Uludağ Üniversitesi Tıp Fakültesi dergisi, Aug 1, 2019
Vitamin D steroid yapıda bir hormon olup kemik ve mineral metabolizması için çok önemlidir. Günüm... more Vitamin D steroid yapıda bir hormon olup kemik ve mineral metabolizması için çok önemlidir. Günümüzde eksikliği ve yetersizliği giderek artan sıklıkta görülmektedir. Vitamin D eksikliğinin kemik ve mineral metabolizması dışında farklı akut ve kronik hastalıklarla ilişkili olabileceğinin gösterilmesi son yıllarda vitamin D’ye olan ilgiyi artırmıştır. Bu derlemede vitamin D, eksikliğine yol açan nedenler, tanı, tedavi ve takipte önemli faktörler ve güncel yaklaşımlar tartışılmıştır.
Psoriasis is a chronic, recurrent, inflammatory and common skin disease of unknown aetiology. Amy... more Psoriasis is a chronic, recurrent, inflammatory and common skin disease of unknown aetiology. Amyloidosis is defined as a heterogeneous group of diseases in which generally soluble plasma proteins accumulate in the extracellular space as insoluble abnormal fibrils. Type AA amyloidosis is a late and severe complication of chronic inflammatory disorders and some chronic infections. Although psoriasis is a common inflammatory skin disease, the development of amyloidosis is rare. Herein, we presented a case of psoriasis who developed AA-type amyloidosis.
Renal vein thrombosis (RVT) is the presence of thrombi in major renal veins or their branches and... more Renal vein thrombosis (RVT) is the presence of thrombi in major renal veins or their branches and is a rare clinical entity. RVT is one of the common thrombotic complications of nephrotic syndrome or renal cell carcinoma. Hormonal contraception can also rarely cause this complication. Herein, we presented a case of renal vein thrombosis accompanied by subnephrotic proteinuria after oral contraception.
Purpose: BK virus nephropathy (BKVN) is a latent infection and it is closely associated with immu... more Purpose: BK virus nephropathy (BKVN) is a latent infection and it is closely associated with immunsuppressive therapy. We aimed in this study to evaluate biopsy-proven BKVN and investigate frequency, risk factors and treatment management. Materials and Methods: In this study, 422 kidney transplant recipients were analysed retrospectively between April 2014 and April 2020 for biopsy-proven BK virus nephropathy. Group I included 16 kidney transplant patients with biopsy-proven BK nephropathy and group II included 36 kidney transplant patients with negative BK virus nephropathy. We aimed demographic, clinical features of kidney transplant recipients with BKVN (group I, n: 16 ) and non-BKVN (group II, n:36) were compared and the factors affecting of BKVN. Results: The mean age of grup I and group II were were 41±14.8 years and 39±15.2 respectively. The patients mean follow-up period of 43±11.2 months. Serum creatinine and proteinuria degree were significantly higher in the group with BK...
In Turkey, there is 22953 end-stage kidney disease patient in national deceased kidney waiting li... more In Turkey, there is 22953 end-stage kidney disease patient in national deceased kidney waiting list (1). According to the 2019 Registry Report of the Turkish Society of Nephrology, the number of patients receiving hemodialysis (HD) and peritoneal dialysis (PD) treatment is 64633 (2). However, patients registered on the national kidney waiting list consist of preemptive, PD, and HD patients. Due to the increase in the average life expectancy of the elderly population in our country, chronic kidney disease and comorbid diseases are increasing day by day. In this study, the patients’ characteristics on the deceased kidney waiting list from our kidney transplant center were evaluated retrospectively. Our center's patient data were obtained from Transplantation Dialysis Monitoring System records. Turkey’s general patient data were obtained from the Turkish Statistical Institute and the 2019 Registry Report of the Turkish Society of Nephrology. In our center, the number of patients on...
BACKGROUND: Semen analysis is a routine predictor of male fertility, and however, measurements of... more BACKGROUND: Semen analysis is a routine predictor of male fertility, and however, measurements of sperm morphology, motility, and concentration do not always evince genomic defects. OBJECTIVE: To investigate sperm parameters of renal transplant patients and to evaluate sperm DNA defects. METHODS: Seminal samples from 25 healthy controls and 56 transplantation patients were analyzed to evaluate DNA fragmentation by TUNEL. The differences in TUNEL-assay results and seminal parameters were compared between kidney transplant patients and controls. RESULTS: Among the azoospermic patients, 37.5% had fathered children before the disease. Three patients receiving sirolimus treatment had oligoasthenoteratozoospermia and infertility. In kidney transplant patients, DNA fragmentation was slightly higher than controls. Total motility (%) of the spermatozoa from the kidney transplant patients (42.2±21.9) was significantly lower (P < 0.05) than those of the control group (64.3±11.9). Moreover, ...
The novel coronavirus disease was declared as a pandemic and CKD is an important risk factor for ... more The novel coronavirus disease was declared as a pandemic and CKD is an important risk factor for morbidity and mortality. Dialysis has additional contributions on transmission risk so prompt preventive strategies were implemented for dialysis patients. We aimed to evaluate pandemic‐related perceptions and concerns of dialysis patients and differences between dialysis modalities. An anonymous survey for assessing concerns, knowledge, and attitudes about the pandemic was sent online to a total of 339 patients on maintenance dialysis at four tertiary dialysis centers in Turkey. A total of 309 patients (54.9 ± 15.1 years, 51.6% females, 55.7% in‐center HD, 44.3% peritoneal dialysis) enrolled. The anonymous online survey was conducted at the end of April 2020. HD patients were more concerned about transmission risk (p = 0.002) and risks associated with the dialysis treatment environment and the transport methods (p < 0.001). The total concern score was significantly higher in the HD g...
Uludağ Üniversitesi Tıp Fakültesi dergisi, Aug 1, 2019
Vitamin D steroid yapıda bir hormon olup kemik ve mineral metabolizması için çok önemlidir. Günüm... more Vitamin D steroid yapıda bir hormon olup kemik ve mineral metabolizması için çok önemlidir. Günümüzde eksikliği ve yetersizliği giderek artan sıklıkta görülmektedir. Vitamin D eksikliğinin kemik ve mineral metabolizması dışında farklı akut ve kronik hastalıklarla ilişkili olabileceğinin gösterilmesi son yıllarda vitamin D’ye olan ilgiyi artırmıştır. Bu derlemede vitamin D, eksikliğine yol açan nedenler, tanı, tedavi ve takipte önemli faktörler ve güncel yaklaşımlar tartışılmıştır.
Psoriasis is a chronic, recurrent, inflammatory and common skin disease of unknown aetiology. Amy... more Psoriasis is a chronic, recurrent, inflammatory and common skin disease of unknown aetiology. Amyloidosis is defined as a heterogeneous group of diseases in which generally soluble plasma proteins accumulate in the extracellular space as insoluble abnormal fibrils. Type AA amyloidosis is a late and severe complication of chronic inflammatory disorders and some chronic infections. Although psoriasis is a common inflammatory skin disease, the development of amyloidosis is rare. Herein, we presented a case of psoriasis who developed AA-type amyloidosis.
Renal vein thrombosis (RVT) is the presence of thrombi in major renal veins or their branches and... more Renal vein thrombosis (RVT) is the presence of thrombi in major renal veins or their branches and is a rare clinical entity. RVT is one of the common thrombotic complications of nephrotic syndrome or renal cell carcinoma. Hormonal contraception can also rarely cause this complication. Herein, we presented a case of renal vein thrombosis accompanied by subnephrotic proteinuria after oral contraception.
Purpose: BK virus nephropathy (BKVN) is a latent infection and it is closely associated with immu... more Purpose: BK virus nephropathy (BKVN) is a latent infection and it is closely associated with immunsuppressive therapy. We aimed in this study to evaluate biopsy-proven BKVN and investigate frequency, risk factors and treatment management. Materials and Methods: In this study, 422 kidney transplant recipients were analysed retrospectively between April 2014 and April 2020 for biopsy-proven BK virus nephropathy. Group I included 16 kidney transplant patients with biopsy-proven BK nephropathy and group II included 36 kidney transplant patients with negative BK virus nephropathy. We aimed demographic, clinical features of kidney transplant recipients with BKVN (group I, n: 16 ) and non-BKVN (group II, n:36) were compared and the factors affecting of BKVN. Results: The mean age of grup I and group II were were 41±14.8 years and 39±15.2 respectively. The patients mean follow-up period of 43±11.2 months. Serum creatinine and proteinuria degree were significantly higher in the group with BK...
In Turkey, there is 22953 end-stage kidney disease patient in national deceased kidney waiting li... more In Turkey, there is 22953 end-stage kidney disease patient in national deceased kidney waiting list (1). According to the 2019 Registry Report of the Turkish Society of Nephrology, the number of patients receiving hemodialysis (HD) and peritoneal dialysis (PD) treatment is 64633 (2). However, patients registered on the national kidney waiting list consist of preemptive, PD, and HD patients. Due to the increase in the average life expectancy of the elderly population in our country, chronic kidney disease and comorbid diseases are increasing day by day. In this study, the patients’ characteristics on the deceased kidney waiting list from our kidney transplant center were evaluated retrospectively. Our center's patient data were obtained from Transplantation Dialysis Monitoring System records. Turkey’s general patient data were obtained from the Turkish Statistical Institute and the 2019 Registry Report of the Turkish Society of Nephrology. In our center, the number of patients on...
BACKGROUND: Semen analysis is a routine predictor of male fertility, and however, measurements of... more BACKGROUND: Semen analysis is a routine predictor of male fertility, and however, measurements of sperm morphology, motility, and concentration do not always evince genomic defects. OBJECTIVE: To investigate sperm parameters of renal transplant patients and to evaluate sperm DNA defects. METHODS: Seminal samples from 25 healthy controls and 56 transplantation patients were analyzed to evaluate DNA fragmentation by TUNEL. The differences in TUNEL-assay results and seminal parameters were compared between kidney transplant patients and controls. RESULTS: Among the azoospermic patients, 37.5% had fathered children before the disease. Three patients receiving sirolimus treatment had oligoasthenoteratozoospermia and infertility. In kidney transplant patients, DNA fragmentation was slightly higher than controls. Total motility (%) of the spermatozoa from the kidney transplant patients (42.2±21.9) was significantly lower (P < 0.05) than those of the control group (64.3±11.9). Moreover, ...
The novel coronavirus disease was declared as a pandemic and CKD is an important risk factor for ... more The novel coronavirus disease was declared as a pandemic and CKD is an important risk factor for morbidity and mortality. Dialysis has additional contributions on transmission risk so prompt preventive strategies were implemented for dialysis patients. We aimed to evaluate pandemic‐related perceptions and concerns of dialysis patients and differences between dialysis modalities. An anonymous survey for assessing concerns, knowledge, and attitudes about the pandemic was sent online to a total of 339 patients on maintenance dialysis at four tertiary dialysis centers in Turkey. A total of 309 patients (54.9 ± 15.1 years, 51.6% females, 55.7% in‐center HD, 44.3% peritoneal dialysis) enrolled. The anonymous online survey was conducted at the end of April 2020. HD patients were more concerned about transmission risk (p = 0.002) and risks associated with the dialysis treatment environment and the transport methods (p < 0.001). The total concern score was significantly higher in the HD g...
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