A novel nano-magnetite supported N-heterocyclic carbene-gold complex with pendant ferrocenyl grou... more A novel nano-magnetite supported N-heterocyclic carbene-gold complex with pendant ferrocenyl group has been prepared by using a multi-step procedure. The complex displayed significantly higher anticancer activity against the MCF-7 breast cancer cell line with IC50 = 32.38 µg/mL as compared with standard drug 5-fluorouracil (IC50 = 25.29 µg/mL) in the MTT assay. The in-ovo antiangiogenic activity of the complex using chicken chorioallantoic membrane assay showed significant decrease in secondary blood vessels indicating that it is efficient angiogenesis inhibitor. The hyperthermia studies of the complex revealed a significant specific absorption rate (SAR) value of 246.974 Wg-1 with therapeutic temperature of 46.8 oC.
Two new series of structurally diverse ferrocene tethered pyrimidobenzothiazoles and pyrimidobenz... more Two new series of structurally diverse ferrocene tethered pyrimidobenzothiazoles and pyrimidobenzimidazoles were rationally designed, synthesized and evaluated for their in vitro anticancer activity against human breast cancer cell lines. Among the synthesized series, five molecules displayed significantly higher anticancer activity against breast carcinoma MCF-7 and MDA-MB-231 cell lines (GI50 0.018–0.022 µM) as compared to the standard drug doxorubicin (GI50 0.018 µM). Furthermore, most of the synthesized compounds were found to exhibit significant antioxidant activity in DPPH, SOD and FRAP assays as compared to standard ascorbic acid and trolox. Moreover, some of the compounds were found to be potent anti-angiogenic agents with angiogenic score ranging 0.8–1.4 in in-ovo chick allantoic membrane (CAM) assay. The in-silico molecular docking analysis ascertained the mode of action of target compounds via inhibition of heat shock protein90 (Hsp90).
Launea procumbens commonly known as Pathari belonging to family asteraceae has been investigated ... more Launea procumbens commonly known as Pathari belonging to family asteraceae has been investigated for its anti-urolithiatic activity by constructing an in-vitro model. Various crude extracts of Launea procumbens were evaluated for their potential to dissolve experimentally prepared kidney stones of Calcium oxalate,Calcium phosphate and the results were compared with cystone as a standard polyherbal drug. The detailed phytochemical screening was done to identify active phytoconstituents and photo-micrography was carried out to understand dissolution of stones by extracts.Chloroform ,alcoholic and acetone fractions of plant leaves showed highest dissolution of Calcium oxalate stones as compare to others (63,49,40% resp.) while ethyl acetate, pet ether, acetone fractions of plant leaves were more effective in dissolving Calcium Phosphate (80,30,25% resp.) compared to reference standard-formulation Cystone.
Augmented reality is a technology which can formulate interactive learning environment and foster... more Augmented reality is a technology which can formulate interactive learning environment and foster intellectual curiosity of the students. This study has targeted ‘‘the NMR spectroscopy of hydrocarbons’’ segment of senior college level chemistry classes and, it involved the design and development of a set of Augmented Reality learning tools. Students could control and interact with virtual images using markers and conduct a series of experiments. The AR tool was tested in practice at a senior college in Sangola, Maharashtra, India. Through data analysis and discussion, we conclude that the AR tool has a significant supplemental learning effect as a computer-assisted learning tool and students have positive attitudes toward this software.
The flavonoids present in the tea are known to exhibit anticarcinogenic, antimicrobial, antiviral... more The flavonoids present in the tea are known to exhibit anticarcinogenic, antimicrobial, antiviral, antiarteriosclerosis, antihypertensive, antidiabetic, anti-inflammatory and antidiuretic activities and thus they are therapeutically important class of compounds. Therefore it is necessary to find out levels of bioactive compounds in various tea samples. In the present investigation six commercial varieties including black and green tea from Indian market were analyzed for their total flavonoid content using uv-visible spectrophotometer. The total amounts of flavonoid were determined by aluminium chloride method with some modifications and the total flavonoids were expressed as mg/g of quercetin equivalents. The results shown that all tea samples tested found to contain comparable high total flavonoids as rich sources of bioactive compounds and it justifies their use for human health benefits.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Potentially antibreast cancer enamidines were synthesized and evaluated against human breast canc... more Potentially antibreast cancer enamidines were synthesized and evaluated against human breast cancer cell line MCF7 displaying GI50values lower than doxorubicin.
A novel nano-magnetite supported N-heterocyclic carbene-gold complex with pendant ferrocenyl grou... more A novel nano-magnetite supported N-heterocyclic carbene-gold complex with pendant ferrocenyl group has been prepared by using a multi-step procedure. The complex displayed significantly higher anticancer activity against the MCF-7 breast cancer cell line with IC50 = 32.38 µg/mL as compared with standard drug 5-fluorouracil (IC50 = 25.29 µg/mL) in the MTT assay. The in-ovo antiangiogenic activity of the complex using chicken chorioallantoic membrane assay showed significant decrease in secondary blood vessels indicating that it is efficient angiogenesis inhibitor. The hyperthermia studies of the complex revealed a significant specific absorption rate (SAR) value of 246.974 Wg-1 with therapeutic temperature of 46.8 oC.
Two new series of structurally diverse ferrocene tethered pyrimidobenzothiazoles and pyrimidobenz... more Two new series of structurally diverse ferrocene tethered pyrimidobenzothiazoles and pyrimidobenzimidazoles were rationally designed, synthesized and evaluated for their in vitro anticancer activity against human breast cancer cell lines. Among the synthesized series, five molecules displayed significantly higher anticancer activity against breast carcinoma MCF-7 and MDA-MB-231 cell lines (GI50 0.018–0.022 µM) as compared to the standard drug doxorubicin (GI50 0.018 µM). Furthermore, most of the synthesized compounds were found to exhibit significant antioxidant activity in DPPH, SOD and FRAP assays as compared to standard ascorbic acid and trolox. Moreover, some of the compounds were found to be potent anti-angiogenic agents with angiogenic score ranging 0.8–1.4 in in-ovo chick allantoic membrane (CAM) assay. The in-silico molecular docking analysis ascertained the mode of action of target compounds via inhibition of heat shock protein90 (Hsp90).
Launea procumbens commonly known as Pathari belonging to family asteraceae has been investigated ... more Launea procumbens commonly known as Pathari belonging to family asteraceae has been investigated for its anti-urolithiatic activity by constructing an in-vitro model. Various crude extracts of Launea procumbens were evaluated for their potential to dissolve experimentally prepared kidney stones of Calcium oxalate,Calcium phosphate and the results were compared with cystone as a standard polyherbal drug. The detailed phytochemical screening was done to identify active phytoconstituents and photo-micrography was carried out to understand dissolution of stones by extracts.Chloroform ,alcoholic and acetone fractions of plant leaves showed highest dissolution of Calcium oxalate stones as compare to others (63,49,40% resp.) while ethyl acetate, pet ether, acetone fractions of plant leaves were more effective in dissolving Calcium Phosphate (80,30,25% resp.) compared to reference standard-formulation Cystone.
Augmented reality is a technology which can formulate interactive learning environment and foster... more Augmented reality is a technology which can formulate interactive learning environment and foster intellectual curiosity of the students. This study has targeted ‘‘the NMR spectroscopy of hydrocarbons’’ segment of senior college level chemistry classes and, it involved the design and development of a set of Augmented Reality learning tools. Students could control and interact with virtual images using markers and conduct a series of experiments. The AR tool was tested in practice at a senior college in Sangola, Maharashtra, India. Through data analysis and discussion, we conclude that the AR tool has a significant supplemental learning effect as a computer-assisted learning tool and students have positive attitudes toward this software.
The flavonoids present in the tea are known to exhibit anticarcinogenic, antimicrobial, antiviral... more The flavonoids present in the tea are known to exhibit anticarcinogenic, antimicrobial, antiviral, antiarteriosclerosis, antihypertensive, antidiabetic, anti-inflammatory and antidiuretic activities and thus they are therapeutically important class of compounds. Therefore it is necessary to find out levels of bioactive compounds in various tea samples. In the present investigation six commercial varieties including black and green tea from Indian market were analyzed for their total flavonoid content using uv-visible spectrophotometer. The total amounts of flavonoid were determined by aluminium chloride method with some modifications and the total flavonoids were expressed as mg/g of quercetin equivalents. The results shown that all tea samples tested found to contain comparable high total flavonoids as rich sources of bioactive compounds and it justifies their use for human health benefits.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Potentially antibreast cancer enamidines were synthesized and evaluated against human breast canc... more Potentially antibreast cancer enamidines were synthesized and evaluated against human breast cancer cell line MCF7 displaying GI50values lower than doxorubicin.
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