Best Practice & Research in Clinical Obstetrics & Gynaecology, Nov 1, 2016
During the last decades, a substantial body of research has focused on the role of the two major ... more During the last decades, a substantial body of research has focused on the role of the two major inositol (Ins) stereoisomers, myoinositol (myoIns) and D-chiroinositol (D-chiroIns), both second messengers of insulin, in insulin-dependent processes, including polycystic ovary syndrome (PCOS). MyoIns has been shown to affect different pathways at both ovarian and non-ovarian level. On the contrary, D-chiroIns alone is unable to exert significant improvements in the ovarian cell functions, as its beneficial effects are mainly limited to the non-ovarian tissue in which it may significantly inhibit the negative cellular consequences of hyperinsulinemia. However, both Ins isomers can be positively associated in the management of PCOS patients in a ratio corresponding to their physiological plasma ratio (40:1). This appears to exert a synergistic effect according to a multi-targeted design. In this respect, new fundamental insights into the biological mechanisms displayed by Ins, as well as clinical trials based on the myoIns + D-chiroIns formulations, have already provided encouraging results.
Sarcoma of the breast is a rare and heterogeneous lesion. We describe a case of a patient surgica... more Sarcoma of the breast is a rare and heterogeneous lesion. We describe a case of a patient surgically treated for a breast lesion during pregnancy. The lesion resulted in a concentric neoplasia with the histological features of high grade sarcoma growing in a phyllodes tumor which was at the time grown in a fibroadenoma. Key words: Breast sarcoma, Non-epithelial breast tumour, Phillode, Pregnancy.
Inositol is a physiological compound belonging to the sugar family. The two inositol stereoisomer... more Inositol is a physiological compound belonging to the sugar family. The two inositol stereoisomers, myo-inositol and D-chiroinositol are the two main stereisomers present in our body. Myo-inositol is the precursor of inositol triphosphate, a second messenger regulating many hormones such as TSH, FSH and insulin. D-chiroinositol is synthetized by an insulin dependent epimerase that converts myo-inositol into D-chiro-inositol. Polycistic Ovary Syndrome (PCOS) is a metabolic and hormonal disorder and a common cause of infertility. Insulin resistance and the consequent hyperinsulinaemia contribute to hyperandrogenism development, typical marker of PCOS. In these patients myo and/or D-chiro-inositol administration improves insulin sensivity while only myo-inositol is a quality marker for oocytes evaluation. Myo-inositol produces second messengers for FSH and glucose uptake, while D-chiroinositol provides second messengers promoting glucose uptake and glycogen synthesis. The physiological ratio of these two isomers is 40:1 (MI/DCI) and seems to be an optimal approach for the treatment of PCOS disorders.
Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia, Nov 1, 2008
Space exploration obliges man to confront a hostile environment of cosmic radiation, microgravity... more Space exploration obliges man to confront a hostile environment of cosmic radiation, microgravity, and magnetic field changes. Although the people who will go to Mars have been born, many new discoveries will be needed and new disciplines will have to be created before they can actually go there. All of this will have a tremendous impact on our health technology. For one thing, universities will work together with enterprises, creating a new way to carry out research. Space exploration has already generated new insight into osteoporosis, muscle atrophy, and motor coordination disorders. Space research has produced a long list of utilities including bone fixation devices and wheelchairs. Over the next 5 to 7 years, in the International Space Station many programs ranging from molecular biology to direct observation of human subjects will be developed. This will mean that, while awaiting the first expedition to Mars (which will take place after 2080), the collaboration of scientists with small and medium enterprises will continue to produce useful devices for people on earth.
Best Practice & Research in Clinical Obstetrics & Gynaecology, Nov 1, 2016
During the last decades, a substantial body of research has focused on the role of the two major ... more During the last decades, a substantial body of research has focused on the role of the two major inositol (Ins) stereoisomers, myoinositol (myoIns) and D-chiroinositol (D-chiroIns), both second messengers of insulin, in insulin-dependent processes, including polycystic ovary syndrome (PCOS). MyoIns has been shown to affect different pathways at both ovarian and non-ovarian level. On the contrary, D-chiroIns alone is unable to exert significant improvements in the ovarian cell functions, as its beneficial effects are mainly limited to the non-ovarian tissue in which it may significantly inhibit the negative cellular consequences of hyperinsulinemia. However, both Ins isomers can be positively associated in the management of PCOS patients in a ratio corresponding to their physiological plasma ratio (40:1). This appears to exert a synergistic effect according to a multi-targeted design. In this respect, new fundamental insights into the biological mechanisms displayed by Ins, as well as clinical trials based on the myoIns + D-chiroIns formulations, have already provided encouraging results.
Sarcoma of the breast is a rare and heterogeneous lesion. We describe a case of a patient surgica... more Sarcoma of the breast is a rare and heterogeneous lesion. We describe a case of a patient surgically treated for a breast lesion during pregnancy. The lesion resulted in a concentric neoplasia with the histological features of high grade sarcoma growing in a phyllodes tumor which was at the time grown in a fibroadenoma. Key words: Breast sarcoma, Non-epithelial breast tumour, Phillode, Pregnancy.
Inositol is a physiological compound belonging to the sugar family. The two inositol stereoisomer... more Inositol is a physiological compound belonging to the sugar family. The two inositol stereoisomers, myo-inositol and D-chiroinositol are the two main stereisomers present in our body. Myo-inositol is the precursor of inositol triphosphate, a second messenger regulating many hormones such as TSH, FSH and insulin. D-chiroinositol is synthetized by an insulin dependent epimerase that converts myo-inositol into D-chiro-inositol. Polycistic Ovary Syndrome (PCOS) is a metabolic and hormonal disorder and a common cause of infertility. Insulin resistance and the consequent hyperinsulinaemia contribute to hyperandrogenism development, typical marker of PCOS. In these patients myo and/or D-chiro-inositol administration improves insulin sensivity while only myo-inositol is a quality marker for oocytes evaluation. Myo-inositol produces second messengers for FSH and glucose uptake, while D-chiroinositol provides second messengers promoting glucose uptake and glycogen synthesis. The physiological ratio of these two isomers is 40:1 (MI/DCI) and seems to be an optimal approach for the treatment of PCOS disorders.
Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia, Nov 1, 2008
Space exploration obliges man to confront a hostile environment of cosmic radiation, microgravity... more Space exploration obliges man to confront a hostile environment of cosmic radiation, microgravity, and magnetic field changes. Although the people who will go to Mars have been born, many new discoveries will be needed and new disciplines will have to be created before they can actually go there. All of this will have a tremendous impact on our health technology. For one thing, universities will work together with enterprises, creating a new way to carry out research. Space exploration has already generated new insight into osteoporosis, muscle atrophy, and motor coordination disorders. Space research has produced a long list of utilities including bone fixation devices and wheelchairs. Over the next 5 to 7 years, in the International Space Station many programs ranging from molecular biology to direct observation of human subjects will be developed. This will mean that, while awaiting the first expedition to Mars (which will take place after 2080), the collaboration of scientists with small and medium enterprises will continue to produce useful devices for people on earth.
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