Directora de Investigación y Posgrado Universidad SEK Chile. PhD en Farmacología, experta en desarrollo de nuevos fármacos, nanotecnología, prospectiva tecnológica, planificación de escenarios, ecosistema de ciencia, tecnología e innovación, diplomacia científica, políticas de largo plazo y estudios de futuro. Editora Revista Prospectiva y Estrategia, parte del directorio del Consejo Chileno de Prospectiva y Estrategia y de la Fundacion Spatio Australis.
In this contribution, we explore the potential of atomic layer deposition (ALD) techniques for de... more In this contribution, we explore the potential of atomic layer deposition (ALD) techniques for developing new semiconductor metal oxide composites. Specifically, we investigate the functionalization of multi-wall trititanate nanotubes, H2Ti3O7 NTs (sample T1) with zinc oxide employing two different ALD approaches: vapor phase metalation (VPM) using diethylzinc (Zn(C2H5)2, DEZ) as a unique ALD precursor, and multiple pulsed vapor phase infiltration (MPI) using DEZ and water as precursors. We obtained two different types of tubular H2Ti3O7 species containing ZnO in their structures. Multi-wall trititanate nanotubes with ZnO intercalated inside the tube wall sheets were the main products from the VPM infiltration (sample T2). On the other hand, MPI (sample T3) principally leads to single-wall nanotubes with a ZnO hierarchical bi-modal functionalization, thin film coating, and surface decorated with ZnO particles. The products were mainly characterized by electron microscopy, energy dis...
Journal of Chemical, Biological and Physical Sciences
Progresses in microstructure materials have developed original strategies that allow the creation... more Progresses in microstructure materials have developed original strategies that allow the creation of new specific devices aimed at the field of research for controlled drug release. The use of micro structured polymers could facilitate the process of controlled release for different type of drugs over time. It is well-known that these processes depend mainly on the chemical structure and properties of the polymer. In this work, the preparation and characterization of empty polymeric micro particles (MPs) based on Poly (3-hydroxybutyric acid-co-hydroxyvaleric acid) (PHBV) are reported. Moreover, PHBV micro particles (PHBV MPs) loaded with Ceftiofur, an antibiotic drug, are also studied. The Characterization techniques used were Atomic Force Microscopy (AFM), Zeta Potential, UV–Visible, FT-IR and DSC (Differential Scanning Calorimetry). The morphology and size distribution of polymeric microparticles were analysed using Transmission Electron Microscopy (TEM) and Dynamic Light Scatteri...
ABSTRACT This report is an integrated study to include the molecular simulation, physicochemical ... more ABSTRACT This report is an integrated study to include the molecular simulation, physicochemical characterization and biological analysis of a paclitaxel-loaded PHBV nanoparticle that demonstrates uptake, release and cytotoxicity in cancer cell lines. Taking this nanoparticle one step closer to its use in a clinical setting, we demonstrate that it causes significant cell death in primary cultures of stage IIIc serous ovarian cancer cells isolated from six patients. Molecular simulations revealed a high affinity of paclitaxel for the water-polymer interface, thus the drug is delivered only when the polymer near it is degraded. The Fourier transform infrared spectroscopy suggests the formation of a short-lived crystalline phase, also observed in the CG simulations, and transmission electron microscopy revealed branched structures on the surface of particles, which disappeared after 4 days. Biological analyses indicated that these particles have a 48-h window of toxicity protection, allowing for the endocytosis of the particle by the cells; this finding was corroborated by confocal microscopy and flow cytometry. The low cost to synthesize PHBV using microorganisms and the potential chemical modifications of the polymer make it attractive for inexpensive, large-scale pharmaceutical production.
In this contribution, we explore the potential of atomic layer deposition (ALD) techniques for de... more In this contribution, we explore the potential of atomic layer deposition (ALD) techniques for developing new semiconductor metal oxide composites. Specifically, we investigate the functionalization of multi-wall trititanate nanotubes, H2Ti3O7 NTs (sample T1) with zinc oxide employing two different ALD approaches: vapor phase metalation (VPM) using diethylzinc (Zn(C2H5)2, DEZ) as a unique ALD precursor, and multiple pulsed vapor phase infiltration (MPI) using DEZ and water as precursors. We obtained two different types of tubular H2Ti3O7 species containing ZnO in their structures. Multi-wall trititanate nanotubes with ZnO intercalated inside the tube wall sheets were the main products from the VPM infiltration (sample T2). On the other hand, MPI (sample T3) principally leads to single-wall nanotubes with a ZnO hierarchical bi-modal functionalization, thin film coating, and surface decorated with ZnO particles. The products were mainly characterized by electron microscopy, energy dis...
Journal of Chemical, Biological and Physical Sciences
Progresses in microstructure materials have developed original strategies that allow the creation... more Progresses in microstructure materials have developed original strategies that allow the creation of new specific devices aimed at the field of research for controlled drug release. The use of micro structured polymers could facilitate the process of controlled release for different type of drugs over time. It is well-known that these processes depend mainly on the chemical structure and properties of the polymer. In this work, the preparation and characterization of empty polymeric micro particles (MPs) based on Poly (3-hydroxybutyric acid-co-hydroxyvaleric acid) (PHBV) are reported. Moreover, PHBV micro particles (PHBV MPs) loaded with Ceftiofur, an antibiotic drug, are also studied. The Characterization techniques used were Atomic Force Microscopy (AFM), Zeta Potential, UV–Visible, FT-IR and DSC (Differential Scanning Calorimetry). The morphology and size distribution of polymeric microparticles were analysed using Transmission Electron Microscopy (TEM) and Dynamic Light Scatteri...
ABSTRACT This report is an integrated study to include the molecular simulation, physicochemical ... more ABSTRACT This report is an integrated study to include the molecular simulation, physicochemical characterization and biological analysis of a paclitaxel-loaded PHBV nanoparticle that demonstrates uptake, release and cytotoxicity in cancer cell lines. Taking this nanoparticle one step closer to its use in a clinical setting, we demonstrate that it causes significant cell death in primary cultures of stage IIIc serous ovarian cancer cells isolated from six patients. Molecular simulations revealed a high affinity of paclitaxel for the water-polymer interface, thus the drug is delivered only when the polymer near it is degraded. The Fourier transform infrared spectroscopy suggests the formation of a short-lived crystalline phase, also observed in the CG simulations, and transmission electron microscopy revealed branched structures on the surface of particles, which disappeared after 4 days. Biological analyses indicated that these particles have a 48-h window of toxicity protection, allowing for the endocytosis of the particle by the cells; this finding was corroborated by confocal microscopy and flow cytometry. The low cost to synthesize PHBV using microorganisms and the potential chemical modifications of the polymer make it attractive for inexpensive, large-scale pharmaceutical production.
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Papers by Paula Solar