On-load tap changing (OLTC) regulators are widely used to maintain a constant voltage. However, t... more On-load tap changing (OLTC) regulators are widely used to maintain a constant voltage. However, the typical response time of an OLTC varies from 100 ms to several seconds. The development of modern power devices allows implementation of new types of OLTC regulators with a faster response in order to correct other perturbances like flicker, noise and harmonic distortion. This paper
Two Candida antarctica lipases catalyze the enantioselective acylation of N-substituted trans-4-(... more Two Candida antarctica lipases catalyze the enantioselective acylation of N-substituted trans-4-(4'-fluorophenyl)-3-hydroxymethylpiperidines in organic solvents. These two lipases show opposite stereochemical preference in these processes. Both enantiomers can be obtained in their optically pure forms. The (3S,4R) isomer, is an intermediate for the synthesis of (-)-Paroxetine.
Aminolyses of racemic and prochiral 3-hydroxyesters with racemic amines are effectively catalyzed... more Aminolyses of racemic and prochiral 3-hydroxyesters with racemic amines are effectively catalyzed by Candida antarctica lipase. In these processes, the simultaneous resolution of the ester and the amine, or the corresponding asymmetrization-resolution, takes place. In all cases, the high enantioselectivity shown by the lipase toward all the reactants allows the preparation of enantiopure 3-hydroxyamides with very high diastereomeric ratios. These 3-hydroxyamides are used as starting materials in the synthesis of 3-hydroxy- and 2-oxopyrrolidines, both containing two stereogenic centers in their structures.
During the IML-2 space shuttle mission, the RAMSES instrument was operated in the Spacelab module... more During the IML-2 space shuttle mission, the RAMSES instrument was operated in the Spacelab module. This continuous-flow electrophoresis device performs separation and purification of protein solutions on a preparative scale. Samples containing artificial mixtures of pure proteins were used to test the capabilities of the device, and useful separations were obtained for proteins having a mobility difference of only 3 x 10(-9) m2 V-1 s-1. Operating conditions that cannot be applied on earth were explored for two different sample concentrations, one of which is too high to allow treatment on earth. It agrees well with a previously published numerical model in that the main cause of loss in resolution in this process is the electrohydrodynamic spreading of the protein filaments.
On-load tap changing (OLTC) regulators are widely used to maintain a constant voltage. However, t... more On-load tap changing (OLTC) regulators are widely used to maintain a constant voltage. However, the typical response time of an OLTC varies from 100 ms to several seconds. The development of modern power devices allows implementation of new types of OLTC regulators with a faster response in order to correct other perturbances like flicker, noise and harmonic distortion. This paper
Two Candida antarctica lipases catalyze the enantioselective acylation of N-substituted trans-4-(... more Two Candida antarctica lipases catalyze the enantioselective acylation of N-substituted trans-4-(4'-fluorophenyl)-3-hydroxymethylpiperidines in organic solvents. These two lipases show opposite stereochemical preference in these processes. Both enantiomers can be obtained in their optically pure forms. The (3S,4R) isomer, is an intermediate for the synthesis of (-)-Paroxetine.
Aminolyses of racemic and prochiral 3-hydroxyesters with racemic amines are effectively catalyzed... more Aminolyses of racemic and prochiral 3-hydroxyesters with racemic amines are effectively catalyzed by Candida antarctica lipase. In these processes, the simultaneous resolution of the ester and the amine, or the corresponding asymmetrization-resolution, takes place. In all cases, the high enantioselectivity shown by the lipase toward all the reactants allows the preparation of enantiopure 3-hydroxyamides with very high diastereomeric ratios. These 3-hydroxyamides are used as starting materials in the synthesis of 3-hydroxy- and 2-oxopyrrolidines, both containing two stereogenic centers in their structures.
During the IML-2 space shuttle mission, the RAMSES instrument was operated in the Spacelab module... more During the IML-2 space shuttle mission, the RAMSES instrument was operated in the Spacelab module. This continuous-flow electrophoresis device performs separation and purification of protein solutions on a preparative scale. Samples containing artificial mixtures of pure proteins were used to test the capabilities of the device, and useful separations were obtained for proteins having a mobility difference of only 3 x 10(-9) m2 V-1 s-1. Operating conditions that cannot be applied on earth were explored for two different sample concentrations, one of which is too high to allow treatment on earth. It agrees well with a previously published numerical model in that the main cause of loss in resolution in this process is the electrohydrodynamic spreading of the protein filaments.
Uploads
Papers by victor sanchez