Abstract RNA interference via exogenous small interference RNAs (siRNA) is a powerful tool in gen... more Abstract RNA interference via exogenous small interference RNAs (siRNA) is a powerful tool in gene function study and disease treatment. Designing efficient and specific siRNA on target gene remains the key issue in RNAi. Although various in silico models have been proposed for rational siRNA design, most of them focus on the efficiencies of selected siRNAs, while limited effort has been made to improve their specificities targeted on specific mRNAs, which is related to reducing off-target effects (OTEs) in RNAi.
Abstract Social communities connect people of similar interests together and play essential roles... more Abstract Social communities connect people of similar interests together and play essential roles in social network applications. Examples of such communities include people who like the same objects on Facebook, follow common subjects on Twitter, or join similar groups on LinkedIn. Among communities, we notice that some of them are {\ em magnetic} to people. A {\ em magnet community} is such a community that attracts significantly more people's interests and attentions than other communities of similar topics.
Abstract Combining correlated data sources may help improve the learning performance of a given t... more Abstract Combining correlated data sources may help improve the learning performance of a given task. For example, in recommendation problems, one can combine (1) user profile database ({eg} genders, age,{etc}),(2) users' log data ({eg}, click through data, purchasing records,{etc}), and (3) users' social network (useful in social targeting) to build a recommendation model. All these data sources provide informative but heterogeneous features.
To maintain ultra-low particle concentrations, cleanrooms can require several hundred air changes... more To maintain ultra-low particle concentrations, cleanrooms can require several hundred air changes per hour. These ventilation rates make cleanrooms 30���50 times more energy intensive than the average US commercial building. There are an estimated 12millionm2 of cleanroom space in the US, consuming over 370PJ of energy each year. This paper explores opportunities to improve the energy efficiency of cleanrooms while maintaining or improving operating conditions.
Abstract In many applications, it is difficult to obtain a lot of labeled examples. One practical... more Abstract In many applications, it is difficult to obtain a lot of labeled examples. One practically important problem is: can the labeled data from other related sources help predict the target task, even if they have (a) different feature spaces (eg, image vs. text data),(b) different data distributions, and (c) different output spaces? This paper proposes a solution and discusses the conditions where this is highly likely to produce better results. It first unifies the feature spaces of the target and source data sets by spectral embedding, even when they are with ...
Abstract RNA interference via exogenous small interference RNAs (siRNA) is a powerful tool in gen... more Abstract RNA interference via exogenous small interference RNAs (siRNA) is a powerful tool in gene function study and disease treatment. Designing efficient and specific siRNA on target gene remains the key issue in RNAi. Although various in silico models have been proposed for rational siRNA design, most of them focus on the efficiencies of selected siRNAs, while limited effort has been made to improve their specificities targeted on specific mRNAs, which is related to reducing off-target effects (OTEs) in RNAi.
Abstract Social communities connect people of similar interests together and play essential roles... more Abstract Social communities connect people of similar interests together and play essential roles in social network applications. Examples of such communities include people who like the same objects on Facebook, follow common subjects on Twitter, or join similar groups on LinkedIn. Among communities, we notice that some of them are {\ em magnetic} to people. A {\ em magnet community} is such a community that attracts significantly more people's interests and attentions than other communities of similar topics.
Abstract Combining correlated data sources may help improve the learning performance of a given t... more Abstract Combining correlated data sources may help improve the learning performance of a given task. For example, in recommendation problems, one can combine (1) user profile database ({eg} genders, age,{etc}),(2) users' log data ({eg}, click through data, purchasing records,{etc}), and (3) users' social network (useful in social targeting) to build a recommendation model. All these data sources provide informative but heterogeneous features.
To maintain ultra-low particle concentrations, cleanrooms can require several hundred air changes... more To maintain ultra-low particle concentrations, cleanrooms can require several hundred air changes per hour. These ventilation rates make cleanrooms 30���50 times more energy intensive than the average US commercial building. There are an estimated 12millionm2 of cleanroom space in the US, consuming over 370PJ of energy each year. This paper explores opportunities to improve the energy efficiency of cleanrooms while maintaining or improving operating conditions.
Abstract In many applications, it is difficult to obtain a lot of labeled examples. One practical... more Abstract In many applications, it is difficult to obtain a lot of labeled examples. One practically important problem is: can the labeled data from other related sources help predict the target task, even if they have (a) different feature spaces (eg, image vs. text data),(b) different data distributions, and (c) different output spaces? This paper proposes a solution and discusses the conditions where this is highly likely to produce better results. It first unifies the feature spaces of the target and source data sets by spectral embedding, even when they are with ...
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Papers by Xiaoxiao Shi