Page 1. The Annals of Statistics 1999, Vol. 27, No. 4, 1230-1239 TESTS OF GOODNESS OF FIT BASED O... more Page 1. The Annals of Statistics 1999, Vol. 27, No. 4, 1230-1239 TESTS OF GOODNESS OF FIT BASED ON THE L2-WASSERSTEIN DISTANCE1 BY EUSTASIO DEL BARRIO, JUAN A. CUESTA-ALBERTOS, CARLOS MATRAN AND JESUIS M. RODRiGUEZ-RODRiGUEZ ...
In total, 438 (1.7%) Escherichia coli and 125 (3.98%) Klebsiella pneumoniae isolates were found t... more In total, 438 (1.7%) Escherichia coli and 125 (3.98%) Klebsiella pneumoniae isolates were found to be producers of extended-spectrum β-lactamase (ESBL) during 1995–2003 in southern Spain. There was a significant increase in the frequency of ESBL-producing E. coli isolates, from < 0.36% before 1999 to 4.8% in 2003, while the frequency of ESBL-producing K. pneumoniae isolates decreased during the same period. The most common ESBLs detected in K. pneumoniae were SHV type, whereas both CTX-M and SHV types were detected in E. coli. In addition, E. coli isolates showed greater clonal diversity (84 distinct REP-PCR patterns, compared with five in K. pneumoniae), fewer enzymes per isolate, and a higher number of isolates recovered from outpatients. These differences may have implications for the control measures that should be used for these two microorganisms.
Twenty-six patients with cysticercosis of the brain parenchyma were treated with the antihelminti... more Twenty-six patients with cysticercosis of the brain parenchyma were treated with the antihelmintic agent praziquantel (50 mg per kilogram of body weight daily for 15 days). During treatment a strong inflammatory reaction occurred, as evidenced by increased protein and cells in the cerebrospinal fluid. This finding correlated with headache, exacerbation of neurologic symptoms, and edema and inflammation around cystic lesions. After three months of treatment all patients had improved clinically, and 13 (50 per cent) were asymptomatic. The total number of cysts on CT scans had decreased from 152 at the beginning of treatment to 51, and the mean diameter of cysts was reduced by 72 per cent. CT scans showed improvement in 25 of the 26 patients, with total remission of all cysts in nine. Seventeen control patients followed with CT studies for a mean of 9 +/- 2 months had no spontaneous remission of lesions, and in many cases the scans showed worsening during the observation period. Our results indicate that praziquantel is effective in cysticercosis of the brain parenchyma.
Acinetobacter baumannii is an important cause of nosocomial infections in many hospitals. It is d... more Acinetobacter baumannii is an important cause of nosocomial infections in many hospitals. It is difficult to control and infection caused is difficult to treat due to its high resistance in the environment and its ability to develop resistance to antimicrobials. Bacteremia, followed by respiratory tract and surgical wound infections, is the most significant infection caused by A. baumannii. The known risk factors for A. baumannii bacteremia are invasive procedures and the use of broad-spectrum antimicrobials. Consequently, episodes of bacteremia due to A. baumannii occur most frequently in critically-ill patients admitted to an intensive care unit. The clinical manifestations of bacteremia by A. baumannii are not specific. The most common sources of bacteremia are intravascular catheters and the respiratory tract. A. baumannii bacteremia is associated with a high crude mortality rate, but it is difficult to distinguish morbidity and mortality attributable to A. baumannii from that attributable to the common and severe co-morbidity in these patients. A. baumannii is a bacterium that appears to have a propensity for developing multiple antimicrobial resistance extremely rapidly. These data are disturbing because the therapeutic possibilities decrease while inappropriate antimicrobial treatment contributes to patient mortality. Generally, imipenem is the most active agent against A. baumannii. However, the description of imipenem-resistant A. baumannii strains is becoming increasingly common. The usual treatment for A. baumannii bacteremia is an active beta-lactam alone, preferably one with a limited spectrum. Before beginning treatment of a bacteremia by A. baumannii, it is very important to carry out a clinical evaluation of the patient to eliminate the possibility of a pseudobacteremia, and thereby avoid unnecessary treatment.
Start-up of the laboratory (3 l) UASB-reactor treating raw high-strength (up to 77 g COD/l) chees... more Start-up of the laboratory (3 l) UASB-reactor treating raw high-strength (up to 77 g COD/l) cheese-whey wastewaters as well as the treatment efficiencies (TE) and the maximal admissible organic loading rates (OLR) have been investigated under mesophilic (35°C) and ...
... C and an impregnation ratio of 2.3, where the highest contribution of mesoporosity was observ... more ... C and an impregnation ratio of 2.3, where the highest contribution of mesoporosity was observed, the mesopore volume reached a value of ... suggests a fairly homogeneous distribution of the activating agent favored by the softening and partial fusion which kraft lignin undergoes ...
Page 1. The Annals of Statistics 1999, Vol. 27, No. 4, 1230-1239 TESTS OF GOODNESS OF FIT BASED O... more Page 1. The Annals of Statistics 1999, Vol. 27, No. 4, 1230-1239 TESTS OF GOODNESS OF FIT BASED ON THE L2-WASSERSTEIN DISTANCE1 BY EUSTASIO DEL BARRIO, JUAN A. CUESTA-ALBERTOS, CARLOS MATRAN AND JESUIS M. RODRiGUEZ-RODRiGUEZ ...
In total, 438 (1.7%) Escherichia coli and 125 (3.98%) Klebsiella pneumoniae isolates were found t... more In total, 438 (1.7%) Escherichia coli and 125 (3.98%) Klebsiella pneumoniae isolates were found to be producers of extended-spectrum β-lactamase (ESBL) during 1995–2003 in southern Spain. There was a significant increase in the frequency of ESBL-producing E. coli isolates, from < 0.36% before 1999 to 4.8% in 2003, while the frequency of ESBL-producing K. pneumoniae isolates decreased during the same period. The most common ESBLs detected in K. pneumoniae were SHV type, whereas both CTX-M and SHV types were detected in E. coli. In addition, E. coli isolates showed greater clonal diversity (84 distinct REP-PCR patterns, compared with five in K. pneumoniae), fewer enzymes per isolate, and a higher number of isolates recovered from outpatients. These differences may have implications for the control measures that should be used for these two microorganisms.
Twenty-six patients with cysticercosis of the brain parenchyma were treated with the antihelminti... more Twenty-six patients with cysticercosis of the brain parenchyma were treated with the antihelmintic agent praziquantel (50 mg per kilogram of body weight daily for 15 days). During treatment a strong inflammatory reaction occurred, as evidenced by increased protein and cells in the cerebrospinal fluid. This finding correlated with headache, exacerbation of neurologic symptoms, and edema and inflammation around cystic lesions. After three months of treatment all patients had improved clinically, and 13 (50 per cent) were asymptomatic. The total number of cysts on CT scans had decreased from 152 at the beginning of treatment to 51, and the mean diameter of cysts was reduced by 72 per cent. CT scans showed improvement in 25 of the 26 patients, with total remission of all cysts in nine. Seventeen control patients followed with CT studies for a mean of 9 +/- 2 months had no spontaneous remission of lesions, and in many cases the scans showed worsening during the observation period. Our results indicate that praziquantel is effective in cysticercosis of the brain parenchyma.
Acinetobacter baumannii is an important cause of nosocomial infections in many hospitals. It is d... more Acinetobacter baumannii is an important cause of nosocomial infections in many hospitals. It is difficult to control and infection caused is difficult to treat due to its high resistance in the environment and its ability to develop resistance to antimicrobials. Bacteremia, followed by respiratory tract and surgical wound infections, is the most significant infection caused by A. baumannii. The known risk factors for A. baumannii bacteremia are invasive procedures and the use of broad-spectrum antimicrobials. Consequently, episodes of bacteremia due to A. baumannii occur most frequently in critically-ill patients admitted to an intensive care unit. The clinical manifestations of bacteremia by A. baumannii are not specific. The most common sources of bacteremia are intravascular catheters and the respiratory tract. A. baumannii bacteremia is associated with a high crude mortality rate, but it is difficult to distinguish morbidity and mortality attributable to A. baumannii from that attributable to the common and severe co-morbidity in these patients. A. baumannii is a bacterium that appears to have a propensity for developing multiple antimicrobial resistance extremely rapidly. These data are disturbing because the therapeutic possibilities decrease while inappropriate antimicrobial treatment contributes to patient mortality. Generally, imipenem is the most active agent against A. baumannii. However, the description of imipenem-resistant A. baumannii strains is becoming increasingly common. The usual treatment for A. baumannii bacteremia is an active beta-lactam alone, preferably one with a limited spectrum. Before beginning treatment of a bacteremia by A. baumannii, it is very important to carry out a clinical evaluation of the patient to eliminate the possibility of a pseudobacteremia, and thereby avoid unnecessary treatment.
Start-up of the laboratory (3 l) UASB-reactor treating raw high-strength (up to 77 g COD/l) chees... more Start-up of the laboratory (3 l) UASB-reactor treating raw high-strength (up to 77 g COD/l) cheese-whey wastewaters as well as the treatment efficiencies (TE) and the maximal admissible organic loading rates (OLR) have been investigated under mesophilic (35°C) and ...
... C and an impregnation ratio of 2.3, where the highest contribution of mesoporosity was observ... more ... C and an impregnation ratio of 2.3, where the highest contribution of mesoporosity was observed, the mesopore volume reached a value of ... suggests a fairly homogeneous distribution of the activating agent favored by the softening and partial fusion which kraft lignin undergoes ...
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