A growing consensus among concussion experts is that a formal gait assessment is an essential com... more A growing consensus among concussion experts is that a formal gait assessment is an essential component in return-to-play decisions. Concussion research illustrates that gait variables follow a pattern of recovery that may be more protracted than cognitive recovery, suggesting that gait dynamics may be more sensitive to the sequelae of concussion, and accelerometer data may enhance that sensitivity. However, pediatric neuropsychologists have few available options for quantitatively assessing gait. We here introduce a novel gait technology, the BioKinetoGraph (BKG), that provides multiple metrics for assessing gait, including within the domains of power, stride, balance (stability), and symmetry. We demonstrate how BKG data can be collected using a mobile application called SportGait, which is available for use on any smartphone. We present data illustrating the test–retest reliability of the mobile BKG in a sample of 4150 ostensibly healthy individuals, with an overall mean correlat...
Background Gait accelerometer (sensor) technology has proven effective in predicting several medi... more Background Gait accelerometer (sensor) technology has proven effective in predicting several medical outcomes, but less is known regarding its prediction of concussion symptoms relative to conventional measures of gait and balance. Objective To establish the reliability and validity of gait accelerometer data. We first examine test-retest reliability and the impact of footwear and walking surfaces on gait. We then examine the convergent validity between gait accelerometer data and the NIH 4-meter gait test. Finally, we compare gait accelerometer data to gait speed and balance measures for predicting concussion symptoms. Methods Study 1 used a crossover study design with 60 participants to evaluate retest reliability and examine the effects of footwear (shoes/no-shoes) and walking surface (tile floor/grass) on gait accelerometer data. Study 2 employed a cross-sectional design with 1008 participants to assess gait accelerometer correlations with NIH 4-meter gait and the prediction of ...
Drug recalls and lawsuits against pharmaceutical manufacturers are accompanied by announcements e... more Drug recalls and lawsuits against pharmaceutical manufacturers are accompanied by announcements emphasizing harmful drug side-effects. Those with elevated health anxiety may be more reactive to such announcements. We evaluated whether health anxiety and financial incentives affect subjective symptom endorsement, and objective outcomes of cognitive and physiological functioning during a mock drug recall. Hundred and sixty-one participants reported use of over-the-counter pain medications and presented with a fictitious medication recall via a mock Food and Drug Administration (FDA) website. The opportunity to join a class-action lawsuit was manipulated. We assessed health anxiety, recalled drug usage, blood pressure, heart rate, and performance on a computerized Trail Making Test (TMT). Symptom endorsement was strongly predicted by health anxiety. When combined, three health anxiety measures explained 28.5% variance (Cohen’s d = 1.26). These effects remain strong after controlling fo...
Studies were done using dogs to determine: (1) the ED 50 of Etamon when given as an infusion over... more Studies were done using dogs to determine: (1) the ED 50 of Etamon when given as an infusion over 30 minutes; (2) the possibility of an accumulative toxicity when Etamon is given in multiple small doses over long periods of time; and (3) the effect of various measures in preventing death after the administration of a lethal dose (LD 100 ) of Etamon. The ED 50 of Etamon given as an infusion was found to be nearly twice that of Etamon given as a fast injection intravenously. There seemed to be an accumulative toxic effect following the use of Etamon in multiple small doses over a long period of time as evidenced by the difference between the ED 50 of those receiving a single large infusion and those receiving multiple small infusions. Intermittent controlled positive pressure respirations were found to be effective in preventing death after the infusion of a lethal dose of Etamon.
USING DANCE TO IMPROVE EXECUTIVE FUNCITONING IN OLDER ADULTS Deborah Kalnen Kemp ... Such interve... more USING DANCE TO IMPROVE EXECUTIVE FUNCITONING IN OLDER ADULTS Deborah Kalnen Kemp ... Such interventions have included drugs and supplements, a brain-healthy diet, mental stimulation, and aerobic exercise (Colcombe, Erickson, Scalf, Kim, Prakash, McAuley, ...
Objective Chronic pain is common in military veterans with traumatic brain injury (TBI) and post-... more Objective Chronic pain is common in military veterans with traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD). Neurofeedback, or electroencephalograph (EEG) biofeedback, has been associated with lower pain but requires frequent travel to a clinic. The current study examined feasibility and explored effectiveness of neurofeedback delivered with a portable EEG headset linked to an application on a mobile device. Design Open-label, single-arm clinical trial. Setting Home, outside of clinic. Subjects N = 41 veterans with chronic pain, TBI, and PTSD. Method Veterans were instructed to perform “mobile neurofeedback” on their own for three months. Clinical research staff conducted two home visits and two phone calls to provide technical assistance and troubleshoot difficulties. Results N = 36 veterans returned for follow-up at three months (88% retention). During this time, subjects completed a mean of 33.09 neurofeedback sessions (10 minutes each). Analyses revealed th...
A growing consensus among concussion experts is that a formal gait assessment is an essential com... more A growing consensus among concussion experts is that a formal gait assessment is an essential component in return-to-play decisions. Concussion research illustrates that gait variables follow a pattern of recovery that may be more protracted than cognitive recovery, suggesting that gait dynamics may be more sensitive to the sequelae of concussion, and accelerometer data may enhance that sensitivity. However, pediatric neuropsychologists have few available options for quantitatively assessing gait. We here introduce a novel gait technology, the BioKinetoGraph (BKG), that provides multiple metrics for assessing gait, including within the domains of power, stride, balance (stability), and symmetry. We demonstrate how BKG data can be collected using a mobile application called SportGait, which is available for use on any smartphone. We present data illustrating the test–retest reliability of the mobile BKG in a sample of 4150 ostensibly healthy individuals, with an overall mean correlat...
Background Gait accelerometer (sensor) technology has proven effective in predicting several medi... more Background Gait accelerometer (sensor) technology has proven effective in predicting several medical outcomes, but less is known regarding its prediction of concussion symptoms relative to conventional measures of gait and balance. Objective To establish the reliability and validity of gait accelerometer data. We first examine test-retest reliability and the impact of footwear and walking surfaces on gait. We then examine the convergent validity between gait accelerometer data and the NIH 4-meter gait test. Finally, we compare gait accelerometer data to gait speed and balance measures for predicting concussion symptoms. Methods Study 1 used a crossover study design with 60 participants to evaluate retest reliability and examine the effects of footwear (shoes/no-shoes) and walking surface (tile floor/grass) on gait accelerometer data. Study 2 employed a cross-sectional design with 1008 participants to assess gait accelerometer correlations with NIH 4-meter gait and the prediction of ...
Drug recalls and lawsuits against pharmaceutical manufacturers are accompanied by announcements e... more Drug recalls and lawsuits against pharmaceutical manufacturers are accompanied by announcements emphasizing harmful drug side-effects. Those with elevated health anxiety may be more reactive to such announcements. We evaluated whether health anxiety and financial incentives affect subjective symptom endorsement, and objective outcomes of cognitive and physiological functioning during a mock drug recall. Hundred and sixty-one participants reported use of over-the-counter pain medications and presented with a fictitious medication recall via a mock Food and Drug Administration (FDA) website. The opportunity to join a class-action lawsuit was manipulated. We assessed health anxiety, recalled drug usage, blood pressure, heart rate, and performance on a computerized Trail Making Test (TMT). Symptom endorsement was strongly predicted by health anxiety. When combined, three health anxiety measures explained 28.5% variance (Cohen’s d = 1.26). These effects remain strong after controlling fo...
Studies were done using dogs to determine: (1) the ED 50 of Etamon when given as an infusion over... more Studies were done using dogs to determine: (1) the ED 50 of Etamon when given as an infusion over 30 minutes; (2) the possibility of an accumulative toxicity when Etamon is given in multiple small doses over long periods of time; and (3) the effect of various measures in preventing death after the administration of a lethal dose (LD 100 ) of Etamon. The ED 50 of Etamon given as an infusion was found to be nearly twice that of Etamon given as a fast injection intravenously. There seemed to be an accumulative toxic effect following the use of Etamon in multiple small doses over a long period of time as evidenced by the difference between the ED 50 of those receiving a single large infusion and those receiving multiple small infusions. Intermittent controlled positive pressure respirations were found to be effective in preventing death after the infusion of a lethal dose of Etamon.
USING DANCE TO IMPROVE EXECUTIVE FUNCITONING IN OLDER ADULTS Deborah Kalnen Kemp ... Such interve... more USING DANCE TO IMPROVE EXECUTIVE FUNCITONING IN OLDER ADULTS Deborah Kalnen Kemp ... Such interventions have included drugs and supplements, a brain-healthy diet, mental stimulation, and aerobic exercise (Colcombe, Erickson, Scalf, Kim, Prakash, McAuley, ...
Objective Chronic pain is common in military veterans with traumatic brain injury (TBI) and post-... more Objective Chronic pain is common in military veterans with traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD). Neurofeedback, or electroencephalograph (EEG) biofeedback, has been associated with lower pain but requires frequent travel to a clinic. The current study examined feasibility and explored effectiveness of neurofeedback delivered with a portable EEG headset linked to an application on a mobile device. Design Open-label, single-arm clinical trial. Setting Home, outside of clinic. Subjects N = 41 veterans with chronic pain, TBI, and PTSD. Method Veterans were instructed to perform “mobile neurofeedback” on their own for three months. Clinical research staff conducted two home visits and two phone calls to provide technical assistance and troubleshoot difficulties. Results N = 36 veterans returned for follow-up at three months (88% retention). During this time, subjects completed a mean of 33.09 neurofeedback sessions (10 minutes each). Analyses revealed th...
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