The clinical and laboratory findings of subacute thyroiditis have been repeatedly reported as bei... more The clinical and laboratory findings of subacute thyroiditis have been repeatedly reported as being associated with acute Sars-Cov-2 infection and post-COVID-19 syndrome. The exact mechanisms and histopathological correlations underlying thyroid involvement remained unresolved, but current insights suggest either direct viral damage, systemic inflammatory reaction, or an autoimmune response as possible noxious effectors. Here we present findings of immunohistochemical/immunofluorescence detection of Sars-Cov-2 viral proteins (spike/S and nucleocapside proteins) in relation to histoarchitectonic changes of autoptic thyroid tissue obtained from patient who deceased from COVID-19.
Mounting evidence indicates that new arrhythmic events frequently occur during and after coronavi... more Mounting evidence indicates that new arrhythmic events frequently occur during and after coronavirus disease (COVID-19), posing additional mortality risk in older-aged and critically ill patients. However, the underlying mechanisms and cardio pathological substrates of COVID-related arrhythmias have not been clarified yet. Here, we report findings of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens and genes in the atrioventricular node (AV-node) of a cardiac conduction system, pointing to its direct infection as a possible arrhythmogenic factor.
With the increasing incidence of obesity and metabolic syndrome the incidence of nonalcoholic fat... more With the increasing incidence of obesity and metabolic syndrome the incidence of nonalcoholic fatty liver disease (NAFLD) is increasing as well. These patients have a significant risk of progression to the end-stage liver disease, but also these patients are at increased risk of developing hepatocellular carcinoma. In recent years there is a growing number of publications that support the idea that NAFLD is not just a disease that is limited to the liver, but is associated with a number of extrahepatic manifestations. For example, NAFLD increases the risk of type 2 diabetes mellitus, cardiovascular diseases and chronic kidney disease. Consequently NAFLD has become a growing public health problem. A number of sub-specialists as well as primary care physicians should be aware of these potential extrahepatic associations, given the availability of numerous methods for screening in clinical practice. The above approach is important in order to recognize potentially modifiable events i...
Objectives An increase in the prevalence of carbapenem resistant A.baumannii was observed in Gene... more Objectives An increase in the prevalence of carbapenem resistant A.baumannii was observed in General Hospital (GH) in Pula. Three clones of A. baumannii based on routine antimicrobial susceptibility testing were observed: one cluster susceptible, the second intermediate susceptibile and the third resistant to carbapenems. Methods In total 60 A. baumannii strains were analyzed: 9 strains susceptible to carbapenems, 14 intermediate susceptibile and 27 strains resistant to carbapenems. The isolates were collected from June 2013 till June 2014. Antimicrobial susceptibility testing was performed by broth microdilution method. PCR was used to detect genes encoding carbapenemases of group A, B (MBL-metallo-β-lactamases) and D (CHDL) and extended-spectrum β-lactamases (ESBL). Epidemiologic typing was performed by determination of sequence groups (SG). Results The first group of strains susceptible to carbapenems (9 strains) showed resistance cefotaxime and ceftriaxone. All strains were susc...
Prikazom smrti do koje se dolazi utapanjem, cestom nesrecom u cijoj je podlozi asfiksija, pružamo... more Prikazom smrti do koje se dolazi utapanjem, cestom nesrecom u cijoj je podlozi asfiksija, pružamo jedinstven pogled na noviju literaturu, te se n
Although drowning in rainwater tanks is a generally rare phenomenon, this method for suicide has ... more Although drowning in rainwater tanks is a generally rare phenomenon, this method for suicide has been observed in parts of Croatia. Review of autopsy records at the University of Rijeka, Croatia, was undertaken from 1987 to 2016 to examine this phenomenon. Of 469 drowning deaths, there were 35 suicides in rainwater tanks (7.5%). Overall drowning deaths showed no temporal trends. In contrast, suicidal drownings in rain water tanks showed a marked decline over the years, with 15 cases in 1987-1991, seven in 1992-1996, six in 1997-2001, six in 2002-2006, one in 2007-2011, and none in 2012-2016. Thus, suicidal drowning cases as a percentage of overall drownings dropped from 18% to zero (p<0.001). This study reports a very unusual method of suicide that may have occurred because of the ready availability of large water reservoirs in homes. The recent fall in numbers may relate to less reliance on domestic reservoirs of water.
Journal of global antimicrobial resistance, Jan 19, 2017
During routine diagnostic laboratory work, the clinical microbiologist observed an increase of Ac... more During routine diagnostic laboratory work, the clinical microbiologist observed an increase of Acinetobacter baumannii isolates with three different carbapenem susceptibility patterns: susceptible, intermediate and resistant. Isolates belonging to the same carbapenem susceptibility phenotype exhibited identical susceptibility/resistance patterns to non-β-lactam antibiotics. This prompted us to analyse the mechanisms of carbapenem-resistance and the molecular epidemiology of the isolates. A total of 59 A. baumannii isolates were analysed and grouped according to their susceptibility to imipenem: group 1 were susceptible (N=24), group 2 were intermediate (N=8) and group 3 were resistant (N=27) to imipenem. PCR and sequencing was used to detect resistance genes. Genotyping of the isolates was performed by PFGE and MLST. Out of 27 resistant isolates, 20 harboured blaOXA-40-like and 7 blaOXA-23-like genes. ISAba1 was found upstream of blaOXA-51 and blaOXA-23 genes. PFGE genotyping demons...
Although drowning in rainwater tanks is a generally rare phenomenon, this method for suicide has ... more Although drowning in rainwater tanks is a generally rare phenomenon, this method for suicide has been observed in parts of Croatia. Review of autopsy records at the University of Rijeka, Croatia, was undertaken from 1987 to 2016 to examine this phenomenon. Of 469 drowning deaths, there were 35 suicides in rainwater tanks (7.5%). Overall drowning deaths showed no temporal trends. In contrast, suicidal drownings in rain water tanks showed a marked decline over the years, with 15 cases in 1987-1991, seven in 1992-1996, six in 1997-2001, six in 2002-2006, one in 2007-2011, and none in 2012-2016. Thus, suicidal drowning cases as a percentage of overall drownings dropped from 18% to zero (p<0.001). This study reports a very unusual method of suicide that may have occurred because of the ready availability of large water reservoirs in homes. The recent fall in numbers may relate to less reliance on domestic reservoirs of water.
The clinical and laboratory findings of subacute thyroiditis have been repeatedly reported as bei... more The clinical and laboratory findings of subacute thyroiditis have been repeatedly reported as being associated with acute Sars-Cov-2 infection and post-COVID-19 syndrome. The exact mechanisms and histopathological correlations underlying thyroid involvement remained unresolved, but current insights suggest either direct viral damage, systemic inflammatory reaction, or an autoimmune response as possible noxious effectors. Here we present findings of immunohistochemical/immunofluorescence detection of Sars-Cov-2 viral proteins (spike/S and nucleocapside proteins) in relation to histoarchitectonic changes of autoptic thyroid tissue obtained from patient who deceased from COVID-19.
Mounting evidence indicates that new arrhythmic events frequently occur during and after coronavi... more Mounting evidence indicates that new arrhythmic events frequently occur during and after coronavirus disease (COVID-19), posing additional mortality risk in older-aged and critically ill patients. However, the underlying mechanisms and cardio pathological substrates of COVID-related arrhythmias have not been clarified yet. Here, we report findings of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens and genes in the atrioventricular node (AV-node) of a cardiac conduction system, pointing to its direct infection as a possible arrhythmogenic factor.
With the increasing incidence of obesity and metabolic syndrome the incidence of nonalcoholic fat... more With the increasing incidence of obesity and metabolic syndrome the incidence of nonalcoholic fatty liver disease (NAFLD) is increasing as well. These patients have a significant risk of progression to the end-stage liver disease, but also these patients are at increased risk of developing hepatocellular carcinoma. In recent years there is a growing number of publications that support the idea that NAFLD is not just a disease that is limited to the liver, but is associated with a number of extrahepatic manifestations. For example, NAFLD increases the risk of type 2 diabetes mellitus, cardiovascular diseases and chronic kidney disease. Consequently NAFLD has become a growing public health problem. A number of sub-specialists as well as primary care physicians should be aware of these potential extrahepatic associations, given the availability of numerous methods for screening in clinical practice. The above approach is important in order to recognize potentially modifiable events i...
Objectives An increase in the prevalence of carbapenem resistant A.baumannii was observed in Gene... more Objectives An increase in the prevalence of carbapenem resistant A.baumannii was observed in General Hospital (GH) in Pula. Three clones of A. baumannii based on routine antimicrobial susceptibility testing were observed: one cluster susceptible, the second intermediate susceptibile and the third resistant to carbapenems. Methods In total 60 A. baumannii strains were analyzed: 9 strains susceptible to carbapenems, 14 intermediate susceptibile and 27 strains resistant to carbapenems. The isolates were collected from June 2013 till June 2014. Antimicrobial susceptibility testing was performed by broth microdilution method. PCR was used to detect genes encoding carbapenemases of group A, B (MBL-metallo-β-lactamases) and D (CHDL) and extended-spectrum β-lactamases (ESBL). Epidemiologic typing was performed by determination of sequence groups (SG). Results The first group of strains susceptible to carbapenems (9 strains) showed resistance cefotaxime and ceftriaxone. All strains were susc...
Prikazom smrti do koje se dolazi utapanjem, cestom nesrecom u cijoj je podlozi asfiksija, pružamo... more Prikazom smrti do koje se dolazi utapanjem, cestom nesrecom u cijoj je podlozi asfiksija, pružamo jedinstven pogled na noviju literaturu, te se n
Although drowning in rainwater tanks is a generally rare phenomenon, this method for suicide has ... more Although drowning in rainwater tanks is a generally rare phenomenon, this method for suicide has been observed in parts of Croatia. Review of autopsy records at the University of Rijeka, Croatia, was undertaken from 1987 to 2016 to examine this phenomenon. Of 469 drowning deaths, there were 35 suicides in rainwater tanks (7.5%). Overall drowning deaths showed no temporal trends. In contrast, suicidal drownings in rain water tanks showed a marked decline over the years, with 15 cases in 1987-1991, seven in 1992-1996, six in 1997-2001, six in 2002-2006, one in 2007-2011, and none in 2012-2016. Thus, suicidal drowning cases as a percentage of overall drownings dropped from 18% to zero (p<0.001). This study reports a very unusual method of suicide that may have occurred because of the ready availability of large water reservoirs in homes. The recent fall in numbers may relate to less reliance on domestic reservoirs of water.
Journal of global antimicrobial resistance, Jan 19, 2017
During routine diagnostic laboratory work, the clinical microbiologist observed an increase of Ac... more During routine diagnostic laboratory work, the clinical microbiologist observed an increase of Acinetobacter baumannii isolates with three different carbapenem susceptibility patterns: susceptible, intermediate and resistant. Isolates belonging to the same carbapenem susceptibility phenotype exhibited identical susceptibility/resistance patterns to non-β-lactam antibiotics. This prompted us to analyse the mechanisms of carbapenem-resistance and the molecular epidemiology of the isolates. A total of 59 A. baumannii isolates were analysed and grouped according to their susceptibility to imipenem: group 1 were susceptible (N=24), group 2 were intermediate (N=8) and group 3 were resistant (N=27) to imipenem. PCR and sequencing was used to detect resistance genes. Genotyping of the isolates was performed by PFGE and MLST. Out of 27 resistant isolates, 20 harboured blaOXA-40-like and 7 blaOXA-23-like genes. ISAba1 was found upstream of blaOXA-51 and blaOXA-23 genes. PFGE genotyping demons...
Although drowning in rainwater tanks is a generally rare phenomenon, this method for suicide has ... more Although drowning in rainwater tanks is a generally rare phenomenon, this method for suicide has been observed in parts of Croatia. Review of autopsy records at the University of Rijeka, Croatia, was undertaken from 1987 to 2016 to examine this phenomenon. Of 469 drowning deaths, there were 35 suicides in rainwater tanks (7.5%). Overall drowning deaths showed no temporal trends. In contrast, suicidal drownings in rain water tanks showed a marked decline over the years, with 15 cases in 1987-1991, seven in 1992-1996, six in 1997-2001, six in 2002-2006, one in 2007-2011, and none in 2012-2016. Thus, suicidal drowning cases as a percentage of overall drownings dropped from 18% to zero (p<0.001). This study reports a very unusual method of suicide that may have occurred because of the ready availability of large water reservoirs in homes. The recent fall in numbers may relate to less reliance on domestic reservoirs of water.
Uploads
Papers by Antun Ferenčić