Latar Belakang: Kusta merupakan penyakit tropis terabaikan. Pada perjalan penyakit kusta yang kro... more Latar Belakang: Kusta merupakan penyakit tropis terabaikan. Pada perjalan penyakit kusta yang kronis, sering terjadi reaksi kusta dengan episode subakut akibat respon imunologis terhadap antigen Mycobacterium. leprae . Pada kusta, penting diketahui berbagai faktor pemicu yang mungkin akan mencetuskan reaksi kusta, karena memiliki efek signifikan terhadap kualitas hidup. Metode: Studi ini merupakan studi retrospektif analitik dengan data yang diambil dari rekam medis seluruh pasien kusta baru dari tahun 2015-2020. Seluruh varian data dianalisis dengan Pearson’s Chi Square dan Kruskal Wallis test. Analisis regresi logistik multivariat digunakan untuk mengkalkulasi risiko reaksi kusta.Hasil & Diskusi: Reaksi tipe 1 lebih sering terjadi pada kusta borderline dengan indeks bakteri (IB) dan indeks morfologi (IM) negatif. Reaksi tipe 2 umum terjadi pada kusta tipe lepromatosa dengan IB  ≥3 + (p=0.001) dan IM 1-5%. Pada analisis multivariat, hanya IB 3+ atau lebih yang memilik...
Erythema nodosum leprosum (ENL) is an acute immune complex-mediated condition of the dermis, subc... more Erythema nodosum leprosum (ENL) is an acute immune complex-mediated condition of the dermis, subcutaneous tissue, and other tissues seen in patients with multibacillary (MB) leprosy, causing severe impairment to patients’ quality of life. To date, there is no standard diagnostic criteria for ENL. We aimed to study the diagnostic value and accuracy of Neutrophil-to-Lymphocyte ratio (NLR), Lymphocyte-to-Monocyte ratio (LMR), and Platelet-to-Lymphocyte ratio (PLR) in diagnosing ENL. This is an analytic retrospective study with a cross-sectional design that describes the distribution and clinical characteristics of all newly diagnosed MB patients of Dr. Soetomo General Hospital Surabaya in the years 2018–2020. NLR, LMR, and PLR were calculated for all patients, and a receiver operating characteristic curve (ROC) was generated to identify the cut-off points. Among a total of 182 patients with MB leprosy, 22 cases (12.09%) were reported with ENL. WBC, neutrophils, monocytes, and thrombocy...
Background: Leprosy is a neglected tropical disease caused by chronic granulomatous infection of ... more Background: Leprosy is a neglected tropical disease caused by chronic granulomatous infection of Mycobacterium leprae. Indonesia ranks third in new case findings, with 84% of the case being multibacillary (MB) leprosy. MB leprosy cases have a higher risk of leprosy reactions and physical disabilities that decrease quality of life. Purpose: To determine the demographic, clinical characteristics, and white blood analysis of newly diagnosed MB leprosy patients, especially concerning leprosy reactions. Methods: This is a descriptive retrospective study with a cross-sectional design that describe the following data: domicile, gender, age, treatment status, disabilities, body mass index (BMI); bacterial index (BI), morphological index (MI), white blood cell (WBC) and differential counts, and thrombocyte count. Result: This study included 176 adult MB cases, predominantly male aged 20–39 years old with average BMI, lived in Surabaya with negative history of multi-drug therapy, disability, ...
Latar Belakang: Kusta merupakan penyakit tropis terabaikan. Pada perjalan penyakit kusta yang kro... more Latar Belakang: Kusta merupakan penyakit tropis terabaikan. Pada perjalan penyakit kusta yang kronis, sering terjadi reaksi kusta dengan episode subakut akibat respon imunologis terhadap antigen Mycobacterium. leprae . Pada kusta, penting diketahui berbagai faktor pemicu yang mungkin akan mencetuskan reaksi kusta, karena memiliki efek signifikan terhadap kualitas hidup. Metode: Studi ini merupakan studi retrospektif analitik dengan data yang diambil dari rekam medis seluruh pasien kusta baru dari tahun 2015-2020. Seluruh varian data dianalisis dengan Pearson’s Chi Square dan Kruskal Wallis test. Analisis regresi logistik multivariat digunakan untuk mengkalkulasi risiko reaksi kusta.Hasil & Diskusi: Reaksi tipe 1 lebih sering terjadi pada kusta borderline dengan indeks bakteri (IB) dan indeks morfologi (IM) negatif. Reaksi tipe 2 umum terjadi pada kusta tipe lepromatosa dengan IB  ≥3 + (p=0.001) dan IM 1-5%. Pada analisis multivariat, hanya IB 3+ atau lebih yang memilik...
Erythema nodosum leprosum (ENL) is an acute immune complex-mediated condition of the dermis, subc... more Erythema nodosum leprosum (ENL) is an acute immune complex-mediated condition of the dermis, subcutaneous tissue, and other tissues seen in patients with multibacillary (MB) leprosy, causing severe impairment to patients’ quality of life. To date, there is no standard diagnostic criteria for ENL. We aimed to study the diagnostic value and accuracy of Neutrophil-to-Lymphocyte ratio (NLR), Lymphocyte-to-Monocyte ratio (LMR), and Platelet-to-Lymphocyte ratio (PLR) in diagnosing ENL. This is an analytic retrospective study with a cross-sectional design that describes the distribution and clinical characteristics of all newly diagnosed MB patients of Dr. Soetomo General Hospital Surabaya in the years 2018–2020. NLR, LMR, and PLR were calculated for all patients, and a receiver operating characteristic curve (ROC) was generated to identify the cut-off points. Among a total of 182 patients with MB leprosy, 22 cases (12.09%) were reported with ENL. WBC, neutrophils, monocytes, and thrombocy...
Background: Leprosy is a neglected tropical disease caused by chronic granulomatous infection of ... more Background: Leprosy is a neglected tropical disease caused by chronic granulomatous infection of Mycobacterium leprae. Indonesia ranks third in new case findings, with 84% of the case being multibacillary (MB) leprosy. MB leprosy cases have a higher risk of leprosy reactions and physical disabilities that decrease quality of life. Purpose: To determine the demographic, clinical characteristics, and white blood analysis of newly diagnosed MB leprosy patients, especially concerning leprosy reactions. Methods: This is a descriptive retrospective study with a cross-sectional design that describe the following data: domicile, gender, age, treatment status, disabilities, body mass index (BMI); bacterial index (BI), morphological index (MI), white blood cell (WBC) and differential counts, and thrombocyte count. Result: This study included 176 adult MB cases, predominantly male aged 20–39 years old with average BMI, lived in Surabaya with negative history of multi-drug therapy, disability, ...
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