... more This meta-analysis investigated the significant association between human leukocyte antigen (HLA)-G 14-bp insertion/deletion and +3142G>C polymorphisms with susceptibility to rheumatoid arthritis (RA). This relationship has been scrutinized in several studies, and the findings are controversial. The association studies related to HLA-G gene polymorphisms and RA were extracted from PubMed, Mendeley, ScienceDirect, and Google Scholar databases up to December 31, 2020. Finally, a total of 1516 cases and 1683 control samples were chosen from 7 published research articles for this meta-analysis. A significant association was evaluated using the pooled odds ratios (ORs) and 95% confidence intervals (CIs) under allelic, dominant, recessive, and additive models. Overall, there is absence of significant association between 14-bp ins/del polymorphism and RA (recessive model:
Indian journal of clinical biochemistry : IJCB, 2013
Immunoglobulin (Ig) E has been shown to be a major contributing factor for the development of bro... more Immunoglobulin (Ig) E has been shown to be a major contributing factor for the development of bronchial hyperresponsiveness in asthma. An elevation in serum IgE levels contributes to asthma and is considered a potent predictor of the development of asthma. The objectives of the present study were to estimate the levels of total serum IgE in asthmatic and healthy control subjects and to investigate the relationship of various demographic and clinical characteristics with the total serum IgE level in asthmatics. We measured the levels of total serum IgE using the ELISA kits (AccuBind, Monobind Inc., USA). The relevant demographic and clinical data were obtained using the questionnaire. The results showed that asthmatic children had significantly elevated level of total serum IgE compared to that of the healthy controls. The levels of total IgE and IL-4 in sera of 44 asthmatic children showed a significant positive correlation. Total serum IgE >150 IU/mL was found to be significantl...
Asthma is a heterogeneous disease for which a strong genetic basis is firmly established. It is a... more Asthma is a heterogeneous disease for which a strong genetic basis is firmly established. It is a complex disorder influenced by gene-environment interaction. Human leukocyte antigen (HLA) genes have been shown to be consistently associated with asthma and its related phenotypes in various populations. The aim of this study was to determine the frequency of the selected HLA classes I and II allelic groups in asthmatic and control groups. HLA typing was performed using polymerase chain reaction-sequence-specific typing (PCR-SSP) method. The allele frequency was estimated by direct counting. Frequency of each HLA allelic group was compared between asthmatic group and control group using χ(2) test. P-value was corrected by multiplying with the number of the allelic groups studied. Odds ratio (OR) and its corresponding 95% confidence interval (CI) for each allelic group were calculated using graphpad instat 3.10. The results of this study showed a significantly higher frequency of HLA-D...
Uploads
Papers by Manoj Lama