ABSTRACT A series of novel condensed 2-fluoromethylpyrimidines has been synthesized and evaluated... more ABSTRACT A series of novel condensed 2-fluoromethylpyrimidines has been synthesized and evaluated for antihyperlipidemic activity in high fat diet fed hyperlipidemic Sprague–Dawley rats. The aim of this study was to investigate the effect of the fluorine atom at the 2-methyl position of these compounds. Most of the synthesized compounds significantly affected the lipid profile of the test animals. Compound IIIb exhibited remarkably best effects in lowering the serum cholesterol and triglyceride levels and elevating the serum HDL levels, of the test animals. Graphical abstract A series of novel condensed 2-fluoromethylpyrimidines was synthesized and evaluated for antihyperlipidemic activity in hyperlipidemic Spargue–Dawley rats. All compounds, especially IIIb, significantly affected the lipid profile of test animals.
The harmful and hazardous use of alcohol is a serious problem in the world. It results in serious... more The harmful and hazardous use of alcohol is a serious problem in the world. It results in serious health, social and economic harms, and is the third-leading risk factor for death and disability. The primary goal of ayurvedic medicine is to help people live long, healthy and balanced lifewith lesser side effects and higher efficacy. The present study evaluated the effect of ethanolic extract of Clitoria ternatea in ethanol withdrawal induced depression. Ethanol dependence was produced in mice to ethanol withdrawal signs; mice were individually housed in small cages and provided a nutritionally balanced control liquid diet on day 0 as their sole nutrient source (600 kcal/l). From day 1 to day 4, ethanol (1.8% v/v) was incorporated in to the liquid diet, followed by 3.6% v/v of ethanol (from day 5 to 7) and 6.3% v/v of ethanol (from day 8 to10). On day 11, at 8.00 h, ethanol liquid diet was replaced with nutritionally balanced control liquid. Clitoria ternatea extracts (100,200 and 40...
ABSTRACT A series of novel condensed 2-fluoromethylpyrimidines has been synthesized and evaluated... more ABSTRACT A series of novel condensed 2-fluoromethylpyrimidines has been synthesized and evaluated for antihyperlipidemic activity in high fat diet fed hyperlipidemic Sprague–Dawley rats. The aim of this study was to investigate the effect of the fluorine atom at the 2-methyl position of these compounds. Most of the synthesized compounds significantly affected the lipid profile of the test animals. Compound IIIb exhibited remarkably best effects in lowering the serum cholesterol and triglyceride levels and elevating the serum HDL levels, of the test animals. Graphical abstract A series of novel condensed 2-fluoromethylpyrimidines was synthesized and evaluated for antihyperlipidemic activity in hyperlipidemic Spargue–Dawley rats. All compounds, especially IIIb, significantly affected the lipid profile of test animals.
ABSTRACT A series of novel condensed 2-fluoromethylpyrimidines has been synthesized and evaluated... more ABSTRACT A series of novel condensed 2-fluoromethylpyrimidines has been synthesized and evaluated for antihyperlipidemic activity in high fat diet fed hyperlipidemic Sprague–Dawley rats. The aim of this study was to investigate the effect of the fluorine atom at the 2-methyl position of these compounds. Most of the synthesized compounds significantly affected the lipid profile of the test animals. Compound IIIb exhibited remarkably best effects in lowering the serum cholesterol and triglyceride levels and elevating the serum HDL levels, of the test animals. Graphical abstract A series of novel condensed 2-fluoromethylpyrimidines was synthesized and evaluated for antihyperlipidemic activity in hyperlipidemic Spargue–Dawley rats. All compounds, especially IIIb, significantly affected the lipid profile of test animals.
The harmful and hazardous use of alcohol is a serious problem in the world. It results in serious... more The harmful and hazardous use of alcohol is a serious problem in the world. It results in serious health, social and economic harms, and is the third-leading risk factor for death and disability. The primary goal of ayurvedic medicine is to help people live long, healthy and balanced lifewith lesser side effects and higher efficacy. The present study evaluated the effect of ethanolic extract of Clitoria ternatea in ethanol withdrawal induced depression. Ethanol dependence was produced in mice to ethanol withdrawal signs; mice were individually housed in small cages and provided a nutritionally balanced control liquid diet on day 0 as their sole nutrient source (600 kcal/l). From day 1 to day 4, ethanol (1.8% v/v) was incorporated in to the liquid diet, followed by 3.6% v/v of ethanol (from day 5 to 7) and 6.3% v/v of ethanol (from day 8 to10). On day 11, at 8.00 h, ethanol liquid diet was replaced with nutritionally balanced control liquid. Clitoria ternatea extracts (100,200 and 40...
ABSTRACT A series of novel condensed 2-fluoromethylpyrimidines has been synthesized and evaluated... more ABSTRACT A series of novel condensed 2-fluoromethylpyrimidines has been synthesized and evaluated for antihyperlipidemic activity in high fat diet fed hyperlipidemic Sprague–Dawley rats. The aim of this study was to investigate the effect of the fluorine atom at the 2-methyl position of these compounds. Most of the synthesized compounds significantly affected the lipid profile of the test animals. Compound IIIb exhibited remarkably best effects in lowering the serum cholesterol and triglyceride levels and elevating the serum HDL levels, of the test animals. Graphical abstract A series of novel condensed 2-fluoromethylpyrimidines was synthesized and evaluated for antihyperlipidemic activity in hyperlipidemic Spargue–Dawley rats. All compounds, especially IIIb, significantly affected the lipid profile of test animals.
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