I studied medicine at the Uludag University Faculty of Medicine, Bursa, Turkey, and became a specialist in Infectious Dis. and Clin. Microbiology at the same university in 1998. I did my MSc and PhD (1992-1997) at the Imperial College in London, UK. My main research interests are tolerance inducing gene and dendritic cell therapy, immunogenetics of diseases, immune mechanisms involved in transition of brucellosis into chronic form and recently, transfusion-related immune modulation.
Objectives: The aim of our study is to reveal the prevalence of HLA-B*57 in the Turkish populatio... more Objectives: The aim of our study is to reveal the prevalence of HLA-B*57 in the Turkish population and to provide new perspectives to physicians starting abacavir therapy in HIV patients. Background: Abacavir, one of the drugs used to treat HIV infection, can cause hypersensitivity reactions in some patients. These hypersensitivity reactions have been shown to be associated with the HLA-B*57:01 allele. High-resolution HLA-B*57:01 scanning has a time and cost disadvantage compared with low-resolution HLA-B*57 scanning. Before starting abacavir treatment, we will discuss whether high-resolution scanning is more beneficial in individuals who are positive on HLA-B*57 screening. This is the study with the largest cohort to investigate the prevalence of HLA-B*57 in Turkey. Methods: The results of 25 thousand 318 people who applied to Bursa Uludağ University Faculty of Medicine, Department of Immunology for HLA-B* typing were scanned. Results: In our study, the HLA-B*57 serotype was detect...
Makrofajlar immün sistemin önemli hücreleridir ve eksiklikleri ya da disfonksiyonları vücutta cid... more Makrofajlar immün sistemin önemli hücreleridir ve eksiklikleri ya da disfonksiyonları vücutta ciddi hastalıklara yol açar. Bir pirimidin nükleotidi olan üridin-5’-trifosfat’ın (UTP) makrofajlar için bir sinyal molekülü gibi davrandığı bilinmektedir. Ancak UTP’nin makrofaj canlılığı ya da proliferasyonu üzerine etkileri henüz araştırılmamıştır. Dolayısıyla bu çalışmada farklı konsantrasyonlarda (1, 10 ve 100 μM) uygulanan UTP’nin RAW 264.7 fare makrofaj hücrelerinin canlılığı üzerine etkileri farklı zaman noktalarında MTT [3-(4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolyum bromür] testi kullanılmak suretiyle incelenmiştir. UTP uygulandıktan 24 ya da 48 saat sonra hücre canlılığında kontrole göre herhangi bir fark gözlenmezken, 10 μM konsantrasyonda uygulanan UTP’nin 72 saat sonra hücre canlılığını kontrole göre %27,7 oranında (p
Aims and Background: Suppressor of cytokine signaling 1 (SOCS1) is a prototype molecule of the SO... more Aims and Background: Suppressor of cytokine signaling 1 (SOCS1) is a prototype molecule of the SOCS family. Alterations in the SOCS1 expression have been reported in human cancers and some studies suggest that SOCS1 might act as a tumor suppressor in carcinogenesis. In the present study, we aimed to evaluate the association of SOCS1 promoter -1478CA/del gene polymorphism detected in DNA isolated from the tissues of patients with colorectal cancer (CRC) for histopathological characteristics and survival. Patients and Methods: For the study, we retrospectively enrolled 53 patients with resected colon due to CRC and 23 control subjects with no systemic illness. SOCS1- 1478CA/del gene polymorphism was determined using the polymerase chain reaction-restriction fragment length polymorphism methodology. These results were evaluated in relation to histopathological features and survival results and analyzed statistically. A P value equal to or less than 0.05 was considered significant. Results: Neither control subjects nor the CRC group showed a significant association with SOCS1 -1478CA/del gene polymorphism (p = 0.248). SOCS1 -1478CA/del gene polymorphism was not significantly associated with histopathological features either. However, in the overall survival (OS) analysis, those patients with the del/del allele were found to have a 3.9-fold greater risk of mortality compared to those with CA/CA allele (p = 0.05). Progression-free survival (PFS) was also significantly different in such patients (p = 0.05). Conclusion: The present study examining the association of SOCS1 -1478CA/del gene polymorphism with CRC showed that CRC patients with del/del allele had both significantly shorter PFS and OS versus those with CA/CA or CA/del allele.
COVID‐19 is a disease characterized by acute respiratory failure and is a major health problem wo... more COVID‐19 is a disease characterized by acute respiratory failure and is a major health problem worldwide. Here, we aimed to investigate the role of CD39 expression in Treg cell subsets in COVID‐19 immunopathogenesis and its relationship to disease severity. One hundred and ninety COVID‐19 patients (juveniles, adults) and 43 volunteers as healthy controls were enrolled in our study. Flow cytometric analysis was performed using a 10‐color monoclonal antibody panel from peripheral blood samples. In adult patients, CD39+ Tregs increased with disease severity. In contrast, CD39+ Tregs were decreased in juvenile patients in an age‐dependent manner. Overall, our study reveals an interesting profile of CD39‐expressing Tregs in adult and juvenile cases of COVID‐19. Our results provide a better understanding of the possible role of Tregs in the mechanism of immune response in COVID‐19 cases.
Hepatitis C virus can be transmitted to health care workers through needlestick accidents. In thi... more Hepatitis C virus can be transmitted to health care workers through needlestick accidents. In this report, the result of short-term therapy with interferon-alpha2b plus ribavirin combination of acute hepatitis C in a health care worker who infected through laboratory accident was presented. The patient received combination of interferon-alpha2b (5 MU three times a week) plus ribavirin (1000 mg daily) for three months. Aminotransferase levels were normalised and clearance of HCV RNA was obtained in the first month of the therapy. After 19 months of follow-up, he had undetectable levels of HCV RNA so sustained response (clearance of HCV RNA and normalisation of aminotransferases at least six months after cessation of therapy) was achieved. According to this result, short-term therapy of acute hepatitis C with interferon-alpha2b plus ribavirin may be an alternate to others.
ÖZET Hemodiyaliz biyouyumluluğu başlıca kan ile ekstrakorporal materyalin temasının başlattığı re... more ÖZET Hemodiyaliz biyouyumluluğu başlıca kan ile ekstrakorporal materyalin temasının başlattığı reaksiyonları ifade etmektedir. Membran sterilizasyon yönteminin biyouyumluluk üzerine etkisine ilişkin veri sınırlıdır. Bu çalışmada farklı yöntemlerle sterilize edilmiş iki polisülfon (PS) ...
Objectives: The aim of our study is to reveal the prevalence of HLA-B*57 in the Turkish populatio... more Objectives: The aim of our study is to reveal the prevalence of HLA-B*57 in the Turkish population and to provide new perspectives to physicians starting abacavir therapy in HIV patients. Background: Abacavir, one of the drugs used to treat HIV infection, can cause hypersensitivity reactions in some patients. These hypersensitivity reactions have been shown to be associated with the HLA-B*57:01 allele. High-resolution HLA-B*57:01 scanning has a time and cost disadvantage compared with low-resolution HLA-B*57 scanning. Before starting abacavir treatment, we will discuss whether high-resolution scanning is more beneficial in individuals who are positive on HLA-B*57 screening. This is the study with the largest cohort to investigate the prevalence of HLA-B*57 in Turkey. Methods: The results of 25 thousand 318 people who applied to Bursa Uludağ University Faculty of Medicine, Department of Immunology for HLA-B* typing were scanned. Results: In our study, the HLA-B*57 serotype was detect...
Makrofajlar immün sistemin önemli hücreleridir ve eksiklikleri ya da disfonksiyonları vücutta cid... more Makrofajlar immün sistemin önemli hücreleridir ve eksiklikleri ya da disfonksiyonları vücutta ciddi hastalıklara yol açar. Bir pirimidin nükleotidi olan üridin-5’-trifosfat’ın (UTP) makrofajlar için bir sinyal molekülü gibi davrandığı bilinmektedir. Ancak UTP’nin makrofaj canlılığı ya da proliferasyonu üzerine etkileri henüz araştırılmamıştır. Dolayısıyla bu çalışmada farklı konsantrasyonlarda (1, 10 ve 100 μM) uygulanan UTP’nin RAW 264.7 fare makrofaj hücrelerinin canlılığı üzerine etkileri farklı zaman noktalarında MTT [3-(4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolyum bromür] testi kullanılmak suretiyle incelenmiştir. UTP uygulandıktan 24 ya da 48 saat sonra hücre canlılığında kontrole göre herhangi bir fark gözlenmezken, 10 μM konsantrasyonda uygulanan UTP’nin 72 saat sonra hücre canlılığını kontrole göre %27,7 oranında (p
Aims and Background: Suppressor of cytokine signaling 1 (SOCS1) is a prototype molecule of the SO... more Aims and Background: Suppressor of cytokine signaling 1 (SOCS1) is a prototype molecule of the SOCS family. Alterations in the SOCS1 expression have been reported in human cancers and some studies suggest that SOCS1 might act as a tumor suppressor in carcinogenesis. In the present study, we aimed to evaluate the association of SOCS1 promoter -1478CA/del gene polymorphism detected in DNA isolated from the tissues of patients with colorectal cancer (CRC) for histopathological characteristics and survival. Patients and Methods: For the study, we retrospectively enrolled 53 patients with resected colon due to CRC and 23 control subjects with no systemic illness. SOCS1- 1478CA/del gene polymorphism was determined using the polymerase chain reaction-restriction fragment length polymorphism methodology. These results were evaluated in relation to histopathological features and survival results and analyzed statistically. A P value equal to or less than 0.05 was considered significant. Results: Neither control subjects nor the CRC group showed a significant association with SOCS1 -1478CA/del gene polymorphism (p = 0.248). SOCS1 -1478CA/del gene polymorphism was not significantly associated with histopathological features either. However, in the overall survival (OS) analysis, those patients with the del/del allele were found to have a 3.9-fold greater risk of mortality compared to those with CA/CA allele (p = 0.05). Progression-free survival (PFS) was also significantly different in such patients (p = 0.05). Conclusion: The present study examining the association of SOCS1 -1478CA/del gene polymorphism with CRC showed that CRC patients with del/del allele had both significantly shorter PFS and OS versus those with CA/CA or CA/del allele.
COVID‐19 is a disease characterized by acute respiratory failure and is a major health problem wo... more COVID‐19 is a disease characterized by acute respiratory failure and is a major health problem worldwide. Here, we aimed to investigate the role of CD39 expression in Treg cell subsets in COVID‐19 immunopathogenesis and its relationship to disease severity. One hundred and ninety COVID‐19 patients (juveniles, adults) and 43 volunteers as healthy controls were enrolled in our study. Flow cytometric analysis was performed using a 10‐color monoclonal antibody panel from peripheral blood samples. In adult patients, CD39+ Tregs increased with disease severity. In contrast, CD39+ Tregs were decreased in juvenile patients in an age‐dependent manner. Overall, our study reveals an interesting profile of CD39‐expressing Tregs in adult and juvenile cases of COVID‐19. Our results provide a better understanding of the possible role of Tregs in the mechanism of immune response in COVID‐19 cases.
Hepatitis C virus can be transmitted to health care workers through needlestick accidents. In thi... more Hepatitis C virus can be transmitted to health care workers through needlestick accidents. In this report, the result of short-term therapy with interferon-alpha2b plus ribavirin combination of acute hepatitis C in a health care worker who infected through laboratory accident was presented. The patient received combination of interferon-alpha2b (5 MU three times a week) plus ribavirin (1000 mg daily) for three months. Aminotransferase levels were normalised and clearance of HCV RNA was obtained in the first month of the therapy. After 19 months of follow-up, he had undetectable levels of HCV RNA so sustained response (clearance of HCV RNA and normalisation of aminotransferases at least six months after cessation of therapy) was achieved. According to this result, short-term therapy of acute hepatitis C with interferon-alpha2b plus ribavirin may be an alternate to others.
ÖZET Hemodiyaliz biyouyumluluğu başlıca kan ile ekstrakorporal materyalin temasının başlattığı re... more ÖZET Hemodiyaliz biyouyumluluğu başlıca kan ile ekstrakorporal materyalin temasının başlattığı reaksiyonları ifade etmektedir. Membran sterilizasyon yönteminin biyouyumluluk üzerine etkisine ilişkin veri sınırlıdır. Bu çalışmada farklı yöntemlerle sterilize edilmiş iki polisülfon (PS) ...
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