Artificial intelligence (AI) plays a more and more important role in our everyday life due to the... more Artificial intelligence (AI) plays a more and more important role in our everyday life due to the advantages that it brings when used, such as 24/7 availability, a very low percentage of errors, ability to provide real time insights, or performing a fast analysis. AI is increasingly being used in clinical medical and dental healthcare analyses, with valuable applications, which include disease diagnosis, risk assessment, treatment planning, and drug discovery. This paper presents a narrative literature review of AI use in healthcare from a multi-disciplinary perspective, specifically in the cardiology, allergology, endocrinology, and dental fields. The paper highlights data from recent research and development efforts in AI for healthcare, as well as challenges and limitations associated with AI implementation, such as data privacy and security considerations, along with ethical and legal concerns. The regulation of responsible design, development, and use of AI in healthcare is sti...
Introduction and aim of the study: The IL-1 family of cytokines is proved to be involved in both ... more Introduction and aim of the study: The IL-1 family of cytokines is proved to be involved in both periodontal disease and osteoporosis mechanisms. We aimed to assess the differences in gingival crevicular fluid of IL-1α and IL-1β in periodontal impaired postmenopausal osteoporosis and systemically healthy subjects. Material and method: The study was conducted on 38 post-menopausal female patients, divided in osteoporosis patients (n=20) and systemically healthy subjects (n=18). All the subjects were examined, with the recording of the periodontal probing depth (PPD), clinical attachment loss (CAL) and bleeding on probing (BOP). The IL-1α and IL-1β levels in gingival crevicular fluid were determined by ELISA tests. Results: The periodontal parameters were more severe for the osteoporosis patients; these patients also presented higher values of IL-1α and IL-1β. Discussion: The periodontal parameters can be inexact predictors of the periodontal disease progression, while the cytokine le...
Romanian Journal of Medical and Dental Education, 2020
The aim of the study was to evaluate the composite resin-tooth interface when using a universal a... more The aim of the study was to evaluate the composite resin-tooth interface when using a universal adhesive applied in different etching strategies. Materials and method: 20 class V cavities were prepared in extracted teeth and restored with a composite resin using a universal adhesive system. Half of the restorations were applied using etch-and-rinse technique and the other half were applied with self-etch technique. The samples had been subjected to a dye penetration microleakage test and then the teeth were axially sectioned. The microleakage scores and the morphology of the adhesive joint were evaluated using an optical microscope and a scanning electron microscope. Results: The microleakage scores did not show a significant difference between the self-etch group and the total etch-group. For both groups, no significant gaps were noticed, however few cracks were visible within the adhesive layer. The SEM images showed the preservation of a tide contact between the composite resin a...
DOAJ (DOAJ: Directory of Open Access Journals), Jul 1, 2012
Introduction Mononucleosis is an infectious disease caused by Epstein-Barr virus (EBV) and charac... more Introduction Mononucleosis is an infectious disease caused by Epstein-Barr virus (EBV) and characterized clinically by fever, angina, adenosplenomegalie, haematological by leucocytosis with atypical mononucleosis and immunologic by appearance of specific and nonspecific antibody. The purpose of the study This clinical and statistical evaluation study aimed total gingivo-periodontal manifestations due to infectious mononucleosis generally correlated with clinical, laboratory examination results and general demographic characteristics. Material and methods We took a group study consisting of 95 people hospitalized with the diagnosis of infectious mononucleosis in which we evaluated the clinical aspects of muco-gingival lesions in correlation with oral lesions and the emergence stage of the infectious mononucleosis. Results Most cases 20.6% of the total study group showed at intraoral clinical examination haemorrhagic pickets, diffuse gingival erythema and a smaller percentage had gingivo-necrotic acute ulcerative stomatitis. Conclusions Acute human infection, transmission, usually benign, occurring more frequently in younger age (children and adolescents), infectious mononucleosis is characterized by clinical polymorphism, diagnostic difficulties, possible complications as well as the existence of possible relationships with other oral pathological entities (aggressive periodontitis) or systemic (Hodgkin disease), characters emphasizes the need for numerous clinical biological research on this disease.
DOAJ (DOAJ: Directory of Open Access Journals), 2017
Host modulation therapy, although not a novelty in medicine, has recently been proposed as an adj... more Host modulation therapy, although not a novelty in medicine, has recently been proposed as an adjunct to conventional treatment of periodontal disease. This innovative therapeutic approach has its origin in the latest data from fundamental research on the etiopathogeny of periodontal disease. Understanding the mechanisms of the disease as well as the ways in which different substances can intervene in the sense of both alleviating signs of disease or stimulating the host's protective mechanisms or increasing the effectiveness of conventional therapies has nowadays considered adjunctive therapy in Periodontal disease, the methods that are grouped into the concept of host modulation therapy.
Study Design Cross-sectional. Objectives To investigate the relationship between subjective measu... more Study Design Cross-sectional. Objectives To investigate the relationship between subjective measures of function and quality of life, and objective measures of balance in individuals with Chronic Ankle Instability (CAI). Background CAI results due to an inadequately healed ankle sprain, and may impact the individual’s balance and quality of life. However, it is unknown how they are related. Methods and Measures Participants: 1) CAI group (n=18; age 22.4±2.8 years) had a history of at least 1 significant ankle sprain with feelings of instability and/or recurrent sprain, 2) Copers (n=15; age 22.4±3.2 years) also sustained 1 significant ankle sprain, but are able to return to their pre-injury levels without residual symptoms and 3) Control (n=18; 22.2±3.0 years), who never had ankle injury. Static balance was tested using single leg standing on the Biodex Balance System platform set to levels of varying stability. Dynamic balance was tested using Y-balance system. Foot and Ankle Ability Measure (FAAM) and the Foot and Ankle Outcome Score (FAOS) surveys were administered. Results For CAI group, the FAOS quality of life subscale was negatively correlated with sway index and area when the platform was stable (both r>=−0.52; p<0.026). Also the FAOS activities of daily living and pain subscales negatively correlated with maximum reach in the posteromedial direction of the Y-balance test (both r>=−0.49; p<0.037). For Copers, the FAOS symptoms subscale negatively correlated with sway index when the platform was stable (r=−0.54; p=0.037). For Controls the FAOS symptoms subscale showed negative moderate significant correlation with sway index and area on the very unstable platform level. Conclusions For those with a history of ankle sprain, subjective measures seemed to be related to performance on the least challenging static balance and dynamic balance test. Subjective measures of quality of life and function do not seem to be related to more challenging static balance tests.
International Journal of Environmental Research and Public Health
The COVID-19 pandemic has forced the transfer of traditional on-site educational activities to th... more The COVID-19 pandemic has forced the transfer of traditional on-site educational activities to the online environment. This study aimed to evaluate the perception and acceptance of remote learning among fixed prosthodontic students attending the Faculty of Dental Medicine of “Grigore T. Popa” University of Medicine and Pharmacy in Iasi, Romania, and to analyze the feedback regarding their experience with the new online methods, the perceived quality thereof and suggestions for improvement. An observational cross-sectional, online study based on 22 questions was conducted with 259 students. The general opinion of online education was good or very good (40.15%); regarding its efficiency, 28.57% found it efficient while 34.36% found it inefficient or very inefficient; regarding the pleasure of learning online, 45.95% of students enjoyed online learning, while 36.64% did not enjoy it. The problem that was most cited by respondents was that of keeping all students motivated and involved ...
Numerous technologies and materials were developed with the aim of repairing and reconstructing t... more Numerous technologies and materials were developed with the aim of repairing and reconstructing the tissue loss in patients with periodontitis. Periodontal guided bone regeneration (GBR) and guided tissue regeneration (GTR) involves the use of a membrane which prevents epithelial cell migration, and helps to maintain the space, creating a protected area in which tissue regeneration is favored. Over the time, manufacturing procedures of such barrier membranes followed important improvements. Three-dimensional (3D) printing technology has led to major innovations in periodontal regeneration methods, using technologies such as inkjet printing, light-assisted 3D printing or micro-extrusion. Besides the 3D printing of monophasic and multi-phasic scaffolds, bioprinting and tissue engineering have emerged as innovative technologies which can change the way we see GTR and GBR.
The inflammatory response of the host in periodontitis is the phenomenon that underlies the onset... more The inflammatory response of the host in periodontitis is the phenomenon that underlies the onset and evolution of periodontal destructive phenomena. A number of systemic factors, such as diabetes mellitus (DM), can negatively affect the patient with periodontitis, just as the periodontal disease can aggravate the status of the DM patient. Host response modulation therapy involves the use of anti-inflammatory and anti-oxidant products aimed at resolving inflammation, stopping destructive processes, and promoting periodontal healing, all important aspects in patients with high tissue loss rates, such as diabetic patients. This paper reviews the data available in the literature on the relationship between DM and periodontitis, the main substances modulating the inflammatory response (nonsteroidal anti-inflammatory drugs, sub-antimicrobial doses of doxycycline, or omega-3 fatty acids and their products, specialized pro-resolving mediators), as well as their application in diabetic pati...
Artificial intelligence (AI) plays a more and more important role in our everyday life due to the... more Artificial intelligence (AI) plays a more and more important role in our everyday life due to the advantages that it brings when used, such as 24/7 availability, a very low percentage of errors, ability to provide real time insights, or performing a fast analysis. AI is increasingly being used in clinical medical and dental healthcare analyses, with valuable applications, which include disease diagnosis, risk assessment, treatment planning, and drug discovery. This paper presents a narrative literature review of AI use in healthcare from a multi-disciplinary perspective, specifically in the cardiology, allergology, endocrinology, and dental fields. The paper highlights data from recent research and development efforts in AI for healthcare, as well as challenges and limitations associated with AI implementation, such as data privacy and security considerations, along with ethical and legal concerns. The regulation of responsible design, development, and use of AI in healthcare is sti...
Introduction and aim of the study: The IL-1 family of cytokines is proved to be involved in both ... more Introduction and aim of the study: The IL-1 family of cytokines is proved to be involved in both periodontal disease and osteoporosis mechanisms. We aimed to assess the differences in gingival crevicular fluid of IL-1α and IL-1β in periodontal impaired postmenopausal osteoporosis and systemically healthy subjects. Material and method: The study was conducted on 38 post-menopausal female patients, divided in osteoporosis patients (n=20) and systemically healthy subjects (n=18). All the subjects were examined, with the recording of the periodontal probing depth (PPD), clinical attachment loss (CAL) and bleeding on probing (BOP). The IL-1α and IL-1β levels in gingival crevicular fluid were determined by ELISA tests. Results: The periodontal parameters were more severe for the osteoporosis patients; these patients also presented higher values of IL-1α and IL-1β. Discussion: The periodontal parameters can be inexact predictors of the periodontal disease progression, while the cytokine le...
Romanian Journal of Medical and Dental Education, 2020
The aim of the study was to evaluate the composite resin-tooth interface when using a universal a... more The aim of the study was to evaluate the composite resin-tooth interface when using a universal adhesive applied in different etching strategies. Materials and method: 20 class V cavities were prepared in extracted teeth and restored with a composite resin using a universal adhesive system. Half of the restorations were applied using etch-and-rinse technique and the other half were applied with self-etch technique. The samples had been subjected to a dye penetration microleakage test and then the teeth were axially sectioned. The microleakage scores and the morphology of the adhesive joint were evaluated using an optical microscope and a scanning electron microscope. Results: The microleakage scores did not show a significant difference between the self-etch group and the total etch-group. For both groups, no significant gaps were noticed, however few cracks were visible within the adhesive layer. The SEM images showed the preservation of a tide contact between the composite resin a...
DOAJ (DOAJ: Directory of Open Access Journals), Jul 1, 2012
Introduction Mononucleosis is an infectious disease caused by Epstein-Barr virus (EBV) and charac... more Introduction Mononucleosis is an infectious disease caused by Epstein-Barr virus (EBV) and characterized clinically by fever, angina, adenosplenomegalie, haematological by leucocytosis with atypical mononucleosis and immunologic by appearance of specific and nonspecific antibody. The purpose of the study This clinical and statistical evaluation study aimed total gingivo-periodontal manifestations due to infectious mononucleosis generally correlated with clinical, laboratory examination results and general demographic characteristics. Material and methods We took a group study consisting of 95 people hospitalized with the diagnosis of infectious mononucleosis in which we evaluated the clinical aspects of muco-gingival lesions in correlation with oral lesions and the emergence stage of the infectious mononucleosis. Results Most cases 20.6% of the total study group showed at intraoral clinical examination haemorrhagic pickets, diffuse gingival erythema and a smaller percentage had gingivo-necrotic acute ulcerative stomatitis. Conclusions Acute human infection, transmission, usually benign, occurring more frequently in younger age (children and adolescents), infectious mononucleosis is characterized by clinical polymorphism, diagnostic difficulties, possible complications as well as the existence of possible relationships with other oral pathological entities (aggressive periodontitis) or systemic (Hodgkin disease), characters emphasizes the need for numerous clinical biological research on this disease.
DOAJ (DOAJ: Directory of Open Access Journals), 2017
Host modulation therapy, although not a novelty in medicine, has recently been proposed as an adj... more Host modulation therapy, although not a novelty in medicine, has recently been proposed as an adjunct to conventional treatment of periodontal disease. This innovative therapeutic approach has its origin in the latest data from fundamental research on the etiopathogeny of periodontal disease. Understanding the mechanisms of the disease as well as the ways in which different substances can intervene in the sense of both alleviating signs of disease or stimulating the host's protective mechanisms or increasing the effectiveness of conventional therapies has nowadays considered adjunctive therapy in Periodontal disease, the methods that are grouped into the concept of host modulation therapy.
Study Design Cross-sectional. Objectives To investigate the relationship between subjective measu... more Study Design Cross-sectional. Objectives To investigate the relationship between subjective measures of function and quality of life, and objective measures of balance in individuals with Chronic Ankle Instability (CAI). Background CAI results due to an inadequately healed ankle sprain, and may impact the individual’s balance and quality of life. However, it is unknown how they are related. Methods and Measures Participants: 1) CAI group (n=18; age 22.4±2.8 years) had a history of at least 1 significant ankle sprain with feelings of instability and/or recurrent sprain, 2) Copers (n=15; age 22.4±3.2 years) also sustained 1 significant ankle sprain, but are able to return to their pre-injury levels without residual symptoms and 3) Control (n=18; 22.2±3.0 years), who never had ankle injury. Static balance was tested using single leg standing on the Biodex Balance System platform set to levels of varying stability. Dynamic balance was tested using Y-balance system. Foot and Ankle Ability Measure (FAAM) and the Foot and Ankle Outcome Score (FAOS) surveys were administered. Results For CAI group, the FAOS quality of life subscale was negatively correlated with sway index and area when the platform was stable (both r>=−0.52; p<0.026). Also the FAOS activities of daily living and pain subscales negatively correlated with maximum reach in the posteromedial direction of the Y-balance test (both r>=−0.49; p<0.037). For Copers, the FAOS symptoms subscale negatively correlated with sway index when the platform was stable (r=−0.54; p=0.037). For Controls the FAOS symptoms subscale showed negative moderate significant correlation with sway index and area on the very unstable platform level. Conclusions For those with a history of ankle sprain, subjective measures seemed to be related to performance on the least challenging static balance and dynamic balance test. Subjective measures of quality of life and function do not seem to be related to more challenging static balance tests.
International Journal of Environmental Research and Public Health
The COVID-19 pandemic has forced the transfer of traditional on-site educational activities to th... more The COVID-19 pandemic has forced the transfer of traditional on-site educational activities to the online environment. This study aimed to evaluate the perception and acceptance of remote learning among fixed prosthodontic students attending the Faculty of Dental Medicine of “Grigore T. Popa” University of Medicine and Pharmacy in Iasi, Romania, and to analyze the feedback regarding their experience with the new online methods, the perceived quality thereof and suggestions for improvement. An observational cross-sectional, online study based on 22 questions was conducted with 259 students. The general opinion of online education was good or very good (40.15%); regarding its efficiency, 28.57% found it efficient while 34.36% found it inefficient or very inefficient; regarding the pleasure of learning online, 45.95% of students enjoyed online learning, while 36.64% did not enjoy it. The problem that was most cited by respondents was that of keeping all students motivated and involved ...
Numerous technologies and materials were developed with the aim of repairing and reconstructing t... more Numerous technologies and materials were developed with the aim of repairing and reconstructing the tissue loss in patients with periodontitis. Periodontal guided bone regeneration (GBR) and guided tissue regeneration (GTR) involves the use of a membrane which prevents epithelial cell migration, and helps to maintain the space, creating a protected area in which tissue regeneration is favored. Over the time, manufacturing procedures of such barrier membranes followed important improvements. Three-dimensional (3D) printing technology has led to major innovations in periodontal regeneration methods, using technologies such as inkjet printing, light-assisted 3D printing or micro-extrusion. Besides the 3D printing of monophasic and multi-phasic scaffolds, bioprinting and tissue engineering have emerged as innovative technologies which can change the way we see GTR and GBR.
The inflammatory response of the host in periodontitis is the phenomenon that underlies the onset... more The inflammatory response of the host in periodontitis is the phenomenon that underlies the onset and evolution of periodontal destructive phenomena. A number of systemic factors, such as diabetes mellitus (DM), can negatively affect the patient with periodontitis, just as the periodontal disease can aggravate the status of the DM patient. Host response modulation therapy involves the use of anti-inflammatory and anti-oxidant products aimed at resolving inflammation, stopping destructive processes, and promoting periodontal healing, all important aspects in patients with high tissue loss rates, such as diabetic patients. This paper reviews the data available in the literature on the relationship between DM and periodontitis, the main substances modulating the inflammatory response (nonsteroidal anti-inflammatory drugs, sub-antimicrobial doses of doxycycline, or omega-3 fatty acids and their products, specialized pro-resolving mediators), as well as their application in diabetic pati...
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