Introduction: Our knowledge has gaps regarding severe acute respiratory syndrome coronavirus 2 (S... more Introduction: Our knowledge has gaps regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication levels and its association to severity of Coronavirus disease 2019 (COVID-19). The aim of this study was to investigate the association of SARS-CoV-2 viral load with disease severity and serum biomarkers in COVID-19 patients. Methodology: Viral load was determined via cycle threshold (Ct) values of SARS-CoV-2 real-time reverse transcriptase-polymerase chain reaction (RT-PCR) in 214 adult patients. Ct values were compared with clinical severity, biochemical and hematological biomarkers. Results: Clinical course of the disease was mild (49.1%), moderate (40.2%), and severe (10.7%). Median Ct value was 28.2 (IQR: 22.2–33.8) during the first week of the disease. Ct values were lower within five days after symptom onset [lowest Ct value on the third day (median: 24, IQR: 20.6–32.3)], but they increased significantly during the second and third weeks. No association was ...
ObjectiveTo learn about the attitudes and behaviours of patients with idiopathic pulmonary fibros... more ObjectiveTo learn about the attitudes and behaviours of patients with idiopathic pulmonary fibrosis (IPF) in relation to the difficulties experienced during the COVID-19 pandemic.DesignA cross-sectional, multicentre phone call survey.SettingFour university hospitals in Turkey.ParticipantsThe study included patients with IPF receiving antifibrotics for at least 3 months and with doctor appointment and/or scheduled routine blood analysis between March and May 2020 (the first 3 months after the official announcement of the COVID-19 pandemic in Turkey).InterventionsPhone calls (a 5 min interview) were performed in June 2020. A questionnaire and the Hospital Anxiety-Depression Scale were applied.Main outcome measuresPatients’ preferences for disease monitoring, patients’ attitudes and behaviours towards IPF, drug continuation, COVID-19 diagnosis and anxiety/depression status.ResultsThe study included 115 patients with IPF (82 male; mean age, 68.43±7.44 years). Of the patients, 73.9% had ...
... An analysis of patients diagnosed with pulmonary embolism in terms of clinical and meteorolog... more ... An analysis of patients diagnosed with pulmonary embolism in terms of clinical and meteorological data. Ercan I, Coskun F, Cangur S, Ursavas A, Uzaslan E, Ege E, Kan I. Department of Biostatistics, Uludag University Medical School, Gorukle 16059, Bursa, Turkey. ...
between disease severity and D-dimer levels measured with two different methods in pulmonary embo... more between disease severity and D-dimer levels measured with two different methods in pulmonary embolism patients Rapporto tra gravità di malattia e livelli di D-dimero misurati con due metodiche differenti nei pazienti con embolia polmonare
INTRODUCTION: Intrapleural fibrinolytics are considered as an acceptable treatment modality in se... more INTRODUCTION: Intrapleural fibrinolytics are considered as an acceptable treatment modality in selected patients with complicated parapneumonic effusion (CPE) and empyema that may reduce the need for surgery. METHODS: In order to assess the clinical efficacy of streptokinase use, we retrospectively analysed data of patients with empyema and CPE in patients whom were treated with intrapleural streptokinase treatment in last five years. RESULTS: Eighty-eight patients treated with intrapleural streptokinase between 2007-2012 in Uludag University Pulmonology Department were recruited. The mean age of the study group was 54±17 and 74% were male. According to the Light’s pleural effusion classification 30% of the patients were Stage2 while 17% were Stage3, 37% were Stage4, 10% were Stage5, 4% were Stage6 and 2% were Stage7.Hemorrhagic complications were noted in 10 patients.Successful drainage was obtained in 61% in the overall group.75% of the patients recovered without need for surgery ...
Dunya Saglik Orgutu'ne gore yaslilik cevresel faktorlere uyum saglayabilme yeteneginin azalma... more Dunya Saglik Orgutu'ne gore yaslilik cevresel faktorlere uyum saglayabilme yeteneginin azalmasi olarak tanimlanmaktadir. Solunum sistemi 25 yasindan itibaren yaslanmaya baslar. Uzayan yasam omruyle iliskili olarak solunum sistemi hastaliklarinda yasli hastaya yaklasim onem kazanmaktadir. Tani ve tedavi suresince dogal yaslanma belirtilerini bilmek hastalarimiza dogru tedavi secenekleri sunmamizi saglayacaktir. Bu derlemenin amaci yaslanmayla birlikte solunum sisteminde gelisen fizyolojik degisiklikleri irdelemek ve cok siklikla gordugumuz bir hastalik olan KOAH ile yaslanmanin birlikteligini incelemektir.
Background: Sarcoidosis is a multisystem granulomatous inflammatory disorder. Extrapulmonary invo... more Background: Sarcoidosis is a multisystem granulomatous inflammatory disorder. Extrapulmonary involvement (EPI) is common and frequently accompany pulmonary involvement (PI). Methods: We retrospectively reviewed the medical records of sarcoidosis patients in a university hospital in the last eight years. We aimed to investigate the clinical properties of sarcoidosis patients with extrapulmonary involvement. Results: Two hundred and nineteen sarcoidosis patients (72.1%females,27.9%males) were included. Females were older than the male patients at the moment of diagnosis (50.4±11.9 females,47.8±14.9 males, p <0.05). Of these 72.6% had PI, while 27.4% had concomitant EPI. Eye and skin were the most common EPI sites. Cough and fever were most frequent initial symptoms in patients with lone PI. Skin lesions and peripheral lymphadenopathy were more frequent initial signs in patients with concomitant EPI. Pulmonary nodules were more common in patients with concomitant EPI on radioloy. Fo...
Objective: Allergen immunotherapy has been proven to be effective and potentially curative therap... more Objective: Allergen immunotherapy has been proven to be effective and potentially curative therapy in allergic respiratory diseases and in venom allergy. But occurance of adverse systemic reactions due to specific allergen immunotherapy (SIT) remains still major problem. In this study we aimed to assess the adverse reactions of SIT which has been given to patients diagnosed as allergic asthma and/or rhinitis. Materials and Methods: The 58 patients (37 female/ 21 male) followed up at Allergy Outpatient and received SIT were included to the study. Local or systemic reactions that occured during total 2939 injections were analyzed. Results: Total 2939 injections with standardized allergen extracts were administered to patients diagnosed as allergic asthma (n= 9), allergic rhinitis (n= 6), allergic asthma and allergic rhinitis (n= 43). Total 39 (1.3%) reactions were observed in 15 (25.8%) patients. Among these reactions 20 ones were local and 19 ones were systemic reactions. Among react...
Introduction: Our knowledge has gaps regarding severe acute respiratory syndrome coronavirus 2 (S... more Introduction: Our knowledge has gaps regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication levels and its association to severity of Coronavirus disease 2019 (COVID-19). The aim of this study was to investigate the association of SARS-CoV-2 viral load with disease severity and serum biomarkers in COVID-19 patients. Methodology: Viral load was determined via cycle threshold (Ct) values of SARS-CoV-2 real-time reverse transcriptase-polymerase chain reaction (RT-PCR) in 214 adult patients. Ct values were compared with clinical severity, biochemical and hematological biomarkers. Results: Clinical course of the disease was mild (49.1%), moderate (40.2%), and severe (10.7%). Median Ct value was 28.2 (IQR: 22.2–33.8) during the first week of the disease. Ct values were lower within five days after symptom onset [lowest Ct value on the third day (median: 24, IQR: 20.6–32.3)], but they increased significantly during the second and third weeks. No association was ...
ObjectiveTo learn about the attitudes and behaviours of patients with idiopathic pulmonary fibros... more ObjectiveTo learn about the attitudes and behaviours of patients with idiopathic pulmonary fibrosis (IPF) in relation to the difficulties experienced during the COVID-19 pandemic.DesignA cross-sectional, multicentre phone call survey.SettingFour university hospitals in Turkey.ParticipantsThe study included patients with IPF receiving antifibrotics for at least 3 months and with doctor appointment and/or scheduled routine blood analysis between March and May 2020 (the first 3 months after the official announcement of the COVID-19 pandemic in Turkey).InterventionsPhone calls (a 5 min interview) were performed in June 2020. A questionnaire and the Hospital Anxiety-Depression Scale were applied.Main outcome measuresPatients’ preferences for disease monitoring, patients’ attitudes and behaviours towards IPF, drug continuation, COVID-19 diagnosis and anxiety/depression status.ResultsThe study included 115 patients with IPF (82 male; mean age, 68.43±7.44 years). Of the patients, 73.9% had ...
... An analysis of patients diagnosed with pulmonary embolism in terms of clinical and meteorolog... more ... An analysis of patients diagnosed with pulmonary embolism in terms of clinical and meteorological data. Ercan I, Coskun F, Cangur S, Ursavas A, Uzaslan E, Ege E, Kan I. Department of Biostatistics, Uludag University Medical School, Gorukle 16059, Bursa, Turkey. ...
between disease severity and D-dimer levels measured with two different methods in pulmonary embo... more between disease severity and D-dimer levels measured with two different methods in pulmonary embolism patients Rapporto tra gravità di malattia e livelli di D-dimero misurati con due metodiche differenti nei pazienti con embolia polmonare
INTRODUCTION: Intrapleural fibrinolytics are considered as an acceptable treatment modality in se... more INTRODUCTION: Intrapleural fibrinolytics are considered as an acceptable treatment modality in selected patients with complicated parapneumonic effusion (CPE) and empyema that may reduce the need for surgery. METHODS: In order to assess the clinical efficacy of streptokinase use, we retrospectively analysed data of patients with empyema and CPE in patients whom were treated with intrapleural streptokinase treatment in last five years. RESULTS: Eighty-eight patients treated with intrapleural streptokinase between 2007-2012 in Uludag University Pulmonology Department were recruited. The mean age of the study group was 54±17 and 74% were male. According to the Light’s pleural effusion classification 30% of the patients were Stage2 while 17% were Stage3, 37% were Stage4, 10% were Stage5, 4% were Stage6 and 2% were Stage7.Hemorrhagic complications were noted in 10 patients.Successful drainage was obtained in 61% in the overall group.75% of the patients recovered without need for surgery ...
Dunya Saglik Orgutu'ne gore yaslilik cevresel faktorlere uyum saglayabilme yeteneginin azalma... more Dunya Saglik Orgutu'ne gore yaslilik cevresel faktorlere uyum saglayabilme yeteneginin azalmasi olarak tanimlanmaktadir. Solunum sistemi 25 yasindan itibaren yaslanmaya baslar. Uzayan yasam omruyle iliskili olarak solunum sistemi hastaliklarinda yasli hastaya yaklasim onem kazanmaktadir. Tani ve tedavi suresince dogal yaslanma belirtilerini bilmek hastalarimiza dogru tedavi secenekleri sunmamizi saglayacaktir. Bu derlemenin amaci yaslanmayla birlikte solunum sisteminde gelisen fizyolojik degisiklikleri irdelemek ve cok siklikla gordugumuz bir hastalik olan KOAH ile yaslanmanin birlikteligini incelemektir.
Background: Sarcoidosis is a multisystem granulomatous inflammatory disorder. Extrapulmonary invo... more Background: Sarcoidosis is a multisystem granulomatous inflammatory disorder. Extrapulmonary involvement (EPI) is common and frequently accompany pulmonary involvement (PI). Methods: We retrospectively reviewed the medical records of sarcoidosis patients in a university hospital in the last eight years. We aimed to investigate the clinical properties of sarcoidosis patients with extrapulmonary involvement. Results: Two hundred and nineteen sarcoidosis patients (72.1%females,27.9%males) were included. Females were older than the male patients at the moment of diagnosis (50.4±11.9 females,47.8±14.9 males, p <0.05). Of these 72.6% had PI, while 27.4% had concomitant EPI. Eye and skin were the most common EPI sites. Cough and fever were most frequent initial symptoms in patients with lone PI. Skin lesions and peripheral lymphadenopathy were more frequent initial signs in patients with concomitant EPI. Pulmonary nodules were more common in patients with concomitant EPI on radioloy. Fo...
Objective: Allergen immunotherapy has been proven to be effective and potentially curative therap... more Objective: Allergen immunotherapy has been proven to be effective and potentially curative therapy in allergic respiratory diseases and in venom allergy. But occurance of adverse systemic reactions due to specific allergen immunotherapy (SIT) remains still major problem. In this study we aimed to assess the adverse reactions of SIT which has been given to patients diagnosed as allergic asthma and/or rhinitis. Materials and Methods: The 58 patients (37 female/ 21 male) followed up at Allergy Outpatient and received SIT were included to the study. Local or systemic reactions that occured during total 2939 injections were analyzed. Results: Total 2939 injections with standardized allergen extracts were administered to patients diagnosed as allergic asthma (n= 9), allergic rhinitis (n= 6), allergic asthma and allergic rhinitis (n= 43). Total 39 (1.3%) reactions were observed in 15 (25.8%) patients. Among these reactions 20 ones were local and 19 ones were systemic reactions. Among react...
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